Modifications of nuclear architecture and chromatin organization in ataxia telangiectasia cells are coupled to changes of gene transcription.

abstract：:Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differe...

journal_title：Journal of cellular biochemistry

authors： Altun G,Loring JF,Laurent LC

更新日期：2010-01-01 00:00:00

abstract：:Bone formation is under the control of a set of transcription factors. Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D. However, the function of Ids during bone formation in vivo has not yet ...

journal_title：Journal of cellular biochemistry

authors： Maeda Y,Tsuji K,Nifuji A,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Our laboratory pioneered patient-derived orthotopic xenograft (PDOX) mouse models using surgical orthotopic implantation (SOI). PDOX models are patient-like, in contrast to the ectopic subcutaneous-transplant cancer models. In the present study, we demonstrate that an undifferentiated pleomorphic soft-tissue sarcoma (...

journal_title：Journal of cellular biochemistry

authors： Kiyuna T,Murakami T,Tome Y,Igarashi K,Kawaguchi K,Russell T,Eckardt MA,Crompton J,Singh A,Bernthal N,Bukata S,Federman N,Kanaya F,Eilber FC,Hoffman RM

更新日期：2017-02-01 00:00:00

abstract：:Gastric cancer (GC) is the fifth most frequent cancer and the third-leading cause of cancer-related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs con...

journal_title：Journal of cellular biochemistry

authors： Kangarlouei R,Irani S,Noormohammadi Z,Memari F,Mirfakhraie R

更新日期：2019-08-01 00:00:00

abstract：:We have examined the effect of polyoma virus infection of primary mouse embryo cells on the tyrosyl kinase activity associated with the cellular src gene product, pp60c-src. The results of our studies demonstrate that infection of mouse cells with wild-type polyoma virus or viral mutants capable of transforming rodent...

journal_title：Journal of cellular biochemistry

authors： Bolen JB,Lewis AM Jr,Israel MA

更新日期：1985-01-01 00:00:00

abstract：:Burkitt lymphoma (BL) commonly exhibits Epstein-Barr virus (EBV) positivity associated with latent chronic infection. Models of acute EBV infection have been associated with cellular resistance to apoptosis. However, the effect of latent long-term EBV infection on apoptosis induced by drugs is not well defined. To det...

journal_title：Journal of cellular biochemistry

authors： Lima RT,Seca H,Soares P,Nascimento MS,Vasconcelos MH

更新日期：2011-01-01 00:00:00

abstract：:microRNAs (miRNAs) are noncoding RNAs that regulates the expression of target messenger RNAs (mRNAs). c-FLIP is an inhibitor of cell apoptosis through inhibition of caspase 8. miR-150, miR-504, and miR-519d were related to cancer cell proliferation, invasion, and migration in colorectal cancer (CRC). However, the role...

journal_title：Journal of cellular biochemistry

authors： Rong G,Yang X,Wu H,Wu Y

更新日期：2018-12-12 00:00:00

abstract：:Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP14) is an efficient extracellular matrix (ECM) degrading enzyme that plays important roles in tissue homeostasis and cell invasion. Like a number of type I membrane proteins, MT1-MMP can be internalized from the cell surface through early and recycling endosomes to...

journal_title：Journal of cellular biochemistry

authors： Hakulinen J,Sankkila L,Sugiyama N,Lehti K,Keski-Oja J

更新日期：2008-12-01 00:00:00

abstract：:Inhibition of metabolic features which distinguish cancer cells from their non-malignant counterparts is a promising approach to cancer treatment. Energy support for drug extrusion in multidrug resistance (MDR) is a potential target for metabolic inhibition. Two major sources of ATP-based metabolic energy are partial ...

journal_title：Journal of cellular biochemistry

authors： Koshkin V,Ailles LE,Liu G,Krylov SN

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The impact of aberrant expression of miRNAs, small noncoding RNAs of 19 to 23 nucleotide, has been reported in different types of cancer, such as breast cancer. Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer. MATERIALS AND METHODS:miRNA-3...

