The new paradigm: Integrating genomic function and nuclear architecture.

abstract：:Occupational exposure to nickel has been epidemiologically linked to increased cancer risk in the respiratory tract. Nickel-induced cell transformation is associated with both genotoxic and epigenetic mechanisms that are poorly understood. Prolidase [E.C.3.4.13.9] is a cytosolic Mn(II)-activated metalloproteinase that...

journal_title：Journal of cellular biochemistry

authors： Miltyk W,Surazynski A,Kasprzak KS,Fivash MJ Jr,Buzard GS,Phang JM

更新日期：2005-04-15 00:00:00

abstract：:Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. I...

journal_title：Journal of cellular biochemistry

authors： Nie YQ,Cao J,Zhou YJ,Liang X,Du YL,Wan YJ,Li YY

更新日期：2014-05-01 00:00:00

abstract：:During the past several years, numerous laboratories have reported isolation and purification of proteinase inhibitors from human urine. Many of these molecules were incompletely characterized and some of them may have been artifacts in part because of harsh procedures used for their isolation. Consequently, there is ...

journal_title：Journal of cellular biochemistry

authors： Chawla RK,Lawson DH,Ahmad M,Travis J

更新日期：1992-11-01 00:00:00

abstract：:Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differe...

journal_title：Journal of cellular biochemistry

authors： Altun G,Loring JF,Laurent LC

更新日期：2010-01-01 00:00:00

abstract：:The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression of oncogenic PML-RAR...

journal_title：Journal of cellular biochemistry

authors： Yeung PL,Denissova NG,Nasello C,Hakhverdyan Z,Chen JD,Brenneman MA

更新日期：2012-05-01 00:00:00

abstract：:Skin epidermis is a constantly renewing epithelium that is composed of various cell types and provides an ideal model system for tissue regeneration and heterogeneity studies. Integrins are a family of transmembrane receptors that mediate cell adhesion in the epidermis, and integrin expression spatially reflects epide...

journal_title：Journal of cellular biochemistry

authors： He W,Ye J,Xu H,Lin Y,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPases) play an important role in the regulation of insulin action by dephosphorylating the active (autophosphorylated) form of the insulin receptor and attenuating its tyrosine kinase activity. PTPases can also modulate post-receptor signalling by catalyzing the dephosphorylation of ce...

journal_title：Journal of cellular biochemistry

authors： Goldstein BJ

更新日期：1992-01-01 00:00:00

abstract：:Excessive plasma triglyceride (TG) and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, is abundant in tissues with very active lipid catabolism and is involved in...

journal_title：Journal of cellular biochemistry

authors： Zhou PL,Li M,Han XW,Bi YH,Zhang WG,Wu ZY,Wu G

更新日期：2019-11-01 00:00:00

abstract：:The promoter of the mouse thymidylate synthase (TS) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter also plays an essential role in the p...

journal_title：Journal of cellular biochemistry

authors： Kapadia F,Johnson LF

更新日期：2006-02-15 00:00:00

abstract：:We used non-insulin producing pancreatic carcinoma cell line, MIA PaCa-2 and have modulated its culture conditions by using 1% matrigel as extracellular matrix, N2, B27 growth supplements and serum free conditions. Expression of markers was analyzed using qRT-PCR, immunofluorescence and in vitro functional assay for i...

journal_title：Journal of cellular biochemistry

authors： Bose B,Shenoy P S

更新日期：2013-07-01 00:00:00

abstract：:We explored the feasibility of studying nuclear matrix protein (NMP) expressions of the hepatocytes in normal and cirrhotic rat livers with liver regeneration after partial hepatectomy. Sixteen Wistar healthy rats were studied with experimental liver regeneration and/or liver cirrhosis. Two-dimensional (2-D) gel elect...

journal_title：Journal of cellular biochemistry

authors： Yun JP,Liew CT,Chew EC,Yin XY,Lai PB,Fai YH,Li HK,Jin ML,Ding MX,Li MT,Lin HL,Lau WY

