DNA methylation in embryonic stem cells.

abstract：:Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

journal_title：Journal of cellular biochemistry

authors： Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

更新日期：2012-07-01 00:00:00

abstract：:Diclofenac is the most commonly used phenylacetic acid derivative non-steroidal anti-inflammatory drug (NSAID) that demonstrates significant analgesic, antipyretic, and anti-inflammatory effects. Several epidemiological studies have demonstrated anti-proliferative activity of NSAIDs and examined their apoptotic induct...

journal_title：Journal of cellular biochemistry

authors： Amanullah A,Upadhyay A,Chhangani D,Joshi V,Mishra R,Yamanaka K,Mishra A

更新日期：2017-05-01 00:00:00

abstract：:Integrins may play important roles in many cellular events, such as cell proliferation, differentiation, and apoptosis. We showed previously that overexpression of integrin beta1 inhibits cell proliferation in SMMC-7721 cells. Here we reported that one of the cyclin-dependent kinase (CDK) inhibitors, p27(Kip1) was inv...

journal_title：Journal of cellular biochemistry

authors： Fu Y,Fang Z,Liang Y,Zhu X,Prins P,Li Z,Wang L,Sun L,Jin J,Yang Y,Zha X

更新日期：2007-10-15 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by bone and exerts its function in the target organs by binding the FGF receptor (FGFR) and Klotho. Since recent studies suggested that extracellular inorganic phosphate (Pi) itself triggers signal transduction and regulates gene expression in some...

journal_title：Journal of cellular biochemistry

authors： Yamazaki M,Ozono K,Okada T,Tachikawa K,Kondou H,Ohata Y,Michigami T

更新日期：2010-12-01 00:00:00

abstract：:17β-Estradiol (E2 ) protects several nonreproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2 O2 in skeletal myoblasts, reverting PKCδ, JNK, and p66Shc activation and exerting a beneficial action over mitochondria...

journal_title：Journal of cellular biochemistry

authors： La Colla A,Vasconsuelo A,Milanesi L,Pronsato L

更新日期：2017-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

journal_title：Journal of cellular biochemistry

authors： Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

更新日期：2018-04-01 00:00:00

abstract：:Endothelins (ETs) are vasoconstrictive peptides produced mainly by endothelial cells. The ET receptors are expressed in many types of cells including osteoblast-like cells. The purpose of this study was to examine the effects of endothelin on the expression of osteoblastic phenotype-related genes. We found that endoth...

journal_title：Journal of cellular biochemistry

authors： Shioide M,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Currently, the only available treatments for Trypanosoma cruzi are benznidazole (Bz) and nifurtimox (Nfx). The mechanisms of action and resistance to these drugs in this parasite are not complete known. In order to identify differentially expressed transcripts between sensitive and resistant parasites, a massive pyros...

journal_title：Journal of cellular biochemistry

authors： García-Huertas P,Mejía-Jaramillo AM,González L,Triana-Chávez O

更新日期：2017-07-01 00:00:00

abstract：:In this study, we examined the effects of shark cartilage extract on the attachment and spreading properties and the focal adhesion structure of cultured bovine pulmonary artery endothelial cells. Treatment with cartilage extract resulted in cell detachment from the substratum. Immunofluorescence staining of those tre...

journal_title：Journal of cellular biochemistry

authors： Chen JS,Chang CM,Wu JC,Wang SM

更新日期：2000-06-06 00:00:00

abstract：:The low density lipoprotein receptor related protein-1 (LRP-1) is a cargo transport receptor that undergoes constitutive endocytosis and recycling. Platelet-derived growth factor-BB (PDGF-BB) binds to LRP-1 and may bridge LRP-1 to PDGF receptors. Bridging of LRP-1 to other receptors by bifunctional ligands may represe...

journal_title：Journal of cellular biochemistry

authors： Wu L,Arandjelovic S,Gonias SL

更新日期：2004-12-15 00:00:00

abstract：:Suppressor of cytokine signaling-3 (SOCS3) has multiple functions including inhibition of Janus kinase (Jak) activity, regulation of protein degradation, and suppression of cytokine signaling. SOCS3 modulates macrophage response to cytokines such as IL-6 and leptin that are systemically induced in obesity. Obesity is ...