journal_title：Journal of cellular biochemistry

authors： Swellam M,Mahmoud MS,Hashim M,Hassan NM,Sobeih ME,Nageeb AM

更新日期：2019-06-01 00:00:00

abstract：:Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1). However, the underlying mechanisms involved in the effect of OA on HO-1 expression are unclear. In the current study, prima...

journal_title：Journal of cellular biochemistry

authors： Feng J,Zhang P,Chen X,He G

更新日期：2011-06-01 00:00:00

abstract：:Periodontitis, a common chronic inflammatory disease of the periodontium, is caused by dental plaque formation induced by microorganisms. Recent studies have demonstrated that lncRNAs play a critical role in the regulation of gene expression and in the pathogenesis of diseases. To demonstrate that periodontitis is ass...

journal_title：Journal of cellular biochemistry

authors： Zou Y,Li C,Shu F,Tian Z,Xu W,Xu H,Tian H,Shi R,Mao X

更新日期：2015-04-01 00:00:00

abstract：:Many regions of the adult central nervous system contain cycling cells. Such cells comprise a relatively small fraction of the total population of the CNS. Work over decades has attempted to determine the normal fates of these cells and their fates under pathological conditions. The recent interest in "stem" cells and...

journal_title：Journal of cellular biochemistry

authors： Goldman JE

更新日期：2003-01-01 00:00:00

abstract：:The levels of organic pollutants, such as optical brightener (OB) compounds, in the global environment have been increasing in recent years. The toxicological effects and signal transduction systems associated with OB toxicity have not been thoroughly studied. The ubiquitin-proteasome system (UPS) plays a crucial role...

journal_title：Journal of cellular biochemistry

authors： Castro I,Ekinci E,Huang X,Cheaito HA,Ahn YH,Olivero-Verbel J,Dou QP

更新日期：2019-08-01 00:00:00

abstract：:Using a yeast two-hybrid library screen, we have identified that the heart specific FHL2 protein, four-and-a-half LIM protein 2, interacted with human DNA-binding nuclear protein, hNP220. Domain studies by the yeast two-hybrid interaction assay revealed that the second LIM domain together with the third and the fourth...

journal_title：Journal of cellular biochemistry

authors： Ng EK,Chan KK,Wong CH,Tsui SK,Ngai SM,Lee SM,Kotaka M,Lee CY,Waye MM,Fung KP

更新日期：2002-01-01 00:00:00

abstract：:The basement membrane (BM) protein laminin-332 (Lm332) (laminin-5) has unique activity and structure as compared with other laminins: it strongly promotes cellular adhesion and migration, and its alpha3, beta3, and gamma2 chains are all truncated in their N-terminal regions (short arms). In the present study, we inves...

journal_title：Journal of cellular biochemistry

authors： Nakashima Y,Kariya Y,Miyazaki K

更新日期：2007-02-15 00:00:00

abstract：:Withangulatin A induced cell rounding up and the morphological alteration resulted from the reorganization of all of the major cytoskeletal components, i.e., vimentin, tubulin, and actin, as revealed by immunofluorescence techniques. When the withangulatin A-treated cells changed to a round-up morphology, vimentin int...

journal_title：Journal of cellular biochemistry

authors： Lee WC,Lee YC,Perng MD,Chen CM,Lai YK

更新日期：1993-07-01 00:00:00

abstract：:Deregulation of microRNAs contributes to the abnormal cell growth which is frequently observed in cancer. In the current study, we detected the expression and regulatory relationship between miR-10a and Lysine-specific demethylase 4A (KDM4A) to reveal their function in prostate cancer (PCa) progression. We found that ...

journal_title：Journal of cellular biochemistry

authors： Mu H,Xiang L,Li S,Rao D,Wang S,Yu K

更新日期：2019-04-01 00:00:00

abstract：:P-selectin glycoprotein ligand-1 (PSGL-1) is the best-characterized selectin ligand that has been demonstrated to mediate leukocytes rolling on endothelium and leukocytes recruitment into inflamed tissue in vivo. In addition to its direct role in leukocyte capturing, PSGL-1 also functions as a signal-transducing recep...

journal_title：Journal of cellular biochemistry

authors： Ba X,Chen C,Gao Y,Zeng X

更新日期：2005-02-01 00:00:00

abstract：:Our previous studies have shown that vanadium, a dietary micronutrient, has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. In this study, we evaluated the role of vanadium on some potential protein expression markers of carcinogenesis, such as metallothionein (MT), an intracellular metal...

