Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.

abstract：:Protein synthesis inhibitors paradoxically increase the expression of early-gene products, including various cytokines, through a process known as superinduction. Superinduction is cell-specific and the mechanisms involved are not fully understood but are usually attributed to decreased mRNA degradation. There is, how...

journal_title：Journal of cellular biochemistry

authors： Hershko DD,Robb BW,Wray CJ,Luo GJ,Hasselgren PO

更新日期：2004-04-01 00:00:00

abstract：:The levels of organic pollutants, such as optical brightener (OB) compounds, in the global environment have been increasing in recent years. The toxicological effects and signal transduction systems associated with OB toxicity have not been thoroughly studied. The ubiquitin-proteasome system (UPS) plays a crucial role...

journal_title：Journal of cellular biochemistry

authors： Castro I,Ekinci E,Huang X,Cheaito HA,Ahn YH,Olivero-Verbel J,Dou QP

更新日期：2019-08-01 00:00:00

abstract：:The matrix metalloproteinases (MMP-9 and MMP-2) production and smooth muscle cell (SMC) migration may play key roles in the pathogenesis of atherosclerotic lesions. In particular, the cancer cell invasion and SMC migration through vascular wall were shown to be directly associated with inducible MMP-9 expression. Prev...

journal_title：Journal of cellular biochemistry

authors： Suh SJ,Cho KJ,Moon TC,Chang HW,Park YG,Kim CH

更新日期：2008-10-01 00:00:00

abstract：:Ceruloplasmin (CP) is essential for brain iron homeostasis. However, its precise function in brain iron transport has not been definitely determined. In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and ...

journal_title：Journal of cellular biochemistry

authors： Ke Y,Ho K,Du J,Zhu L,Xu Y,Wang Q,Wang CY,Li L,Ge X,Chang Y,Qian ZM

更新日期：2006-07-01 00:00:00

abstract：:TNF is a key inflammatory cytokine with antiviral properties. Human adenoviruses encode several intracellular proteins that mediate the effects of TNF. Expression of the adenovirus immediate early E1A proteins induces viral genes and a host of cellular genes, drives G0 cells into S-phase, and induces apoptosis and sus...

journal_title：Journal of cellular biochemistry

authors： Wold WS

更新日期：1993-12-01 00:00:00

abstract：:The DNA tumor virus oncogenes (adenovirus E1A, simian virus 40 (SV40) large T antigen, and papillomavirus E7) have been instrumental in illuminating the molecules and mechanisms of cell cycle progression and carcinogenesis. However, since these multifunctional proteins target so many important cellular regulators, it ...

journal_title：Journal of cellular biochemistry

authors： Kalejta RF

更新日期：2004-09-01 00:00:00

abstract：:CD133 and CD44 are commonly used markers of cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical value and significance of CD133 and CD44 in lung metastasis of osteosarcoma (OS) remains controversial. The purpose of this study was to investigate ...

journal_title：Journal of cellular biochemistry

authors： He A,Yang X,Huang Y,Feng T,Wang Y,Sun Y,Shen Z,Yao Y

更新日期：2015-08-01 00:00:00

abstract：:The nucleolus is a multifunctional nuclear compartment widely known to be involved in several cellular processes, including mRNA maturation and shuttling to cytoplasmic sites, control of the cell cycle, cell proliferation, and apoptosis; thus, it is logical that many viruses, including herpesvirus, target the nucleolu...

journal_title：Journal of cellular biochemistry

authors： Arcangeletti MC,Rodighiero I,Mirandola P,De Conto F,Covan S,Germini D,Razin S,Dettori G,Chezzi C

更新日期：2011-01-01 00:00:00

abstract：:CD4-positive helper T cells and CD8-positive cytotoxic T cells comprise the majority of T lymphocytes present in secondary lymphoid organs and are essential for acquired immunity. These two populations are derived from common precursors in the thymus and selected through interaction between their clonal T-cell recepto...

journal_title：Journal of cellular biochemistry

authors： Egawa T

更新日期：2009-08-15 00:00:00

abstract：:Lung cancer is the leading cause of death among all cancers. Non-small cell lung cancer accounts for 80% of lung cancer with a 5-year survival rate of 16%. Notch pathway, especially Notch-1 is up-regulated in a subgroup of non-small cell lung cancer patients. Since Notch-1 signaling plays an important role in cell pro...

