Fastigial nucleus stimulation ameliorates cognitive impairment via modulating autophagy and inflammasomes activation in a rat model of vascular dementia.

abstract：:Muscular dystrophies are characterized by continuous cycles of degeneration and regeneration that result in extensive fibrosis and a progressive diminution of muscle mass. Cell surface heparan sulfate proteoglycans are found almost ubiquitously on the surface and in the extracellular matrix (ECM) of mammalian cells. T...

journal_title：Journal of cellular biochemistry

authors： Alvarez K,Fadic R,Brandan E

更新日期：2002-01-01 00:00:00

abstract：:The expression of receptors belonging to the epidermal growth factor receptor subfamily has been largely studied these last years in epithelial cells mainly as involved in cell proliferation and malignant progression. Although much work has focused on the role of these growth factor receptors in the differentiation of...

journal_title：Journal of cellular biochemistry

authors： Pagano E,Calvo JC

更新日期：2003-10-15 00:00:00

abstract：:Bladder cancer-associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small-cell lung cancer (SCLC) remained unknown. The aim of our...

journal_title：Journal of cellular biochemistry

authors： Chen W,Hang Y,Xu W,Wu J,Chen L,Chen J,Mao Y,Song J,Song J,Wang H

更新日期：2018-09-11 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) is of fundamental importance in a cell's response to environmental stresses, cytokines and DNA damage. p38 resides in the cytoplasm of resting cells, and translocates into the nucleus upon activation, yet the exact mechanisms remain largely unclear. We show here that the pho...

journal_title：Journal of cellular biochemistry

authors： Gong X,Ming X,Deng P,Jiang Y

更新日期：2010-08-15 00:00:00

abstract：OBJECTIVES:Hepatocarcinoma is one of the most lethal cancers, leading to a 5-year survival rate as low as 30% due to recurrence and metastasis. The treatment of liver cancer includes surgery and medication, of which, the former is more effective. However, surgical resection is applicable in less than 40% of patients. T...

journal_title：Journal of cellular biochemistry

authors： Shen X,Cui X,Cui H,Jin Y,Jin W,Sun H

更新日期：2019-04-01 00:00:00

abstract：:Rabbit lymphocytes exposed to hyposmotic media first swell and then recover their initial volume within 6 min. During volume recovery, free amino acids (FAA) decrease from 451.1 to 208 nmoles/mg protein. Taurine was the dominating FAA, accounting for 70% of the FAA pool. The time course of 3H-taurine release induced b...

journal_title：Journal of cellular biochemistry

authors： Jesuś García J,Sánchez Olea R,Pasantes-Morales H

更新日期：1991-02-01 00:00:00

abstract：:Our previous studies have shown that vanadium, a dietary micronutrient, has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. In this study, we evaluated the role of vanadium on some potential protein expression markers of carcinogenesis, such as metallothionein (MT), an intracellular metal...

journal_title：Journal of cellular biochemistry

authors： Chakraborty T,Samanta S,Ghosh B,Thirumoorthy N,Chatterjee M

更新日期：2005-03-01 00:00:00

abstract：:We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

journal_title：Journal of cellular biochemistry

authors： Larsson B,Nemere I

更新日期：2003-12-01 00:00:00

abstract：:As the most common neurodegenerative disease, Alzheimer's disease (AD) is characterized by memory, perception, and behavioral damage, which may ultimately lead to emotional fluctuation and even lethal delirium. Increasing studies indicate that microRNAs (miRNAs) are associated with pathological features of AD. However...

journal_title：Journal of cellular biochemistry

authors： Li J,Chen W,Yi Y,Tong Q

更新日期：2019-06-01 00:00:00

abstract：:The retinoblastoma protein (RB) recruits histone deacetylase (HDAC) to repress E2F-mediated transactivation that plays a critical role in cell cycle regulation. RB is also involved in activation of expression of a number of tissue specific- and differentiation-related genes. In this study, we examined the mechanism by...

