Abstract:
:Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was determined in 3T3-L1 adipocytes. Interestingly, APP protein synthesis and mRNA expression were significantly increased by TNFalpha in a time-dependent manner with maximal induction observed after 24 h of treatment. Furthermore, TNFalpha induced APP mRNA expression dose-dependently with maximal 6.4-fold upregulation seen at 100 ng/ml effector. Moreover, inhibitor experiments suggested that TNFalpha-induced APP expression was mediated by nuclear factor kappa B. Taken together, we show for the first time a potent upregulation of APP by TNFalpha suggesting a potential role of this adipocyte-secreted protein in TNFalpha-induced insulin resistance and inflammatory disease.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer Mdoi
10.1002/jcb.22382subject
Has Abstractpub_date
2009-12-15 00:00:00pages
1418-22issue
6eissn
0730-2312issn
1097-4644journal_volume
108pub_type
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