Effect of sex hormone-binding globulin polymorphisms on the outcome of in vitro fertilization-embryo transfer for polycystic ovary syndrome patients: A case-control study.


:Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Correlations of SHBG rs6259 and rs727428 with the risk factors in PCOS were analyzed, followed by the evaluation of the effect of SHBG polymorphisms on the outcome of IVF-ET in PCOS patients. At last, unconditional logistic regression analysis was performed to study the risk factors for IVF-ET treatment outcome. Compared with SHBG rs6259 GG carriers, the incidence of PCOS was found to be elevated in SHBG rs6259 GA+AA carriers which indicated that the A allele was a risk factor for PCOS. Compared with SHBG rs6259 TT carriers, the number of retrieved oocytes and embryo as well as the fertility rate in SHBG rs6259 GA+AA carriers was found to be decreased, while the abortion rate, incidence of ovarian hyperstimulation syndrome, transplant rejection rate, estradiol, and testosterone in serum, as well as testosterone in follicular fluid were elevated. The luteal hormone, serum testosterone, and progesterone and GA+AA genotype of rs6259 were the risk factors for IVF-ET treatment outcome. Taken together, the study showed that SHBG rs6259 polymorphisms might be correlated with the risk of PCOS and the outcome of IVF-ET treatment.


J Cell Biochem


Liu Y,Zhao XX,Hu XJ,Yang F,Lin P,Cui SC,Zhao W,Cao XY,Wang YS




Has Abstract


2019-03-01 00:00:00












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    abstract::Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mou...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Medina RJ,Kataoka K,Takaishi M,Miyazaki M,Huh NH

    更新日期:2006-05-01 00:00:00

  • Paeoniflorin inhibits mast cell-mediated allergic inflammation in allergic rhinitis.

    abstract::Paeoniflorin (PF), one of the main effective ingredients from the root of Paeonia lactiflora Pall., was reported to possess antitumor, anti-inflammatory, and antiallergic properties. However, the roles of PF in activated human mast cell line, HMC-1 cells, have not yet been elucidated. Thus, the aim of this study was t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang G,Cheng N

    更新日期:2018-11-01 00:00:00

  • Effects of S100A12 gene silencing on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats through the ERK signaling pathway.

    abstract::We explored the effect of S100A12 gene on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats by activating the extracellular signal-regulated kinase (ERK) signaling pathway. A total of 180 specific pathogen-free (SPF) rats were purchased to establish cecal ligation and puncture (CLP) model. Ra...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wen X,Han XR,Wang YJ,Fan SH,Zhang ZF,Wu DM,Lu J,Zheng YL

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  • Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments.

    abstract::The interaction of the low-molecular-weight GTP-binding protein rap2 with the cytoskeleton from thrombin-aggregated platelets was investigated by inducing depolymerization of the actin filaments, followed by in vitro-promoted repolymerization. We found that the association of rap2 with the cytoskeleton was spontaneous...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells.

    abstract::The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Immune cells as anti-cancer therapeutic targets and tools.

    abstract::Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


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  • Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4.

    abstract::Human eosinophil-derived neurotoxin (EDN, RNase2) and eosinophil cationic protein (ECP, RNase3) sequences possess as high as 92% identity in their promoter regions. The major difference within this region is a 34-nucleotide (34-nt) segment appeared only in the edn promoter. In addition, six discrete segments existed i...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang HY,Ho PC,Lan CY,Chang MD

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  • Differentiation of HL-60 promyelocytic leukemia cells is accompanied by a modification of magnesium homeostasis.

    abstract::Magnesium homeostasis in HL-60 promyelocytic leukemia cells was compared to that in neutrophyl-like HL-60 cells obtained by 1.3% DMSO treatment. Magnesium homeostasis was studied by the characterization of magnesium efflux, the identification of intracellular magnesium pools, and the regulation of intracellular ionize...

    journal_title:Journal of cellular biochemistry

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  • Molecular interactions between p-coumaric acid and snake venom toxins.

    abstract::A large number of natural compounds, such as phenolic compounds, have been scientifically evaluated in the search for enzyme inhibitors. The interactions between the phenolic compound p-coumaric acid and the enzymes present in snake venoms (used as research tools) were evaluated in vitro and in silico. The p-coumaric ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Cesar PHS,Cardoso Trento MV,Sales TA,Marques TR,Braga MA,Ramalho TC,Marcussi S

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  • Fenofibrate improves renal function by amelioration of NOX-4, IL-18, and p53 expression in an experimental model of diabetic nephropathy.

    abstract::Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is no evidence about it...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yaribeygi H,Mohammadi MT,Rezaee R,Sahebkar A

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  • Promyelocytic leukemia nuclear bodies support a late step in DNA double-strand break repair by homologous recombination.

    abstract::The PML protein and PML nuclear bodies (PML-NB) are implicated in multiple cellular functions relevant to tumor suppression, including DNA damage response. In most cases of acute promyelocytic leukemia, the PML and retinoic acid receptor alpha (RARA) genes are translocated, resulting in expression of oncogenic PML-RAR...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Neuroprotective effects of PrxI over-expression in an in vitro human Alzheimer's disease model.

    abstract::Peroxiredoxins are ubiquitous proteins that recently attracted major interests in view of the strict correlation observed in several cell lines and/or tissues between different levels of their expression and the increased capacity of cells to survive in different pathophysiological conditions. They are recently consid...