journal_title：Journal of cellular biochemistry

authors： Ji X,Wang Z,Geamanu A,Sarkar FH,Gupta SV

更新日期：2011-10-01 00:00:00

abstract：:Excitatory amino acids (EAAs) are found present in the nervous and reproductive systems of animals. Numerous studies have demonstrated a regulatory role for Glutamate (Glu), d-aspartate ( d-Asp) and N-methyl- d-aspartate (NMDA) in the control of spermatogenesis. EAAs are able to stimulate the Glutamate receptors, incl...

journal_title：Journal of cellular biochemistry

authors： Santillo A,Falvo S,Di Fiore MM,Di Giacomo Russo F,Chieffi P,Usiello A,Pinelli C,Baccari GC

更新日期：2019-02-14 00:00:00

abstract：:Erbb4-IR is a recently identified lncRNA with pivotal functions in renal injury. The present study investigated the roles of Erbb4-IR in esophageal squamous cell carcinoma (ESCC). It was observed that Erbb4-IR was upregulated in tumor tissues of patients with ESCC. Plasma levels of Erbb4-IR in patients with ESCC were ...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Zhang L,Wang R,Wang B,Hua P,Li J

更新日期：2019-10-01 00:00:00

abstract：:Preeclampsia is a pathologic complication of pregnancy, associated with increased apoptosis in the cytotrophoblasts as the main cause of this disorder. Caspase-3 is a key apoptosis-related enzyme that both mitochondrial and death receptor apoptotic pathways can activate. In this study, we aimed to investigate the effe...

journal_title：Journal of cellular biochemistry

authors： Teimoori B,Yazdi A,Rezaei M,Mohammadpour-Gharehbagh A,Jahantigh D,Salimi S

更新日期：2018-08-01 00:00:00

abstract：:Vascular smooth-muscle cell (VSMC) proliferation plays a vital role in hypertension, atherosclerosis and restenosis. It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if emodin exerts similar anti-atherogenic effects in TNF-alpha...

journal_title：Journal of cellular biochemistry

authors： Heo SK,Yun HJ,Park WH,Park SD

更新日期：2008-09-01 00:00:00

abstract：:The role of murine Hsp25 phosphorylation in the protection mediated by this protein against TNFalpha- or H2O2-mediated cytotoxicity was investigated in L929 cell lines expressing wild type (wt-) or nonphosphorylatable (mt-) Hsp25. We show that mt-Hsp25, in which the phosphorylation sites, serines 15 and 86, were repla...

journal_title：Journal of cellular biochemistry

authors： Préville X,Schultz H,Knauf U,Gaestel M,Arrigo AP

更新日期：1998-06-15 00:00:00

abstract：:Reactive oxygen species (ROS) produced by endothelial cells and macrophages play important roles in atherogenesis because they promote the formation of oxidized low-density lipoproteins (oxLDL). Extracellular-superoxide dismutase (EC-SOD) is mainly produced by vascular smooth muscle cells (VSMCs), is secreted into the...

journal_title：Journal of cellular biochemistry

authors： Makino J,Asai R,Hashimoto M,Kamiya T,Hara H,Ninomiya M,Koketsu M,Adachi T

更新日期：2016-11-01 00:00:00

abstract：:Active nucleo-cytoplasmic transport is mediated by dynamic signal-mediated pathways. We investigated the effects of transcription inhibitors or fluorescent lectins on nuclear import mediated by nuclear localization signals (NLSs). Therefore, a novel experimental approach that allows the controlled sequential introduct...

journal_title：Journal of cellular biochemistry

authors： Stauber RH,Krätzer F,Schneider G,Hirschmann N,Hauber J,Rosorius O

更新日期：2001-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are vital mediators involved in cancer progression. Previous studies confirmed that FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is upregulated in tumor diseases. The potential influence of FOXD2-AS1 in glioma progression, however, remains unknown. In this paper, FOXD2-AS1 was found t...

