Anti-Inflammatory and Antioxidant Actions of Copaiba Oil Are Related to Liver Cell Modifications in Arthritic Rats.

abstract：:Serpentine receptors coupled to the heterotrimeric G protein, Gi2, are capable of stimulating DNA synthesis in a variety of cell types. A common feature of the Gi2-coupled stimulation of DNA synthesis is the activation of the mitogen-activated protein kinases (MAPKs). The regulation of MAPK activation by the Gi2-coupl...

journal_title：Journal of cellular biochemistry

authors： Johnson GL,Gardner AM,Lange-Carter C,Qian NX,Russell M,Winitz S

更新日期：1994-04-01 00:00:00

abstract：:The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the c...

journal_title：Journal of cellular biochemistry

authors： Fofie CK,Katekhaye S,Borse S,Sharma V,Nivsarkar M,Nguelefack-Mbuyo EP,Kamanyi A,Singh V,Nguelefack TB

更新日期：2019-02-14 00:00:00

abstract：:Platelet-derived growth factor (PDGF) has been implicated in smooth muscle cell (SMC) proliferation, a key event in the development of myointimal hyperplasia in vascular grafts. Recent evidence suggests that the PDGF receptor (PDGFR) tyrosine kinase inhibitor, imatinib, can prevent arterial proliferative diseases. Bec...

journal_title：Journal of cellular biochemistry

authors： Li L,Blumenthal DK,Masaki T,Terry CM,Cheung AK

更新日期：2006-12-15 00:00:00

abstract：:The interaction of the low-molecular-weight GTP-binding protein rap2 with the cytoskeleton from thrombin-aggregated platelets was investigated by inducing depolymerization of the actin filaments, followed by in vitro-promoted repolymerization. We found that the association of rap2 with the cytoskeleton was spontaneous...

journal_title：Journal of cellular biochemistry

authors： Torti M,Bertoni A,Canobbio I,Sinigaglia F,Lapetina EG,Balduini C

更新日期：1999-12-15 00:00:00

abstract：:The bcl-2 gene has a unique function among mammalian oncogenes as a negative regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent with a role in maintaining in vivo survival of specific cell types. The biochemical function of bcl-2 is unknown, but its localization to mitochondria...

journal_title：Journal of cellular biochemistry

authors： Park JR,Hockenbery DM

更新日期：1996-01-01 00:00:00

abstract：:Tissue factor, the cellular initiator of blood coagulation, has been implicated as a determinant of metastatic potential in human melanoma cells. Here, we report that differential expression of tissue factor in murine melanoma cell lines of known metastatic behavior is mediated by AP-1-dependent and 12S E1A oncoprotei...

journal_title：Journal of cellular biochemistry

authors： Voigtländer C,Rand A,Liu SL,Wilson TJ,Pittelkow MR,Getz MJ,Kelm RJ Jr

更新日期：2002-01-01 00:00:00

abstract：:Bone formation is under the control of a set of transcription factors. Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D. However, the function of Ids during bone formation in vivo has not yet ...

journal_title：Journal of cellular biochemistry

authors： Maeda Y,Tsuji K,Nifuji A,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Prostate cancer (PCa) cells frequently invade the surrounding stroma, leading to heterogeneous formation of structural atypia. The surrounding stroma contains multiple functionally diverse populations of fibroblasts that trigger numerous changes in PCa cells including motility. Thus, we hypothesized that direct or ind...

journal_title：Journal of cellular biochemistry

authors： Ishii K,Nakagawa Y,Matsuda C,Katoh D,Ichishi M,Shirai T,Hirokawa Y,Fujiwara M,Sugimura Y,Watanabe M

更新日期：2021-01-22 00:00:00

abstract：:As an aggressive breast cancer (BCa) subtype, triple-negative breast cancer (TNBC) responses poorly to chemotherapy and endocrine therapy, and usually has a worse prognosis. This is largely due to the lack of specific therapeutic targets, laying claim to an imperious demand to clarify the key signaling pathways potent...

journal_title：Journal of cellular biochemistry

authors： Tang X,Zhou Y,Liu Y,Zhang W,Liu C,Yan C

更新日期：2020-11-01 00:00:00

abstract：:Several molecules extracted from natural products exhibit different biological activities, such as ion channel modulation, activation of signaling pathways, and anti-inflammatory or antitumor activity. In this study, we tested the antitumor ability of natural compounds extracted from the Raputia praetermissa plant. Am...

