Signaling function of PSGL-1 in neutrophil: tyrosine-phosphorylation-dependent and c-Abl-involved alteration in the F-actin-based cytoskeleton.

abstract：:Protein phosphatase 2A (PP2A) is an important enzyme within various signal transduction pathways. The present study was investigated PP2A mediates JS-K-induced apoptosis by affecting Bcl-2 family protein. JS-K showed diverse inhibitory effects in five HCC cell lines, especially HepG2 cells. JS-K caused a dose- and tim...

journal_title：Journal of cellular biochemistry

authors： Liu L,Huang Z,Chen J,Wang J,Wang S

更新日期：2018-08-01 00:00:00

abstract：:Photodynamic treatment is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with activation of a photosensitizer agent at a specific light. Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of can...

journal_title：Journal of cellular biochemistry

authors： Khorsandi K,Hosseinzadeh R,Shahidi FK

更新日期：2019-04-01 00:00:00

abstract：:Diacylglycerol (DG) kinase (DGK), which phosphorylates DG to generate phosphatidic acid (PA), consists of ten isozymes (α-к). Recently, we identified a novel small molecule inhibitor, CU-3, that selectively inhibits the activity of the α isozyme. In addition, we newly obtained Compound A, which selectively and strongl...

journal_title：Journal of cellular biochemistry

authors： Yamaki A,Akiyama R,Murakami C,Takao S,Murakami Y,Mizuno S,Takahashi D,Kado S,Taketomi A,Shirai Y,Goto K,Sakane F

更新日期：2019-06-01 00:00:00

abstract：:In mice, the first round of DNA replication occurs in fertilized eggs (1-cell embryos), while the onset of zygotic gene transcription begins approximately 20 hours after fertilization, a time that normally coincides with formation of a 2-cell embryo. One approach to investigating the mechanisms that control these deve...

journal_title：Journal of cellular biochemistry

authors： Majumder S,DePamphilis ML

更新日期：1994-05-01 00:00:00

abstract：:Vacuolar H+ -ATPases (V-ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of V-ATPases cause autosomal recessive osteopetrosis, a rare disease due to impaired bone resorption. Patients with osteopetrosis also display dental anomalies, such as ename...

journal_title：Journal of cellular biochemistry

authors： Johnson L,Ganss B,Wang A,Zirngibl RA,Johnson DE,Owen C,Bradley G,Voronov I

更新日期：2017-10-01 00:00:00

abstract：:The role of murine Hsp25 phosphorylation in the protection mediated by this protein against TNFalpha- or H2O2-mediated cytotoxicity was investigated in L929 cell lines expressing wild type (wt-) or nonphosphorylatable (mt-) Hsp25. We show that mt-Hsp25, in which the phosphorylation sites, serines 15 and 86, were repla...

journal_title：Journal of cellular biochemistry

authors： Préville X,Schultz H,Knauf U,Gaestel M,Arrigo AP

更新日期：1998-06-15 00:00:00

abstract：:Angiogenesis, the formation of new capillary blood vessels, occurs almost exclusively in the microcirculation. This process is controlled by the interaction between factors with positive and negative regulatory activity. In this study, we have compared the effect of two well described positive regulators, vascular end...

journal_title：Journal of cellular biochemistry

authors： Cavallaro U,Tenan M,Castelli V,Perilli A,Maggiano N,Van Meir EG,Montesano R,Soria MR,Pepper MS

更新日期：2001-01-01 00:00:00

abstract：:Epidermal Differentiation Complex (EDC) is a gene cluster on human chromosome 1 q21, which comprises genes encoding four protein families: S100, S100 fused (SFTP), small proline-rich region (SPRR) and late cornified envelope (LCE) proteins. Contrary to the latter three families, which group proteins important for skin...

journal_title：Journal of cellular biochemistry

authors： Sobiak B,Graczyk-Jarzynka A,Leśniak W

更新日期：2016-05-01 00:00:00

abstract：:Resident T lymphocytes have been found to exert helper and suppressor regulatory influences with regard to polyclonal activation of murine splenic B lymphocytes elicited by lipopolysaccharide. In the normal adult spleen, only T cell helper influences are exercised over polyclonal B cell activation. This activity is a ...