journal_title：Journal of cellular biochemistry

authors： Chakraborty T,Samanta S,Ghosh B,Thirumoorthy N,Chatterjee M

更新日期：2005-03-01 00:00:00

abstract：:Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Our aim is to study the function and me...

journal_title：Journal of cellular biochemistry

authors： Zhang G,Sun W,Zhu L,Feng Y,Wu L,Li T

更新日期：2019-06-01 00:00:00

abstract：:Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-alpha2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-alpha1(I) trimer collagen (Lim et a...

journal_title：Journal of cellular biochemistry

authors： Lim AL,Doyle SA,Balian G,Smith BD

更新日期：1998-11-01 00:00:00

abstract：:The role of circular RNAs (circRNAs) in regulating cartilage homeostasis in osteoarthritis (OA) has been reported. However, the regulatory mechanisms of circRNAs in OA synovium remains basically unidentified. The current study intended to divulge the expression profile of circRNAs in OA synovium and investigate the po...

journal_title：Journal of cellular biochemistry

authors： Xiang S,Li Z,Bian Y,Weng X

更新日期：2019-10-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is currently the third most common cause of end stage liver disease necessitating transplantation. The question remains how inflammation and NASH develop in the setting of nonalcoholic fatty liver disease (NAFLD) and steatosis. Understand the roles of toll-like receptor 4 (TLR4) and...

journal_title：Journal of cellular biochemistry

authors： Sutter AG,Palanisamy AP,Lench JH,Esckilsen S,Geng T,Lewin DN,Cowart LA,Chavin KD

更新日期：2016-07-01 00:00:00

abstract：:Metallo Beta (β) Lactamases (MBL) are metal dependent bacterial enzymes that hydrolyze the β-lactam antibiotics. In recent years, MBL have received considerable attention because it inactivates most of the β-lactam antibiotics. Increase in dissemination of MBL encoding antibiotic resistance genes in pathogenic bacteri...

journal_title：Journal of cellular biochemistry

authors： Parimelzaghan A,Anbarasu A,Ramaiah S

更新日期：2016-06-01 00:00:00

abstract：:Butyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non-small cell lung cancer cell line, using microarray. We found 33 up-regulated microRNAs and 22 down-regulated microRNAs (log2 ≥1.5 f...

journal_title：Journal of cellular biochemistry

authors： Xiao X,Cao Y,Chen H

更新日期：2018-04-01 00:00:00

abstract：:Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured a...

journal_title：Journal of cellular biochemistry

authors： Huang H,Shi Y,Lin L,Li L,Lin X,Li X,Xu D

更新日期：2011-03-01 00:00:00

abstract：:We have recently described the isolation and purification to homogeneity of a new sialoglycopeptide from bovine brain cell surfaces that reversibly inhibits protein synthesis and DNA synthesis of normal but not transformed cells. Active inhibitory preparations, however, were shown to contain a protease activity that w...

journal_title：Journal of cellular biochemistry

authors： Sharifi BG,Bascom CC,Fattaey H,Nash S,Johnson TC

更新日期：1986-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short non-coding single-stranded RNAs, which play significant roles in the regulation of a myriad of biological processes. Overwhelmingly increasing high-impact research has also deepened our understanding about the central role of miRNAs in cancer development, metastatic spread, and development...

journal_title：Journal of cellular biochemistry

authors： Wen R,Umeano AC,Essegian DJ,Sabitaliyevich UY,Wang K,Farooqi AA

更新日期：2018-11-01 00:00:00

abstract：:Recent studies demonstrate that reactive oxygen species (ROS) are important mediators of acute pancreatitis, whether induced experimentally or in necrotizing pancreatitis in humans; however, the cellular processes involved remain unclear. Adapter protein CrkII, plays a central role for convergence of cellular signals ...

journal_title：Journal of cellular biochemistry

authors： Andreolotti AG,Bragado MJ,Tapia JA,Jensen RT,Garcia-Marin LJ

更新日期：2006-02-01 00:00:00