Delimitation of a DNA sequence which confers inducibility by glucocorticoid hormones.

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world for early metastasis, extensive invasion, and poor prognosis with a 5-year survival rate less than 5%. However, the underlying mechanisms are poorly understood. Therefore, it is urgent to explore molecular markers for early diag...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Wang Y,Liu S,Zhao X,Jia R,Xiao Y,Zhang M,Li X,Li J,Wang W

更新日期：2018-11-28 00:00:00

abstract：:The initiation of DNA replication in T lymphocytes appears to be regulated by two distinct activities: one associated with proliferation which mediates initiation, and another associated with quiescence which blocks initiation. Activated lymphocytes and proliferating lymphoid cell lines produce an activity, termed ADR...

journal_title：Journal of cellular biochemistry

authors： Coffman FD,Fresa KL,Cohen S

更新日期：1991-01-01 00:00:00

abstract：:Ataxia telangiectasia (AT) is a rare genetic disorder caused by mutations of ATM gene. ATM kinase is a "master controller" of DNA-damage response and signal transducer of external stimuli. The complex role of ATM may explain the pleiotropic phenotype characteristic of AT syndrome, only partially. In our hypothesis, th...

journal_title：Journal of cellular biochemistry

authors： Grattarola M,Borghi C,Emionite L,Lulli P,Chessa L,Vergani L

更新日期：2006-11-01 00:00:00

abstract：:The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration an...

journal_title：Journal of cellular biochemistry

authors： Li S,Huang NF,Hsu S

更新日期：2005-12-15 00:00:00

abstract：:Estrogen and androgen are both critical for the maintenance of bone, but the target cells, mechanisms, and responses could be sex-specific. To compare sex-specific actions of estrogen and androgen on osteoclasts, human peripheral blood mononuclear precursor cells from adult Caucasian males (n = 3) and females (n = 3) ...

journal_title：Journal of cellular biochemistry

authors： Wang J,Stern PH

更新日期：2011-12-01 00:00:00

abstract：:Angiogenesis plays an important role in many pathological processes. Identification of novel anti-angiogenic agents will provide new insights into the mechanisms for angiogenesis as well as potential lead compounds for developing new drugs. In the present study, a series of resveratrol methylated derivatives have been...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Jing H,Cui L,Li H,Zhou B,Zhou G,Dai F

更新日期：2013-03-01 00:00:00

abstract：:Despite the historical use of estrogens in the treatment of prostate cancer (PCa) little is known about their direct biological effects on the prostate, their role in carcinogenesis, and what mechanisms mediate their therapeutic effects on PCa. It is now known that estrogens alone, or in synergism with an androgen, ar...

journal_title：Journal of cellular biochemistry

authors： Ho SM

更新日期：2004-02-15 00:00:00

abstract：:The BRCA1 tumor suppressor involved in breast and ovarian cancer is linked to several fundamental cell regulatory processes. Recently, it was reported that BRCA1 supports localization of XIST RNA to the inactive X chromosome (Xi) in women. The apparent cytological overlap between BRCA1 and XIST RNA across the Xi raise...

journal_title：Journal of cellular biochemistry

authors： Pageau GJ,Hall LL,Lawrence JB

更新日期：2007-03-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differe...

journal_title：Journal of cellular biochemistry

authors： Altun G,Loring JF,Laurent LC

更新日期：2010-01-01 00:00:00

abstract：:Deregulated proliferation of vascular smooth muscle cells (VSMCs) is one common phenomenon of atherosclerosis progression. Long noncoding RNAs (lncRNAs) are one group of noncoding RNAs that play essential roles in many cell biological processes, including cell development, growth, and migration. However, the role of a...

journal_title：Journal of cellular biochemistry

authors： Wang H,Jin Z,Pei T,Song W,Gong Y,Chen D,Zhang L,Zhang M,Zhang G

更新日期：2019-03-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two mi...