journal_title：Journal of cellular biochemistry

authors： Scheller EL,Hankenson KD,Reuben JS,Krebsbach PH

更新日期：2011-11-01 00:00:00

abstract：:In a human lymphoblastoid cell line (Z83) in which rDNA genes on chromosome 22 are amplified but transcribed at a low level, immunocytological studies with antibodies to 5 methylcytidine provided evidence for hypermethylation of the rDNA. The extent of methylation of the 5' flanking sequences of the ribosomal DNA was ...

journal_title：Journal of cellular biochemistry

authors： Dante R,Percy ME,Baldini A,Markovic VD,Miller DA,Rocchi M,Niveleau A,Miller OJ

更新日期：1992-12-01 00:00:00

abstract：:Isoflavones widely distributed in plants prevent diabetes. This study investigated the in vivo and in vitro effect of 3',4'-dihydroxy-6″,6″,6″',6″'-tetramethylbis(pyrano[2″,3″:5,6::2″',3″':7,8]isoflavone (bis-pyrano prenyl isoflavone) on glucose homeostasis in hyperglycemic rats. The ethyl acetate fraction from aerial...

journal_title：Journal of cellular biochemistry

authors： Altenhofen D,da Luz G,Frederico MJ,Venzke D,Brich M,Vigil S,Fröde TS,Linares CE,Pizzolatti MG,Silva FR

更新日期：2017-01-01 00:00:00

abstract：:Poor prognosis and low survival are commonly seen in patients with glioblastoma multiforme (GBM). Due to the specific nature of solid tumors such as GBM, delivery of therapeutic agents to the tumor sites is difficult. So, one of the major challenges in the treatment of these tumors is a selection of appropriate method...

journal_title：Journal of cellular biochemistry

authors： Jabbarpour Z,Kiani J,Keshtkar S,Saidijam M,Ghahremani MH,Ahmadbeigi N

更新日期：2020-02-01 00:00:00

abstract：:Hypoxia inducible factor 1α (HIF-1α), an essential transcriptional factor, is negatively regulated by two different types of oxygen and Fe(2+) -dependent HIF hydroxylases, proline hydroxylase (PHD) and factor inhibiting HIF (FIH), under normoxia. Iron chelators have therefore been used for inducing HIF-1α expression b...

journal_title：Journal of cellular biochemistry

authors： Cho EA,Song HK,Lee SH,Chung BH,Lim HM,Lee MK

更新日期：2013-04-01 00:00:00

abstract：:Primary chicken mesenchymal cells from limb buds and vertebral chondrocytes have been used to study the changes that occur in alternative mRNA splicing of fibronectin exon EIIIA during chondrogenesis. The mesenchymal cell phenotype (exon EIIIA included) and chondrocyte phenotype (exon EIIIA excluded) were preserved in...

journal_title：Journal of cellular biochemistry

authors： Uporova TM,Norton PA,Tuan RS,Bennett VD

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lnc...

journal_title：Journal of cellular biochemistry

authors： Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

更新日期：2019-06-01 00:00:00

abstract：:The cellular distribution and nature of proteoglycans synthesised by human breast cancer cells in culture were studied. Proteoglycans were labelled with [35S] sulfate, purified, and characterised after ion-exchange chromatography followed by gel-filtration chromatography and treatment with glycosaminoglycan degrading ...

journal_title：Journal of cellular biochemistry

authors： Delehedde M,Deudon E,Boilly B,Hondermarck H

更新日期：1997-03-15 00:00:00

abstract：:Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

journal_title：Journal of cellular biochemistry

authors： Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00

abstract：:Sea urchin CS histone variants are electrophoretically heterogeneous when analyzed in two dimensional polyacrylamide gels (2D-PAGE). Previous results suggested that this heterogeneity is due to the poly (ADP-ribosylation) of these proteins. Consequently, native CS histone variants were subjected to different treatment...

