Abstract:
:The bcl-2 gene has a unique function among mammalian oncogenes as a negative regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent with a role in maintaining in vivo survival of specific cell types. The biochemical function of bcl-2 is unknown, but its localization to mitochondrial and microsomal membranes suggests several possibilities. bcl-2 is protective against oxidative stress in mammalian cells and can be replaced by antioxidants in a factor-deprivation model of apoptosis. These results are consistent with a model of apoptotic death involving oxidative stress in a central pathway. The recent discovery of several bcl-2-related genes, some of which also inhibit apoptosis and others that unexpectedly promote apoptosis, has shed new light on several aspects of bcl-2 action.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Park JR,Hockenbery DMdoi
10.1002/(sici)1097-4644(19960101)60:1<12::aid-jcb3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
12-7issue
1eissn
0730-2312issn
1097-4644pii
10.1002/(SICI)1097-4644(19960101)60:1<12::AID-JCB3journal_volume
60pub_type
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