Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata.

Abstract:

BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lncRNA profiles were obtained by microarray from 10 samples, including five alopecia areata samples and five normal samples. Based on bioinformatics generated from miRcode, starBase, and miRTarBase, we constructed an lncRNA-miRNA-mRNA network (ceRNA network) in alopecia areata. RESULTS:We found 154 differentially expressed lncRNAs and 46 differentially expressed genes (DEGs). The functional enrichment indicated that the DEGs mainly regulated the pathways of focal adhesion, Mucin type O-glycan biosynthesis, and so on. The differentially expressed lncRNA (DElncRNA) involved in the pathway of thyronamine and iodothyronamine metabolism and so on. Through integrated lncRNA-mRNA and miRNA-mRNA pairs, the ceRNA network was constructed, thereafter, six ceRNA subnetworks were identified and subnetwork 1 were found to be significantly associated with the occurrence of alopecia areata. CONCLUSION:Our results showed blood lncRNA expression patterns and a complex ceRNA network in alopecia areata. However, futher studies on blood and tissue verification of these lncRNAs and relative pathways are needed.

journal_name

J Cell Biochem

authors

Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

doi

10.1002/jcb.28365

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

10737-10747

issue

6

eissn

0730-2312

issn

1097-4644

journal_volume

120

pub_type

杂志文章
  • Yak OXGR1 promotes fibroblast proliferation via the PI3K/AKT pathways.

    abstract::Oxoglutarate receptor 1 (OXGR1), as one of the intermediates in G protein-coupled receptors (GPCRs), plays a crucial role in the citric acid cycle receptor of α-ketoglutarate and metabolism. GPCR can control the cell proliferation by regulating the downstream signaling of G protein signaling pathways. The PI3K/AKT pat...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27970

    authors: Wang Q,Zhang Q,Zhang Y,Zhao X

    更新日期:2019-04-01 00:00:00

  • Nuclear membrane cholesterol can modulate nuclear nucleoside triphosphatase activity.

    abstract::Previous work has suggested that changes in nuclear membrane cholesterol may induce a stimulation in nuclear nucleoside triphosphatase (NTPase) activity. The purpose of the present study was to directly investigate if nuclear membrane cholesterol can stimulate nuclear NTPase activity. The cholesterol content of nuclei...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19961215)63:4<442::aid-jcb

    authors: Ramjiawan B,Czubryt MP,Gilchrist JS,Pierce GN

    更新日期:1996-12-15 00:00:00

  • Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling.

    abstract::Previous studies related impaired myocardial microcirculation in diabetes to oxidative stress and endothelial dysfunction. Thus, this study was aimed to determine the effect of up-regulating pAMPK-pAKT signaling on coronary microvascular reactivity in the isolated heart of diabetic mice. We measured coronary resistanc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22486

    authors: Kusmic C,L'abbate A,Sambuceti G,Drummond G,Barsanti C,Matteucci M,Cao J,Piccolomini F,Cheng J,Abraham NG

    更新日期:2010-04-01 00:00:00

  • Oncogene expression in mammary epithelial cells.

    abstract::Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strains: (1) Molecular a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240490205

    authors: Groner B

    更新日期:1992-06-01 00:00:00

  • Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression.

    abstract::Wip1 belongs to the protein phosphatase C (PP2C) family, of which expression is up-regulated by a number of external stresses, and serves as a stress modulator in normal physiological conditions. When overexpressed, premature dephosphorylation of stress-mediators by Wip1 results in abrogation of tumor surveillance, th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25114

    authors: Jeong HC,Gil NY,Lee HS,Cho SJ,Kim K,Chun KH,Cho H,Cha HJ

    更新日期:2015-08-01 00:00:00

  • Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells.

    abstract::Ubiquitin activating enzyme 2 (UBA2) is a basic component of E1-activating enzyme in the SUMOylation system. Expression and function of UBA2 in human cancers are largely unknown. In this study we investigate UBA2 expression the function in human non-small-cell lung cancer. Immunochemistry study showed that UBA2 was ov...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28543

    authors: Jiang B,Fan X,Zhang D,Liu H,Fan C

    更新日期:2019-08-01 00:00:00

  • Proteinase expression during differentiation of human osteoclasts in vitro.

    abstract::Osteoclasts are macrophage-derived polykaryons that degrade bone in an acidic extracellular space. This differentiation includes expression of proteinases and acid transport proteins, cell fusion, and bone attachment, but the sequence of events is unclear. We studied two proteins expressed at high levels only in the o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/1097-4644(20000915)78:4<627::aid-jcb12>3.0

    authors: Blair HC,Sidonio RF,Friedberg RC,Khan NN,Dong SS

    更新日期:2000-06-12 00:00:00

  • Monoclonal antibody recognizing a determinant on type 2 chain blood group A and B oligosaccharides detects oncodevelopmental changes in azoxymethane-induced rat colon tumors and human colon cancer cell lines.

