BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner.

abstract：:Primary cultures fill a unique niche among the repertoire of in vitro model systems available to investigate the biology of the normal and malignant human prostate. This review summarizes some of the properties of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas reall...

journal_title：Journal of cellular biochemistry

authors： Peehl DM

更新日期：2004-01-01 00:00:00

abstract：:The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. A novel transcript of the MDMX gene has been previously identified that has a short internal deletion of 68 base pairs, producing a shift in the reading frame after codon 114, resulting in the inclusion of 1...

journal_title：Journal of cellular biochemistry

authors： Rallapalli R,Strachan G,Tuan RS,Hall DJ

更新日期：2003-06-01 00:00:00

abstract：:Thymosin β-4 (Tβ4) is a ubiquitous protein, which has been suggested to regulate multiple cell signal pathways and a variety of cellular functions. However, the role Tβ4 plays in the cardiac microvascular endothelial cells (CMECs) under myocardial ischemia/reperfusion injury is currently unknown. Here we investigated ...

journal_title：Journal of cellular biochemistry

authors： Li Y,Zhu X,Liu X,Du A,Yu B

更新日期：2019-11-01 00:00:00

abstract：:We have used a retroviral vector (RCAS) to overexpress wild-type chicken c-Jun or a deletion mutant of chicken c-Jun (Jun delta 7) lacking the DNA binding region to investigate the possible role of c-Jun in lens epithelial cell proliferation and differentiation. Both constructs were efficiently expressed in primary cu...

journal_title：Journal of cellular biochemistry

authors： Rinaudo JA,Vacchiano E,Zelenka PS

更新日期：1995-06-01 00:00:00

abstract：:Uroplakin II (UPII) gene expression is highly tissue and cell specific, with mRNA present in the suprabasal cell layers of the bladder and urethra. Previous reports described the mouse UPII (mUPII) promoter as primarily urothelium selective. However, ectopic expression of a transgene under the 3.6 kb mUPII promoter wa...

journal_title：Journal of cellular biochemistry

authors： Kwon DN,Choi YJ,Park JY,Cho SK,Kim MO,Lee HT,Kim JH

更新日期：2006-10-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:Hsp47, Grp78, and Grp94 have been implicated with procollagen maturation events. In particular, Hsp47 has been shown to nascent procollagen alpha 1(I) chains in the course of synthesis and/or translocation into the endoplasmic reticulum (ER). Although, Hsp47 binding to gelatin and collagen has previously been suggeste...

journal_title：Journal of cellular biochemistry

authors： Ferreira LR,Norris K,Smith T,Hebert C,Sauk JJ

更新日期：1994-12-01 00:00:00

abstract：:Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation are not defined. In this...

journal_title：Journal of cellular biochemistry

authors： Zhang Q,Wang S,Sheng Y,Zhao S,Jiang Y,Zhou D,Yang H

更新日期：2019-03-01 00:00:00

abstract：:Prion diseases are characterized by high accumulation of infectious prion proteins (PrP(Sc)) in brains. PrP(Sc) are propagated by the conversion of host-encoded cellular prion proteins (PrP(C)) which are essential for developing the disease but are heterogeneously expressed in brains. The disease can be transmitted to...

journal_title：Journal of cellular biochemistry

authors： Kuczius T,Kleinert J,Karch H,Sibrowski W,Kelsch R

更新日期：2011-03-01 00:00:00

abstract：:We provided evidence that calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells. In cells labeled for 16 hr with 3H-arachidonic acid, ionomycin and Ca2(+)-mobilizing hormones such as bradykinin, thrombin and platelet activating factor induced arachidoni...

journal_title：Journal of cellular biochemistry

authors： Briand SI,Bernier SG,Guillemette G

更新日期：1996-12-01 00:00:00

abstract：:It is well accepted, that there is communication between osteoblasts and endothelial cells. However, the influence of endothelial cells on the differentiation of bone precursors into mature osteoblasts is not yet well understood. We therefore studied the effect of human umbilical vein endothelial cells (HUVEC) on huma...

journal_title：Journal of cellular biochemistry

authors： Meury T,Verrier S,Alini M

更新日期：2006-07-01 00:00:00

abstract：:The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

journal_title：Journal of cellular biochemistry

authors： Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

更新日期：2000-01-01 00:00:00

abstract：:We examined the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA-damage as evidenced by Comet measurements. Despite appearance of DNA lesions, p53 protein was not ...

journal_title：Journal of cellular biochemistry

authors： Wesierska-Gadek J,Gueorguieva M,Schloffer D,Uhl M,Wojciechowski J

更新日期：2003-08-15 00:00:00

abstract：:This study aims to explore how microRNA-133a (miR-133a) affects cell apoptosis and radio-sensitivity by targeting EGFR via regulating MEK/ERK pathway in esophageal cancer (EC). A total of 358 EC patients were selected and assigned into the resistant and sensitive groups. Human EC KYSE 150 cell line was assigned into t...

journal_title：Journal of cellular biochemistry

authors： Yang QS,Jiang LP,He CY,Tong YN,Liu YY

更新日期：2017-09-01 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:The non-receptor tyrosine kinase c-Src is activated in many human cancer types, and induces deregulation of cadherin-based cell-cell contacts and actin cytoskeleton. Because ezrin, a protein which cross-links the plasma membrane with the actin cytoskeleton, is often over-expressed in human cancers, and participates in...

