Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice.

abstract：:Integrins may play important roles in many cellular events, such as cell proliferation, differentiation, and apoptosis. We showed previously that overexpression of integrin beta1 inhibits cell proliferation in SMMC-7721 cells. Here we reported that one of the cyclin-dependent kinase (CDK) inhibitors, p27(Kip1) was inv...

journal_title：Journal of cellular biochemistry

authors： Fu Y,Fang Z,Liang Y,Zhu X,Prins P,Li Z,Wang L,Sun L,Jin J,Yang Y,Zha X

更新日期：2007-10-15 00:00:00

abstract：OBJECTIVES:Collagen is a core protein that maintains the homeostasis of the extracellular matrix (ECM), and its dysregulation in human cancers has attracted increasing attention. In tumors, increased lysyl oxidase (LOX)-catalyzed collagen cross-linking plays a critical role in collagen dysregulation. However, the expre...

journal_title：Journal of cellular biochemistry

authors： Yu M,Shen W,Shi X,Wang Q,Zhu L,Xu X,Yu J,Liu L

更新日期：2019-09-01 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) 2 is a carboxypeptidase that shares 42% amino acid homology with ACE. Little is known about the regulation or pattern of expression of ACE2 in the mouse lung, including its definitive cellular distribution or developmental changes. Based on Northern blot and RT-PCR data, we report t...

journal_title：Journal of cellular biochemistry

authors： Wiener RS,Cao YX,Hinds A,Ramirez MI,Williams MC

更新日期：2007-08-01 00:00:00

abstract：:HepG2 is an immortalized human hepatoma cell line that has been used for research into bioartificial liver systems. However, a low level of ammonia detoxification is its biggest drawback. In this work, a recombinant HepG2 cell line with stable overexpression of human arginase I (hArgI) and human ornithine transcarbamy...

journal_title：Journal of cellular biochemistry

authors： Tang N,Wang Y,Wang X,Zhou L,Zhang F,Li X,Chen Y

更新日期：2012-02-01 00:00:00

abstract：:Osteoporosis (OP) is a multifactorial and common bone disease worldwide. The clinical diagnosis and treatment of osteoporosis has limitations since changes in bone density occur slightly. Thus, it is critically needed to look for new biomarkers to identify and cure osteoporosis. CircRNAs are important molecular regula...

journal_title：Journal of cellular biochemistry

authors： Huang Y,Xie J,Li E

更新日期：2019-09-01 00:00:00

abstract：:We recently demonstrated the activation of extracellular signal- regulated protein kinase 1 and 2 (ERK1 and ERK2) by IGF-1, FGF-2, and PDGF-BB in normal human osteoblastic (HOB) cells as well as in rat and mouse osteoblastic cells. In this report, we have examined whether c-Jun NH2-Terminal Kinase (JNK) pathway is act...

journal_title：Journal of cellular biochemistry

authors： Chaudhary LR,Avioli LV

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:MIAT may be implicated in the pathogenesis of age-related hearing loss (AHL). This study aimed to clarify the effect of a MIAT signaling pathway on the risk of AHL. METHODS:Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, auditory brainstem response (ABR) and quantitative hair cell counts...

journal_title：Journal of cellular biochemistry

authors： Hao S,Wang L,Zhao K,Zhu X,Ye F

更新日期：2019-04-01 00:00:00

abstract：:The effects of a ligand regulated neu tyrosine kinase were examined in NIH 3T3 cells. A chimeric construct encoding the human EGF receptor extracellular domain fused to the tyrosine kinase domain of the rat neu cDNA was expressed under the transcriptional control of the Moloney murine leukemia virus LTR promoter. This...

journal_title：Journal of cellular biochemistry

authors： Lehväslaiho H,Sistonen L,diRenzo F,Partanen J,Comoglio P,Hölttä E,Alitalo K

