Abstract:
:Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue-specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Stein GS,Stein JL,Lian JB,van Wijnen AJ,Montecino Mdoi
10.1002/(SICI)1097-4644(199608)62:2%3C198::AID-JCBsubject
Has Abstractpub_date
1996-08-01 00:00:00pages
198-209issue
2eissn
0730-2312issn
1097-4644pii
10.1002/(SICI)1097-4644(199608)62:2<198::AID-JCB8>journal_volume
62pub_type
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