journal_title：Journal of cellular biochemistry

authors： Wu J,Chen Z,Zhang L,Cao J,Li X,Gong Z,Bo H,Zhang S,He D

更新日期：2020-01-01 00:00:00

abstract：:Epidermal growth factor (EGF)-receptor is a 170 kDa transmembrane glycoprotein that contains a ligand-binding external domain, and a catalytically active cytoplasmic region. The expression of this receptor as well as a 100 kDa homolog that contains only the external domain is enhanced by the ligand EGF. EGF acts at tr...

journal_title：Journal of cellular biochemistry

authors： Das M,Kesavan P,Khire J

更新日期：1990-09-01 00:00:00

abstract：:Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up-regulated in prostate c...

journal_title：Journal of cellular biochemistry

authors： Lv H,Fan E,Sun S,Ma X,Zhang X,Han DM,Cong YS

更新日期：2009-03-01 00:00:00

abstract：:The retinal pigmented epithelium (RPE) is a monolayer of polarized cells located between retinal photoreceptors and blood vessels of the choroid. The basal surface of RPE cells rests on Bruch's membrane, a complex extracellular matrix structure which becomes abnormal in several disease processes, including age-related...

journal_title：Journal of cellular biochemistry

authors： Mousa SA,Lorelli W,Campochiaro PA

更新日期：1999-07-01 00:00:00

abstract：:Neutrophils are essential for host defense and their programmed cell death and removal are critical for the optimal expression as well as for efficient resolution of inflammation. Delayed neutrophil apoptosis or impaired clearance of apoptotic neutrophils by macrophages contributes to the progression of chronic inflam...

journal_title：Journal of cellular biochemistry

authors： Filep JG,El Kebir D

更新日期：2009-12-01 00:00:00

abstract：:We investigated activity and mechanism of action of two AhR ligand antitumor agents, AFP 464 and 5F 203 on human renal cancer cells, specifically examining their effects on cell cycle progression, apoptosis, and migration. TK-10, SN12C, Caki-1, and ACHN human renal cancer cell lines were treated with AFP 464 and 5F 20...

journal_title：Journal of cellular biochemistry

authors： Luzzani GA,Callero MA,Kuruppu AI,Trapani V,Flumian C,Todaro L,Bradshaw TD,Loaiza Perez AI

更新日期：2017-12-01 00:00:00

abstract：:We previously developed and characterized a highly invasive and metastatic triple-negative breast cancer (TNBC) variant by serial orthotopic implantation of MDA-MB-231 human breast cancer cells in nude mice. Eventually, a highly invasive and metastatic variant of human TNBC was isolated after lymph node metastases was...

journal_title：Journal of cellular biochemistry

authors： Yano S,Takehara K,Tazawa H,Kishimoto H,Kagawa S,Bouvet M,Fujiwara T,Hoffman RM

更新日期：2017-03-01 00:00:00

abstract：:Multiple regulatory elements and intricate protein-DNA interactions mediate the transcription of the human histone H4 genes in a cell growth-dependent manner. Upon analysis of the regulatory elements of the FO108 histone H4 gene, we identified several potential YY1 binding sites. In this study, we have analyzed the ab...

journal_title：Journal of cellular biochemistry

authors： Last TJ,van Wijnen AJ,Birnbaum MJ,Stein GS,Stein JL

更新日期：1999-03-15 00:00:00

abstract：:Rat CYP1A1 promoter-luciferase, transiently transfected wild-type and 4S PAH receptor (glycine N-methyl transferase, GNMT)-transformed Chinese hamster ovary (CHO) cells were exposed to benzo[a]pyrene and assayed for luciferase activity as an indicator of CYP1A1 promoter activity. CHO cells transformed with the rat 4S ...

journal_title：Journal of cellular biochemistry

authors： Sterling KM

更新日期：2011-08-01 00:00:00

abstract：:Mammalian sperm gain the ability to fertilize an egg successfully by the capacitation process. An unregulated capacitation process causes sperm to undergo a spontaneous acrosome reaction (AR) and resulting in loss of their fertilization activity. Thus, functional sperm activation is tightly regulated by a capacitation...

