Mining TCGA database for screening and identification of hub genes in kidney renal clear cell carcinoma microenvironment.

abstract：:Fibroblasts play a major role in processes such as wound repair, scarring, and fibrosis. Differentiation into myofibroblasts, characterized by upregulation of smooth muscle alpha-actin (smalpha) in response to profibrotic agents such as TGFbeta is believed to be an important step in fibrosis. Therefore, elucidating me...

journal_title：Journal of cellular biochemistry

authors： Sousa AM,Liu T,Guevara O,Stevens J,Fanburg BL,Gaestel M,Toksoz D,Kayyali US

更新日期：2007-04-15 00:00:00

abstract：:Breast cancer is a highly aggressive disease contributing to high mortality rate among females across the globe owing to wide geographical variations, change in lifestyle along with rapid tumor growth, drug resistance, and high metastasis rate. To understand the molecular and genetic basis of breast cancer progression...

journal_title：Journal of cellular biochemistry

authors： Nazir SU,Kumar R,Dil-Afroze,Rasool I,Bondhopadhyay B,Singh A,Tripathi R,Singh N,Khan A,Tanwar P,Agrawal U,Mehrotra R,Hussain S

更新日期：2019-09-01 00:00:00

abstract：:Fluorescent proteins have enabled the color-coding of cells growing in vivo. Noninvasive imaging of cells expressing fluorescent proteins has allowed the real-time determination of the behavior of cancer cells, the progression of infection, the differentiation of stem cells, and interaction of stromal and cancer cells...

journal_title：Journal of cellular biochemistry

authors： Hoffman RM

更新日期：2017-09-01 00:00:00

abstract：:Primary chicken mesenchymal cells from limb buds and vertebral chondrocytes have been used to study the changes that occur in alternative mRNA splicing of fibronectin exon EIIIA during chondrogenesis. The mesenchymal cell phenotype (exon EIIIA included) and chondrocyte phenotype (exon EIIIA excluded) were preserved in...

journal_title：Journal of cellular biochemistry

authors： Uporova TM,Norton PA,Tuan RS,Bennett VD

更新日期：1999-12-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is an organoselenium radical scavenger compound, which has strong antioxidant and anti-inflammatory effects. However, evidence suggests that this compound could exert deleterious actions on cell physiology. In this study, we have analyzed the effect of ebselen on rat p...

journal_title：Journal of cellular biochemistry

authors： Santofimia-Castaño P,Izquierdo-Alvarez A,Plaza-Davila M,Martinez-Ruiz A,Fernandez-Bermejo M,Mateos-Rodriguez JM,Salido GM,Gonzalez A

更新日期：2018-01-01 00:00:00

abstract：:The mouse macrophage Fc gamma 2b/gamma 1R has previously been purified with the aid of the monoclonal antibody 2.4G2. That this Fc gamma R functions as a ligand-dependent ion channel is supported by the following evidence. Employing [3H]tetraphenylphosphonium ([3H]Ph4P+) as a probe for membrane potential changes in in...

journal_title：Journal of cellular biochemistry

authors： Young JD,Unkeless JC,Cohn ZA

更新日期：1985-01-01 00:00:00

abstract：:Runx2 is an essential transcription factor for skeletal mineralization because it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy, and contributes to endothelial cell migration and vascular invasion of developing bones. Runx2 is also expressed during mouse embryo devel...

journal_title：Journal of cellular biochemistry

authors： Westendorf JJ

更新日期：2006-05-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistant to TRAIL cytoxicity, including...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu N,Zhang J,Liu S,Liu Y,Zheng D

更新日期：2005-10-15 00:00:00

abstract：:We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

journal_title：Journal of cellular biochemistry

authors： Larsson B,Nemere I

更新日期：2003-12-01 00:00:00

abstract：:We investigated the early effects of the anti-idiotypic antibody (clone 1D5), which recognized the estrogen receptor (ER), on cytosolic free calcium concentration ([Ca2+]i) and its long term effects on creatine kinase (CK) specific activity in female human and rat osteoblasts. These actions were compared to the known ...

