Human T-lymphotropic virus 1 (HTLV-1) pathogenesis: A systems virology study.

abstract：:Craniosynostosis is a condition in which some or all of the sutures in the skull of an infant close prematurely. Fibroblast growth factor receptor 2 (FGFR2) mutations are a well-known cause of craniosynostosis. Many syndromes that comprise craniosynostosis, such as Apert syndrome, Crouzon syndrome, and Pfeiffer syndro...

journal_title：Journal of cellular biochemistry

authors： Park J,Park OJ,Yoon WJ,Kim HJ,Choi KY,Cho TJ,Ryoo HM

更新日期：2012-02-01 00:00:00

abstract：:Papillary renal cell carcinoma (pRCC) is a heterogeneous disease containing multifocal or solitary tumors with an aggressive phenotype. Increasing evidence has indicated the involvement of aberrant splicing variants in renal cell cancer, while systematic profiling of aberrant alternative splicing (AS) in pRCC was lack...

journal_title：Journal of cellular biochemistry

authors： Duan Y,Zhang D

更新日期：2020-01-01 00:00:00

abstract：:Matrine, a natural product extracted from the root of Sophora flavescens Ait, was the main chemical ingredient of compounds of Kushen injection, which has been widely used for its remarkable anticancer effects for years. The underlying mechanisms for Matrine regulations of human breast cancer stem cells (BrCSCs) are b...

journal_title：Journal of cellular biochemistry

authors： Li X,Liang T,Chen SS,Wang M,Wang R,Li K,Wang JC,Xu CW,Du N,Qin S,Ren H

更新日期：2020-03-01 00:00:00

abstract：:Recent studies have shown that exposure to fluoxetine treatment induces excessive production of ROS, and alters the antioxidant defense system in various tissues and cell types, mainly the liver. When fluoxetine is administered intraperitoneally, the drug rapidly reaches high concentrations in the liver, has potential...

journal_title：Journal of cellular biochemistry

authors： Simões-Alves AC,Silva-Filho RC,Braz GRF,Silva SCA,da Silva AI,Lagranha CJ,Fernandes MP

更新日期：2018-08-01 00:00:00

abstract：:To study hematopoietic differentiation a variety of in vitro systems have been established using hematopoietic precursors derived from various explanted adult and fetal tissues. In this prospective we describe and discuss the potential of a novel system for studying the earliest stages of hematopoietic development. In...

journal_title：Journal of cellular biochemistry

authors： Snodgrass HR,Schmitt RM,Bruyns E

更新日期：1992-07-01 00:00:00

abstract：:Adult human mesenchymal stem cells (MSCs) hold promise for an increasing list of therapeutic uses due to their ease of isolation, expansion, and multi-lineage differentiation potential. To maximize the clinical potential of MSCs, the underlying mechanisms by which MSC functionality is controlled must be understood. We...

journal_title：Journal of cellular biochemistry

authors： Pricola KL,Kuhn NZ,Haleem-Smith H,Song Y,Tuan RS

更新日期：2009-10-15 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) is of fundamental importance in a cell's response to environmental stresses, cytokines and DNA damage. p38 resides in the cytoplasm of resting cells, and translocates into the nucleus upon activation, yet the exact mechanisms remain largely unclear. We show here that the pho...

journal_title：Journal of cellular biochemistry

authors： Gong X,Ming X,Deng P,Jiang Y

更新日期：2010-08-15 00:00:00

abstract：:The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the associati...

journal_title：Journal of cellular biochemistry

authors： Guan C,Liu Z,Lu C,Xiao M,Shi H,Ni R,Bian Z

更新日期：2019-02-21 00:00:00

abstract：:The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman ra...

journal_title：Journal of cellular biochemistry

authors： Castro Ghizoni CV,Arssufi Ames AP,Lameira OA,Bersani Amado CA,Sá Nakanishi AB,Bracht L,Marçal Natali MR,Peralta RM,Bracht A,Comar JF

