Peripheral nuclear matrix actin forms perinuclear shells.

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:Telomeres are TTAGGG repetitive motifs found at the ends of vertebrate chromosomes. In humans, telomeres are protected by shelterin, a complex of six proteins (de Lange [2005] Genes Dev. 19: 2100-2110). Since (Müller [1938] Collecting Net. 13: 181-198; McClintock [1941] Genetics 26: 234-282), their function in maintai...

journal_title：Journal of cellular biochemistry

authors： Mai S,Garini Y

更新日期：2006-04-01 00:00:00

abstract：:Oncostatin M (OSM) is a member of the interleukin (IL)-6 family cytokines. We previously demonstrated that OSM induces blood-brain barrier (BBB) impairment. However, functional characterization of IL-6 family cytokines in BBB regulation and the cytokine-related intracellular signaling pathway remain unclear. In this s...

journal_title：Journal of cellular biochemistry

authors： Takata F,Dohgu S,Matsumoto J,Machida T,Sakaguchi S,Kimura I,Yamauchi A,Kataoka Y

更新日期：2018-11-01 00:00:00

abstract：:Butyrate inhibits growth of lung cancer. However, the molecular mechanism is still unclear. Here we profiled miRNAs that responded to sodium butyrate(NaB) stimulation in A549 cells, a non-small cell lung cancer cell line, using microarray. We found 33 up-regulated microRNAs and 22 down-regulated microRNAs (log2 ≥1.5 f...

journal_title：Journal of cellular biochemistry

authors： Xiao X,Cao Y,Chen H

更新日期：2018-04-01 00:00:00

abstract：:Herbal plants are enriched with compounds with a wide range of biological activities. Furanodiene is a sesquiterpene isolated from Rhizoma Curcumae. Growing evidence shows furanodiene exhibits diversified activities of hepatoprotection, anti-inflammation, anti-angiogenesis, and anti-tumor. However, its biological acti...

journal_title：Journal of cellular biochemistry

authors： Zhong ZF,Li YB,Wang SP,Tan W,Chen XP,Chen MW,Wang YT

更新日期：2012-08-01 00:00:00

abstract：:The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites. We have recently found that Sam68 is a substrate of the insulin receptor (IR) that translocates from the nucleus to the cytoplasm and that Tyr-phosphorylated Sam68 associates with t...

journal_title：Journal of cellular biochemistry

authors： Najib S,Sánchez-Margalet V

更新日期：2002-01-01 00:00:00

abstract：:Connexin43 (Cx43) is a ubiquitously expressed member of the gap junction protein family that mediates gap junction intercellular communication (GJIC) by allowing exchange of cytosolic materials. Previous studies have used Cx43 truncated at the cytoplasmic tail (C-tail) to demonstrate that the C-tail is essential to re...

journal_title：Journal of cellular biochemistry

authors： Crespin S,Bechberger J,Mesnil M,Naus CC,Sin WC

更新日期：2010-06-01 00:00:00

abstract：:Toxoplasma gondii an obligate intracellular parasite causes toxoplasmosis in homeothermic animals. Host invasion of this parasite is mediated by the formation of Moving Junction (MJ) complex which encompasses a network of microneme and Rhoptry Neck proteins (RONs) 2/4/5/8. Among these proteins, RON4 is the only cytoso...

journal_title：Journal of cellular biochemistry

authors： Vetrivel U,Nagarajan H,Thirumudi I

更新日期：2018-04-01 00:00:00

abstract：:In a previous work, taking advantage of the gene-array screening technology, we analysed the effects of histone deacetylase (HDAC) inhibitor sodium butyrate (NaBt), on gene transcription in HT29 human adenocarcinoma cell line. In this study, we focused our attention on p55CDC/Cdc20 gene, whose expression was dramatica...

journal_title：Journal of cellular biochemistry

authors： Iacomino G,Medici MC,Napoli D,Russo GL

更新日期：2006-11-01 00:00:00

abstract：:Rhodopsin mutations cause autosomal dominant form of retinitis pigmentosa (RP). T17M rhodopsin predisposes cells to endoplasmic reticulum stress induced apoptosis. However, the pathogenic role of T17M rhodopsin in RP is not completely understood. Complement C3 has a protective role in RP pathogenesis. This study aimed...