journal_title：Journal of cellular biochemistry

authors： Imschenetzky M,Morín V,Carvajal N,Montecino M,Puchi M

更新日期：1996-04-01 00:00:00

abstract：:The current study aimed to explore the functions and roles of microRNA-193b (miR-193b) in the myocardium with ischemia-reperfusion (I/R) injury and a potential therapeutic method for myocardial I/R injury. The mice were subjected to myocardial I/R with or without miR-193b pretreatment. The infarct size and myocardial ...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Niu J,Tian B,Zhao M

更新日期：2019-08-01 00:00:00

abstract：:Hepatocytes can be generated from embryonic stem cells (ESCs) using inducers such as chemical compounds and cytokines, but issues related to low differentiation efficiencies remain to be resolved. Recent work has shown that overexpression of lineage-specific transcription factors can directly cause cells phenotypic ch...

journal_title：Journal of cellular biochemistry

authors： Liu T,Zhang S,Xiang D,Wang Y

更新日期：2013-11-01 00:00:00

abstract：:We have cloned and sequenced a genomic DNA fragment of chicken containing a cluster of DNase I hypersensitive sites (DHS) located 11-15 kb upstream from the first gene of the alpha-globin gene domain and including a constitutive DHS flanked by two erythroid-specific ones. A 1.2-kb subfragment of the DNA fragment under...

journal_title：Journal of cellular biochemistry

authors： Razin SV,Shen K,Ioudinkova E,Scherrer K

更新日期：1999-07-01 00:00:00

abstract：:The study was conducted for comparing the effects of 12 DNA damage response gene mutations (CHEK1, CHEK2, RAD51, BRCA1, BRCA2, MLH1, MSH2, ATM, ATR, MDC1, PARP1, and FANCF) on the overall survival (OS) of breast cancer (BC) patients. We searched the Cancer Genome Atlas (TCGA) database from inception to September 2016....

journal_title：Journal of cellular biochemistry

authors： Liu C,Chang H,Li XH,Qi YF,Wang JO,Zhang Y,Yang XH

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. T...

journal_title：Journal of cellular biochemistry

authors： Shen X,Cui X,Cui H,Jin Y,Jin W,Sun H

更新日期：2019-04-01 00:00:00

abstract：:The immediate-early (IE) promoter of human cytomegalovirus (HCMV) constitutes a primary genetic switch, which determines the progression of viral infection. Earlier reports by others have shown mitogen-activated protein kinase kinase kinase-1 (MEKK1) to be able to up-regulate HCMV-IE promoter through downstream mitoge...

journal_title：Journal of cellular biochemistry

authors： Sun B,Harrowe G,Reinhard C,Yoshihara C,Chu K,Zhuo S

更新日期：2001-01-01 00:00:00

abstract：:O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is a post-translational modification, which is believed antagonises phosphorylation. We have studied the O-GlcNAc level during Xenopus oocyte meiotic resumption, taking advantage of the high synchrony of this model which is dependent upon a burst of phosphorylation...

journal_title：Journal of cellular biochemistry

authors： Lefebvre T,Baert F,Bodart JF,Flament S,Michalski JC,Vilain JP

更新日期：2004-11-15 00:00:00

abstract：:Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expre...

journal_title：Journal of cellular biochemistry

authors： Zhuang B,Hu Y,Fan X,Li M,Zhu J,Liu H,Cao L,Liang D,Zhang J,Yu Z,Han S

更新日期：2018-01-01 00:00:00

abstract：:Cancer stem cells (CSC) have a central role in driving tumor growth. Since metabolism is becoming an important diagnostic and therapeutic target, characterization of CSC line energetic properties is an emerging need. Embryonic and adult stem cells, compared to differentiated cells, exhibit a reduced mitochondrial acti...

journal_title：Journal of cellular biochemistry

authors： Palorini R,Votta G,Balestrieri C,Monestiroli A,Olivieri S,Vento R,Chiaradonna F

更新日期：2014-02-01 00:00:00