journal_title：Journal of cellular biochemistry

authors： Goodman MG,Weigle WO

更新日期：1982-01-01 00:00:00

abstract：:Transplantation of functional insulin-producing cells (IPCs) provides a novel mode for insulin replacement, but is often accompanied by many undesirable side effects. Our previous studies suggested that IPCs could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells. To obtain...

journal_title：Journal of cellular biochemistry

authors： Shi Q,Luo S,Jia H,Feng L,Lu X,Zhou L,Cai J

更新日期：2013-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a severe disease with high mortality in the world. It has been shown that long noncoding RNA (lncRNA) might play a role in HCC. The aim of the present study was to identify the role of long intergenic noncoding RNA 01551 (LINC01551) in the HCC development and explore the underlying me...

journal_title：Journal of cellular biochemistry

authors： Gao J,Yin X,Yu X,Dai C,Zhou F

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:It has been reported that the fastigial nucleus (FSN) plays an important role in the development of vascular dementia (VD). Both autophagy and inflammation are functionally involved in the pathogenesis of VD. In this study, we aimed to evaluate the therapeutic effect of electrical cerebellar fastigial nucleu...

journal_title：Journal of cellular biochemistry

authors： Xia D,Sui R,Min L,Zhang L,Zhang Z

更新日期：2019-04-01 00:00:00

abstract：:The role of circular RNAs (circRNAs) in regulating cartilage homeostasis in osteoarthritis (OA) has been reported. However, the regulatory mechanisms of circRNAs in OA synovium remains basically unidentified. The current study intended to divulge the expression profile of circRNAs in OA synovium and investigate the po...

journal_title：Journal of cellular biochemistry

authors： Xiang S,Li Z,Bian Y,Weng X

更新日期：2019-10-01 00:00:00

abstract：:Breast cancer remains the major cause of cancer-related deaths in women world-wide. The heterogeneity of breast cancer has further complicated the progress of target-based therapies. Triple negative breast cancers, lacking estrogen receptor, progesterone receptor and the Her-2/neu (ErbB2), represent a highly aggressiv...

journal_title：Journal of cellular biochemistry

authors： Ahmad A,Banerjee S,Wang Z,Kong D,Sarkar FH

更新日期：2008-12-15 00:00:00

abstract：:Reveromycin A (RM-A), a small natural product isolated from Streptomyces bacteria, is a potential osteoporosis therapeutic in that it specifically induces apoptosis in osteoclasts but not osteoblasts. The purpose of the study presented here was to further elucidate the intracellular mechanisms of RM-A death effects in...

journal_title：Journal of cellular biochemistry

authors： Mead B,Morgan H,Mann-Knowlton A,Tedeschi L,Sloan C,Lang S,Hines C,Gragg M,Stofer J,Riemann K,Derr T,Heller E,Collins D,Landis P,Linna N,Jones D

更新日期：2015-08-01 00:00:00

abstract：:To determine the role of thrombin high-affinity receptor occupancy and enzymic activity in thrombin initiation of cell proliferation, we have utilized thrombin derivatives which separate these functions. We previously showed that enzymically active gamma-thrombin stimulates ion fluxes without binding to high-affinity ...

journal_title：Journal of cellular biochemistry

authors： Carney DH,Stiernberg J,Fenton JW 2nd

更新日期：1984-01-01 00:00:00

abstract：:Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apop...

journal_title：Journal of cellular biochemistry

authors： Panahi Y,Abdolghaffari AH,Sahebkar A

更新日期：2018-01-01 00:00:00

abstract：:Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but its role in regulating liver regeneration is unknown. Here we investigated the effects of GSK-3beta inhibition on liver regeneration after partial hepatectomy in the rat. The potent and selective GSK-...

journal_title：Journal of cellular biochemistry

authors： Chen H,Yang S,Yang Z,Ma L,Jiang D,Mao J,Jiao B,Cai Z

更新日期：2007-12-01 00:00:00

abstract：:HOXB13 exerts a close relation in several human cancers. This study explored the role of HOXB13 in glioblastoma (GBM), a brain tissue with the highest aggressive rate and mortality in adults. Through microarray and immunohistochemistry analyses, HOXB13 was highly expressed in GBM tissues. Furthermore, we showed that h...

