Comparison of DNA Methylation and Expression Pattern of S100 and Other Epidermal Differentiation Complex Genes in Differentiating Keratinocytes.

abstract：:Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably...

journal_title：Journal of cellular biochemistry

authors： Li C,Ke J,Liu J,Su J

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Long noncoding RNA (lncRNA) is emerging as a vital regulator in various cancers. Recently, it was found that lncRNA colorectal neoplasia differentially expressed (CRNDE) plays an oncogenic role, promoting cell proliferation and migration in hepatocellular carcinoma (HCC). However, the underlying regulatory m...

journal_title：Journal of cellular biochemistry

authors： Tang D,Zhao L,Peng C,Ran K,Mu R,Ao Y

更新日期：2019-09-01 00:00:00

abstract：:Secreted phosphoprotein 24 kD (spp24) is a bone matrix protein isolated during attempts to identify osteogenic proteins. It is not osteogenic but performs other important roles in the regulation of bone metabolism, at least in part, by binding to and affecting the activity of members of the BMP/TGF-β family of cytokin...

journal_title：Journal of cellular biochemistry

authors： Tian H,Li CS,Zhao KW,Wang JC,Duarte ME,David CL,Phan K,Atti E,Brochmann EJ,Murray SS

更新日期：2015-04-01 00:00:00

abstract：:This study aimed to address the insufficiency of traditional meta-analysis and provide improved guidelines for the clinical practice of osteosarcoma treatment. The heterogeneity of the fixed-effect model was calculated, and when necessary, a random-effect model was adopted. Furthermore, the direct and indirect evidenc...

journal_title：Journal of cellular biochemistry

authors： Zhang T,Zhang S,Yang F,Wang L,Zhu S,Qiu B,Li S,Deng Z

更新日期：2018-01-01 00:00:00

abstract：:Evidence indicates that agonists of neuronal nicotinic receptors (nAChRs), including nicotine, can induce neuroprotective and anti-apoptotic effects in the CNS. To study these mechanisms, the present study focused on nicotine-mediated modulation of the extracellular regulated kinase 1 and 2 (ERK1/2) pathway in culture...

journal_title：Journal of cellular biochemistry

authors： Toborek M,Son KW,Pudelko A,King-Pospisil K,Wylegala E,Malecki A

更新日期：2007-02-01 00:00:00

abstract：:Given its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate-limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two of these therapeutic agents already in clinical use. Bevacizumab was first used for c...

journal_title：Journal of cellular biochemistry

authors： Costa R,Carneiro A,Rocha A,Pirraco A,Falcão M,Vasques L,Soares R

更新日期：2009-12-15 00:00:00

abstract：:microRNA (miRNA) is a family of small, non-coding RNA first discovered as an important regulator of development in Caenorhabditis elegans (C. elegans). Numerous miRNAs have been found in C. elegans, and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely...

journal_title：Journal of cellular biochemistry

authors： Liu J,Yang B,Ai J

更新日期：2013-05-01 00:00:00

abstract：:Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

journal_title：Journal of cellular biochemistry

authors： Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

更新日期：1996-06-01 00:00:00

abstract：:Prostate cancer has a propensity to metastasize to the bone. Currently the only effective systemic treatment for these patients is androgen ablation therapy. However, the tumor will invariably progress to an androgen-independent stage and the patient will succumb to his disease within approximately 2 years. The earlie...

journal_title：Journal of cellular biochemistry

authors： Wang G,Sadar MD

更新日期：2006-05-01 00:00:00

abstract：:In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a putative L-leucine r...

journal_title：Journal of cellular biochemistry

authors： Lynch CJ,Fox HL,Vary TC,Jefferson LS,Kimball SR

更新日期：2000-03-01 00:00:00

abstract：:Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strains: (1) Molecular a...

journal_title：Journal of cellular biochemistry

authors： Groner B

更新日期：1992-06-01 00:00:00

abstract：:The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-alpha (ER-alpha) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-alpha protein concentration by 3 h, and the amount of ER-al...

journal_title：Journal of cellular biochemistry

authors： Stoica A,Saceda M,Fakhro A,Joyner M,Martin MB

更新日期：2000-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling p...

journal_title：Journal of cellular biochemistry

authors： Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty C

更新日期：2020-11-01 00:00:00

abstract：:Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downreg...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu H,Zhao P,Zhou H,Mao T

更新日期：2019-03-01 00:00:00

abstract：:Interleukin-1 beta-converting enzyme (ICE) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. ICE and homologous proteases also appear to mediate intracellular protein degradation during programmed cell death. Inhibit...

journal_title：Journal of cellular biochemistry

authors： Livingston DJ

更新日期：1997-01-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a leading cause of adult visual impairment and loss. This study aims to explore the effects of microRNA-9 (miR-9) on retinal neovascularization during DR by targeting the vascular endothelial growth factor A (VEGFA). DR rat models were successfully established. Retinal microvascular endoth...