journal_title：Journal of cellular biochemistry

authors： Sömjen D,Kohen F,Lieberherr M

更新日期：1997-04-01 00:00:00

abstract：:The inhibitor of growth (ING) family of proteins is an evolutionarily conserved family, with members present from yeast to humans. The mammalian ING proteins are candidate tumor suppressor proteins and accordingly can cooperate with p53 to arrest proliferation and induce apoptosis. ING proteins are also reported to fu...

journal_title：Journal of cellular biochemistry

authors： Shi X,Gozani O

更新日期：2005-12-15 00:00:00

abstract：:Myopia has become a major public health issue worldwide. Identification of genetic loci related to myopia in young children may advance our knowledge of the pathogenesis of myopia. Fibroblast growth factor 10 (FGF10) plays essential roles for the development of myopia through modulating extracellular matrix-associated...

journal_title：Journal of cellular biochemistry

authors： Sun W,Li Y,Li J,Zhang X,Feng Q,Zhang Z,Kang J,Huang X

更新日期：2019-09-01 00:00:00

abstract：:Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on other sirtuins (SIRT2-7) are unknown. The present study shows that exposure of H9c2 cells to 50 microM H(2)O(2) for 6 h caused a signifi...

journal_title：Journal of cellular biochemistry

authors： Yu W,Fu YC,Zhou XH,Chen CJ,Wang X,Lin RB,Wang W

更新日期：2009-07-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), the major green tea polyphenol, can reach the brain following oral intake and could thus act as an anti-tumoral agent targeting several key steps of brain cancer cells invasive activity. Because integrin-mediated extracellular matrix recognition is crucial during the cell adhesion pr...

journal_title：Journal of cellular biochemistry

authors： Pilorget A,Berthet V,Luis J,Moghrabi A,Annabi B,Béliveau R

更新日期：2003-11-01 00:00:00

abstract：:The role of TatD DNases as DNA repair enzymes or cell death (apoptotic) nucleases is well established in prokaryotes as well as eukaryotes. The current study aims to characterize the TatD nuclease from Bacillus anthracis (Ba TatD) and to explore its key histidine catalytic residues. Ba TatD was found to be a metal-dep...

journal_title：Journal of cellular biochemistry

authors： Singh D,Rahi A,Kumari R,Gupta V,Gautam G,Aggarwal S,Rehan M,Bhatnagar R

更新日期：2019-02-05 00:00:00

abstract：:We previously suggested that keratinocyte releasable factors might modulate the wound healing process by regulating the expression of key extracellular matrix components such as collagenase (matrix metalloproteinase-1) and type I collagen in fibroblasts. The first one, we called it keratinocyte-derived anti-fibrogenic...

journal_title：Journal of cellular biochemistry

authors： Chavez-Muñoz C,Hartwell R,Jalili RB,Jafarnejad SM,Lai A,Nabai L,Ghaffari A,Hojabrpour P,Kanaan N,Duronio V,Guns E,Cherkasov A,Ghahary A

更新日期：2012-08-01 00:00:00

abstract：:Roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrests human estrogen receptor-α (ER-α) positive MCF-7 breast cancer cells in the G(2) phase of the cell cycle and concomitantly induces apoptosis via a p53-dependent pathway. The effect of ROSC is markedly diminished in MCF-7 cells maintained i...

journal_title：Journal of cellular biochemistry

authors： Węsierska-Gądek J,Gritsch D,Zulehner N,Komina O,Maurer M

更新日期：2011-03-01 00:00:00

abstract：:In this study, we found that wounding of a confluent monolayer of squamous cell carcinoma (SCC) cells induced epithelial-mesenchymal transition (EMT) specifically at the edge of the wound. This process required the combined stimulation of TGFβ, TNFα, and PDGF-D. Such a combined cytokine treatment of confluent monolaye...

journal_title：Journal of cellular biochemistry

authors： Okui G,Tobiume K,Rizqiawan A,Yamamoto K,Shigeishi H,Ono S,Higashikawa K,Kamata N