更新日期：2017-10-01 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：:The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

journal_title：Journal of cellular biochemistry

authors： Weich HA,Iberg N,Klagsbrun M,Folkman J

更新日期：1991-10-01 00:00:00

abstract：:The activated c-Ha-rasVal12 oncogene is often involved in the genesis of human malignancies. We show here that in c-Ha-rasVal12 oncogene-transformed mouse NIH 3T3 fibroblasts the copy number and expression level of the mutant ras oncogene correlates with the degree of chromatin decondensation, as assessed by micrococc...

journal_title：Journal of cellular biochemistry

authors： Laitinen J,Sistonen L,Alitalo K,Hölttä E

更新日期：1995-01-01 00:00:00

abstract：:Osteosarcoma (OS) is the most malignant primary bone tumor in children and adolescents with limited treatment options and poor prognosis. Recently, aberrant expression of Runx2 has been found in OS, thereby contributing to the development, and progression of OS. However, the upstream signaling molecules that regulate ...

journal_title：Journal of cellular biochemistry

authors： Liang GH,Liu N,He MT,Yang J,Liang ZJ,Gao XJ,Rahhal AH,He QY,Zhang HT,Zha ZG

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:This study is aimed to explore the functions of long noncoding RNA (lncRNA) HEIH on the proliferation as well as metastasis of non-small cell lung cancer (NSCLC). METHODS:HEIH was shown to be increased in NSCLC by a microarray study on lncRNA profiling. We detected the expression of HEIH in different human ...

journal_title：Journal of cellular biochemistry

authors： Jia K,Chen F,Xu L

更新日期：2019-03-01 00:00:00

abstract：:All-trans retinoic acid and 9-cis-retinoic acid stimulate the activity of steroid sulfatase in HL60 acute myeloid leukemia cells in a concentration- and time-dependent manner. Neither of these 'natural retinoids' augmented steroid sulfatase activity in a HL60 sub-line that expresses a dominant-negative retinoic acid r...

journal_title：Journal of cellular biochemistry

authors： Hughes PJ,Zhao Y,Chandraratna RA,Brown G

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii has emerged as a major cause of nosocomial infections. Various resistance mechanisms of A. baumannii against antibiotics have transformed it into a successful nosocomial pathogen. Because of the limited number of available antibiotics, we used a medicinal plant with an antibacterial e...

journal_title：Journal of cellular biochemistry

authors： Hassannejad N,Bahador A,Rudbari NH,Modarressi MH,Parivar K

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Endometrial carcinoma (EC), a common gynecological malignancy with high incidence, affects the mental and physical health of women. Mounting evidence shows that long noncoding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) have instrumental roles in various biological processes associated with t...

journal_title：Journal of cellular biochemistry

authors： Zhao D,Ren C,Yao Y,Wang Q,Li F,Li Y,Jiang A,Wang G

更新日期：2020-03-01 00:00:00

abstract：:During the life cycle of human papillomaviruses (HPVs), the L1 capsid proteins seem to enter the nucleus twice: once after the virions infect the cells, and later during the productive phase when they assemble the replicated HPV genomic DNA into infectious virions. We established for the high-risk HPV45 that when digi...

journal_title：Journal of cellular biochemistry

authors： Nelson LM,Rose RC,LeRoux L,Lane C,Bruya K,Moroianu J

更新日期：2000-08-02 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CC) is devastating neoplasm and very few specific biomarkers could be used in clinical diagnosis. A study was taken to find novel serum biomarkers for CC. METHODS:Surface enhanced laser desorption/ionization (SELDI) technology was used to analyze 427 serum samples including 56 CCs, 49 he...

journal_title：Journal of cellular biochemistry

authors： Liu L,Wang J,Liu B,Dai S,Wang X,Chen J,Huang L,Xiao X,He D

更新日期：2008-06-01 00:00:00

abstract：:AKT and its substrate BAD have been shown to promote prostate cancer cell survival. Agonists, such as carbachol, and hormones that increase intracellular calcium concentration can activate AKT leading to cancer cell survival. The LNCaP prostate cancer cells express the carbachol-sensitive M(3) -subtype of G protein-co...