更新日期：2004-04-15 00:00:00

abstract：:Ultraprofound hypothermia (< 5 degrees C) induces changes to cell membranes such as liquid-to-gel lipid transitions and oxidative stress that have a negative effect on membrane function and cell survival. We hypothesized that fatty acid substitution of endothelial cell lipids and alterations in their unsaturation woul...

journal_title：Journal of cellular biochemistry

authors： Zieger MA,Gupta MP,Siddiqui RA

更新日期：2006-10-15 00:00:00

abstract：:The reactive metabolites of benzo[a]pyrene (B[a]P) and cyclopenta[c,d]pyrene (CPP) induced an accumulation/phosphorylation of p53 in Hepa1c1c7 cells, whereas inhibition of p53 reduced the apoptosis. Judged by the inhibiting effect of wortmannin, phosphatidyl-inositol-3 (PI-3) kinases such as DNA-dependent protein kina...

journal_title：Journal of cellular biochemistry

authors： Solhaug A,Refsnes M,Holme JA

更新日期：2004-12-15 00:00:00

abstract：:The interaction of the low-molecular-weight GTP-binding protein rap2 with the cytoskeleton from thrombin-aggregated platelets was investigated by inducing depolymerization of the actin filaments, followed by in vitro-promoted repolymerization. We found that the association of rap2 with the cytoskeleton was spontaneous...

journal_title：Journal of cellular biochemistry

authors： Torti M,Bertoni A,Canobbio I,Sinigaglia F,Lapetina EG,Balduini C

更新日期：1999-12-15 00:00:00

abstract：:Inflammation, elicited in the skin following tissue damage or pathogen invasion, may become chronic with deleterious consequences. Tumor necrosis factor (TNF) is a key mediator of cutaneous inflammation and the keratinocyte an important protagonist of skin immunity. Calcitriol, the hormonally active vitamin D metaboli...

journal_title：Journal of cellular biochemistry

authors： Ziv E,Rotem C,Miodovnik M,Ravid A,Koren R

更新日期：2008-05-15 00:00:00

abstract：:Liver selected B16-LS9 melanoma cells show a dramatic overexpression of the proto-oncogene c-met, the cellular receptor for hepatocyte growth factor/scatter factor. As a consequence, c-met becomes constitutively active, and the cells become more responsive to hepatocyte growth factor stimulation. We have investigated ...

journal_title：Journal of cellular biochemistry

authors： Elia G,Ren Y,Lorenzoni P,Zarnegar R,Burger MM,Rusciano D

更新日期：2001-01-01 00:00:00

abstract：:As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 in invasion of breast cancers is still unclear. Here we report that the expression of UCH-L1 is significantly higher in cancer cells with higher invasive abilit...

journal_title：Journal of cellular biochemistry

authors： Luo Y,He J,Yang C,Orange M,Ren X,Blair N,Tan T,Yang JM,Zhu H

更新日期：2018-01-01 00:00:00

abstract：:Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanism...

journal_title：Journal of cellular biochemistry

authors： Stein GS,van Wijnen AJ,Stein JL,Lian JB,McNeil S,Pockwinse SM

更新日期：1999-01-01 00:00:00

abstract：:Glomerular podocytes are the major components of the renal filtration barrier, and altered podocyte permselectivity is a key event in the pathogenesis of proteinuric conditions. Clinical conditions such as ischemia and sleep apnea and extreme physiological conditions such as high-altitude sickness are presented with r...

journal_title：Journal of cellular biochemistry

authors： Nakuluri K,Mukhi D,Mungamuri SK,Pasupulati AK

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Wang L,Cao L,Chen L,Liu Q

更新日期：2018-10-28 00:00:00

abstract：:Telomeres are TTAGGG repetitive motifs found at the ends of vertebrate chromosomes. In humans, telomeres are protected by shelterin, a complex of six proteins (de Lange [2005] Genes Dev. 19: 2100-2110). Since (Müller [1938] Collecting Net. 13: 181-198; McClintock [1941] Genetics 26: 234-282), their function in maintai...

