Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments.

abstract：:Fibronectin (FN) is an extracellular matrix (ECM) glycoprotein that self-assembles into FN fibrils, forming a FN matrix contributing to the stiffness of the ECM. Stromal FN stiffness in cancer has been shown to impact epithelial functions such as migration, cancer metastasis, and epithelial-to-mesenchymal transition. ...

journal_title：Journal of cellular biochemistry

authors： Magdaleno C,House T,Pawar JS,Carvalho S,Rajasekaran N,Varadaraj A

更新日期：2021-01-13 00:00:00

abstract：:Avian progesterone receptor exists as two forms, A and B, with molecular weights of 79,000 and 110,000 daltons, respectively. The origin and significance of these two forms is an area of active investigation and debate. Monoclonal antibodies produced against these two forms were used to examine receptor stability in c...

journal_title：Journal of cellular biochemistry

authors： Sullivan WP,Smith DF,Beito TG,Krco CJ,Toft DO

更新日期：1988-02-01 00:00:00

abstract：:Sexual differences on thyroxin 5'-deiodinase (5'-D) in the Harderian gland of Syrian hamsters were investigated. We compared the 24-h profile of 5'-D activity in male and female hamsters, observing a clear rhythm in males but not in females. Female values were always significantly higher than male ones. After pinealec...

journal_title：Journal of cellular biochemistry

authors： Rubio A,Menendez-Pelaez A,Buzzell GR,Vaughan MK,Vaughan GM,Reiter RJ

更新日期：1996-09-01 00:00:00

abstract：:Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unkn...

journal_title：Journal of cellular biochemistry

authors： Lim S,Jang HJ,Park EH,Kim JK,Kim JM,Kim EK,Yea K,Kim YH,Lee-Kwon W,Ryu SH,Suh PG

更新日期：2012-11-01 00:00:00

abstract：:The mouse macrophage Fc gamma 2b/gamma 1R has previously been purified with the aid of the monoclonal antibody 2.4G2. That this Fc gamma R functions as a ligand-dependent ion channel is supported by the following evidence. Employing [3H]tetraphenylphosphonium ([3H]Ph4P+) as a probe for membrane potential changes in in...

journal_title：Journal of cellular biochemistry

authors： Young JD,Unkeless JC,Cohn ZA

更新日期：1985-01-01 00:00:00

abstract：:Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Svoboda KK

更新日期：2005-08-15 00:00:00

abstract：:The bone marrow stroma contains pre-adipocyte cells which are part of the hemopoietic microenvironment. Cloned stromal cell lines differ both in their ability to support myeloid and lymphoid development and in their ability to undergo adipocyte differentiation in vitro. These processes have been examined in the +/+2.4...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Youkhana K,Hua X,Bass H,Medina K,Sullivan M,Greenberger J,Wang CS

更新日期：1992-09-01 00:00:00

abstract：:Characteristic changes in vimentin were studied in 9L rat brain tumor cells treated at 45 degrees C. During heat-shock treatment, vimentin molecules were rapidly phosphorylated and reorganized from a filamentous form into a perinuclear higher-order structure that was less extractable by nonionic detergent. These effec...

journal_title：Journal of cellular biochemistry

authors： Cheng TJ,Lai YK

更新日期：1994-01-01 00:00:00

abstract：:IQGAP1, is a recently discovered scaffold protein proposed to regulate membrane cytoskeleton events through protein-protein interactions with F-actin, E-cadherin, beta-catenin, and CLIP170. The binding of IQGAP1 to its partners is regulated by calcium/calmodulin (Ca(++)/CaM) and the small molecular weight guanine nucl...

journal_title：Journal of cellular biochemistry

authors： Nauert JB,Rigas JD,Lester LB

更新日期：2003-09-01 00:00:00

abstract：:The four-subunit protease complex γ-secretase cleaves many single-pass transmembrane (TM) substrates, including Notch and β-amyloid precursor protein to generate amyloid-β (Aβ), central to Alzheimer's disease. Two of the subunits anterior pharynx-defective 1 (APH-1) and presenilin (PS) exist in two homologous forms AP...

