Effects of c-Jun and a negative dominant mutation of c-Jun on differentiation and gene expression in lens epithelial cells.

abstract：:The secretion pathway of Saccharomyces cerevisiae was challenged by constitutively overexpressing plasmid-encoded acid phosphatase, a secreted endogenous glycoprotein. A 2-microns-based multicopy plasmid carrying the coding sequence of acid phosphatase under the control of a truncated variant of the strong constitutiv...

journal_title：Journal of cellular biochemistry

authors： Kleene R,Janes M,Meyhack B,Pulfer K,Hinnen A

更新日期：1995-02-01 00:00:00

abstract：:Mounting evidence showed that microRNAs involve in development and chemoresistance of various human cancers. We explored the roles and mechanisms of miR-144 in resistance to cisplatin (CDDP) of cervical cancer cells. miR-144 and LIM homeobox 2 (LHX2) expression in CDDP-resistant and the parental cells was determined b...

journal_title：Journal of cellular biochemistry

authors： Shi F,Su J,Liu Z,Wang J,Wang T

更新日期：2019-09-01 00:00:00

abstract：:Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largel...

journal_title：Journal of cellular biochemistry

authors： Sui J,Liu Q,Zhang H,Kong Y

更新日期：2019-06-01 00:00:00

abstract：:The presented results show for the first time that the neurogenic transdifferentiation of hUC-MSCs considerably changes the elements of purinergic signaling profile. Although, it has been demonstrated in the literature that extracellular nucleotides and nucleosides determine the fate of mesenchymal and neural stem cel...

journal_title：Journal of cellular biochemistry

authors： Czarnecka J,Porowińska D,Bajek A,Hołysz M,Roszek K

更新日期：2017-03-01 00:00:00

abstract：:Thymoquinone (TQ) is the major active compound derived from the medicinal Nigella sativa. A few studies have shown that TQ exhibits anti-inflammatory activities in experimental models of rheumatoid arthritis (RA) through mechanisms that are not fully understood. The aim of this work was to evaluate the in vitro and in...

journal_title：Journal of cellular biochemistry

authors： Vaillancourt F,Silva P,Shi Q,Fahmi H,Fernandes JC,Benderdour M

更新日期：2011-01-01 00:00:00

abstract：:Our study was aimed to investigate the mechanism of rs4759314 located in HOTAIR involved in congenital heart disease. Luciferase assay was performed to evaluate whether rs4759314 affected the transcription efficiency of HOTAIR promoter, and confirm miR-545 target gene. Real-time PCR, Western-blot and IHC were carried ...

journal_title：Journal of cellular biochemistry

authors： Li Y,Zhao W,Shi R,Jia J,Li X,Cheng J

更新日期：2018-11-01 00:00:00

abstract：:Human DNA replication depends on the activation of thousands of origins distributed within the genome. The actual distribution of origins is not known, nor whether this distribution is unique to a cell type, or if it changes with the proliferative state of the cell. In this study, we have employed a real-time PCR-base...

journal_title：Journal of cellular biochemistry

authors： Valenzuela MS,Hu L,Lueders J,Walker R,Meltzer PS

更新日期：2012-01-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare genetic disease associated with the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues up to the deposition of melanin-like pigments (ochronosis). Since little is known on the effects of HGA and its metabolites on articular cells, we carried...

journal_title：Journal of cellular biochemistry

authors： Braconi D,Laschi M,Taylor AM,Bernardini G,Spreafico A,Tinti L,Gallagher JA,Santucci A

更新日期：2010-11-01 00:00:00

abstract：:Alkaline phosphatase (ALP) refers to a group of nonspecific phosphomonoesterases located primarily in cell plasma membrane. It has been described in different cell lines that ecto-ALP is directly or indirectly involved in the modulation of organic cation transport. We aimed to investigate, in Caco-2 cells, a putative ...

journal_title：Journal of cellular biochemistry

authors： Calhau C,Martel F,Hipólito-Reis C,Azevedo I

更新日期：2002-01-01 00:00:00

abstract：:Our previous study demonstrate that vitamin D3 induces the binding of vitamin D3 receptor (VDR) to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as the transcription comp...