journal_title：Journal of cellular biochemistry

authors： Mai S,Garini Y

更新日期：2006-04-01 00:00:00

abstract：:Large doses of bone morphogenetic protein 2 (BMP2) are used clinically to induce bone formation in challenging bone defects. However, complications after treatment include swelling, ectopic bone formation, and adjacent bone resorption. While BMP2 can be effective, it is important to characterize the mechanism of the d...

journal_title：Journal of cellular biochemistry

authors： Hyzy SL,Olivares-Navarrete R,Schwartz Z,Boyan BD

更新日期：2012-10-01 00:00:00

abstract：:We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

journal_title：Journal of cellular biochemistry

authors： Larsson B,Nemere I

更新日期：2003-12-01 00:00:00

abstract：:Caveolae are plasma membrane subcompartments that have been implicated in signal transduction. In many cellular systems, caveolae are rich in signal transduction molecules such as G proteins and receptor-associated tyrosine kinases. An important structural component of the caveolae is caveolin. Recent evidence show th...

journal_title：Journal of cellular biochemistry

authors： De Luca A,Sargiacomo M,Puca A,Sgaramella G,De Paolis P,Frati G,Morisco C,Trimarco B,Volpe M,Condorelli G

更新日期：2000-04-01 00:00:00

abstract：:The efficiency of in vitro mesenchymal stem cell (MSC) differentiation into the myocardial lineage is generally poor. In order to improve cardiac commitment, bone marrow GFP+MSCs obtained from transgenic rats were cultured with adult wild type rat cardiomyocytes for 5 days in the presence of difluoromethylornithine (D...

journal_title：Journal of cellular biochemistry

authors： Muscari C,Bonafé F,Carboni M,Govoni M,Stanic I,Gamberini C,Ricci F,Tazzari PL,Caldarera CM,Guarnieri C

更新日期：2008-03-01 00:00:00

abstract：:The development and survival of male germ cells depend on the antioxidant capacity of the seminiferous tubule. Glutathione (GSH) plays an important role in the antioxidant defenses of the spermatogenic epithelium. Autophagy can act as a pro-survival response during oxidative stress or nutrient deficiency. In this work...

journal_title：Journal of cellular biochemistry

authors： Mancilla H,Maldonado R,Cereceda K,Villarroel-Espíndola F,Montes de Oca M,Angulo C,Castro MA,Slebe JC,Vera JC,Lavandero S,Concha II

更新日期：2015-10-01 00:00:00

abstract：:Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting. Androgen independent prostate cancer cell lines DU145 and PC3 have constitutive expression of CYP1A and CYP1A1 and CYP1A2, respectively. Four microm...

journal_title：Journal of cellular biochemistry

authors： Sterling KM Jr,Cutroneo KR

更新日期：2004-02-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are vital mediators involved in cancer progression. Previous studies confirmed that FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is upregulated in tumor diseases. The potential influence of FOXD2-AS1 in glioma progression, however, remains unknown. In this paper, FOXD2-AS1 was found t...

journal_title：Journal of cellular biochemistry

authors： Wang J,Li B,Wang C,Luo Y,Zhao M,Chen P

更新日期：2019-12-01 00:00:00

abstract：:Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calcul...

journal_title：Journal of cellular biochemistry

authors： Rucci N,Migliaccio S,Zani BM,Taranta A,Teti A

更新日期：2002-01-01 00:00:00

abstract：:D-Galactose (D-gal) can induce oxidative stress in non-cancer cells and result in cell damage by disturbing glucose metabolism. However, the effect of D-gal on cancer cells is yet to be explored. In this study, we investigated the toxicity of D-gal to malignant cells specifically neuroblastoma cells. As the results, h...

journal_title：Journal of cellular biochemistry

authors： Li N,He Y,Wang L,Mo C,Zhang J,Zhang W,Li J,Liao Z,Tang X,Xiao H

更新日期：2011-12-01 00:00:00