Pancreatic stellate cell-potentiated insulin secretion from Min6 cells is independent of interleukin 6-mediated pathway.

abstract：:Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role ...

journal_title：Journal of cellular biochemistry

authors： Lee MS,Lowe GN,Strong DD,Wergedal JE,Glackin CA

更新日期：1999-12-15 00:00:00

abstract：:We have partially purified and characterized an 87 kDa gelatinase activity expressed in later stage sea urchin embryos. Cleavage activity was specific for gelatin and no cleavage of sea urchin peristome type I collagen, bovine serum albumin or casein was detected. Magnesium and Zn2+ inhibited the gelatinase and Ca2+ p...

journal_title：Journal of cellular biochemistry

authors： Robinson JJ

更新日期：1997-09-01 00:00:00

abstract：:Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this t...

journal_title：Journal of cellular biochemistry

authors： Lewis MR,Jia F

更新日期：2003-10-15 00:00:00

abstract：:Esophageal carcinoma is aggressive in nature and its prognosis is largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as the most unique member of HDACs family, has the positive activity to promote initiation and progression of various cancers via targeting multiple non-histone proteins in cyto...

journal_title：Journal of cellular biochemistry

authors： Tao H,Chen YY,Sun ZW,Chen HL,Chen M

更新日期：2018-08-01 00:00:00

abstract：:DNA methylation has been studied with regard to chemotherapeutics for a number of years. The radiation field has just begun to look at this in the context of radiotherapy or radiation exposure. So far, the data suggest that radiation induces epigenetic reprogramming which indicates a purposeful response that influence...

journal_title：Journal of cellular biochemistry

authors： Zielske SP

更新日期：2015-02-01 00:00:00

abstract：AIM:Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes-associated aortic endothelial dysfunction in a rat model of diabetes and its mec...

journal_title：Journal of cellular biochemistry

authors： Wang L,Li X,Zhang Y,Huang Y,Zhang Y,Ma Q

更新日期：2018-11-19 00:00:00

abstract：:Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Our aim is to study the function and me...

journal_title：Journal of cellular biochemistry

authors： Zhang G,Sun W,Zhu L,Feng Y,Wu L,Li T

更新日期：2019-06-01 00:00:00

abstract：:The F1F0 ATP synthase has recently become the focus of anti-cancer research. It was once thought that ATP synthases were located strictly on the inner mitochondrial membrane; however, in 1994, it was found that some ATP synthases localized to the cell surface. The cell surface ATP synthases are involved in angiogenesi...

journal_title：Journal of cellular biochemistry

authors： Wang WJ,Shi XX,Liu YW,He YQ,Wang YZ,Yang CX,Gao F

更新日期：2013-07-01 00:00:00

abstract：:17β-Estradiol (E2 ) protects several nonreproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2 O2 in skeletal myoblasts, reverting PKCδ, JNK, and p66Shc activation and exerting a beneficial action over mitochondria...

journal_title：Journal of cellular biochemistry

authors： La Colla A,Vasconsuelo A,Milanesi L,Pronsato L

更新日期：2017-01-01 00:00:00

abstract：:Understanding how the information is conveyed from outside to inside the cell is a critical challenge for all biologists involved in signal transduction. The flow of information initiated by cell-cell and cell-extracellular matrix contacts is mediated by the formation of adhesion complexes involving multiple proteins....

journal_title：Journal of cellular biochemistry

authors： Lelièvre SA,Bissell MJ

更新日期：1998-01-01 00:00:00

abstract：:The aim of the present study was to test the hypothesis that the decreased renal tubular reabsorption of calcium observed in estrogen deficiency is associated with a local regulation of either PTHrP or PTH/PTHrP receptor genes in the kidney. Rats were randomly sham-operated (S) or ovariectomized receiving either vehic...

