当前位置： SCI文献检索 > JOURNAL OF CELLULAR BIOCHEMISTRY期刊下所有文献 > Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer.

Cytokine stimulation of MUC4 expression in human female reproductive tissue carcinoma cell lines and endometrial cancer.

Abstract：

:MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT-PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse uteri. Previous studies from our labs have demonstrated MUC4 mRNA was expressed at levels <1% of MUC1 mRNA in human endometrium and endometriotic tissue. Multiple human endometrial adenocarcinoma cell lines were assayed for MUC4 mRNA expression revealing extremely low basal expression in the Ishikawa, RL-95-2, AN3CA, and KLE lines. Moderate to high expression was observed in HEC50 and HEC-1A cells. MUC4 mRNA expression was not affected by progesterone and/or estrogen treatment, but was greatly stimulated at both mRNA and protein levels by proinflammatory cytokines (IFN-γ and TNF-α), particularly when used in combination. In endometrial tissue, MUC4 mRNA levels did not change significantly between normal or cancerous samples; although, a subset of patients with grade 1 and 2 tumors displayed substantially higher expression. Likewise, immunostaining of human endometrial adenocarcinoma tissues revealed little to no staining in many patients (low MUC4), but strong staining in some patients (high MUC4) independent of cancer grade. In cases where staining was observed, it was heterogeneous with some cells displaying robust MUC4 expression and others displaying little or no staining. Collectively, these observations demonstrate that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.

journal_name

J Cell Biochem

journal_title

Journal of cellular biochemistry

authors

Chapela PJ,Broaddus RR,Hawkins SM,Lessey BA,Carson DD

doi

10.1002/jcb.25213

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

2649-57

issue

11

eissn

0730-2312

issn

1097-4644

journal_volume

116

pub_type

杂志文章

相关文献

JOURNAL OF CELLULAR BIOCHEMISTRY文献大全
  • The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single-nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta-analysis.

    abstract：:Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27975

    authors： Li J,Liu R,Tang S,Feng F,Wang X,Qi L,Liu C,Yao Y,Sun C

    更新日期：2018-11-28 00:00:00

  • Nanotopography drives stem cell fate toward osteoblast differentiation through α1β1 integrin signaling pathway.

    abstract：:The aim of our study was to investigate the osteoinductive potential of a titanium (Ti) surface with nanotopography, using mesenchymal stem cells (MSCs) and the mechanism involved in this phenomenon. Polished Ti discs were chemically treated with H2 SO4 /H2 O2 to yield nanotopography and rat MSCs were cultured under o...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24688

    authors： Rosa AL,Kato RB,Castro Raucci LM,Teixeira LN,de Oliveira FS,Bellesini LS,de Oliveira PT,Hassan MQ,Beloti MM

    更新日期：2014-03-01 00:00:00

  • Depletion of A-type lamins and Lap2α reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2α protein is responsible for compactness of irradiated chromatin.

    abstract：:We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally observed for well-known marker of DNA lesions, 53BP1...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.26770

    authors： Bártová E,Legartová S,Krejčí J,Řezníčková P,Kovaříková AS,Suchánková J,Fedr R,Smirnov E,Hornáček M,Raška I

    更新日期：2018-11-01 00:00:00

  • Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment.

    abstract：:Every year about 500,000 people in the United States die as a result of cancer. Among them, 90% exhibit systemic disease with metastasis. Considering this high rate of incidence and mortality, it is critical to understand the mechanisms behind metastasis and identify new targets for therapy. In recent years, two broad...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.21215

    authors： Tse JC,Kalluri R

    更新日期：2007-07-01 00:00:00

  • Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells.

    abstract：:Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unkn...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24220

    authors： Lim S,Jang HJ,Park EH,Kim JK,Kim JM,Kim EK,Yea K,Kim YH,Lee-Kwon W,Ryu SH,Suh PG

    更新日期：2012-11-01 00:00:00

  • Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type Ia receptor regions: generation of fully functional hybrids showing characteristic signaling of the AT1a receptor.

    abstract：:The intracellular (IC) face of the G-protein coupled receptors (GPCR), bradykinin (BK) B2 and angiotensin (AT) 1a, is similar in sequence homology and in size. Both receptors are known to link to Galphai and Galphaq but differ markedly in a number of physiologic actions, particularly with respect to their hemodynamic ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.10171

    authors： Yu J,Prado GN,Taylor L,Piserchio A,Gupta A,Mierke DF,Polgar P

    更新日期：2002-01-01 00:00:00

  • Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats.

    abstract：:Recycled iron from reticuloendothelial macrophages to erythroid precursors is important to maintain the iron homeostasis. However, the molecular mechanisms underlying iron homeostasis in macrophages are poorly understood. In this study, male Sprague-Dawley rats were treated with recombinant human erythropoietin (rHuEp...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.21654

    authors： Kong WN,Zhao SE,Duan XL,Yang Z,Qian ZM,Chang YZ

    更新日期：2008-05-15 00:00:00

  • Heparan sulfate proteoglycans as trastuzumab targets in anoikis-resistant endothelial cells.

