GLP-1 could improve the similarity of IPCs and pancreatic beta cells in cellular ultrastructure and function.

abstract：:Muscle progenitor cells differentiate to myoblasts, and subsequently myotubes, upon expression of muscle specific genes. We and others have previously shown that myotube nuclei, even in the absence of nerve, express AChR alpha subunit RNA at varying levels, with a small subset (about ten percent) of the nuclei express...

journal_title：Journal of cellular biochemistry

authors： Su X,Berman SA,Sullivan T,Bursztajn S

更新日期：1995-05-01 00:00:00

abstract：:Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present study, we have used immunofluores...

journal_title：Journal of cellular biochemistry

authors： Haddad N,Paulin-Levasseur M

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (M...

journal_title：Journal of cellular biochemistry

authors： Xiang Z,Zhou Q,Hu M,Sanders YY

更新日期：2020-07-01 00:00:00

abstract：:The retinoblastoma susceptibility gene product, p105Rb (RB), is generally believed to be an important regulator in the control of cell growth, differentiation, and apoptosis. Several cellular factors that form complexes with RB and exert their cellular regulatory functions have been identified, such as the newly ident...

journal_title：Journal of cellular biochemistry

authors： Cui Y,Mirkia K,Florence Fu YH,Zhu L,Yokoyama KK,Chiu R

更新日期：2002-01-01 00:00:00

abstract：:The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of ...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Zaidi SK,Stein JL,Lian JB,van Wijnen AJ,Montecino M,Young DW,Javed A,Pratap J,Choi JY,Ali SA,Pande S,Hassan MQ

更新日期：2008-08-15 00:00:00

abstract：:The influence of concentration of simvastatin (SIM) on free radicals in A-2058 human melanoma malignum cells was studied. The proliferation assay for melanoma A-2058 cells with SIM in concentration range from 0.1 to 20 µM was performed. SIM in the concentrations of 0.1, 0.3, and 1 μM only slightly changed the growth o...

journal_title：Journal of cellular biochemistry

authors： Zdybel M,Chodurek E,Pilawa B

更新日期：2018-09-11 00:00:00

abstract：:Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

journal_title：Journal of cellular biochemistry

authors： Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

更新日期：2009-12-15 00:00:00

abstract：:Vascularization is essential for bone development, fracture healing, and bone tissue engineering. We have previously described that coculture of primary human osteoblasts (hOBs) and human umbilical vein endothelial cells (HUVECs) improves differentiation of both cell types. Investigating the role of microRNAs (miRNAs)...

journal_title：Journal of cellular biochemistry

authors： Strassburg S,Nabar N,Lampert F,Goerke SM,Pfeifer D,Finkenzeller G,Stark GB,Simunovic F

更新日期：2017-07-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs), via their interactions with numerous effector molecules such as FGF-2, IL-8, and VEGF, regulate the biological activity of cells by acting as co-receptors that promote signaling. The extent and nature of their role as co-receptors is often misregulated in cancer as manifested by ...

journal_title：Journal of cellular biochemistry

authors： Sanderson RD,Yang Y,Kelly T,MacLeod V,Dai Y,Theus A

更新日期：2005-12-01 00:00:00

abstract：:The mouse macrophage Fc gamma 2b/gamma 1R has previously been purified with the aid of the monoclonal antibody 2.4G2. That this Fc gamma R functions as a ligand-dependent ion channel is supported by the following evidence. Employing [3H]tetraphenylphosphonium ([3H]Ph4P+) as a probe for membrane potential changes in in...

journal_title：Journal of cellular biochemistry

authors： Young JD,Unkeless JC,Cohn ZA

更新日期：1985-01-01 00:00:00

abstract：:Astrocytes, the major glial population in the central nervous system (CNS), can secrete thrombospondin (TSP)-1 that plays the role in synaptogenesis and axonal sprouting during CNS development and tissue repair. However, little is known about the regulation of TSP-1 expression in astrocytes under oxidative stress cond...