journal_title：Journal of cellular biochemistry

authors： Wang X,Sun Y,Xu T,Qian K,Huang B,Zhang K,Song Z,Qian T,Shi J,Li L

更新日期：2019-09-01 00:00:00

abstract：:The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. A novel transcript of the MDMX gene has been previously identified that has a short internal deletion of 68 base pairs, producing a shift in the reading frame after codon 114, resulting in the inclusion of 1...

journal_title：Journal of cellular biochemistry

authors： Rallapalli R,Strachan G,Tuan RS,Hall DJ

更新日期：2003-06-01 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：:Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and functi...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Yang N,Du G,Li C,Liu G,Liu S,Xu Y,Di Y,Pan W,Li X

更新日期：2018-11-14 00:00:00

abstract：:Cutaneous melanoma (CM) has become a major public health concern. Studies illustrate that minichromosome maintenance protein 7 (MCM7) participate in various diseases including skin disease. Our study aimed to study the effects of MCM7 silencing on CM cell autophagy and apoptosis by modulating the AKT threonine kinase ...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Ma S,Ye Z,Zhou X

更新日期：2020-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding ribonucleic acids known to affect gene expression at the translational level and there is mounting evidence that miRNAs play a role in the function of tumor-associated macrophages (TAMs). To aid the functional analyses of miRNAs in an in-vitro model of TAMs known as M2 macrophage...

journal_title：Journal of cellular biochemistry

authors： Ng YS,Roca H,Fuller D,Sud S,Pienta KJ

更新日期：2012-05-01 00:00:00

abstract：:Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related si...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Stein JL,Lian JB,van Wijnen AJ,Montecino M

更新日期：1996-08-01 00:00:00

abstract：:Adequate regulation of endolymphatic pH is essential for maintaining inner ear function. The Na(+)-H(+) exchanger (NHE) is a major determinant of intracellular pH (pH(i)), and facilitates Na(+) and fluid absorption in various epithelia. We determined the functional and molecular expression of NHEs in cultured human en...

journal_title：Journal of cellular biochemistry

authors： Son EJ,Moon IS,Kim SH,Kim SJ,Choi JY

更新日期：2009-08-01 00:00:00

abstract：:Homocysteine-thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT and low density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL). Structural and functional alt...

journal_title：Journal of cellular biochemistry

authors： Ferretti G,Bacchetti T,Moroni C,Vignini A,Nanetti L,Curatola G

更新日期：2004-05-15 00:00:00

abstract：:Gold nanoparticles (AuNP's) facilitate cancer cell recognition and can be manufactured by green synthesis using nutrient rich medicinal plants such as Moringa oleifera (MO). Targeting dysregulated oncogenes and tumor suppressor genes is crucial for cancer therapeutics. We investigated the antiproliferative effects of ...

journal_title：Journal of cellular biochemistry

authors： Tiloke C,Phulukdaree A,Anand K,Gengan RM,Chuturgoon AA

更新日期：2016-10-01 00:00:00

abstract：:The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy can act as a pro-survival response during oxidative stress or nutrient deficiency. In this work...

journal_title：Journal of cellular biochemistry

authors： Mancilla H,Maldonado R,Cereceda K,Villarroel-Espíndola F,Montes de Oca M,Angulo C,Castro MA,Slebe JC,Vera JC,Lavandero S,Concha II

更新日期：2015-10-01 00:00:00

abstract：:It has drawn a lot of attention to target signal transducer and activator of transcription 3 (STAT3) as a potential strategy for cancer therapeutics. Using several myelogenous cell lines, the effect of genipin (an active compound of Gardenia fruit) on the STAT3 pathway and apoptosis was investigated. Genipin suppresse...

journal_title：Journal of cellular biochemistry

authors： Lee JC,Ahn KS,Jeong SJ,Jung JH,Kwon TR,Rhee YH,Kim SH,Kim SY,Yoon HJ,Zhu S,Chen CY,Kim SH

更新日期：2011-06-01 00:00:00