journal_title：Journal of cellular biochemistry

authors： Cros M,Silve C,Graulet AM,Morieux C,Ureña P,de Vernejoul MC,Bouizar Z

更新日期：1998-07-01 00:00:00

abstract：:Carotenoid cleavage dioxygenase (CCD) gene, ubiquitously found in numerous types of plants, are eminent in synthesizing the various volatile compounds (β-ionone, C13 -norisoprenoid, geranylacetone) known as apocarotenoids. These apocarotenoids have various biological functions such as volatile signals, allelopathic in...

journal_title：Journal of cellular biochemistry

authors： Priya R,Sneha P,Rivera Madrid R,Doss CGP,Singh P,Siva R

更新日期：2017-09-01 00:00:00

abstract：:C. difficile toxin B is a potent cytotoxin known to disrupt the microfilaments of cultured cells. We have recently shown also increased phospholipase A2 activity in cells treated with toxin B. The activity was detected as a toxin-induced, dose-dependent release of 14C-arachidonic acid from prelabeled fibroblasts. Here...

journal_title：Journal of cellular biochemistry

authors： Shoshan MC,Florin I,Thelestam M

更新日期：1993-05-01 00:00:00

abstract：:Whitmania pigra is a unique, fluid-sucking ectoparasite and an anticoagulant medical leech. The codon usage bias (CUB) is the nonuniform usage of synonymous codons in which some codons are more preferred than others. Here, we performed a comprehensive analysis of CUB of genes in W. pigra, analyzing 140 780 transcripts...

journal_title：Journal of cellular biochemistry

authors： Khan MS,Guan DL,Ma LB,Xie JY,Xu SQ

更新日期：2019-06-01 00:00:00

abstract：:Regulation of cytoplasmic free calcium concentration [Ca(2+)]i is a key factor for the maintenance of cellular homeostasis in different cell types, including lymphocytes. During T lymphocyte activation as well as production of cytokines, sustained Ca(2+) influx is essential, however, it remains unclear how this influx...

journal_title：Journal of cellular biochemistry

authors： Tomilin VN,Cherezova AL,Negulyaev YA,Semenova SB

更新日期：2016-01-01 00:00:00

abstract：:Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably...

journal_title：Journal of cellular biochemistry

authors： Li C,Ke J,Liu J,Su J

更新日期：2020-03-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully ortho-substituted PCB, 2,2',6,6'-tetrachlorobiphenyl (2,2',6,6'-TeCB). ...

journal_title：Journal of cellular biochemistry

authors： Arcaro KF,Yi L,Seegal RF,Vakharia DD,Yang Y,Spink DC,Brosch K,Gierthy JF

更新日期：1999-01-01 00:00:00

abstract：:We have previously shown that protein kinase Cε (PKCε) is involved in mitochondrial dysfunction in renal proximal tubular cells (RPTC). This study examined mitochondrial targets of active PKCε in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP). TBHP exposure augmented the levels of phosphorylated (ac...

journal_title：Journal of cellular biochemistry

authors： Nowak G,Bakajsova-Takacsova D

更新日期：2018-11-01 00:00:00

abstract：:Cumulating evidence has led to the idea that nuclear functions such as DNA replication, RNA transcription, RNA splicing and nucleocytoplasmic transport are facilitated by a proteinaceous architectural framework within the nuclear compartment and at the nuclear envelope. In the present study, we have used immunofluores...

journal_title：Journal of cellular biochemistry

authors： Haddad N,Paulin-Levasseur M

更新日期：2008-12-15 00:00:00

abstract：:The human undifferentiated histiocytic cell-line U937 can be induced to differentiate by incubation with 12-0-tetradecanoylphorbol-13-acetate (TPA) into macrophage-like cells. Dexamethasone reduced the prostaglandin production in TPA-differentiated U937 cells dose dependently, whereas undifferentiated U937 cells were ...