journal_title：Journal of cellular biochemistry

authors： Vital WD,Torquato HFV,Jesus LOP,Judice WAS,Silva MFDGFD,Rodrigues T,Justo GZ,Veiga TAM,Paredes-Gamero EJ

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Endometrial carcinoma (EC), a common gynecological malignancy with high incidence, affects the mental and physical health of women. Mounting evidence shows that long noncoding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) have instrumental roles in various biological processes associated with t...

journal_title：Journal of cellular biochemistry

authors： Zhao D,Ren C,Yao Y,Wang Q,Li F,Li Y,Jiang A,Wang G

更新日期：2020-03-01 00:00:00

abstract：:Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association wi...

journal_title：Journal of cellular biochemistry

authors： Isackson PJ,Dunbar JC,Bradshaw RA

更新日期：1987-01-01 00:00:00

abstract：:4-hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by elucidating the signaling cascad...

journal_title：Journal of cellular biochemistry

authors： Vaillancourt F,Morquette B,Shi Q,Fahmi H,Lavigne P,Di Battista JA,Fernandes JC,Benderdour M

更新日期：2007-04-01 00:00:00

abstract：:The mass and function of bones depend on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. An inhibitor of osteoclast differentiation and/or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid...

journal_title：Journal of cellular biochemistry

authors： Yonezawa T,Mase N,Sasaki H,Teruya T,Hasegawa S,Cha BY,Yagasaki K,Suenaga K,Nagai K,Woo JT

更新日期：2012-02-01 00:00:00

abstract：:In 1981, Chugai Pharmaceutical succeeded in marketing alfacalcidol, a prodrug of calcitriol, as a therapeutic agent for renal osteodystrophy. In 1983, Chugai succeeded in extending the application of alfacalcidol to the treatment of osteoporosis as well. Clinicians in Japan have accepted alfacalcidol as a remedy for o...

journal_title：Journal of cellular biochemistry

authors： Nishii Y

更新日期：2003-02-01 00:00:00

abstract：AIM:To detect the expression and identify the role of Ribosomal protein S15A (RPS15A) in human breast cancer (BC). METHODS:Immunohistochemistry (IHC) was carried out for detecting the levels of RPS15A protein. Quantitative PCR was used to evaluate the mRNA level of RPS15A in one normal breast and three BC cell lines. ...

journal_title：Journal of cellular biochemistry

authors： Kong L,Wei Q,Hu X,Chen L,Li J

更新日期：2020-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) mediated attenuation of insulin signaling pathway is an important cause in several disorders like obesity, obesity linked diabetes mellitus. TNF-alpha actions vary depending upon concentration and time of exposure in various cells. In the present study, the effects of long-term ...

journal_title：Journal of cellular biochemistry

authors： Gupta D,Varma S,Khandelwal RL

更新日期：2007-02-15 00:00:00

abstract：:Diabetes mellitus (DM), one of the most prevalent metabolic diseases in the world population, is associated with a number of comorbid conditions including obesity, pancreatic endocrine changes, and renal and cardio-cerebrovascular alterations, coupled with peripheral neuropathy and neurodegenerative disease, some of t...

journal_title：Journal of cellular biochemistry

authors： Morsi M,Kobeissy F,Magdeldin S,Maher A,Aboelmagd O,Johar D,Bernstein L

更新日期：2019-09-01 00:00:00

abstract：:Complete resection of malignant glioblastomas is usually impossible because of diffuse and widespread invasion of tumor cells, and complementary approaches need to be developed in order to improve the efficacy of current treatments. Consumption of fruits and berries has been associated with decreased risk of developin...

journal_title：Journal of cellular biochemistry

authors： Lamy S,Lafleur R,Bédard V,Moghrabi A,Barrette S,Gingras D,Béliveau R

更新日期：2007-01-01 00:00:00

abstract：:Chrysophanol is a phytochemical typically extracted from rhubarb. Similar to other extracts from rhubarb, chrysophanol possesses anticancer activity against diverse cancerous cells. However, the apoptotic effects of chrysophanol in ovarian cancer remain unknown. In the current study, we examined the antitumorigenic ac...

