Abstract：
:The DNA tumor virus oncogenes (adenovirus E1A, simian virus 40 (SV40) large T antigen, and papillomavirus E7) have been instrumental in illuminating the molecules and mechanisms of cell cycle progression and carcinogenesis. However, since these multifunctional proteins target so many important cellular regulators, it is sometimes difficult to establish the functional importance of any individual interaction. Perhaps a herpesvirus protein, newly defined as a cell cycle regulator, can help address these issues. Like the DNA tumor virus proteins, the human cytomegalovirus (HCMV) pp71 protein contains a retinoblastoma protein (Rb) binding motif (LxCxD), and stimulates DNA synthesis in quiescent cells. Unlike E1A, T antigen, and E7, pp71 expression does not induce apoptosis, nor does it cooperate to transform primary cells. Determining how pp71 induces cell cycle progression without invoking apoptosis or leading to cellular transformation may help in defining the signals that ultimately lead to these processes.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Kalejta RFdoi
10.1002/jcb.20177subject
Has Abstractpub_date
2004-09-01 00:00:00pages
37-45issue
1eissn
0730-2312issn
1097-4644journal_volume
93pub_type
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更新日期：2019-02-11 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1994-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-08-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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更新日期：2019-04-01 00:00:00
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更新日期：2019-10-01 00:00:00
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更新日期：2019-03-01 00:00:00
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更新日期：2013-07-01 00:00:00
abstract：:We have previously demonstrated the direct involvement of a type 1 Ser/Thr phosphatase (PPase 1) in endothelial cell (EC) barrier regulation [Am. J. Physiol. 269:L99-L108, 1995]. To further extend this observation, we microinjected either the Ser/Thr PPase inhibitor, calyculin, or the PPase 1 inhibitory protein, I-2 i...
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pub_type： 杂志文章
doi：
更新日期：2000-07-19 00:00:00