journal_title：Journal of cellular biochemistry

authors： Dehury B,Kepp KP

更新日期：2021-01-01 00:00:00

abstract：:The physiologically active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has influence over osteoclastogenesis and myelopoiesis, but the regulational mechanism is not well-defined. In this report, formation of osteoclast-like (OCL) cells from primitive myeloid colony-forming cells (PM-CFC) as mediated by ...

journal_title：Journal of cellular biochemistry

authors： Qi DY,Perkins SL,Kling SJ,Russell RG

更新日期：1999-03-01 00:00:00

abstract：:Cervical cancer is one of the leading female health-killers among all types of malignancies globally. Human papillomavirus infection combined with genetic and epigenetic alterations have been indicated to be closely associated with the pathogenesis, progression, and malignant transformation of cervical cancer. Notably...

journal_title：Journal of cellular biochemistry

authors： Li C,Ke J,Liu J,Su J

更新日期：2020-03-01 00:00:00

abstract：:We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...

journal_title：Journal of cellular biochemistry

authors： Hubberstey A,Yu G,Loewith R,Lakusta C,Young D

更新日期：1996-06-01 00:00:00

abstract：:The BRCA1 tumor suppressor involved in breast and ovarian cancer is linked to several fundamental cell regulatory processes. Recently, it was reported that BRCA1 supports localization of XIST RNA to the inactive X chromosome (Xi) in women. The apparent cytological overlap between BRCA1 and XIST RNA across the Xi raise...

journal_title：Journal of cellular biochemistry

authors： Pageau GJ,Hall LL,Lawrence JB

更新日期：2007-03-01 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Previous studies from this and other laboratories have shown that variants of tumor cell lines can be selected for resistance to the lytic action of natural killer (NK) cells. One of these (K562-Clone I), when made resistant to the toxic effects of Concanavalin A (Con A-R1), regained its sensitivity to NK. Comparing t...

journal_title：Journal of cellular biochemistry

authors： Bernier LG,Sullivan AK

更新日期：1988-06-01 00:00:00

abstract：:All-trans retinoic acid and 9-cis-retinoic acid stimulate the activity of steroid sulfatase in HL60 acute myeloid leukemia cells in a concentration- and time-dependent manner. Neither of these 'natural retinoids' augmented steroid sulfatase activity in a HL60 sub-line that expresses a dominant-negative retinoic acid r...

journal_title：Journal of cellular biochemistry

authors： Hughes PJ,Zhao Y,Chandraratna RA,Brown G

更新日期：2006-02-01 00:00:00

abstract：:Syndecans are proteoglycans that act as signaling molecules. Previously, we showed that syndecan-2 (SYND2) is involved in the control of osteoblastic (OB) cell apoptosis. Here, we show a novel functional interaction between SYND2 and protein kinase C delta (PKCdelta). Overexpression of SYND2 in MG63 OB cells resulted ...

journal_title：Journal of cellular biochemistry

authors： Orosco A,Fromigué O,Haÿ E,Marie PJ,Modrowski D

更新日期：2006-07-01 00:00:00

abstract：:The SON protein is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. Although several early studies implicated SON in DNA-binding, tumorigenesis and apoptosis, functional significance of this protein had not been recognized until recent studies discovered SON as a novel RNA...

journal_title：Journal of cellular biochemistry

authors： Hickey CJ,Kim JH,Ahn EY

更新日期：2014-02-01 00:00:00

abstract：:Apoptosis has been described extensively in tooth development, which is under tight control of multiple apoptosis regulators, including anti-apoptotic protein Bcl-2. However, it is totally unclear how Bcl-2 is related to odontogenesis, especially dentinogenesis. Using a transgenic mouse Col2.3Bcl-2 in which human Bcl-...

journal_title：Journal of cellular biochemistry

authors： Zhang W,Ju J,Gronowicz G

更新日期：2010-10-01 00:00:00

abstract：:We investigated the role of tetracycline in the transcriptional regulation of matrix metalloproteinases. Using interleukin-1beta (IL-1) induced stromelysin as a model system, we describe the repression of the endogenous stromelysin RNA accumulation, as well as the transcriptional inhibition of various stromelysin prom...