journal_title：Journal of cellular biochemistry

authors： Wang J,Li B,Wang C,Luo Y,Zhao M,Chen P

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (M...

journal_title：Journal of cellular biochemistry

authors： Xiang Z,Zhou Q,Hu M,Sanders YY

更新日期：2020-07-01 00:00:00

abstract：:Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis ...

journal_title：Journal of cellular biochemistry

authors： Wu J,Yan X,Jin G

更新日期：2018-09-22 00:00:00

abstract：:Our previous study demonstrate that vitamin D3 induces the binding of vitamin D3 receptor (VDR) to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as the transcription comp...

journal_title：Journal of cellular biochemistry

authors： Cheng HT,Chen JY,Huang YC,Chang HC,Hung WC

更新日期：2006-08-15 00:00:00

abstract：:Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α is a crucial regulator of breast hormone responsiveness and its hypermethylation...

journal_title：Journal of cellular biochemistry

authors： Daraei A,Izadi P,Khorasani G,Nafissi N,Naghizadeh MM,Younosi N,Meysamie A,Mansoori Y,Nariman-Saleh-Fam Z,Bastami M,Saadatian Z,Zendehbad Z,Tavakkoly-Bazzaz J

更新日期：2019-08-01 00:00:00

abstract：:D-Galactose (D-gal) can induce oxidative stress in non-cancer cells and result in cell damage by disturbing glucose metabolism. However, the effect of D-gal on cancer cells is yet to be explored. In this study, we investigated the toxicity of D-gal to malignant cells specifically neuroblastoma cells. As the results, h...

journal_title：Journal of cellular biochemistry

authors： Li N,He Y,Wang L,Mo C,Zhang J,Zhang W,Li J,Liao Z,Tang X,Xiao H

更新日期：2011-12-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) and signal transducers and activators of transcription (STATs) are commonly expressed and activated in many malignancies. EGFR is an upstream activator of several pathways involved in tumor progression, and STATs activate selected genes involved in oncogenesis. There are sev...

journal_title：Journal of cellular biochemistry

authors： Quesnelle KM,Boehm AL,Grandis JR

更新日期：2007-10-01 00:00:00

abstract：:In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a putative L-leucine r...

journal_title：Journal of cellular biochemistry

authors： Lynch CJ,Fox HL,Vary TC,Jefferson LS,Kimball SR

更新日期：2000-03-01 00:00:00

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00

abstract：:The G(0) growth arrest (quiescent) state is highly conserved in evolution to promote survival under adverse environmental conditions. To maintain viability, G(0) growth arrested cells limit gene expression to essential growth control and pro-survival genes. CCAAT enhancer binding protein delta (C/EBPdelta), a member o...

journal_title：Journal of cellular biochemistry

authors： Li B,Si J,DeWille JW

更新日期：2008-04-01 00:00:00

abstract：:The active vitamin D metabolite 1,25-dihydroxyvitamin D3 [1,25-D3] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on the immune system....

journal_title：Journal of cellular biochemistry

authors： Lemire JM

更新日期：1992-05-01 00:00:00

abstract：:Leishmania, a protozoan parasite that causes leishmaniasis, affects 1-2 million people every year worldwide. Leishmaniasis is a vector born disease and characterized by a diverse group of clinical syndromes. Current treatment is limited because of drug resistance, high cost, poor safety, and low efficacy. The urgent n...

journal_title：Journal of cellular biochemistry

authors： Kashif M,Tabrez S,Husein A,Arish M,Kalaiarasan P,Manna PP,Subbarao N,Akhter Y,Rub A

更新日期：2018-03-01 00:00:00

abstract：:We characterized a human cDNA clone encoding a 36-kDa carboxyl terminal LIM domain protein with a PDZ domain at the amino terminal. This full-length cDNA clone has a predicted open reading frame (ORF) of 329 amino-acid residues. The ORF of this cDNA encodes the human homolog of rat CLP36, and the putative protein is n...

journal_title：Journal of cellular biochemistry

authors： Kotaka M,Ngai SM,Garcia-Barcelo M,Tsui SK,Fung KP,Lee CY,Waye MM

更新日期：1999-02-01 00:00:00