Abstract:
:The human undifferentiated histiocytic cell-line U937 can be induced to differentiate by incubation with 12-0-tetradecanoylphorbol-13-acetate (TPA) into macrophage-like cells. Dexamethasone reduced the prostaglandin production in TPA-differentiated U937 cells dose dependently, whereas undifferentiated U937 cells were dexamethasone insensitive. Concomitantly phospholipase A2, the enzyme liberating the prostaglandin precursor arachidonic acid, was inhibited by dexamethasone in TPA-differentiated but not in undifferentiated U937 cells. The activity of lysophosphatide acyltransferase, the key enzyme of fatty acid reacylation into phospholipids, remained unchanged both in undifferentiated and TPA-differentiated U937 cells. The data suggest that responsiveness to glucocorticoid-dependent regulation of prostanoid synthesis is acquired by cells of the monocyte-macrophage lineage late in differentiation.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Koehler L,Hass R,Goppelt-Struebe M,Kaever V,Resch Kdoi
10.1002/jcb.240400315subject
Has Abstractpub_date
1989-07-01 00:00:00pages
397-406issue
3eissn
0730-2312issn
1097-4644journal_volume
40pub_type
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