Discovery of sonic hedgehog expression in postnatal growth plate chondrocytes: differential regulation of sonic and Indian hedgehog by retinoic acid.

abstract：:Tissue factor, the cellular initiator of blood coagulation, has been implicated as a determinant of metastatic potential in human melanoma cells. Here, we report that differential expression of tissue factor in murine melanoma cell lines of known metastatic behavior is mediated by AP-1-dependent and 12S E1A oncoprotei...

journal_title：Journal of cellular biochemistry

authors： Voigtländer C,Rand A,Liu SL,Wilson TJ,Pittelkow MR,Getz MJ,Kelm RJ Jr

更新日期：2002-01-01 00:00:00

abstract：:It has drawn a lot of attention to target signal transducer and activator of transcription 3 (STAT3) as a potential strategy for cancer therapeutics. Using several myelogenous cell lines, the effect of genipin (an active compound of Gardenia fruit) on the STAT3 pathway and apoptosis was investigated. Genipin suppresse...

journal_title：Journal of cellular biochemistry

authors： Lee JC,Ahn KS,Jeong SJ,Jung JH,Kwon TR,Rhee YH,Kim SH,Kim SY,Yoon HJ,Zhu S,Chen CY,Kim SH

更新日期：2011-06-01 00:00:00

abstract：:The objective of this study was to test the hypothesis that extracellular matrix (ECM) would alter the endoplasmic reticulum (ER) stress response of chondrocytes. Chondrocytes were isolated from calf knees and maintained in monolayer culture or suspended in collagen I to form spot cultures (SCs). Our laboratory has sh...

journal_title：Journal of cellular biochemistry

authors： Nugent AE,McBurney DL,Horton WE Jr

更新日期：2011-04-01 00:00:00

abstract：:A recent burst of findings has shown that neural crest-derived stem cells (NCSCs) can be found in diverse mammalian tissues. In addition to their identification in tissues that are known to be derived from the neural crest, recent studies have revealed NCSCs in tissues that are not specifically derived from the neural...

journal_title：Journal of cellular biochemistry

authors： Nagoshi N,Shibata S,Nakamura M,Matsuzaki Y,Toyama Y,Okano H

更新日期：2009-08-15 00:00:00

abstract：:Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM-1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen-priming T-cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells,...

journal_title：Journal of cellular biochemistry

authors： Jo JH,Kwon MS,Choi HO,Oh HM,Kim HJ,Jun CD

更新日期：2010-12-01 00:00:00

abstract：:Pancreatic-cancer-patient tumor specimens were initially established subcutaneously in NOD/SCID mice immediately after surgery. The patient tumors were then harvested from NOD/SCID mice and passaged orthotopically in transgenic nude mice ubiquitously expressing red fluorescent protein (RFP). The primary patient tumors...

journal_title：Journal of cellular biochemistry

authors： Suetsugu A,Katz M,Fleming J,Truty M,Thomas R,Moriwaki H,Bouvet M,Saji S,Hoffman RM

更新日期：2012-07-01 00:00:00

abstract：:Monoclonal antibodies that bind a large molecular weight plasma membrane protein of Acanthamoeba castellanii cause the cells to differentiate. A different monoclonal antibody that binds specifically to the major plasma membrane protein has no effect upon cell division or differentiation. The induction of differentiati...

journal_title：Journal of cellular biochemistry

authors： Villemez CL,Carlo PL,Russell MA

更新日期：1985-01-01 00:00:00

abstract：:Bone marrow-derived stromal cells (BMSC) possess a population of vascular progenitor cells that enable them to acquire a histology and immunophenotype coherent with endothelial cells (EC). Recent evidence indicates that a hypoxic environment such as that encountered in tumor masses regulates BMSC angiogenic properties...

journal_title：Journal of cellular biochemistry

authors： Annabi B,Naud E,Lee YT,Eliopoulos N,Galipeau J

更新日期：2004-04-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistant to TRAIL cytoxicity, including...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Liu N,Zhang J,Liu S,Liu Y,Zheng D