journal_title：Journal of cellular biochemistry

authors： Charles A,Tang X,Crouch E,Brody JS,Xiao ZX

更新日期：2001-08-21 00:00:00

abstract：:To find the key factors that were involved in the survival and vascular endothelial differentiation of chick blatodisc induced by fibroblast growth factor 2 (FGF-2), we built a chick vasculogenesis model in vitro. Subsequently, the activities of phosphatidylcholine-specific phospholipase C (PC-PLC), including Ca(2+)-d...

journal_title：Journal of cellular biochemistry

authors： Zhao J,Zhao B,Wang W,Huang B,Zhang S,Miao J

更新日期：2007-10-01 00:00:00

abstract：:The core binding factor (CBF) acute myeloid leukemias (AMLs) are a prognostically distinct subgroup that includes patients with the inv(16) and t(8:21) chromosomal rearrangements. Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the...

journal_title：Journal of cellular biochemistry

authors： Hyde RK,Liu PP

更新日期：2010-08-01 00:00:00

abstract：:Compound C, a well-known inhibitor of AMP-activated protein kinase (AMPK), has been reported to exert antitumor activities in some types of cells. Whether compound C can exert antitumor effects in human cholangiocarcinoma (CCA) remains unknown. Here, we demonstrated that compound C is a potent inducer of cell death an...

journal_title：Journal of cellular biochemistry

authors： Zhao X,Luo G,Cheng Y,Yu W,Chen R,Xiao B,Xiang Y,Feng C,Fu W,Duan C,Yao F,Xia X,Tao Q,Wei M,Dai R

更新日期：2018-07-01 00:00:00

abstract：:Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, ...

journal_title：Journal of cellular biochemistry

authors： Zhou Y,Shu C,Huang Y

更新日期：2019-04-11 00:00:00

abstract：:Cancer is characterized by uncontrolled cell division resulting from multiple mutagenic events. Cancer chemoprevention strategies aim to inhibit or reverse these events using natural or synthetic pharmacologic agents. Ideally, this restores normal growth control mechanisms. Diverse classes of compounds have been ident...

journal_title：Journal of cellular biochemistry

authors： Freemantle SJ,Liu X,Feng Q,Galimberti F,Blumen S,Sekula D,Kitareewan S,Dragnev KH,Dmitrovsky E

更新日期：2007-11-01 00:00:00

abstract：:Chromatin immunoprecipitation (ChIP) is an important technique for studying protein-DNA interactions. Whole genome ChIP methods have enjoyed much success, but are limited in that they cannot uncover important long-range chromatin interactions. Chromosome conformation capture (3C) and related methods are capable of det...

journal_title：Journal of cellular biochemistry

authors： Fullwood MJ,Ruan Y

更新日期：2009-05-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) 2 is a carboxypeptidase that shares 42% amino acid homology with ACE. Little is known about the regulation or pattern of expression of ACE2 in the mouse lung, including its definitive cellular distribution or developmental changes. Based on Northern blot and RT-PCR data, we report t...

journal_title：Journal of cellular biochemistry

authors： Wiener RS,Cao YX,Hinds A,Ramirez MI,Williams MC

更新日期：2007-08-01 00:00:00

abstract：:Numerous studies have demonstrated the role of A3 adenosine receptor (A3AR) and signaling pathways in the multiple aspects of the tumor. However, there is a little study about the function of A3AR in the biological processes of cancer stem cells (CSCs). CSCs have a critical role in the maintenance and survival of brea...

journal_title：Journal of cellular biochemistry

authors： Jafari SM,Panjehpour M,Aghaei M,Joshaghani HR,Enderami SE

更新日期：2017-09-01 00:00:00

abstract：:PKCalpha was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the gamma/gamma + beta globin expression...

journal_title：Journal of cellular biochemistry

authors： Di Baldassarre A,Di Rico M,Di Noia A,Bonfini T,Iacone A,Marchisio M,Miscia S,Alfani E,Migliaccio AR,Stamatoyannopoulos G,Migliaccio G

