MicroRNA-9 inhibits retinal neovascularization in rats with diabetic retinopathy by targeting vascular endothelial growth factor A.

abstract：:Cisplatin (DDP)-based chemotherapy is a standard strategy for ovarian cancer (OC), while chemoresistance remains a major therapeutic challenge. Transcription factor SOX9 has been reported to be associated with tumor cell proliferation, metastasis, and chemoresistance. In the current study, we observed a higher SOX9 ex...

journal_title：Journal of cellular biochemistry

authors： Xiao S,Li Y,Pan Q,Ye M,He S,Tian Q,Xue M

更新日期：2019-03-01 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：:Scaffolds porosity has an important role in in vitro and in vivo differentiation process of stem cells with given the amount of space available to the cells to proliferate and differentiate. In the present study, chitosan with three porosities including 10%, 15%, and 20% that created by gelatin were used for investiga...

journal_title：Journal of cellular biochemistry

authors： Ardeshirylajimi A,Delgoshaie M,Mirzaei S,Khojasteh A

更新日期：2018-01-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role ...

journal_title：Journal of cellular biochemistry

authors： Lee MS,Lowe GN,Strong DD,Wergedal JE,Glackin CA

更新日期：1999-12-15 00:00:00

abstract：:Intact embryonic chick neural retina cells have at their surface an N-acetylgalactosaminyltransferase which catalyzes the incorporation of N-acetylgalactosamine from UDP-N-acetylgalactosamine into endogenous macromolecular acceptors. The enzyme along with its endogenous acceptors can be isolated as a particulate compl...

journal_title：Journal of cellular biochemistry

authors： Balsamo J,Pratt RS,Emmerling MR,Grunwald GB,Lilien J

更新日期：1986-01-01 00:00:00

abstract：:Withangulatin A induced cell rounding up and the morphological alteration resulted from the reorganization of all of the major cytoskeletal components, i.e., vimentin, tubulin, and actin, as revealed by immunofluorescence techniques. When the withangulatin A-treated cells changed to a round-up morphology, vimentin int...

journal_title：Journal of cellular biochemistry

authors： Lee WC,Lee YC,Perng MD,Chen CM,Lai YK

更新日期：1993-07-01 00:00:00

abstract：:Carotenoid cleavage dioxygenase (CCD) gene, ubiquitously found in numerous types of plants, are eminent in synthesizing the various volatile compounds (β-ionone, C13 -norisoprenoid, geranylacetone) known as apocarotenoids. These apocarotenoids have various biological functions such as volatile signals, allelopathic in...

journal_title：Journal of cellular biochemistry

authors： Priya R,Sneha P,Rivera Madrid R,Doss CGP,Singh P,Siva R

更新日期：2017-09-01 00:00:00

abstract：:Extracellular matrix metalloproteinases (MMPs) are activated in dilated cardiomyopathic (DCM) hearts [Tyagi et al. (1996): Mol Cell Biochem 155:13-21]. To examine whether the MMP activation is occurring at the gene expression level, we performed differential display mRNA analysis on tissue from six dilated cardiomyopa...

journal_title：Journal of cellular biochemistry

authors： Tyagi SC,Kumar S,Voelker DJ,Reddy HK,Janicki JS,Curtis JJ

更新日期：1996-11-01 00:00:00

abstract：:Lung development follows a stereotypic program orchestrated by key interactions among epithelial and mesenchymal tissues. Deviations from this developmental program can lead to pulmonary diseases including bronchopulmonary dysplasia and pulmonary hypertension. Significant efforts have been made to examine the cellular...

journal_title：Journal of cellular biochemistry

authors： Hines EA,Sun X

更新日期：2014-09-01 00:00:00

abstract：:This study investigated the influence of miR-150 expression on osteoblast matrix mineralization and its mechanisms. The mouse osteoblast cell line MC3T3-E1 was used as an in vitro model of bone formation. On the fifth day of mineralization, transfection experiments using agomiR-150, agomiR-NC, antagomiR-150 antagomiR-...