更新日期：2005-10-15 00:00:00

abstract：:Recently increasing emphasis is placed on preventive health and management of chronic comorbidities avoiding long-term toxicities of antiretroviral therapy (ART). Drawing from this background we decided to use the Saos-2, osteosarcoma cell line, as a cellular model, to evaluate the effects of some antiretroviral drugs...

journal_title：Journal of cellular biochemistry

authors： Esposito V,Perna A,Lucariello A,Carleo MA,Viglietti R,Sangiovanni V,Coppola N,Guerra G,De Luca A,Chirianni A

更新日期：2015-10-01 00:00:00

abstract：:The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes-induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule were prepared and administered p.o. to diabetic mice for 17 we...

journal_title：Journal of cellular biochemistry

authors： Yang X,Zhang P,Zhang F,Ke Z,Chen Q,Liu C

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is one of the most important immune-mediated disorders of the gastrointestinal tract. Besides, IBD is associated with numerous extraintestinal complications such as venous thromboembolism (VTE), an important risk factor for vascular complications, which results in the increas...

journal_title：Journal of cellular biochemistry

authors： Asadzadeh-Aghdaei H,Mashayekhi K,Koushki K,Azimzadeh P,Rostami-Nejad M,Amani D,Chaleshi V,Haftcheshmeh SM,Sahebkar A,Zali MR

更新日期：2019-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding ribonucleic acids known to affect gene expression at the translational level and there is mounting evidence that miRNAs play a role in the function of tumor-associated macrophages (TAMs). To aid the functional analyses of miRNAs in an in-vitro model of TAMs known as M2 macrophage...

journal_title：Journal of cellular biochemistry

authors： Ng YS,Roca H,Fuller D,Sud S,Pienta KJ

更新日期：2012-05-01 00:00:00

abstract：:Telomeres are TTAGGG repetitive motifs found at the ends of vertebrate chromosomes. In humans, telomeres are protected by shelterin, a complex of six proteins (de Lange [2005] Genes Dev. 19: 2100-2110). Since (Müller [1938] Collecting Net. 13: 181-198; McClintock [1941] Genetics 26: 234-282), their function in maintai...

journal_title：Journal of cellular biochemistry

authors： Mai S,Garini Y

更新日期：2006-04-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild-type and P21-activated kinase 1 (PAK1) knockdown mice with the objective of determining the expression of microRNA-542-5p (miR-542-5p...

journal_title：Journal of cellular biochemistry

authors： Wu XM,Ji KQ,Wang HY,Zhao Y,Jia J,Gao XP,Zang B

更新日期：2019-01-01 00:00:00

abstract：:We are interested in understanding the molecular events associated with the growth-arrest of vascular SMCs. We constructed a subtracted cDNA library enriched in nucleotide sequences associated with quiescent SMCs. This library was screened with similarly subtracted 32P-labeled cDNAs to identify growth-arrest associate...

journal_title：Journal of cellular biochemistry

authors： Ge L,Liau G

更新日期：1995-02-01 00:00:00

abstract：:Regulation of mesenchymal stem cell (MSC) lineage selection is important for the generation of bone mass. Inhibition of cyclooxygenase-2 (COX2) may increase adipogenesis at the cost of decreasing osteoprogenitor output. Here we investigated the role of COX2 and its products during MSC differentiation. Indomethacin sti...

journal_title：Journal of cellular biochemistry

authors： Styner M,Sen B,Xie Z,Case N,Rubin J

更新日期：2010-11-01 00:00:00

abstract：:The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman ra...

journal_title：Journal of cellular biochemistry

authors： Castro Ghizoni CV,Arssufi Ames AP,Lameira OA,Bersani Amado CA,Sá Nakanishi AB,Bracht L,Marçal Natali MR,Peralta RM,Bracht A,Comar JF

更新日期：2017-10-01 00:00:00

abstract：:Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

journal_title：Journal of cellular biochemistry

authors： Deshmukh RR,Kim S,Elghoul Y,Dou QP

更新日期：2017-05-01 00:00:00

abstract：:Melphalan (MEL) is a chemotherapeutic agent used in breast cancer therapy; however, MEL's side effects limit its clinical applications. In the last 20 years, resveratrol (RSV), a polyphenol found in grape skins, has been proposed to reduce the risk of cancer development. The aim of this study was to investigate whethe...