    abstract：:Anoikis is a form of programmed cell death induced by loss of contact from neighboring cells or from their extracellular matrix (ECM). Many tumorigenic cells are anoikis resistant, facilitating cancer progression and metastasis. Trastuzumab is a monoclonal antibody used for the treatment of breast and gastric cell can...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28656

    authors： Onyeisi JOS,Castanho de Almeida Pernambuco Filho P,de Araujo Lopes S,Nader HB,Lopes CC

    更新日期：2019-08-01 00:00:00

  • Comparative efficacy and safety of antiplatelet agents in cerebral ischemic disease: A network meta-analysis.

    abstract：:We performed a network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different antiplatelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios and 95% credible intervals. E...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,meta分析

    doi：10.1002/jcb.26065

    authors： Wa D,Zhu P,Long Z

    更新日期：2019-06-01 00:00:00

  • Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade.

    abstract：:4-hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by elucidating the signaling cascad...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.21110

    authors： Vaillancourt F,Morquette B,Shi Q,Fahmi H,Lavigne P,Di Battista JA,Fernandes JC,Benderdour M

    更新日期：2007-04-01 00:00:00

  • Transforming growth factor beta: possible roles in the regulation of normal and leukemic hematopoietic cell growth.

    abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1002/jcb.240390209

    authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

    更新日期：1989-02-01 00:00:00

  • Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1.

    abstract：:Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27335

    authors： Zhao Y,Yuan X,Li X,Zhang Y

    更新日期：2018-10-22 00:00:00

  • Peripheral nuclear matrix actin forms perinuclear shells.

    abstract：:Perinuclear actin shells have been reported in a variety of organisms. The shells have been identified by staining perinuclear material with fluorescently-labelled phalloidin, but have not been localized to a specific subcellular compartment at the ultrastructural level. We show here that the shells of 3T3 cells lie i...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-4644(19980801)70:2<240::aid-jcb

    authors： Clubb BH,Locke M

    更新日期：1998-08-01 00:00:00

  • 17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families.

    abstract：:17β-Estradiol (E2 ) protects several nonreproductive tissues from apoptosis, including skeletal muscle. Previously, we showed that E2 at physiological concentrations prevented apoptosis induced by H2 O2 in skeletal myoblasts, reverting PKCδ, JNK, and p66Shc activation and exerting a beneficial action over mitochondria...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.25616

    authors： La Colla A,Vasconsuelo A,Milanesi L,Pronsato L

    更新日期：2017-01-01 00:00:00

  • Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation.

    abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24805

    authors： Terada N,Shiraishi T,Zeng Y,Aw-Yong KM,Mooney SM,Liu Z,Takahashi S,Luo J,Lupold SE,Kulkarni P,Getzenberg RH

    更新日期：2014-09-01 00:00:00

  • miR-627/HMGB1/NF-κB regulatory loop modulates TGF-β1-induced pulmonary fibrosis.

    abstract：:Pulmonary fibrosis (PF) is a fibroproliferative disease that can eventually lead to fatal lung failure. It is characterized by abnormal proliferation of fibroblasts, dysregulated fibroblast differentiation to myofibroblast, and disorganized collagen and extracellular matrix production, deposition and degradation. Ther...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27038

    authors： Li J,Kong X,Jiang S,Liao W,Zhang Z,Song J,Liang Y,Zhang W

    更新日期：2019-03-01 00:00:00

  • Labeling the Stroma of a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model of Undifferentiated Pleomorphic Soft-Tissue Sarcoma With Red Fluorescent Protein for Rapid Non-Invasive Imaging for Drug Screening.

    abstract：:Our laboratory pioneered patient-derived orthotopic xenograft (PDOX) mouse models using surgical orthotopic implantation (SOI). PDOX models are patient-like, in contrast to the ectopic subcutaneous-transplant cancer models. In the present study, we demonstrate that an undifferentiated pleomorphic soft-tissue sarcoma (...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.25643

    authors： Kiyuna T,Murakami T,Tome Y,Igarashi K,Kawaguchi K,Russell T,Eckardt MA,Crompton J,Singh A,Bernthal N,Bukata S,Federman N,Kanaya F,Eilber FC,Hoffman RM

    更新日期：2017-02-01 00:00:00

  • Association of excision repair cross-complimentary group 1 gene polymorphisms with breast and ovarian cancer susceptibility.

    abstract：:The role of excision repair cross-complimentary group 1 (ERCC1) gene polymorphisms in breast and ovarian cancer development has long been controversial and existing data were inconsistent. Here, we conducted a comprehensive meta-analysis to better clarify the association. Case-control studies published from December 2...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章,meta分析

    doi：10.1002/jcb.28830

    authors： Yang F,Mu X,Bian C,Zhang H,Yi T,Zhao X,Lin X

    更新日期：2019-09-01 00:00:00

  • Upregulation of lincRNA-p21 in thoracic aortic aneurysms is involved in the regulation of proliferation and apoptosis of vascular smooth muscle cells by activating TGF-β1 signaling pathway.