journal_title：Journal of cellular biochemistry

authors： Koehler L,Hass R,Goppelt-Struebe M,Kaever V,Resch K

更新日期：1989-07-01 00:00:00

abstract：:Phosphoinositide 3-kinase proteins are composed by a catalytic p110 subunit and a regulatory p85 subunit. There are three classes of PI3K, named class I-III, on the bases of the protein domain constituting and determining their specificity. The first one is the best characterized and includes a number of key elements ...

journal_title：Journal of cellular biochemistry

authors： Feola A,Cimini A,Migliucci F,Iorio R,Zuchegna C,Rothenberger R,Cito L,Porcellini A,Unteregger G,Tombolini V,Giordano A,Di Domenico M

更新日期：2013-09-01 00:00:00

abstract：:The secretion of matrix metalloproteinase (MMP-9) is stimulated by the glucocorticoid-induced tumor necrosis factor receptor (GITR), a new tumor necrosis factor receptor (TNFR) family, in murine macrophages via an activation of protein kinase C (PKC)delta and phospholipase D (PLD). Secretions of MMP-9 are stimulated b...

journal_title：Journal of cellular biochemistry

authors： Lee HS,Park SY,Lee HW,Choi HS

更新日期：2004-06-01 00:00:00

abstract：:X-ray atomic structure of recombinant Hell's gate globin I (HGbI) from Methylacidophilum infernorum was calculated from the X-ray diffraction data of two different types of crystals: obtained by classical hanging drop and by LB nanotemplate method under the same crystallization conditions. After the accurate compariso...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Scudieri D,Belmonte L,Nicolini C

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore the mechanism of excessive apoptosis of nucleus pulposus cells induced by short hairpin RNA (shRNA) Piezo type mechanosensitive ion channel component 1 (Piezo1) under abnormal mechanical stretch stress. METHODS:In vitro mechanical stretch stress model of nucleus pulposus c...

journal_title：Journal of cellular biochemistry

authors： Yang Q,Zhou Y,Wang J,Fu W,Li X

更新日期：2019-03-01 00:00:00

abstract：:Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines h...

journal_title：Journal of cellular biochemistry

authors： Elmas L,Secme M,Mammadov R,Fahrioglu U,Dodurga Y

更新日期：2019-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding ribonucleic acids known to affect gene expression at the translational level and there is mounting evidence that miRNAs play a role in the function of tumor-associated macrophages (TAMs). To aid the functional analyses of miRNAs in an in-vitro model of TAMs known as M2 macrophage...

journal_title：Journal of cellular biochemistry

authors： Ng YS,Roca H,Fuller D,Sud S,Pienta KJ

更新日期：2012-05-01 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Current study focused on the influence of miR-200b-3p on cardiocyte apoptosis of diabetic cardiomyopathy (DCM) by regulating CD36 and peroxisome proliferator-activated receptor γ (PPAR-γ) signaling pathway. METHODS:Bioinformatic analysis was used to analyze differentially expressed microRNA (miRNAs), messeng...

journal_title：Journal of cellular biochemistry

authors： Xu L,Chen W,Ma M,Chen A,Tang C,Zhang C,Cai L

更新日期：2019-04-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses, and is often significantly overexpressed in solid tumors, but little is known of its role in human lung cancer. In this study, we demonstrated the aberrant expression of HDAC2 in lung cancer ti...

journal_title：Journal of cellular biochemistry

authors： Jung KH,Noh JH,Kim JK,Eun JW,Bae HJ,Xie HJ,Chang YG,Kim MG,Park H,Lee JY,Nam SW

更新日期：2012-06-01 00:00:00

abstract：:Plasminogen activator inhibitor type-1 (PAI-1) is the major negative regulator of the plasmin-dependent pericellular proteolytic cascade. PAI-1 gene expression is normally growth state regulated but frequently elevated in chronic fibroproliferative and neoplastic diseases affecting both stromal restructuring and cellu...

journal_title：Journal of cellular biochemistry

authors： Qi L,Allen RR,Lu Q,Higgins CE,Garone R,Staiano-Coico L,Higgins PJ

更新日期：2006-10-01 00:00:00