    abstract::Altered expression of ABH blood group substances is a common feature of human colorectal carcinoma, yet it remains unclear how these structural changes influence the biological properties of tumor cells. Azoxymethane-induced rat colon tumors display many features of the human disease, thereby providing a potentially u...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240570111

    authors: Laferté S,Prokopishyn NL,Moyana T,Bird RP

    更新日期:1995-01-01 00:00:00

  • PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus.

    abstract::Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25402

    authors: Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

    更新日期:2016-05-01 00:00:00

  • Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappaB.

    abstract::By Western blot and immunostaining we proved that polyvinylpyrrolidone (PVP)-wrapped fullerene molecules (PVP-fullerene) could combine the 8- and 53-kb proteins which localize in the membrane of human skin keratinocytes HaCaT. Only fullerene molecules are able to cross the lipid membrane and conjugate 53-kb proteins i...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22784

    authors: Xiao L,Aoshima H,Saitoh Y,Miwa N

    更新日期:2010-11-01 00:00:00

  • The skewed frequency of B-cell subpopulation CD19+ CD24 hi CD38 hi cells in peripheral blood mononuclear cells is correlated with the elevated serum sCD40L in patients with active systemic lupus erythematosus.

    abstract::CD19+ CD24hi CD38hi cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19+ CD24hi CD38hi cells. Changes in B-cell subpopulations and CD19+ CD24hi CD38hi cells have been observed in systemic lupus erythematosus (SLE) patients. Whether...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28427

    authors: Wang H,Liu C,Chen W,Ding G

    更新日期:2019-02-16 00:00:00

  • Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation.

    abstract::Lung cancer is the leading cause of death among all cancers. Non-small cell lung cancer accounts for 80% of lung cancer with a 5-year survival rate of 16%. Notch pathway, especially Notch-1 is up-regulated in a subgroup of non-small cell lung cancer patients. Since Notch-1 signaling plays an important role in cell pro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.23184

    authors: Ji X,Wang Z,Geamanu A,Sarkar FH,Gupta SV

    更新日期:2011-10-01 00:00:00

  • Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

    abstract::Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27376

    authors: Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

    更新日期:2018-12-01 00:00:00

  • Investigation of nucleo-cytoplasmic transport using UV-guided microinjection.

    abstract::Active nucleo-cytoplasmic transport is mediated by dynamic signal-mediated pathways. We investigated the effects of transcription inhibitors or fluorescent lectins on nuclear import mediated by nuclear localization signals (NLSs). Therefore, a novel experimental approach that allows the controlled sequential introduct...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/1097-4644(20010301)80:3<388::aid-jcb130>3.

    authors: Stauber RH,Krätzer F,Schneider G,Hirschmann N,Hauber J,Rosorius O

    更新日期:2001-01-01 00:00:00

  • Nuclear matrix protein expressions in hepatocytes of normal and cirrhotic rat livers under normal and regenerating conditions.

    abstract::We explored the feasibility of studying nuclear matrix protein (NMP) expressions of the hepatocytes in normal and cirrhotic rat livers with liver regeneration after partial hepatectomy. Sixteen Wistar healthy rats were studied with experimental liver regeneration and/or liver cirrhosis. Two-dimensional (2-D) gel elect...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20034

    authors: Yun JP,Liew CT,Chew EC,Yin XY,Lai PB,Fai YH,Li HK,Jin ML,Ding MX,Li MT,Lin HL,Lau WY

    更新日期:2004-04-15 00:00:00

  • Leukemia fusion proteins and co-repressor complexes: changing paradigms.

    abstract::Many cases of acute myelogenous leukemia (AML) are characterized by non-random chromosomal translocations that fuse a DNA-binding protein with a transcriptional regulator, which in turn may aberrantly recruit a co-repressor complex. The similarities in this pattern between different AML chimeric fusions have led to a ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.20368

    authors: Redner RL,Liu JM

    更新日期:2005-04-01 00:00:00

  • Delimitation of a DNA sequence which confers inducibility by glucocorticoid hormones.

    abstract::A chimeric long terminal repeat-thymidine kinase (LTR-tk) gene has been used to define the sequence requirements for glucocorticoid induction of gene expression. The original LTR-tk gene contains an entire mouse mammary tumor virus (MMTV) LTR preceding the tk gene. This gene can be expressed in a hormone-responsive fa...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240200405

    authors: Groner B,Herrlich P,Kennedy N,Ponta H,Rahmsdorf U,Hynes NE

    更新日期:1982-01-01 00:00:00

  • Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA.

    abstract::We have constructed a phage lambda library of liver DNA fragments from West African patient who died of liver failure due to advanced hepatocellular carcinoma. Four hepatitis B virus (HBV) DNA-carrying recombinants have been isolated, one clone (lambda IA22) being analyzed in greatest detail. It contains approximately...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240200309

    authors: Dejean A,Carloni G,Bréchot C,Tiollais P,Wain-Hobson S

    更新日期:1982-01-01 00:00:00

  • Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer.

    abstract::Prostate cancer is the second highest caused by cancer-related death among males. microRNAs (miRs) have been reported to participate in carcinogenesis, yet their roles in prostate cancer are rarely studied or investigated. Therefore, the present study attempted to explore the effect of miR-137 in prostate cancer via r...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28306

    authors: Wu QQ,Zheng B,Weng GB,Yang HM,Ren Y,Weng XJ,Zhang SW,Zhu WZ

    更新日期:2019-06-01 00:00:00

  • Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade.