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    pub_type: 杂志文章


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  • Rs1894720 polymorphism in MIAT increased susceptibility to age-related hearing loss by modulating the activation of miR-29b/SIRT1/PGC-1α signaling.

    abstract:BACKGROUND:MIAT may be implicated in the pathogenesis of age-related hearing loss (AHL). This study aimed to clarify the effect of a MIAT signaling pathway on the risk of AHL. METHODS:Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, auditory brainstem response (ABR) and quantitative hair cell counts...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hao S,Wang L,Zhao K,Zhu X,Ye F

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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase.

    abstract::The effects of a ligand regulated neu tyrosine kinase were examined in NIH 3T3 cells. A chimeric construct encoding the human EGF receptor extracellular domain fused to the tyrosine kinase domain of the rat neu cDNA was expressed under the transcriptional control of the Moloney murine leukemia virus LTR promoter. This...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Acidic fibroblast growth factor gene 5' non-coding exon and flanking region from hamster DDT1 cells: identification of the promoter region and transcriptional regulation by testosterone and aFGF protein.

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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • Up-regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression.

    abstract::Gastric cancer (GC) is the fourth common cancer and second leading cause of cancer-related mortality in the world. WD repeat domain 5 (WDR5) has been identified that its functions as an important role in various biological functions through the epigenetic regulation of gene transcription. However, the oncogenic effect...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun W,Guo F,Liu M

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  • Association of vanadate-sensitive Mg(2+)-ATPase and shape change in intact red blood cells.

    abstract::Intact human erythrocytes, initially depleted of Mg2+ by EDTA incubation in the presence of A23187, exhibit Mg(2+)-dependent phosphate production of around 1.5 mmol per liter cells.h, half-maximally activated at around 0.4 mM added free Mg2+. This appears to correspond to Mg(2+)-stimulated adenosine triphosphatase (Mg...

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  • PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis.

    abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. However, some cancer cell lines were resistant to TRAIL cytoxicity, including...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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    abstract::Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related si...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


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  • miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation.

    abstract::The ERK-MAPK signaling pathway plays a pivotal role during mesenchymal stem cell (MSC) differentiation. Studies have demonstrated that ERK-MAPK promotes adipogenesis and osteogenesis through the phosphorylation of differentiation-associated transcription factors and that it is the only active signaling in all three li...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Mei Y,Bian C,Li J,Du Z,Zhou H,Yang Z,Zhao RC

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  • Nanotopography drives stem cell fate toward osteoblast differentiation through α1β1 integrin signaling pathway.

    abstract::The aim of our study was to investigate the osteoinductive potential of a titanium (Ti) surface with nanotopography, using mesenchymal stem cells (MSCs) and the mechanism involved in this phenomenon. Polished Ti discs were chemically treated with H2 SO4 /H2 O2 to yield nanotopography and rat MSCs were cultured under o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rosa AL,Kato RB,Castro Raucci LM,Teixeira LN,de Oliveira FS,Bellesini LS,de Oliveira PT,Hassan MQ,Beloti MM

    更新日期:2014-03-01 00:00:00

  • Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.

    abstract:AIM:To detect the expression and identify the role of Ribosomal protein S15A (RPS15A) in human breast cancer (BC). METHODS:Immunohistochemistry (IHC) was carried out for detecting the levels of RPS15A protein. Quantitative PCR was used to evaluate the mRNA level of RPS15A in one normal breast and three BC cell lines. ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kong L,Wei Q,Hu X,Chen L,Li J

    更新日期:2020-01-01 00:00:00

  • Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradation.

    abstract::Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun NK,Huang SL,Chang TC,Chao CC

    更新日期:2013-08-01 00:00:00

  • Amino-terminus domain of the androgen receptor as a molecular target to prevent the hormonal progression of prostate cancer.

    abstract::Prostate cancer has a propensity to metastasize to the bone. Currently the only effective systemic treatment for these patients is androgen ablation therapy. However, the tumor will invariably progress to an androgen-independent stage and the patient will succumb to his disease within approximately 2 years. The earlie...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Wang G,Sadar MD

    更新日期:2006-05-01 00:00:00

  • Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-kappaB and Bcl-2.

    abstract::Breast cancer remains the major cause of cancer-related deaths in women world-wide. The heterogeneity of breast cancer has further complicated the progress of target-based therapies. Triple negative breast cancers, lacking estrogen receptor, progesterone receptor and the Her-2/neu (ErbB2), represent a highly aggressiv...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ahmad A,Banerjee S,Wang Z,Kong D,Sarkar FH

    更新日期:2008-12-15 00:00:00

  • UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.

    abstract::As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 in invasion of breast cancers is still unclear. Here we report that the expression of UCH-L1 is significantly higher in cancer cells with higher invasive abilit...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Luo Y,He J,Yang C,Orange M,Ren X,Blair N,Tan T,Yang JM,Zhu H

    更新日期:2018-01-01 00:00:00

  • Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo.

    abstract::Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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  • The activity of aminoacyl-tRNA synthetase-interacting multi-functional protein 1 (AIMP1) on endothelial cells is mediated by the assembly of a cytoskeletal protein complex.

    abstract::AIMP1 was first found as a factor associated with the aminoacyl-tRNA synthetase (ARS) complex. However, it is also secreted and acts on different target cells such as endothelial cells, macrophages, and fibroblasts as an extracellular regulator, respectively, of angiogenesis, inflammatory responses and dermal regenera...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jackson VC,Dewilde S,Albo AG,Lis K,Corpillo D,Canepa B

    更新日期:2011-07-01 00:00:00