    abstract：OBJECTIVE:Long intergenic noncoding RNA-p21 (lincRNA-p21) has been proved in the pathogenesis of aortic aneurysms, while its functionality in thoracic aortic aneurysms (TAA) and the mechanism of function remains unclear. Therefore our study aimed to investigate the role of lincRNA-p21 in TAA. METHODS:Aortic media spec...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27696

    authors： Hu W,Wang Z,Li Q,Wang J,Li L,Jiang G

    更新日期：2019-03-01 00:00:00

  • A prognostic 11 long noncoding RNA expression signature for breast invasive carcinoma.

    abstract：:Breast cancer, the most common cancer in women worldwide, is associated with high mortality. The long non-coding RNAs (lncRNAs) with a little capacity of coding proteins is playing an increasingly important role in the cancer paradigm. Accumulating evidences demonstrate that lncRNAs have crucial connections with breas...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28927

    authors： He Y,Li X,Meng Y,Fu S,Cui Y,Shi Y,Du H

    更新日期：2019-10-01 00:00:00

  • Fluid flow induces Rankl expression in primary murine calvarial osteoblasts.

    abstract：:Mechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor kappa B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20864

    authors： Mehrotra M,Saegusa M,Wadhwa S,Voznesensky O,Peterson D,Pilbeam C

    更新日期：2006-08-01 00:00:00

  • Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway.

    abstract：:Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28282

    authors： Zhou Y,Shu C,Huang Y

    更新日期：2019-04-11 00:00:00

  • Adsorption of glycosaminoglycans to the cell surface is responsible for cellular donnan effects.

    abstract：:In previous publications, we showed that extracellular glycosaminoglycans reduced the membrane potential, caused cell blebbing and swelling and decreased the intracellular pH independently of cell surface receptors. These phenomena were explained by Donnan effects. The effects were so large that they could not be attr...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.24791

    authors： Hagenfeld D,Kathagen N,Prehm P

    更新日期：2014-07-01 00:00:00

  • C-terminal region of Bfl-1 induces cell death that accompanies caspase activation when fused with GFP.

    abstract：:Previously, we reported that anti-apoptotic Bfl-1 is converted to a pro-apoptotic protein following fusion at its N-terminus with green fluorescent protein (GFP) (GFP-Bfl-1). In this study, we performed a Bfl-1 deletion study in order to elucidate the underlying mechanism of GFP-Bfl-1-induced cell death. We found that...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.20381

    authors： Yang WS,Ko JK,Park SO,Choi HY,Kim YN,Kim CW

    更新日期：2005-04-15 00:00:00

  • The comparative study of the effects of Fe2 O3 and TiO2 micro- and nanoparticles on oxidative states of lung and bone marrow tissues and colony stimulating factor secretion.

    abstract：:Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.28031

    authors： Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

    更新日期：2018-11-28 00:00:00

  • Species differences in cis-elements of the proalpha1(I) procollagen promoter and their binding proteins.

    abstract：:Previous studies suggest that there may be species differences in the utilization of cis-elements of the type I collagen genes. The present study was designed to examine this possibility by focusing on two regions of the proalpha1(I) collagen promoter. One is the GC-rich A1 region (-194/168) that modulates transcripti...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Peterkofsky B,Gosiewska A,Singh K,Pearlman S,Mahmoodian F

    更新日期：1999-06-01 00:00:00

  • Expression and subcellular localization of myogenic regulatory factors during the differentiation of skeletal muscle C2C12 myoblasts.

    abstract：:It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor-specific regulation is available and data on their post-transcriptional and post-translational behavio...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.22360

    authors： Ferri P,Barbieri E,Burattini S,Guescini M,D'Emilio A,Biagiotti L,Del Grande P,De Luca A,Stocchi V,Falcieri E

    更新日期：2009-12-15 00:00:00

  • Expression of osteoprotegerin and receptor activator for the nuclear factor-κB ligand in XACB/LV-bFGF/MSCs transplantation for repair of rabbit femoral head defect necrosis.

    abstract：:The aim of this study is to observe the changes in osteoprotegerin (OPG) and receptor activator for the nuclear factor-κB ligand (RANKL) in a rabbit model, and to explore the therapeutic effect of tissue engineering bone on femoral head necrosis. A total of 60 rabbits were randomly divided into 5 groups. The necrosis ...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.27201

    authors： Peng W,Zhang J,Zhang F,Zhao Y,Dong W

    更新日期：2018-10-18 00:00:00

  • miR-125a-3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11.

    abstract：:The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PT...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.29333

    authors： Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen J

    更新日期：2020-02-01 00:00:00

  • Affinity isolation of active murine erythroleukemia cell chromatin: uniform distribution of ubiquitinated histone H2A between active and inactive fractions.

    abstract：:This laboratory recently reported the development of a biotin-cellulose/streptavidin affinity chromatography method based on the DNase I sensitivity of active chromatin to isolate a DNA fraction from murine erythroleukemia (MEL) cells that is more than 15-fold enriched in active genes (Dawson et al.: Journal of Biolog...

    journal_title：Journal of cellular biochemistry

    pub_type： 杂志文章

    doi：10.1002/jcb.240460210

    authors： Dawson BA,Herman T,Haas AL,Lough J

    更新日期：1991-06-01 00:00:00