journal_title：Journal of cellular biochemistry

authors： Chen JK,Zhan YJ,Yang CS,Tzeng SF

更新日期：2011-01-01 00:00:00

abstract：:Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

journal_title：Journal of cellular biochemistry

authors： Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

更新日期：2020-01-01 00:00:00

abstract：:Leishmania, a protozoan parasite that causes leishmaniasis, affects 1-2 million people every year worldwide. Leishmaniasis is a vector born disease and characterized by a diverse group of clinical syndromes. Current treatment is limited because of drug resistance, high cost, poor safety, and low efficacy. The urgent n...

journal_title：Journal of cellular biochemistry

authors： Kashif M,Tabrez S,Husein A,Arish M,Kalaiarasan P,Manna PP,Subbarao N,Akhter Y,Rub A

更新日期：2018-03-01 00:00:00

abstract：:Extracellular matrix metalloproteinases (MMPs) are activated in dilated cardiomyopathic (DCM) hearts [Tyagi et al. (1996): Mol Cell Biochem 155:13-21]. To examine whether the MMP activation is occurring at the gene expression level, we performed differential display mRNA analysis on tissue from six dilated cardiomyopa...

journal_title：Journal of cellular biochemistry

authors： Tyagi SC,Kumar S,Voelker DJ,Reddy HK,Janicki JS,Curtis JJ

更新日期：1996-11-01 00:00:00

abstract：:Insects possess an antimicrobial defense response that is similar to the mammalian innate immune response. The innate immune system is designed to recognize conserved components of microorganisms called pathogen-associated molecular patterns (PAMPs). How host receptors detect PAMPs and transmit the signals to mount th...

journal_title：Journal of cellular biochemistry

authors： Bettencourt R,Asha H,Dearolf C,Ip YT

更新日期：2004-07-01 00:00:00

abstract：:Osteoclasts are highly differentiated terminal cells formed by fusion of hematopoietic stem cells. Previously, osteoprotegerin (OPG) inhibit osteoclast differentiation and bone resorption by blocking receptor activator of nuclear factor-κB ligand (RANKL) binding to RANK indirect mechanism. Furthermore, autophagy plays...

journal_title：Journal of cellular biochemistry

authors： Tong X,Gu J,Song R,Wang D,Sun Z,Sui C,Zhang C,Liu X,Bian J,Liu Z

更新日期：2018-09-06 00:00:00

abstract：:The promoter of the mouse thymidylate synthase (TS) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter also plays an essential role in the p...

journal_title：Journal of cellular biochemistry

authors： Kapadia F,Johnson LF

更新日期：2006-02-15 00:00:00

abstract：:MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT-PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse ...

journal_title：Journal of cellular biochemistry

authors： Chapela PJ,Broaddus RR,Hawkins SM,Lessey BA,Carson DD

更新日期：2015-11-01 00:00:00

abstract：:The effect of steroid hormones on mouse mammary tumour virus (MMTV) promoter activity has been analysed in the breast cancer cell lines ZR-75-1 and T-47D 11. Both androgens and progestins were stimulatory in both cell lines, whereas glucocorticoids were stimulatory in only ZR-75 cells. A glucocorticoid response was re...

journal_title：Journal of cellular biochemistry

authors： Parker MG,Webb P,Needham M,White R,Ham J

更新日期：1987-12-01 00:00:00

abstract：:Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to fin...

journal_title：Journal of cellular biochemistry

authors： Zhang C,Jiang F,Su C,Xie P,Xu L

更新日期：2019-02-14 00:00:00

abstract：PURPOSE:Endometrial carcinoma (EC), a common gynecological malignancy with high incidence, affects the mental and physical health of women. Mounting evidence shows that long noncoding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) have instrumental roles in various biological processes associated with t...

journal_title：Journal of cellular biochemistry

authors： Zhao D,Ren C,Yao Y,Wang Q,Li F,Li Y,Jiang A,Wang G

更新日期：2020-03-01 00:00:00

abstract：:Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calcul...