journal_title：Journal of cellular biochemistry

authors： Dong CL,Liu HZ,Zhang ZC,Zhao HL,Zhao H,Huang Y,Yao JH,Sun TS

更新日期：2015-12-01 00:00:00

abstract：:Patients with cervical cancer have abnormal cell proliferation and invasion after many years of latency. However, the precise mechanisms remain unclear. Mitogen- and stress-activated kinase 2 (MSK2) is a serine/threonine kinase which displays a phenotype that promotes tumor growth and metastasis in many different type...

journal_title：Journal of cellular biochemistry

authors： Wu Y,Li H,Wang H,Zhang F,Cao H,Xu S

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In this study, we aimed to study the molecular mechanisms underlying the symptoms of hyperresponsiveness during intubation. METHOD:The value of circulating long noncoding RNA (lncRNA)-prognosis-associated gallbladder cancer (PAGBC) in the prediction of hyperresponsiveness upon intubation duri...

journal_title：Journal of cellular biochemistry

authors： Li LX,Li YJ,He JX

更新日期：2018-09-23 00:00:00

abstract：:The effects of serum on inositol 1,4,5-trisphosphate (IP3) formation and Ca2+ mobilization in the human submandibular cell line A253 were studied. Exposure of A253 cells to fetal bovine serum (FBS) elicited a 3.3-fold increase in IP3 formation and a concentration-dependent transient increase in cytosolic free Ca2+ con...

journal_title：Journal of cellular biochemistry

authors： Sun X,Mörk AC,Helmke RJ,Martinez JR,Zhang GH

更新日期：1999-06-15 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：:Endometrial cancer is one of the most common gynecological malignant tumors. The roles of competing endogenous RNAs (ceRNAs) in this disease, however, remain unclear. In this study, we constructed a ceRNA network to reveal the core ceRNAs in endometrial cancer. Differentially expressed genes were summarized from The C...

journal_title：Journal of cellular biochemistry

authors： Wang Y,Huang T,Sun X,Wang Y

更新日期：2019-11-01 00:00:00

abstract：:Heat shock protein (HSP) levels are elevated in breast cancer and are molecular targets for novel therapies. HSPs were first observed as proteins induced in massive amounts in normal cells exposed to stresses that lead to protein denaturation. Their expanded expression in mammary carcinoma appears to be largely due to...

journal_title：Journal of cellular biochemistry

authors： Calderwood SK,Gong J

更新日期：2012-04-01 00:00:00

abstract：:We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

journal_title：Journal of cellular biochemistry

authors： Larsson B,Nemere I

更新日期：2003-12-01 00:00:00

abstract：:The activated c-Ha-rasVal12 oncogene is often involved in the genesis of human malignancies. We show here that in c-Ha-rasVal12 oncogene-transformed mouse NIH 3T3 fibroblasts the copy number and expression level of the mutant ras oncogene correlates with the degree of chromatin decondensation, as assessed by micrococc...

journal_title：Journal of cellular biochemistry

authors： Laitinen J,Sistonen L,Alitalo K,Hölttä E

更新日期：1995-01-01 00:00:00

abstract：:The immediate-early (IE) promoter of human cytomegalovirus (HCMV) constitutes a primary genetic switch, which determines the progression of viral infection. Earlier reports by others have shown mitogen-activated protein kinase kinase kinase-1 (MEKK1) to be able to up-regulate HCMV-IE promoter through downstream mitoge...

journal_title：Journal of cellular biochemistry

authors： Sun B,Harrowe G,Reinhard C,Yoshihara C,Chu K,Zhuo S

更新日期：2001-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis. Increa...

journal_title：Journal of cellular biochemistry

authors： Zakeri Z,Salmaninejad A,Hosseini N,Shahbakhsh Y,Fadaee E,Shahrzad MK,Fadaei S