journal_title：Journal of cellular biochemistry

authors： Cheng HT,Chen JY,Huang YC,Chang HC,Hung WC

更新日期：2006-08-15 00:00:00

abstract：:Immortalization is an early and essential step of human carcinogenesis which is associated with alterations in gene expression and regulation. Suppression subtractive hybridization (SSH) was successfully performed to identify immortalization-associated genes upregulated in SV40-immortalized lung fibroblasts. We identi...

journal_title：Journal of cellular biochemistry

authors： Jung HM,Choi SJ,Kim JK

更新日期：2009-03-01 00:00:00

abstract：:Pyrimidine-specific ribonucleases are a superfamily of structurally related enzymes with distinct catalytic and biological properties. We used a combination of enzymatic and non-enzymatic assays to investigate the release of such enzymes by isolated cells in serum-free and serum-containing media. We found that human e...

journal_title：Journal of cellular biochemistry

authors： Landré JB,Hewett PW,Olivot JM,Friedl P,Ko Y,Sachinidis A,Moenner M

更新日期：2002-01-01 00:00:00

abstract：:Multiple studies demonstrated that early growth response factor 1 (EGR1) induces myocardial damage after acute myocardial infarction (AMI). Recent evidence indicates that microRNAs (miRNA) play an important role in exosome-mediated cardioprotection after AMI. Bioinformatics analysis has shown that miR-146a can regulat...

journal_title：Journal of cellular biochemistry

authors： Pan J,Alimujiang M,Chen Q,Shi H,Luo X

更新日期：2019-03-01 00:00:00

abstract：:A non-toxic and efficient gene carrier is one requirement for clinical gene therapy. In this study, amphiphilic peptides composed of arginines and valines were synthesized and characterized as plasmid DNA (pDNA) carriers. The peptides have a cationic region containing 1-4 arginines and a hydrophobic region containing ...

journal_title：Journal of cellular biochemistry

authors： Ryu DW,Kim HA,Song H,Kim S,Lee M

更新日期：2011-05-01 00:00:00

abstract：:We previously described a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In ND-GFP mice, nascent blood vessels are labeled with GFP. We report here that osteosarcoma cells promote angiogenesis in th...

journal_title：Journal of cellular biochemistry

authors： Uehara F,Tome Y,Miwa S,Hiroshima Y,Yano S,Yamamoto M,Mii S,Maehara H,Bouvet M,Kanaya F,Hoffman RM

更新日期：2014-09-01 00:00:00

abstract：:Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of ...

journal_title：Journal of cellular biochemistry

authors： Zhao Y,Yuan X,Li X,Zhang Y

更新日期：2018-10-22 00:00:00

abstract：:Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for anti inflammation in ancient times. Although it has been shown that pristimerin induces apoptosis in breast cancer cells, the involved mechanism of action is unknown. The purpose of the curr...

journal_title：Journal of cellular biochemistry

authors： Yang H,Landis-Piwowar KR,Lu D,Yuan P,Li L,Reddy GP,Yuan X,Dou QP

更新日期：2008-01-01 00:00:00

abstract：:Dexmedetomidine, an agonist of alpha2-adrenergic receptors, is used for critically ill patients to induce and maintain sedation and analgesia. Brain ischemia/reperfusion (I/R) usually causes severe neuronal injuries to intensive care unit patients. This study was aimed to evaluate the effects of dexmedetomidine on I/R...

journal_title：Journal of cellular biochemistry

authors： Wu GJ,Chen JT,Tsai HC,Chen TL,Liu SH,Chen RM

更新日期：2017-09-01 00:00:00

abstract：:Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However, innate immune responses to adenovirus vectors limit effectiveness of Ad5 based therapies. Moreover, extensive pre-existing Ad5 immunity in human populations will ...

journal_title：Journal of cellular biochemistry

authors： Zaiss AK,Machado HB,Herschman HR

更新日期：2009-11-01 00:00:00

abstract：:Hamster embryo cells metabolize benzo(a)pyrene to derivatives that covalently modify the nuclear macromolecules including proteins. Not all proteins are modified to the same extent nor by the same metabolites. In particular, a protein of apparent molecular weight 32,000 is highly modified by derivatives of trans-9,10-...