journal_title：Journal of cellular biochemistry

authors： Huang YH,Chen YH,Lin CM,Ciou YY,Kuo SP,Chen CT,Shih CM,Chang EE

更新日期：2007-03-01 00:00:00

abstract：:The secretion pathway of Saccharomyces cerevisiae was challenged by constitutively overexpressing plasmid-encoded acid phosphatase, a secreted endogenous glycoprotein. A 2-microns-based multicopy plasmid carrying the coding sequence of acid phosphatase under the control of a truncated variant of the strong constitutiv...

journal_title：Journal of cellular biochemistry

authors： Kleene R,Janes M,Meyhack B,Pulfer K,Hinnen A

更新日期：1995-02-01 00:00:00

abstract：:Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

journal_title：Journal of cellular biochemistry

authors： Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

更新日期：2018-04-01 00:00:00

abstract：:Our previous study demonstrated that, stanniocalcin-1 (STC1) was a target of histone deacetylase (HDAC) inhibitors and was involved in trichostatin A (TSA) induced apoptosis in the human colon cancer cells, HT29. In this study, we reported that the transcriptional factor, specificity protein 1 (Sp1) in association wit...

journal_title：Journal of cellular biochemistry

authors： Law AY,Yeung BH,Ching LY,Wong CK

更新日期：2011-08-01 00:00:00

abstract：:We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

journal_title：Journal of cellular biochemistry

authors： Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

更新日期：2017-12-01 00:00:00

abstract：:The p27(Kip1) (p27) cyclin-dependent kinase inhibitor and c-Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of p27 (CDKN1B) gene transcription by Forkhead box O proteins such as FOXO3a leads to growth arrest and apoptosis. Previously, we observed that B cell receptor ...

journal_title：Journal of cellular biochemistry

authors： Chandramohan V,Mineva ND,Burke B,Jeay S,Wu M,Shen J,Yang W,Hann SR,Sonenshein GE

更新日期：2008-08-15 00:00:00

abstract：:Raman micro-spectroscopy combined with multivariate analysis was employed to monitor real-time biochemical changes induced in living cells in vitro following exposure to a pharmaceutical. The cancer drug etoposide (topoisomerase II inhibitor) was used to induce double-strand DNA breaks in human type II pneumocyte-like...

journal_title：Journal of cellular biochemistry

authors： Owen CA,Selvakumaran J,Notingher I,Jell G,Hench LL,Stevens MM

更新日期：2006-09-01 00:00:00

abstract：:Wnt/β-catenin signaling regulates various cellular events involved in the proliferation and differentiation and these events are affected sensitively by applying to mechanical stimuli. However, the mechanisms by which mechanical force stimulates cardiomyogenesis are not extensively explored. In this study we investiga...

journal_title：Journal of cellular biochemistry

authors： Heo JS,Lee JC

更新日期：2011-07-01 00:00:00

abstract：:A homogeneous preparation of a urinary glycoprotein has been isolated from urine of patients with malignant melanoma and advanced adenocarcinomas of colon and lung. This molecule, Mr 30 kDa, is homologous to EDC1, a proteinase inhibitor antigenically related to plasma inter-alpha-trypsin inhibitor (IATI) originally is...

journal_title：Journal of cellular biochemistry

authors： Chawla RK,Lawson DH,Travis J

更新日期：1990-04-01 00:00:00

abstract：:Phosphoinositide 3-kinase proteins are composed by a catalytic p110 subunit and a regulatory p85 subunit. There are three classes of PI3K, named class I-III, on the bases of the protein domain constituting and determining their specificity. The first one is the best characterized and includes a number of key elements ...

journal_title：Journal of cellular biochemistry

authors： Feola A,Cimini A,Migliucci F,Iorio R,Zuchegna C,Rothenberger R,Cito L,Porcellini A,Unteregger G,Tombolini V,Giordano A,Di Domenico M

更新日期：2013-09-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by bone and exerts its function in the target organs by binding the FGF receptor (FGFR) and Klotho. Since recent studies suggested that extracellular inorganic phosphate (Pi) itself triggers signal transduction and regulates gene expression in some...

journal_title：Journal of cellular biochemistry

authors： Yamazaki M,Ozono K,Okada T,Tachikawa K,Kondou H,Ohata Y,Michigami T

更新日期：2010-12-01 00:00:00