journal_title：Journal of cellular biochemistry

authors： Xiong S,Yu Y,Zhou X,Xia X,Jiang H

更新日期：2017-12-01 00:00:00

abstract：:Human prostatic carcinoma frequently metastasizes to bone tissue and activates bone metabolism, especially bone formation, at the site of metastasis. It has been reported that an extract of prostatic carcinoma and conditioned medium (CM) of a human prostatic carcinoma cell line, PC-3, established from a bone metastast...

journal_title：Journal of cellular biochemistry

authors： Kido J,Yamauchi N,Ohishi K,Kataoka M,Nishikawa S,Nakamura T,Kadono H,Ikedo D,Ueno A,Nonomura N,Okuyama A,Nagata T

更新日期：1997-11-01 00:00:00

abstract：:Arctigenin is a dibenzylbutyrolactone lignan isolated from Bardanae fructus, Arctium lappa L, Saussureamedusa, Torreya nucifera, and Ipomea cairica. It has been reported to exhibit anti-inflammatory activities, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB (NF-κB). But t...

journal_title：Journal of cellular biochemistry

authors： Yao X,Zhu F,Zhao Z,Liu C,Luo L,Yin Z

更新日期：2011-10-01 00:00:00

abstract：:The bcl-2 gene has a unique function among mammalian oncogenes as a negative regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent with a role in maintaining in vivo survival of specific cell types. The biochemical function of bcl-2 is unknown, but its localization to mitochondria...

journal_title：Journal of cellular biochemistry

authors： Park JR,Hockenbery DM

更新日期：1996-01-01 00:00:00

abstract：:Optimization of an in vitro culture that supports blastocyst (BL) development from single blastomeres (SBs) is essential to generate additional embryos for farm animals and humans and unravel the mechanisms that underlie totipotency. In this study, we have examined BL development from SBs that were derived from 2-cell...

journal_title：Journal of cellular biochemistry

authors： Yekani F,Azarnia M,Esfandiari F,Hassani SN,Baharvand H

更新日期：2018-09-01 00:00:00

abstract：:In addition to cholesterol-lowering effect, HMG-CoA reductase inhibition by statins has been shown to have protective effect in many cells type. The loss of vision in retinal degeneration disease associates with oxidative stress and apoptosis in retinal pigment epithelium (RPE) cell. This study was designed to examine...

journal_title：Journal of cellular biochemistry

authors： Qian J,Keyes KT,Long B,Chen G,Ye Y

更新日期：2011-09-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling p...

journal_title：Journal of cellular biochemistry

authors： Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty C

更新日期：2020-11-01 00:00:00

abstract：:Fgf10 has a prominent role in organogenesis. In the developing lung, Fgf10 is dynamically expressed in the distal mesenchyme from where it diffuses and activates its epithelial receptor, Fgfr2b, to trigger budding. Little is known about how Fgf10 expression is regulated. Here we have identified a mouse lung-specific m...

journal_title：Journal of cellular biochemistry

authors： Jean JC,Lü J,Joyce-Brady M,Cardoso WV

更新日期：2008-04-15 00:00:00

abstract：:One of the fundamental goals in cell biology and proteomics is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. Knowledge of subcellular locations of proteins can provide key hints for revealing their functions and understanding how they interact with...

journal_title：Journal of cellular biochemistry

authors： Chou KC,Shen HB

更新日期：2006-10-01 00:00:00

abstract：:Gastric cancer (GC) is the fourth common cancer and second leading cause of cancer-related mortality in the world. WD repeat domain 5 (WDR5) has been identified that its functions as an important role in various biological functions through the epigenetic regulation of gene transcription. However, the oncogenic effect...

journal_title：Journal of cellular biochemistry

authors： Sun W,Guo F,Liu M

更新日期：2018-04-01 00:00:00

abstract：:Angiogenesis plays an important role in many pathological processes. Identification of novel anti-angiogenic agents will provide new insights into the mechanisms for angiogenesis as well as potential lead compounds for developing new drugs. In the present study, a series of resveratrol methylated derivatives have been...