更新日期：2007-05-15 00:00:00

abstract：:Hepassocin (HPS) is a specific mitogenic active factor for hepatocytes, and inhibits growth by overexpression in hepatocellular carcinoma (HCC) cells. However, the mechanism of HPS regulation on growth of liver-derived cells still remains largely unknown. In this study, we found that HPS was expressed and secreted int...

journal_title：Journal of cellular biochemistry

authors： Cao MM,Xu WX,Li CY,Cao CZ,Wang ZD,Yao JW,Yu M,Zhan YQ,Wang XH,Tang LJ,Chen H,Li W,Ge CH,Yang XM

更新日期：2011-10-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:We have purified and characterized a collagenase/gelatinase activity expressed during sea urchin embryonic development. The native molecular mass was determined to be 160 kDa, while gelatin substrate gel zymography revealed an active species of 41 kDa, suggesting that the native enzyme is a tetramer of active subunits...

journal_title：Journal of cellular biochemistry

authors： Mayne J,Robinson JJ

更新日期：1998-12-15 00:00:00

abstract：:By the time of diagnosis, primary neoplasms are biologically heterogeneous and contain subpopulations of cells with different metastatic potentials. The pathogenesis of a metastasis consists of many sequential steps that must be completed to produce clinically relevant lesions. During any of these steps, tumor cells i...

journal_title：Journal of cellular biochemistry

authors： Fidler IJ,Kim SJ,Langley RR

更新日期：2007-07-01 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:The role of beta-catenin in skeletal development and osteogenic cell differentiation is well established, but the molecular mechanisms attending these effects remain largely unknown. We conducted a structure/function analysis of beta-catenin to gain further insights on these mechanisms. Retroviral transduction of a fu...

journal_title：Journal of cellular biochemistry

authors： Salazar VS,Mbalaviele G,Civitelli R

更新日期：2008-06-01 00:00:00

abstract：:Electrical activity in embryonic brain tissue has typically been studied using Micro Electrode Array (MEA) technology to make dozens of simultaneous recordings from dissociated neuronal cultures, brain stem cell progenitors, or brain slices from fetal rodents. Although these rodent neuronal primary culture electrical ...

journal_title：Journal of cellular biochemistry

authors： Napoli A,Obeid I

更新日期：2016-03-01 00:00:00

abstract：:The testis-specific linker histone H1t gene is transcribed exclusively in pachytene primary spermatocytes. Tissue specific expression of the gene is mediated in part by transcriptional factors that bind elements located within the proximal and distal promoter. A 40 bp promoter element, designated H1t/TE, that is locat...

journal_title：Journal of cellular biochemistry

authors： Wilkerson DC,Wolfe SA,Grimes SR

更新日期：2003-04-15 00:00:00

abstract：:Lysis of human culture-derived macrophages by extracellular ATP has recently been described, and treatment of macrophages with interferon-gamma rendered those cells significantly more sensitive to lysis. In addition, cell death occurred more rapidly in interferon (IFN)-treated cells than in untreated macrophages. In a...

journal_title：Journal of cellular biochemistry

authors： Blanchard DK,Hoffman SL,Djeu JY

更新日期：1995-03-01 00:00:00

abstract：:ATP-dependent protein kinase activities were detected in both membrane and cytoplasmic fractions from the oral pathogen Streptococcus mutans. Different polypeptides were phosphorylated by endogenous kinase(s) in the two fractions. In membranes, five phosphoproteins were detected with apparent masses of 82, 37, 22, 12,...

journal_title：Journal of cellular biochemistry

authors： Mimura CS,Poy F,Jacobson GR

更新日期：1987-03-01 00:00:00

abstract：:Embryonic data and ultrastructural analyses suggest that the primitive endothelium signals undifferentiated mesenchymal cells to migrate to the forming blood vessel and subsequently regulates mural cell growth and behavior. Upon maturation of the blood vessel, chemotactic and mitogenic signals are apparently diminishe...

journal_title：Journal of cellular biochemistry

authors： Dodge AB,Lu X,D'Amore PA

更新日期：1993-09-01 00:00:00