journal_title：Journal of cellular biochemistry

authors： Liu WL

更新日期：2018-11-28 00:00:00

abstract：:Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression ...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Liu Y,Xu X

更新日期：2018-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 1 (Stat1) is a critical mediator of gene transcription in type I interferon (IFN-alpha/beta) signaling that is essential for host defense against viruses. In the skeletal system, type I IFNs (IFN-alpha/beta) also play an important physiological role in the inhibition of...

journal_title：Journal of cellular biochemistry

authors： Takayanagi H,Kim S,Koga T,Taniguchi T

更新日期：2005-02-01 00:00:00

abstract：:The three ingredients for the successful tissue engineering of bone and cartilage are regulatory signals, cells, and extracellular matrix. Recent advances in cellular and molecular biology of the growth and differentiation factors have set the stage for a symbiosis of biotechnology and biomaterials. Recent advances pe...

journal_title：Journal of cellular biochemistry

authors： Reddi AH

更新日期：1994-10-01 00:00:00

abstract：:Currently, the only available treatments for Trypanosoma cruzi are benznidazole (Bz) and nifurtimox (Nfx). The mechanisms of action and resistance to these drugs in this parasite are not complete known. In order to identify differentially expressed transcripts between sensitive and resistant parasites, a massive pyros...

journal_title：Journal of cellular biochemistry

authors： García-Huertas P,Mejía-Jaramillo AM,González L,Triana-Chávez O

更新日期：2017-07-01 00:00:00

abstract：:Proteolytic processing of precursor proteins is a phylogenetically ancient and widely used mechanism for producing biologically active peptides. Proteolytic cleavage of proproteins begins only after transport to the Golgi apparatus has been completed and in most systems may continue for many hours within newly formed ...

journal_title：Journal of cellular biochemistry

authors： Steiner DF,Docherty K,Carroll R

更新日期：1984-01-01 00:00:00

abstract：:We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...

journal_title：Journal of cellular biochemistry

authors： Hubberstey A,Yu G,Loewith R,Lakusta C,Young D

更新日期：1996-06-01 00:00:00

abstract：:The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodi...

journal_title：Journal of cellular biochemistry

authors： Butler JT,Hall LL,Smith KP,Lawrence JB

更新日期：2009-07-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta1 and BMP-2 treatment of primar...

journal_title：Journal of cellular biochemistry

authors： Nesti LJ,Caterson EJ,Li WJ,Chang R,McCann TD,Hoek JB,Tuan RS

更新日期：2007-05-15 00:00:00

abstract：:Receptor activator of NF-kappaB ligand (RANKL) is a critical osteoclastogenic factor that is expressed on bone marrow stromal/preosteoblast cells. Most bone resorption stimuli induce osteoclast formation by modulating RANKL expression in these cells. However, little is known about the mechanisms regulating RANKL gene ...

journal_title：Journal of cellular biochemistry

authors： Sundaram K,Mani SK,Kitatani K,Wu K,Pestell RG,Reddy SV

更新日期：2008-04-15 00:00:00

abstract：:The objective of this study was to test the hypothesis that extracellular matrix (ECM) would alter the endoplasmic reticulum (ER) stress response of chondrocytes. Chondrocytes were isolated from calf knees and maintained in monolayer culture or suspended in collagen I to form spot cultures (SCs). Our laboratory has sh...

journal_title：Journal of cellular biochemistry

authors： Nugent AE,McBurney DL,Horton WE Jr

更新日期：2011-04-01 00:00:00

abstract：:The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental role during proliferation and adipogenic induction of preadipocytes. Using 3T3-L1 cells as model, we de...

journal_title：Journal of cellular biochemistry

authors： Pagano E,Coso O,Calvo JC

更新日期：2008-05-01 00:00:00

abstract：:The retinal pigmented epithelium (RPE) is a monolayer of polarized cells located between retinal photoreceptors and blood vessels of the choroid. The basal surface of RPE cells rests on Bruch's membrane, a complex extracellular matrix structure which becomes abnormal in several disease processes, including age-related...

journal_title：Journal of cellular biochemistry

authors： Mousa SA,Lorelli W,Campochiaro PA

更新日期：1999-07-01 00:00:00

abstract：:Syndecans are cell-surface heparan sulfate proteoglycans, which perform a variety of functions in the cell. Most important, they are co-receptors for growth factors and mediate cell-cell and cell-matrix interactions. Four syndecans (syndecan 1-4) have been described in different species. The aim of this work was the c...

journal_title：Journal of cellular biochemistry

authors： Berndt C,Casaroli-Marano RP,Vilaró S,Reina M

更新日期：2001-01-01 00:00:00

abstract：:Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

journal_title：Journal of cellular biochemistry

authors： Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

更新日期：2009-12-15 00:00:00