journal_title：Journal of cellular biochemistry

authors： Zhang L,Jing H,Cui L,Li H,Zhou B,Zhou G,Dai F

更新日期：2013-03-01 00:00:00

abstract：:The differentiation therapy in treatment of acute promyelocytic leukemia (APL), based on the administration of all-trans retinoic acid (ATRA), is currently flanked with the use of As2O3, a safe and effective agent for patients showing a resistance to ATRA treatment. A synergy between ATRA and As3O3 was also reported i...

journal_title：Journal of cellular biochemistry

authors： Brugnoli F,Bovolenta M,Benedusi M,Miscia S,Capitani S,Bertagnolo V

更新日期：2006-05-01 00:00:00

abstract：:The function of the c-myc proto-oncogene in cell cycle progression remains unclear. In order to examine the role c-myc may play in cell cycle progression, we have expressed the hormone-inducible MycER protein in the nontransformed, EGF-dependent mouse keratinocyte cell line BALB/MK. We have found that activation of My...

journal_title：Journal of cellular biochemistry

authors： Alexandrow MG,Moses HL

更新日期：1998-09-15 00:00:00

abstract：:Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably...

journal_title：Journal of cellular biochemistry

authors： Li C,Ke J,Liu J,Su J

更新日期：2020-03-01 00:00:00

abstract：:It has been proposed that buckling of actin stress fibers (SFs) may be associated with their disassembly. However, much of the detail remains unknown partly because the use of an elastic membrane sheet, conventionally necessary for inducing SF buckling with a mechanical compression to adherent cells, may limit high qu...

journal_title：Journal of cellular biochemistry

authors： Deguchi S,Matsui TS,Sato M

更新日期：2012-03-01 00:00:00

abstract：:The expression of matrix metalloproteinase-13 (MMP-13), involved in bone turnover, is elevated in stretched MC3T3-E1 osteoblast-like cells. Strain-mediated forces impact bone remodeling due in large part to the movement of fluid through the canalicular-lacunar network. The resulting fluid shear stress (FSS) over the s...

journal_title：Journal of cellular biochemistry

authors： Charoonpatrapong-Panyayong K,Shah R,Yang J,Alvarez M,Pavalko FM,Gerard-O'Riley R,Robling AG,Templeton E,Bidwell JP

更新日期：2007-12-01 00:00:00

abstract：:Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types, androgen-deprivation insensitive cells exist prior to hormonal manipulation. We established several LNCaP subclones with distinct insensitivities to androgen deprivation from a p...

journal_title：Journal of cellular biochemistry

authors： Terada N,Shiraishi T,Zeng Y,Aw-Yong KM,Mooney SM,Liu Z,Takahashi S,Luo J,Lupold SE,Kulkarni P,Getzenberg RH

更新日期：2014-09-01 00:00:00

abstract：:Evidence is presented for the first time that the cytochrome P450XVII-catalysed androgen formation from progesterone (P) in rat testicular microsomal membranes represents a metabolic sequence that exhibits the ability of intrinsic regulation of intermediate transfer and product formation efficiency. Exposure of this s...

journal_title：Journal of cellular biochemistry

authors： Kühn-Velten WN

更新日期：1990-06-01 00:00:00

abstract：:To determine the role of thrombin high-affinity receptor occupancy and enzymic activity in thrombin initiation of cell proliferation, we have utilized thrombin derivatives which separate these functions. We previously showed that enzymically active gamma-thrombin stimulates ion fluxes without binding to high-affinity ...

journal_title：Journal of cellular biochemistry

authors： Carney DH,Stiernberg J,Fenton JW 2nd

更新日期：1984-01-01 00:00:00

abstract：:Vascular smooth-muscle cell (VSMC) proliferation plays a vital role in hypertension, atherosclerosis and restenosis. It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if emodin exerts similar anti-atherogenic effects in TNF-alpha...

journal_title：Journal of cellular biochemistry

authors： Heo SK,Yun HJ,Park WH,Park SD

更新日期：2008-09-01 00:00:00

abstract：:The receptor for epidermal growth factor (EGF) is a glycosylated transmembrane phosphoprotein that exhibits EGF-stimulable protein tyrosine kinase activity. On EGF stimulation, the receptor undergoes a self-phosphorylation reaction at tyrosine residues located primarily in the extreme carboxyl-terminal region of the p...

journal_title：Journal of cellular biochemistry

authors： Bertics PJ,Weber W,Cochet C,Gill GN

更新日期：1985-01-01 00:00:00