更新日期：1990-03-01 00:00:00

abstract：:Preserving self-renewal, multipotent capacity, and large-scale expansion of highly functional progenitor cells, including endothelial progenitor cells (EPCs), is a controversial issue. These current limitations, therefore, raise the need of developing promising in vitro conditions for prolonged expansion of EPCs witho...

journal_title：Journal of cellular biochemistry

authors： Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R

更新日期：2016-08-01 00:00:00

abstract：:Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short- and long-term repopulating stem cells when compared to more mature bone marrow...

journal_title：Journal of cellular biochemistry

authors： Krivtsov AV,Rozov FN,Zinovyeva MV,Hendrikx PJ,Jiang Y,Visser JW,Belyavsky AV

更新日期：2007-06-01 00:00:00

abstract：:Macromolecules are sulfated during the vegetative growth of Dictyostelium discoideum. A characterisation of the structures of sulfated oligosaccharides associated with these macromolecules indicates that the oligosaccharides are heterogeneous. Endoglycosidase and pronase digestion were used with gel-filtration chromat...

journal_title：Journal of cellular biochemistry

authors： Davis SJ

更新日期：1988-10-01 00:00:00

abstract：:Phospholipase C-gamma1 (PLCgamma1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5-inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCgamma1 in PLCgamma1-mediated cell signaling, we characterized some protei...

journal_title：Journal of cellular biochemistry

authors： Bae JY,Ahn SJ,Lee JE,Kim JE,Han MR,Han W,Kim SW,Shin HJ,Lee SJ,Park D,Noh DY

更新日期：2005-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a severe disease with high mortality in the world. It has been shown that long noncoding RNA (lncRNA) might play a role in HCC. The aim of the present study was to identify the role of long intergenic noncoding RNA 01551 (LINC01551) in the HCC development and explore the underlying me...

journal_title：Journal of cellular biochemistry

authors： Gao J,Yin X,Yu X,Dai C,Zhou F

更新日期：2019-10-01 00:00:00

abstract：:Prolongation of cell survival through prevention of apoptosis is considered to be a significant factor leading to anabolic responses in bone. The current studies were carried out to determine the role of the small GTPase, RhoA, in osteoblast apoptosis, since RhoA has been found to be critical for cell survival in othe...

journal_title：Journal of cellular biochemistry

authors： Yoshida T,Clark MF,Stern PH

更新日期：2009-04-01 00:00:00

abstract：:Extracellular matrix (ECM) accumulation plays a key role in the progression of bladder outlet obstruction (BOO). Muscarinic receptors have been widely reported to serve as pivotal regulators in lung tissue remodeling. However, the influence of them on human bladder smooth muscle cells (HBSMCs) and the underlying molec...

journal_title：Journal of cellular biochemistry

authors： Chen S,Liao B,Jin X,Wei T,He Q,Lin Y,Ai J,Gong L,Li H,Wang K

更新日期：2020-11-01 00:00:00

abstract：:Extracts of serum-free conditioned medium from human rhabdomyosarcoma A673 cells contain high molecular weight (HMW) transforming growth factors (TGFs) that can be partially purified by Bio-Gel P-100 and carboxymethyl (CM)-cellulose chromatography (Todaro et al: Proc Natl Acad Sci USA 77:5258, 1980). Reverse-phase hig...

journal_title：Journal of cellular biochemistry

authors： Stromberg K,Hudgins WR,Fryling CM,Hazarika P,Dedman JR,Pardue RL,Hargreaves WR,Orth DN

更新日期：1986-01-01 00:00:00

abstract：:Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines h...

journal_title：Journal of cellular biochemistry

authors： Elmas L,Secme M,Mammadov R,Fahrioglu U,Dodurga Y

更新日期：2019-03-01 00:00:00

abstract：:Small for gestational age (SGA) has a high risk of mortality and morbidity and is common in obstetrics. To date, no effective prediction and treatment tools are available. Acting as microRNA (miRNA) sponges and disease biomarkers are clear functions of circular RNAs (circRNAs). However, it is still unknown what role c...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Li SF,Dang YJ,Shi XM,Chen L,Wang N,Cai Y,Zhao YY