    abstract::4-hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by elucidating the signaling cascad...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21110

    authors: Vaillancourt F,Morquette B,Shi Q,Fahmi H,Lavigne P,Di Battista JA,Fernandes JC,Benderdour M

    更新日期:2007-04-01 00:00:00

  • Antisense imaging: and miles to go before we sleep?

    abstract::Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.10641

    authors: Lewis MR,Jia F

    更新日期:2003-10-15 00:00:00

  • Effect of cell source and osteoblast differentiation on gene expression profiles of mesenchymal stem cells derived from bone marrow or adipose tissue.

    abstract::Mesenchymal stem cells (MSCs) have been used in therapies for bone tissue healing. The aim of this study was to investigate the effect of cell source and osteoblast differentiation on gene expression profiles of MSCs from bone marrow (BM-MSCs) or adipose tissue (AT-MSCs) to contribute for selecting a suitable cell pop...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28463

    authors: Fideles SOM,Ortiz AC,Assis AF,Duarte MJ,Oliveira FS,Passos GA,Beloti MM,Rosa AL

    更新日期:2019-02-11 00:00:00

  • Gene array identification of osteoclast genes: differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor.

    abstract::Treatment of adherent peripheral blood mononuclear cells (PBMCs) with macrophage colony stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) stimulates the formation of multinucleate osteoclast-like cells. Treatment with M-CSF alone results in the formation of macrophage-like cells. Through th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10780

    authors: Day CJ,Kim MS,Stephens SR,Simcock WE,Aitken CJ,Nicholson GC,Morrison NA

    更新日期:2004-02-01 00:00:00

  • Exploring the concentration-dependent actions of interferon-τ on bovine neutrophils to understand the process of implantation.

    abstract::Interferon-τ (IFNT) is a major cytokine produced by the ruminant trophoectoderm during the peri-implantation period exerting immunomodulatory actions on various cells including neutrophils. The current in vitro study was undertaken to analyze the concentration-dependent effects of IFNT on neutrophil gene dynamics to u...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27345

    authors: Manjari P,Hyder I,Kapoor S,Senthilnathan M,Dang AK

    更新日期:2018-12-01 00:00:00

  • Impact of HMG-CoA reductase inhibition on oxidant-induced injury in human retinal pigment epithelium cells.

    abstract::In addition to cholesterol-lowering effect, HMG-CoA reductase inhibition by statins has been shown to have protective effect in many cells type. The loss of vision in retinal degeneration disease associates with oxidative stress and apoptosis in retinal pigment epithelium (RPE) cell. This study was designed to examine...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.23173

    authors: Qian J,Keyes KT,Long B,Chen G,Ye Y

    更新日期:2011-09-01 00:00:00

  • An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells.

    abstract::Undecylenic acid (UDA), a naturally occurring 11-carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Recently, the potential usefulness of UDA as a neuroprotective drug has been suggested based on the ability of this agent to inhibit μ-calpain ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25236

    authors: Jantas D,Piotrowski M,Lason W

    更新日期:2015-12-01 00:00:00

  • Species differences in cis-elements of the proalpha1(I) procollagen promoter and their binding proteins.

    abstract::Previous studies suggest that there may be species differences in the utilization of cis-elements of the type I collagen genes. The present study was designed to examine this possibility by focusing on two regions of the proalpha1(I) collagen promoter. One is the GC-rich A1 region (-194/168) that modulates transcripti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: Peterkofsky B,Gosiewska A,Singh K,Pearlman S,Mahmoodian F

    更新日期:1999-06-01 00:00:00

  • Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases.

    abstract::Hypoxia inducible factor 1α (HIF-1α), an essential transcriptional factor, is negatively regulated by two different types of oxygen and Fe(2+) -dependent HIF hydroxylases, proline hydroxylase (PHD) and factor inhibiting HIF (FIH), under normoxia. Iron chelators have therefore been used for inducing HIF-1α expression b...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24423

    authors: Cho EA,Song HK,Lee SH,Chung BH,Lim HM,Lee MK

    更新日期:2013-04-01 00:00:00

  • Cellular and molecular properties associated with osteosarcoma cells.

    abstract::Osteosarcoma cells are recognized by abnormal function that causes a primary bone tumor. Osteosarcoma cells U(2)OS and SAOS-2 were analyzed for the expression of cell surface markers. High expression was quantified for hyaloronidase receptor (CD-44) > moderate for integrins (CD-51 and -61), > and lower for selectins (...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1270

    authors: Benayahu D,Shur I,Marom R,Meller I,Issakov J

    更新日期:2001-01-01 00:00:00

  • Geraniol and lupeol inhibit growth and promote apoptosis in human hepatocarcinoma cells through the MAPK signaling pathway.

    abstract:OBJECTIVES:Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. T...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27779

    authors: Shen X,Cui X,Cui H,Jin Y,Jin W,Sun H

    更新日期:2019-04-01 00:00:00