更新日期：2013-09-01 00:00:00

abstract：:Telomeres are TTAGGG repetitive motifs found at the ends of vertebrate chromosomes. In humans, telomeres are protected by shelterin, a complex of six proteins (de Lange [2005] Genes Dev. 19: 2100-2110). Since (Müller [1938] Collecting Net. 13: 181-198; McClintock [1941] Genetics 26: 234-282), their function in maintai...

journal_title：Journal of cellular biochemistry

authors： Mai S,Garini Y

更新日期：2006-04-01 00:00:00

abstract：:CD133 and CD44 are commonly used markers of cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical value and significance of CD133 and CD44 in lung metastasis of osteosarcoma (OS) remains controversial. The purpose of this study was to investigate ...

journal_title：Journal of cellular biochemistry

authors： He A,Yang X,Huang Y,Feng T,Wang Y,Sun Y,Shen Z,Yao Y

更新日期：2015-08-01 00:00:00

abstract：:The four-subunit protease complex γ-secretase cleaves many single-pass transmembrane (TM) substrates, including Notch and β-amyloid precursor protein to generate amyloid-β (Aβ), central to Alzheimer's disease. Two of the subunits anterior pharynx-defective 1 (APH-1) and presenilin (PS) exist in two homologous forms AP...

journal_title：Journal of cellular biochemistry

authors： Dehury B,Kepp KP

更新日期：2021-01-01 00:00:00

abstract：:Panax notoginseng saponin (PNS) constitutes the major effective components of Panax notoginseng, which is widely used to treat microcirculatory disturbance associated diseases. In this study, we designed to investigate the effect of PNS on the treatment of pulmonary fibrosis (PF) and further explored its mechanism. A ...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Li Q,Shao Q,Song J,Zhou B,Shu P

更新日期：2018-11-01 00:00:00

abstract：:A chimeric long terminal repeat-thymidine kinase (LTR-tk) gene has been used to define the sequence requirements for glucocorticoid induction of gene expression. The original LTR-tk gene contains an entire mouse mammary tumor virus (MMTV) LTR preceding the tk gene. This gene can be expressed in a hormone-responsive fa...

journal_title：Journal of cellular biochemistry

authors： Groner B,Herrlich P,Kennedy N,Ponta H,Rahmsdorf U,Hynes NE

更新日期：1982-01-01 00:00:00

abstract：:A key step in human colon cancer development includes the hyperactivation of Wnt/beta-catenin signaling and the induction of beta-catenin-TCF target genes that participate in colon cancer progression. Recent studies identified members of the immunoglobulin-like cell adhesion molecules (IgCAM) of the L1CAM family (L1 a...

journal_title：Journal of cellular biochemistry

authors： Raveh S,Gavert N,Spiegel I,Ben-Ze'ev A

更新日期：2009-09-01 00:00:00

abstract：:X-ray atomic structure of recombinant Hell's gate globin I (HGbI) from Methylacidophilum infernorum was calculated from the X-ray diffraction data of two different types of crystals: obtained by classical hanging drop and by LB nanotemplate method under the same crystallization conditions. After the accurate compariso...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Scudieri D,Belmonte L,Nicolini C

更新日期：2012-07-01 00:00:00

abstract：:Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

journal_title：Journal of cellular biochemistry

authors： Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

更新日期：1996-06-01 00:00:00

abstract：:The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment ...

journal_title：Journal of cellular biochemistry

authors： Beck GR Jr

更新日期：2003-10-01 00:00:00

abstract：:Overweight and obesity are established factors underpin several metabolic impairments, including the cardiovascular. Although the diversity of factors involved in overweight/obesity-induced cardiovascular diseases, mitochondria has been highlighted due to its role in cardiac metabolism. As obesity can be originated in...

journal_title：Journal of cellular biochemistry

authors： de Moura Freitas C,Nascimento LCPD,Braz GRF,Andrade-Silva SC,Lima-Junior NC,de Araujo Silva T,Fernandes MP,Ferreira DJS,Lagranha CJ

更新日期：2018-10-28 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00