journal_title：Journal of cellular biochemistry

authors： Jonat C,Chung FZ,Baragi VM

更新日期：1996-03-01 00:00:00

abstract：:As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6-17), the role of caspases in N(6)-benzylaminopurine riboside (BAPR)-induced apotosis in HL-60 cells was evaluated in this study. Here, BAPR-induced apoptosis was accompanied by activation of caspase-3 and caspase-9. Howeve...

journal_title：Journal of cellular biochemistry

authors： Mlejnek P

更新日期：2001-01-01 00:00:00

abstract：:Ovarian cancer (OC) is a lethal disease diagnosed at advanced stages due to the lack of specific biomarkers. Tyrosine receptor kinase B (TrkB), which has recently been found to be related to OC progression, represents a promising potential biomarker for OC diagnosis and prognosis. The discovery of circulating exosomes...

journal_title：Journal of cellular biochemistry

authors： Li W,Lu Y,Yu X,Yong M,Ma D,Gao Q

更新日期：2019-04-01 00:00:00

abstract：:Pyrimidine-specific ribonucleases are a superfamily of structurally related enzymes with distinct catalytic and biological properties. We used a combination of enzymatic and non-enzymatic assays to investigate the release of such enzymes by isolated cells in serum-free and serum-containing media. We found that human e...

journal_title：Journal of cellular biochemistry

authors： Landré JB,Hewett PW,Olivot JM,Friedl P,Ko Y,Sachinidis A,Moenner M

更新日期：2002-01-01 00:00:00

abstract：:Two pathways operate during Xenopus oogenesis to localize a small number of RNAs to the vegetal cortex. Correct localization of these RNAs is essential to normal development as the proteins they encode are involved in specifying cell type and in patterning the early embryo. Binding these RNAs to the vegetal cortex and...

journal_title：Journal of cellular biochemistry

authors： Bubunenko M,King ML

更新日期：2001-01-01 00:00:00

abstract：:The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of ...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Zaidi SK,Stein JL,Lian JB,van Wijnen AJ,Montecino M,Young DW,Javed A,Pratap J,Choi JY,Ali SA,Pande S,Hassan MQ

更新日期：2008-08-15 00:00:00

abstract：:Recycled iron from reticuloendothelial macrophages to erythroid precursors is important to maintain the iron homeostasis. However, the molecular mechanisms underlying iron homeostasis in macrophages are poorly understood. In this study, male Sprague-Dawley rats were treated with recombinant human erythropoietin (rHuEp...

journal_title：Journal of cellular biochemistry

authors： Kong WN,Zhao SE,Duan XL,Yang Z,Qian ZM,Chang YZ

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Dysfunction of the peritoneum as a dialysis organ may result from progressive membrane injury on peritoneal dialysis (PD). It has been increasingly recognized that the human peritoneal mesothelial cells (HPMCs) play a key role in peritoneal membrane early injury. Recently, it has been reported that bioincomp...

journal_title：Journal of cellular biochemistry

authors： Zhu N,Gu L,Jia J,Wang X,Wang L,Yang M,Yuan W

更新日期：2019-03-01 00:00:00

abstract：:Rapid detection and classification of cancer cells with label-free and non-destructive methods are helpful for rapid screening of cancer patients in clinical settings. Here, surface-enhanced Raman scattering (SERS) was used for rapid, unlabeled, and non-destructive detection of seven different cell types, including hu...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Lin T,Zheng D,Zhu Y,Wang L,Fu Y,Wang H,Wu X,Zhang P

更新日期：2021-02-01 00:00:00

abstract：:Antibodies against pure discoidin I have been used as a tool to ascertain the role of this lectin in aggregation of Dictyostelium discoideum. Discoidin I is widely expressed over the cell surface of aggregation-competent AX-2 cells, as ascertained by indirect immunofluorescence with specific (antidiscoidin I) antibodi...

journal_title：Journal of cellular biochemistry

authors： Cano A,Pestaña A

更新日期：1984-01-01 00:00:00