journal_title：Journal of cellular biochemistry

authors： Casanova F,Quarti J,da Costa DC,Ramos CA,da Silva JL,Fialho E

更新日期：2012-08-01 00:00:00

abstract：:Small molecule inhibitors of cyclin-dependent kinase 5 (CDK5) protect neurons from cell death following various insults. To elucidate the cellular mechanism of action we investigated changes in protein phosphorylation in cultured rat cerebellar granule neurons after administration of the CDK5 inhibitor Indolinone A. B...

journal_title：Journal of cellular biochemistry

authors： Gillardon F,Schrattenholz A,Sommer B

更新日期：2005-07-01 00:00:00

abstract：:Wnt/β-catenin signaling regulates various cellular events involved in the proliferation and differentiation and these events are affected sensitively by applying to mechanical stimuli. However, the mechanisms by which mechanical force stimulates cardiomyogenesis are not extensively explored. In this study we investiga...

journal_title：Journal of cellular biochemistry

authors： Heo JS,Lee JC

更新日期：2011-07-01 00:00:00

abstract：:Protein-tyrosine phosphatases (PTPases) play an important role in the regulation of insulin action by dephosphorylating the active (autophosphorylated) form of the insulin receptor and attenuating its tyrosine kinase activity. PTPases can also modulate post-receptor signalling by catalyzing the dephosphorylation of ce...

journal_title：Journal of cellular biochemistry

authors： Goldstein BJ

更新日期：1992-01-01 00:00:00

abstract：:We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb Magnolia officinalis, induced apoptotic cell death in a dose- and time-dependent manner. A sustained inhibition of the major survival signal, Akt, occurred in magn...

journal_title：Journal of cellular biochemistry

authors： Lee DH,Szczepanski MJ,Lee YJ

更新日期：2009-04-15 00:00:00

abstract：:The signal transduction system that mediates bacterial chemotaxis allows cells to modulate their swimming behavior in response to fluctuations in chemical stimuli. Receptors at the cell surface receive information from the surroundings. Signals are then passed from the receptors to cytoplasmic chemotaxis components: C...

journal_title：Journal of cellular biochemistry

authors： Lukat GS,Stock JB

更新日期：1993-01-01 00:00:00

abstract：:RECK is an anti-tumoral gene whose activity has been associated with its inhibitory effects regulating MMP-2, MMP-9, and MT1-MMP. RECK level decreases as gliobastoma progresses, varying from less invasive grade II gliomas to very invasive human glioblastoma multiforme (GBM). Since RECK expression and glioma invasivene...

journal_title：Journal of cellular biochemistry

authors： Silveira Corrêa TC,Massaro RR,Brohem CA,Taboga SR,Lamers ML,Santos MF,Maria-Engler SS

更新日期：2010-05-01 00:00:00

abstract：:The present study investigates the direct action of 5-methoxytryptophol (5-MTX) in both MC3T3-E1 and RAW264.7 cells and compares it with melatonin (MEL), another 5-methoxyindol known to play a significant role on bone metabolism. We first screened increasing doses of both 5-MTX and MEL to determine their effect on met...

journal_title：Journal of cellular biochemistry

authors： Satué M,Ramis JM,del Mar Arriero M,Monjo M

更新日期：2015-04-01 00:00:00

abstract：:We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

journal_title：Journal of cellular biochemistry

authors： Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

更新日期：2017-12-01 00:00:00

abstract：:Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

journal_title：Journal of cellular biochemistry

authors： Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

更新日期：2018-11-28 00:00:00

abstract：:Fracture repair is a complex process involving timed cellular recruitment, gene expression, and synthesis of compounds that regenerate native tissue to restore the mechanical integrity, and thus function of injured bone. While the majority of fractures heal without complication, this takes time and a subset of patient...

journal_title：Journal of cellular biochemistry

authors： Komatsu DE,Warden SJ

更新日期：2010-02-01 00:00:00