Abstract：
:Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling pathway protein cascade might develop into various types of cancers, either by upregulation or downregulation of the Wnt signaling pathway protein components. In addition, it is reported that activation of the Wnt signaling pathway is associated with the transcriptional activation of microRNAs (miRNAs) by binding to its promoter region, suggesting feedback regulation. Considering the protein regulatory functions of various miRNAs, they can be approached therapeutically as modulatory targets for protein components of the Wnt signaling pathway. In this article, we have discussed the potential role of miRNAs in the regulation of Wnt signaling pathway proteins related to the pathogenesis of CLL via crosstalk between miRNAs and Wnt signaling pathway proteins. This might provide a clear insight into the Wnt protein regulatory function of various miRNAs and provide a better understanding of developing advanced and promising therapeutic approaches against CLL.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty Cdoi
10.1002/jcb.29683subject
Has Abstractpub_date
2020-11-01 00:00:00pages
4654-4666issue
11eissn
0730-2312issn
1097-4644journal_volume
121pub_type
杂志文章,评审abstract：:As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 in invasion of breast cancers is still unclear. Here we report that the expression of UCH-L1 is significantly higher in cancer cells with higher invasive abilit...
journal_title：Journal of cellular biochemistry
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journal_title：Journal of cellular biochemistry
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
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journal_title：Journal of cellular biochemistry
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journal_title：Journal of cellular biochemistry
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abstract：:Hyperglycemia and elevation of methylglyoxal (MG) are symptoms of diabetes mellitus (DM). We previously showed that high glucose (HG; 30 mM) or MG (50-400 microM) could induce apoptosis in mammalian cells, but these doses are higher than the physiological concentrations of glucose and MG in the plasma of DM patients. ...
journal_title：Journal of cellular biochemistry
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更新日期：2007-09-01 00:00:00
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journal_title：Journal of cellular biochemistry
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更新日期：2019-10-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：2009-10-15 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.27442
更新日期：2019-01-01 00:00:00
abstract：:Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to fin...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.28444
更新日期：2019-02-14 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.24735
更新日期：2014-05-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/(sici)1097-4644(199705)65:2<231::aid-jcb8>
更新日期：1997-05-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.240290306
更新日期：1985-01-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.21389
更新日期：2008-01-01 00:00:00
abstract：:Decreased translation initiation adversely impacts protein synthesis and contributes to the myocardial dysfunction produced by sepsis. Therefore, the purpose of the present study was to identify sepsis-induced changes in signal transduction pathways known to regulate translation initiation in cardiac muscle and to det...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.20311
更新日期：2005-02-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.25453
更新日期：2016-07-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
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journal_title：Journal of cellular biochemistry
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journal_title：Journal of cellular biochemistry
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更新日期：1998-08-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
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更新日期：2007-07-01 00:00:00
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journal_title：Journal of cellular biochemistry
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doi：10.1002/jcb.10535
更新日期：2003-06-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章,评审
doi：10.1002/(sici)1097-4644(19991201)75:3<369::aid-jcb
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abstract：:Epithelial-to-mesenchymal transition (EMT) is a major process to regulate cell migration and invasion. Inhibition of epidermal growth factor receptor (EGFR)-mediated EMT by tyrosine kinase inhibitors (TKIs) is a strategy to prevent lung cancer invasion. However, drug resistance is emerged and accelerated invasion thro...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.24805
更新日期：2014-09-01 00:00:00
abstract：:Syndecans are proteoglycans that act as signaling molecules. Previously, we showed that syndecan-2 (SYND2) is involved in the control of osteoblastic (OB) cell apoptosis. Here, we show a novel functional interaction between SYND2 and protein kinase C delta (PKCdelta). Overexpression of SYND2 in MG63 OB cells resulted ...
journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.20826
更新日期：2006-07-01 00:00:00
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journal_title：Journal of cellular biochemistry
pub_type： 杂志文章
doi：10.1002/jcb.28477
更新日期：2019-02-19 00:00:00