journal_title：Journal of cellular biochemistry

authors： Elliott BE,Qiao H,Louvard D,Arpin M

更新日期：2004-05-01 00:00:00

abstract：:The pro-oxidant effect of L-ascorbic acid (LAA) is toxic to leukemia cells. LAA induces the oxidation of glutathione to its oxidized form (GSSG) and this is followed by a concentration-dependent H(2)O(2) accumulation, which occurs in parallel to the induction of apoptosis. To identify early protein targets of LAA in l...

journal_title：Journal of cellular biochemistry

authors： Park S,Lee J,Yeom CH

更新日期：2006-12-15 00:00:00

abstract：:Previously we have reported the production of a monoclonal antibody (Mab 1.2) which recognizes a cytoplasmic protein, terminin, in three different molecular weights: 90 (Tp90), 60 (Tp60), and 30 kDa (Tp30) forms. Further characterization shows that Tp90 is found in young growing and nongrowing quiescent fibroblasts, w...

journal_title：Journal of cellular biochemistry

authors： Wang E,Liu D

更新日期：1996-01-01 00:00:00

abstract：:The aim of our study was to investigate the osteoinductive potential of a titanium (Ti) surface with nanotopography, using mesenchymal stem cells (MSCs) and the mechanism involved in this phenomenon. Polished Ti discs were chemically treated with H2 SO4 /H2 O2 to yield nanotopography and rat MSCs were cultured under o...

journal_title：Journal of cellular biochemistry

authors： Rosa AL,Kato RB,Castro Raucci LM,Teixeira LN,de Oliveira FS,Bellesini LS,de Oliveira PT,Hassan MQ,Beloti MM

更新日期：2014-03-01 00:00:00

abstract：:Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to fin...

journal_title：Journal of cellular biochemistry

authors： Zhang C,Jiang F,Su C,Xie P,Xu L

更新日期：2019-02-14 00:00:00

abstract：:Platelets, which play a central role in thrombosis and hemostasis, develop from megakaryocytes. Signal transduction originated from the megakaryocyte growth and development factor, the Mpl ligand, which leads to megakaryocyte differentiation, polyploidization, and maturation, has been gradually characterized. In this ...

journal_title：Journal of cellular biochemistry

authors： Sun S,Ravid K

更新日期：1999-11-01 00:00:00

abstract：:To ascertain whether p53 deficiency in vivo leads to the deregulation of DNA methylation machinery prior to tumor development, we investigated the expression profile of DNA methyltransferases in the thymus and the liver of p53(+/+), p53(+/-), and p53(-/-) mice at 7 weeks of age before tumor development. The expression...

journal_title：Journal of cellular biochemistry

authors： Park IY,Sohn BH,Choo JH,Joe CO,Seong JK,Lee YI,Chung JH

更新日期：2005-02-15 00:00:00

abstract：:Excessive plasma triglyceride (TG) and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, is abundant in tissues with very active lipid catabolism and is involved in...

journal_title：Journal of cellular biochemistry

authors： Zhou PL,Li M,Han XW,Bi YH,Zhang WG,Wu ZY,Wu G

更新日期：2019-11-01 00:00:00

abstract：:Caveolae are plasma membrane subcompartments that have been implicated in signal transduction. In many cellular systems, caveolae are rich in signal transduction molecules such as G proteins and receptor-associated tyrosine kinases. An important structural component of the caveolae is caveolin. Recent evidence show th...

journal_title：Journal of cellular biochemistry

authors： De Luca A,Sargiacomo M,Puca A,Sgaramella G,De Paolis P,Frati G,Morisco C,Trimarco B,Volpe M,Condorelli G

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii has emerged as a major cause of nosocomial infections. Various resistance mechanisms of A. baumannii against antibiotics have transformed it into a successful nosocomial pathogen. Because of the limited number of available antibiotics, we used a medicinal plant with an antibacterial e...

journal_title：Journal of cellular biochemistry

authors： Hassannejad N,Bahador A,Rudbari NH,Modarressi MH,Parivar K

更新日期：2019-11-01 00:00:00

abstract：:We have analyzed the distribution of type II collagen N- and C-propeptides in the cell layers and culture medium of bovine articular chondrocyte pellet cultures. Two splice variants of the type II collagen N-propeptide were detected by immunoblotting and immunoassay, using a new anti-peptide antibody, while the C-prop...

journal_title：Journal of cellular biochemistry

authors： Rebuck N,Croucher LJ,Hollander AP

更新日期：1999-10-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients ...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Zhao XX,Hu XJ,Yang F,Lin P,Cui SC,Zhao W,Cao XY,Wang YS

更新日期：2019-03-01 00:00:00

abstract：:The differentiation therapy in treatment of acute promyelocytic leukemia (APL), based on the administration of all-trans retinoic acid (ATRA), is currently flanked with the use of As2O3, a safe and effective agent for patients showing a resistance to ATRA treatment. A synergy between ATRA and As3O3 was also reported i...

journal_title：Journal of cellular biochemistry

authors： Brugnoli F,Bovolenta M,Benedusi M,Miscia S,Capitani S,Bertagnolo V

更新日期：2006-05-01 00:00:00

abstract：:As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6-17), the role of caspases in N(6)-benzylaminopurine riboside (BAPR)-induced apotosis in HL-60 cells was evaluated in this study. Here, BAPR-induced apoptosis was accompanied by activation of caspase-3 and caspase-9. Howeve...

journal_title：Journal of cellular biochemistry

authors： Mlejnek P

更新日期：2001-01-01 00:00:00

abstract：:The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1,25(OH)(2)D(3) ind...

journal_title：Journal of cellular biochemistry

authors： Jurutka PW,Thompson PD,Whitfield GK,Eichhorst KR,Hall N,Dominguez CE,Hsieh JC,Haussler CA,Haussler MR

更新日期：2005-04-01 00:00:00