journal_title：Journal of cellular biochemistry

authors： Schmitt JM,Smith S,Hart B,Fletcher L

更新日期：2012-05-01 00:00:00

abstract：:Mechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor kappa B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS ...

journal_title：Journal of cellular biochemistry

authors： Mehrotra M,Saegusa M,Wadhwa S,Voznesensky O,Peterson D,Pilbeam C

更新日期：2006-08-01 00:00:00

abstract：:The sodium-dependent glucose co-transporter (SGLT1) is regulated by protein kinases. The aim of the present study was to examine the role of protein kinase C (PKC) in the regulation of rabbit (rb) SGLT1 activity as determined by alpha-methyl-D-glucopyranoside (AMG) uptake and to identify the cellular mechanisms involv...

journal_title：Journal of cellular biochemistry

authors： Castaneda-Sceppa C,Subramanian S,Castaneda F

更新日期：2010-04-15 00:00:00

abstract：:Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells. Ischemic stroke remains a substantial problem for industrialized countries. Over the previous few decades our understanding about the pathophysiology of stroke has enhanced, nevertheless, more awareness is required to advance t...

journal_title：Journal of cellular biochemistry

authors： Rikhtegar R,Yousefi M,Dolati S,Kasmaei HD,Charsouei S,Nouri M,Shakouri SK

更新日期：2019-06-01 00:00:00

abstract：:A quantitative PCR method was used to map a functional origin of DNA replication in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in normal human fibroblasts. This PCR method measures the abundance of specific sequences in short fragments of newly replicated DNA from logarithmically growing cells. Qua...

journal_title：Journal of cellular biochemistry

authors： Cohen SM,Brylawski BP,Cordeiro-Stone M,Kaufman DG

更新日期：2002-01-01 00:00:00

abstract：:The cholesterol hydroxylase/lyase (CHL) system, consisting of cytochrome P450scc, adrenodoxin (Adx) and adrenodoxin reductase (AdR), initiates mammalian steroidogenesis, converting cholesterol to pregnenolone. The foot-and-mouth disease virus 2A-based method allows to express multiple proteins from a single transcript...

journal_title：Journal of cellular biochemistry

authors： Efimova VS,Isaeva LV,Labudina AA,Tashlitsky VN,Rubtsov MA,Novikova LA

更新日期：2019-03-01 00:00:00

abstract：:Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatmen...

journal_title：Journal of cellular biochemistry

authors： Zhu D,Wu L,Li CR,Wang XW,Ma YJ,Zhong ZY,Zhao HB,Cui J,Xun SF,Huang XL,Zhou Z,Wang SQ

更新日期：2009-09-01 00:00:00

abstract：:From the mouse JB6 epidermal cell line C122 we have isolated a cDNA clone representing a 1.6-kilobase mRNA, called 2ar, that exhibits a biphasic induction in response to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The first phase of induction in subconfluent cells is transient, peaking at 6 h after the addition of TP...

journal_title：Journal of cellular biochemistry

authors： Smith JH,Denhardt DT

更新日期：1987-05-01 00:00:00

abstract：:The identification and purification of murine multipotent mesenchymal stem cells (MSCs) have been difficult due to their low frequency, the presence of contaminating cell types and lack of unambiguous markers. Using a magnetic micro-beads negative selection technique to remove hematopoietic cells from mouse bone marro...

journal_title：Journal of cellular biochemistry

authors： McKenzie KP,Mayer DC,Aubin JE

更新日期：2013-05-01 00:00:00

abstract：:Extracts of thymic lymphoma that are obtained from AKR mice and are kept in the cold for at least several days can induce lipolytic activity in rat adipocyte suspensions. Freshly prepared extracts have low activity but contain a low molecular weight material of less than 10,000 daltons that aggregates on standing in t...

journal_title：Journal of cellular biochemistry

authors： Kitada S,Hays EF,Mead JF,Zabin I

更新日期：1982-01-01 00:00:00

abstract：:We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

journal_title：Journal of cellular biochemistry

authors： Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

更新日期：2017-12-01 00:00:00