journal_title：Journal of cellular biochemistry

authors： Lim W,An Y,Yang C,Bazer FW,Song G

更新日期：2018-12-01 00:00:00

abstract：:Using a yeast two-hybrid library screen, we have identified that the heart specific FHL2 protein, four-and-a-half LIM protein 2, interacted with human DNA-binding nuclear protein, hNP220. Domain studies by the yeast two-hybrid interaction assay revealed that the second LIM domain together with the third and the fourth...

journal_title：Journal of cellular biochemistry

authors： Ng EK,Chan KK,Wong CH,Tsui SK,Ngai SM,Lee SM,Kotaka M,Lee CY,Waye MM,Fung KP

更新日期：2002-01-01 00:00:00

abstract：:The pathways of transduction of oxidative stress signals have been studied using the Jurkat T cell model. The oxidative stress was induced by exposure of the cells to 100 microM H(2)O(2). DNA damage was detected within 15 min after commencement of treatment. DNA damage repair occurred within about 1 h in cells exposed...

journal_title：Journal of cellular biochemistry

authors： Chiaramonte R,Bartolini E,Riso P,Calzavara E,Erba D,Testolin G,Comi P,Sherbet GV

更新日期：2001-01-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:From the mouse JB6 epidermal cell line C122 we have isolated a cDNA clone representing a 1.6-kilobase mRNA, called 2ar, that exhibits a biphasic induction in response to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The first phase of induction in subconfluent cells is transient, peaking at 6 h after the addition of TP...

journal_title：Journal of cellular biochemistry

authors： Smith JH,Denhardt DT

更新日期：1987-05-01 00:00:00

abstract：:Breast cancer remains the major cause of cancer-related deaths in women world-wide. The heterogeneity of breast cancer has further complicated the progress of target-based therapies. Triple negative breast cancers, lacking estrogen receptor, progesterone receptor and the Her-2/neu (ErbB2), represent a highly aggressiv...

journal_title：Journal of cellular biochemistry

authors： Ahmad A,Banerjee S,Wang Z,Kong D,Sarkar FH

更新日期：2008-12-15 00:00:00

abstract：:Loss of mechanical stress causes bone loss. However, the mechanisms underlying the unloading-induced bone loss are largely unknown. Here, we examined the effects of gold-thioglucose (GTG) treatment, which destroys ventromedial hypothalamus (VMH), on unloading-induced bone loss. Unloading reduced bone volume in control...

journal_title：Journal of cellular biochemistry

authors： Hino K,Nifuji A,Morinobu M,Tsuji K,Ezura Y,Nakashima K,Yamamoto H,Noda M

更新日期：2006-10-15 00:00:00

abstract：:We investigated the role of tetracycline in the transcriptional regulation of matrix metalloproteinases. Using interleukin-1beta (IL-1) induced stromelysin as a model system, we describe the repression of the endogenous stromelysin RNA accumulation, as well as the transcriptional inhibition of various stromelysin prom...

journal_title：Journal of cellular biochemistry

authors： Jonat C,Chung FZ,Baragi VM

更新日期：1996-03-01 00:00:00

abstract：:Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence ...

journal_title：Journal of cellular biochemistry

authors： Li J,Liu R,Tang S,Feng F,Wang X,Qi L,Liu C,Yao Y,Sun C

更新日期：2018-11-28 00:00:00

abstract：:Endothelins (ETs) are vasoconstrictive peptides produced mainly by endothelial cells. The ET receptors are expressed in many types of cells including osteoblast-like cells. The purpose of this study was to examine the effects of endothelin on the expression of osteoblastic phenotype-related genes. We found that endoth...

journal_title：Journal of cellular biochemistry

authors： Shioide M,Noda M

更新日期：1993-10-01 00:00:00

abstract：:CD19+ CD24hi CD38hi cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19+ CD24hi CD38hi cells. Changes in B-cell subpopulations and CD19+ CD24hi CD38hi cells have been observed in systemic lupus erythematosus (SLE) patients. Whether...

journal_title：Journal of cellular biochemistry

authors： Wang H,Liu C,Chen W,Ding G

更新日期：2019-02-16 00:00:00