journal_title：Journal of cellular biochemistry

authors： MacLeod MC,Mansfield BK,Selkirk JK

更新日期：1982-01-01 00:00:00

abstract：:We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...

journal_title：Journal of cellular biochemistry

authors： Hubberstey A,Yu G,Loewith R,Lakusta C,Young D

更新日期：1996-06-01 00:00:00

abstract：:The contribution of proximal tubules (PT) to albumin uptake is now well recognized, however, its regulation is understudied area. There are reports suggesting that insulin resistance is associated with the development of albuminuria in nondiabetic individuals. We have previously reported reduced insulin receptor (IR) ...

journal_title：Journal of cellular biochemistry

authors： Kumari M,Sharma R,Pandey G,Ecelbarger CM,Mishra P,Tiwari S

更新日期：2019-06-01 00:00:00

abstract：:Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone health is targeting osteoprogenitor cells in order to stimulate thei...

journal_title：Journal of cellular biochemistry

authors： Amantea CM,Kim WK,Meliton V,Tetradis S,Parhami F

更新日期：2008-10-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection causes chronic gastritis and peptic ulceration and is the strongest risk factor for the development of gastric cancer. The pathogenesis of H. pylori is believed to be associated with infection-initiated chronic gastritis, which is characterized by enhanced expression of many i...

journal_title：Journal of cellular biochemistry

authors： Lamb A,Chen LF

更新日期：2013-03-01 00:00:00

abstract：:In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited...

journal_title：Journal of cellular biochemistry

authors： Butera ST,Perez VL,Besansky NJ,Chan WC,Wu BY,Nabel GJ,Folks TM

更新日期：1991-04-01 00:00:00

abstract：:NS5ATP9, a gene up-regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions, such as starvation, and plays a crucial role in tu...

journal_title：Journal of cellular biochemistry

authors： Quan M,Liu S,Wang Q,Li G,Zhang Y,Feng S,Liang J,Cheng J

更新日期：2015-08-01 00:00:00

abstract：:Phospholipase C-gamma1 (PLCgamma1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5-inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCgamma1 in PLCgamma1-mediated cell signaling, we characterized some protei...

journal_title：Journal of cellular biochemistry

authors： Bae JY,Ahn SJ,Lee JE,Kim JE,Han MR,Han W,Kim SW,Shin HJ,Lee SJ,Park D,Noh DY

更新日期：2005-04-01 00:00:00

abstract：:Interferon-τ (IFNT) is a major cytokine produced by the ruminant trophoectoderm during the peri-implantation period exerting immunomodulatory actions on various cells including neutrophils. The current in vitro study was undertaken to analyze the concentration-dependent effects of IFNT on neutrophil gene dynamics to u...

journal_title：Journal of cellular biochemistry

authors： Manjari P,Hyder I,Kapoor S,Senthilnathan M,Dang AK

更新日期：2018-12-01 00:00:00

abstract：:Recently, it has been revealed that estrogen-related reproductive factors are linked with some early gene expression lesions associated with malignancy in clinically healthy breasts. Accordingly, the aim of the current study was to evaluate the association of expression levels of estrogen-related long noncoding RNAs (...

journal_title：Journal of cellular biochemistry

authors： Mansoori Y,Zendehbad Z,Askari A,Kouhpayeh A,Tavakkoly-Bazzaz J,Nariman-Saleh-Fam Z,Bastami M,Saadatian Z,Mansoori B,Yousefvand A,Mansoori H,Daraei A

更新日期：2019-06-01 00:00:00

abstract：:In vitro assembly of functional liver tissue is a prerequisite for the transplantation of tissue-engineered livers. There is an increasing demand for in vitro models that replicate complex events occurring in the liver. However, tissue engineering of implantable liver systems is currently limited by the difficulty of ...

journal_title：Journal of cellular biochemistry

authors： Alzebdeh DA,Matthew HW

更新日期：2017-09-01 00:00:00