更新日期：2020-01-01 00:00:00

abstract：:MicroRNA-205 (miR-205) is involved in various physiological and pathological processes, but its biological function in follicular atresia remains unclear. In this study, we investigated miR-205 expression in mouse granulosa cells (mGCs) and analyzed its functions in primary mGCs by performing a series of in vitro expe...

journal_title：Journal of cellular biochemistry

authors： Zhang P,Wang J,Lang H,Wang W,Liu X,Liu H,Tan C,Li X,Zhao Y,Wu X

更新日期：2018-12-16 00:00:00

abstract：:The lysosomal cysteine protease cathepsin B is implicated in degradation of extracellular matrix (ECM), a crucial step in a variety of physiological and pathological processes, including tumor dissemination and angiogenesis. In this study, we analyzed the contribution of extracellular and intracellular cathepsin B act...

journal_title：Journal of cellular biochemistry

authors： Premzl A,Turk V,Kos J

更新日期：2006-04-15 00:00:00

abstract：:Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced b...

journal_title：Journal of cellular biochemistry

authors： Biswas C

更新日期：1985-01-01 00:00:00

abstract：:The perinucleolar compartment (PNC) is a distinct nuclear body that localizes to the nucleolar periphery. The PNC is predominantly found in cancer cells, and recent evidence suggests that PNC prevalence can be a pan-cancer marker for tumors of solid tissue origin. The PNC is a heritable structure enriched with newly t...

journal_title：Journal of cellular biochemistry

authors： Pollock C,Huang S

更新日期：2009-05-15 00:00:00

abstract：:The retinal pigmented epithelium (RPE) is a monolayer of polarized cells located between retinal photoreceptors and blood vessels of the choroid. The basal surface of RPE cells rests on Bruch's membrane, a complex extracellular matrix structure which becomes abnormal in several disease processes, including age-related...

journal_title：Journal of cellular biochemistry

authors： Mousa SA,Lorelli W,Campochiaro PA

更新日期：1999-07-01 00:00:00

abstract：:Butyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non-small cell lung cancer cell line, using microarray. We found 33 up-regulated microRNAs and 22 down-regulated microRNAs (log2 ≥1.5 f...

journal_title：Journal of cellular biochemistry

authors： Xiao X,Cao Y,Chen H

更新日期：2018-04-01 00:00:00

abstract：:Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably...

journal_title：Journal of cellular biochemistry

authors： Li C,Ke J,Liu J,Su J

更新日期：2020-03-01 00:00:00

abstract：:Insects possess an antimicrobial defense response that is similar to the mammalian innate immune response. The innate immune system is designed to recognize conserved components of microorganisms called pathogen-associated molecular patterns (PAMPs). How host receptors detect PAMPs and transmit the signals to mount th...

journal_title：Journal of cellular biochemistry

authors： Bettencourt R,Asha H,Dearolf C,Ip YT

更新日期：2004-07-01 00:00:00

abstract：:Understanding mechanisms that govern cell fate decisions will lead to developing techniques for induction of adult stem cell differentiation to desired cell outcomes and, thus, production of an autologos source of cells for regenerative medicine. Recently, we demonstrated that stem cells derived from adult central ner...

journal_title：Journal of cellular biochemistry

authors： Alexanian AR

更新日期：2007-02-01 00:00:00

abstract：:The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodi...

journal_title：Journal of cellular biochemistry

authors： Butler JT,Hall LL,Smith KP,Lawrence JB

更新日期：2009-07-01 00:00:00

abstract：:p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein. In addition, p150(glued) also locates in the mother centriole where it organizes the subdistal appendage. The components of appendage are dynamically regulated t...

journal_title：Journal of cellular biochemistry

authors： Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

更新日期：2015-09-01 00:00:00