更新日期：2019-03-01 00:00:00

abstract：:O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is a post-translational modification, which is believed antagonises phosphorylation. We have studied the O-GlcNAc level during Xenopus oocyte meiotic resumption, taking advantage of the high synchrony of this model which is dependent upon a burst of phosphorylation...

journal_title：Journal of cellular biochemistry

authors： Lefebvre T,Baert F,Bodart JF,Flament S,Michalski JC,Vilain JP

更新日期：2004-11-15 00:00:00

abstract：:We have a long-standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases. HtrA1 has been classified as a secret...

journal_title：Journal of cellular biochemistry

authors： Clawson GA,Bui V,Xin P,Wang N,Pan W

更新日期：2008-09-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is an ATP-binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemotherapy. For stable reversal of BCRP-...

journal_title：Journal of cellular biochemistry

authors： Lv H,He Z,Liu X,Yuan J,Yu Y,Chen Z

更新日期：2007-09-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been implicated as a tumor suppressor gene in several human cancer types. However, little is known regarding its involvement and potential mechanism in human breast cancer. In this study, we explored the effect of MEG3 on the growth of human breast cancer c...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Wu J,Jing H,Huang G,Sun Z,Xu S

更新日期：2019-04-01 00:00:00

abstract：:Pyruvate kinase M2 (M2-PK) controls the rate-limiting step at the end of the glycolytic pathway in normal proliferating and tumor cells. Other functions of M2-PK in addition to its role in glycolysis are little understood. The aim of this study was to identify new cellular interaction partners of M2-PK in order to dis...

journal_title：Journal of cellular biochemistry

authors： Spoden GA,Morandell D,Ehehalt D,Fiedler M,Jansen-Dürr P,Hermann M,Zwerschke W

更新日期：2009-05-15 00:00:00

abstract：:In order to better understand the mechanism by which changes in the fatty acid composition of cellular lipids occur in leukemia cell lines induced to differentiate, the activity of the first enzyme of fatty acid biosynthesis, acetyl-CoA carboxylase (EC 6.4.1.2) was measured in HL-60 promyelocytic leukemia cells before...

journal_title：Journal of cellular biochemistry

authors： Fischkoff SA,Papuchis GC,Nickols WA

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between serum protein level of insulin growth factor 1 (IGF-1) and the degree of liver fibrosis in patients with chronic hepatitis C (CHC) combined with type 2 diabetes mellitus (T2DM). METHODS:The cases are divided into four groups. Then serum levels of IFG-1, alanine aminotra...

journal_title：Journal of cellular biochemistry

authors： Cao LH,Lu FM,Lu XJ,Zhu LY

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:This study is aimed to explore the functions of long noncoding RNA (lncRNA) HEIH on the proliferation as well as metastasis of non-small cell lung cancer (NSCLC). METHODS:HEIH was shown to be increased in NSCLC by a microarray study on lncRNA profiling. We detected the expression of HEIH in different human ...

journal_title：Journal of cellular biochemistry

authors： Jia K,Chen F,Xu L

更新日期：2019-03-01 00:00:00

abstract：:Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N-end rule pathway has been shown to be involved...

journal_title：Journal of cellular biochemistry

authors： Pore SK,Ganguly A,Sau S,Godeshala S,Kanugula AK,Ummanni R,Kotamraju S,Banerjee R

更新日期：2020-01-01 00:00:00

abstract：:The principal problem arising from prostate cancer (PCa) is its propensity to metastasize to bones, and it's crucial to understand the mechanism of tumor progression to metastasis in order to develop therapies that may reduce the morbidity and mortality of PCa patients. Although we had identified that microRNA(miR)-14...

journal_title：Journal of cellular biochemistry

authors： Guo W,Ren D,Chen X,Tu X,Huang S,Wang M,Song L,Zou X,Peng X

更新日期：2013-07-01 00:00:00