journal_title：Journal of cellular biochemistry

authors： Rucci N,Migliaccio S,Zani BM,Taranta A,Teti A

更新日期：2002-01-01 00:00:00

abstract：:Recently, it has been revealed that estrogen-related reproductive factors are linked with some early gene expression lesions associated with malignancy in clinically healthy breasts. Accordingly, the aim of the current study was to evaluate the association of expression levels of estrogen-related long noncoding RNAs (...

journal_title：Journal of cellular biochemistry

authors： Mansoori Y,Zendehbad Z,Askari A,Kouhpayeh A,Tavakkoly-Bazzaz J,Nariman-Saleh-Fam Z,Bastami M,Saadatian Z,Mansoori B,Yousefvand A,Mansoori H,Daraei A

更新日期：2019-06-01 00:00:00

abstract：:DNA methylation plays a role in the etiology of primary breast cancers. We analyzed paired primary and second breast tumors to elucidate the role of methylation in recurrence. Methylation profiles from paired primary and second breast tumors of 23 women were assessed using the HumanMethylation450 BeadChip. Twelve wome...

journal_title：Journal of cellular biochemistry

authors： Williams KE,Jawale RM,Schneider SS,Otis CN,Pentecost BT,Arcaro KF

更新日期：2019-01-01 00:00:00

abstract：:Osteopontin is a multifunctional matricellular protein identified as one of the most upregulated genes in pulmonary fibrosis. Experimental animal models have identified early pro-fibrotic cytokines as essential to the pathogenesis of inflammation-induced pulmonary fibrosis. However, the principal sources of osteoponti...

journal_title：Journal of cellular biochemistry

authors： Serlin DM,Kuang PP,Subramanian M,O'Regan A,Li X,Berman JS,Goldstein RH

更新日期：2006-02-15 00:00:00

abstract：:The 17,180 base-pair Eco-RI-C fragment of Epstein-Barr virus has been sequenced in its entirety. This same fragment has also been analyzed for RNA polymerase II promoters, which are active in a soluble in vitro assay. These data are compared to the availability of predicted open reading frames and potential nucleotide...

journal_title：Journal of cellular biochemistry

authors： Deininger PL,Bankier A,Farrell P,Baer R,Barrell B

更新日期：1982-01-01 00:00:00

abstract：:This study aims to explore how microRNA-133a (miR-133a) affects cell apoptosis and radio-sensitivity by targeting EGFR via regulating MEK/ERK pathway in esophageal cancer (EC). A total of 358 EC patients were selected and assigned into the resistant and sensitive groups. Human EC KYSE 150 cell line was assigned into t...

journal_title：Journal of cellular biochemistry

authors： Yang QS,Jiang LP,He CY,Tong YN,Liu YY

更新日期：2017-09-01 00:00:00

abstract：:Amyloid-β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer disease (AD) patients. Aβ is proteolytically derived from amyloid-β precursor protein by β- and γ-secretases. Secreted Aβ is then eliminated from the central nervous system by multiple clearance mechanisms, including phagocytosis...

journal_title：Journal of cellular biochemistry

authors： Kikuchi K,Kidana K,Tatebe T,Tomita T

更新日期：2017-12-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disabilities worldwide. MicroRNA-377 (miR-377) plays important roles in ischemic injury. The present study focused on the mechanisms of miR-377 in protecting ischemic brain injury in rats. Cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in rats. Primary ...

journal_title：Journal of cellular biochemistry

authors： Fan Y,Ding S,Sun Y,Zhao B,Pan Y,Wan J

更新日期：2018-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) infects millions of people each year. These bacilli can survive inside macrophages. To favor their survival, pathogen alters various signal transduction pathways in host cells. Phospholipase C (PLC) signaling regulates various processes in mammalian cells but has never been investigate...

journal_title：Journal of cellular biochemistry

authors： Paroha R,Chaurasiya SK,Chourasia R

更新日期：2019-04-01 00:00:00