Abstract:
:S49 murine lymphoma cells were examined for expression of various nucleoside transport systems using a non-metabolized nucleoside, formycin B, as substrate. Nitrobenzylthioinosine (NBTI)-sensitive, facilitated transport was the primary nucleoside transport system of the cells. The cells also expressed very low levels of NBTI-resistant, facilitated nucleoside transport as well as of Na(+)-dependent, concentrative formycin B transport. Concentrative transport was specific for uridine and purine nucleosides, just as the concentrative nucleoside transporters of other mouse and rat cells. A nucleoside transport mutant of S49 cells, AE-1, lacked both the NBTI-sensitive, facilitated and Na(+)-dependent, concentrative formycin B transport activity, but Na(+)-dependent, concentrative transport of alpha-aminoisobutyrate was not affected.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Plagemann PGdoi
10.1002/jcb.240460109subject
Has Abstractpub_date
1991-05-01 00:00:00pages
54-9issue
1eissn
0730-2312issn
1097-4644journal_volume
46pub_type
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