Mechanisms regulating c-met overexpression in liver-metastatic B16-LS9 melanoma cells.

abstract：:Chemotherapy drug resistance frequently happens in more than 50% of bladder cancer patients and is the major obstacle for the bladder cancer therapy. Recent studies have shown that long noncoding RNA (lncRNA) is involved in the development of chemoresistance. In this study, we reported hypoxia inducible factor 1α-anti...

journal_title：Journal of cellular biochemistry

authors： Chen X,Liu M,Meng F,Sun B,Jin X,Jia C

更新日期：2019-01-01 00:00:00

abstract：:Endogenous peptides play crucial roles in various biological processes. Their effects on the pathogenesis of human infantile hemangioma remains poorly understood. In this study, we construct a comparative peptidomic profiling between human infantile hemangioma tissue and matched normal skin using liquid chromatography...

journal_title：Journal of cellular biochemistry

authors： Li Q,Li J,Chen L,Gao Y,Li J

更新日期：2018-06-01 00:00:00

abstract：:Rat CYP1A1 promoter-luciferase, transiently transfected wild-type and 4S PAH receptor (glycine N-methyl transferase, GNMT)-transformed Chinese hamster ovary (CHO) cells were exposed to benzo[a]pyrene and assayed for luciferase activity as an indicator of CYP1A1 promoter activity. CHO cells transformed with the rat 4S ...

journal_title：Journal of cellular biochemistry

authors： Sterling KM

更新日期：2011-08-01 00:00:00

abstract：:Chromatin immunoprecipitation (ChIP) is an important technique for studying protein-DNA interactions. Whole genome ChIP methods have enjoyed much success, but are limited in that they cannot uncover important long-range chromatin interactions. Chromosome conformation capture (3C) and related methods are capable of det...

journal_title：Journal of cellular biochemistry

authors： Fullwood MJ,Ruan Y

更新日期：2009-05-01 00:00:00

abstract：:Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. To identify endogenous peptides possibly involved in the progression of TOF, we performed comparative peptidomic profiling of maternal serum between normal fetuses and fetuses suffering from TOF. A total of 278 differentially expre...

journal_title：Journal of cellular biochemistry

authors： Zhuang B,Hu Y,Fan X,Li M,Zhu J,Liu H,Cao L,Liang D,Zhang J,Yu Z,Han S

更新日期：2018-01-01 00:00:00

abstract：:Esophageal carcinoma is aggressive in nature and its prognosis is largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as the most unique member of HDACs family, has the positive activity to promote initiation and progression of various cancers via targeting multiple non-histone proteins in cyto...

journal_title：Journal of cellular biochemistry

authors： Tao H,Chen YY,Sun ZW,Chen HL,Chen M

更新日期：2018-08-01 00:00:00

abstract：:A new method of protein nucleation and crystallization based on Langmuir-Blodgett technology is here utilized for the template stimulation of crystal growth of so far non-crystallized proteins. Microcrystals (60-120 microm) of bovine cytochrome P450scc and human protein kinase CKII alpha subunit were obtained with use...

journal_title：Journal of cellular biochemistry

authors： Pechkova E,Nicolini C

更新日期：2002-01-01 00:00:00

abstract：:We have previously characterized the expression of the alpha nu beta 5 and alpha nu beta 6 integrins as major receptors for the human colonic adenocarcinoma cell line (HT29-D4), on vitronectin and fibronectin, respectively [Lehmann et al. (1994): Cancer Res 54:2102-2107]. In the present work we investigated the glycos...

journal_title：Journal of cellular biochemistry

authors： Lehmann M,El Battari A,Abadie B,Martin JM,Marvaldi J

更新日期：1996-05-01 00:00:00

abstract：:Gastric cancer (GC) is the second most common cause of cancer death worldwide but could be more curable if diagnosed at an earlier stage. At present, the capability to predict the efficaciousness of molecular diagnosis for GC for each patient remains elusive. The purpose of this study was to identify tumor biomarkers ...

journal_title：Journal of cellular biochemistry

authors： Ai K,Jia Y,Li J,Wang C,Wang Y

更新日期：2018-11-13 00:00:00

abstract：:Alpha-fetoprotein (AFP) is one of the major serum proteins in the early life of mammals. We have previously identified a novel cis-acting element designated as DAS at the 5'-flanking region of the AFP gene and demonstrated that the DAS sequence can be specifically recognized by nuclear protein DAP-II in AFP-producing ...

journal_title：Journal of cellular biochemistry

authors： Jiao R,He QY,Chen H,Hua Z,Jiao Q,Chiu JF

更新日期：2006-08-01 00:00:00

abstract：:Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited. Human telomerase catalytic subunit (hTERT) gene transduction can prolong the life span of hMSCs and maintain their potential of osteogenic differ...

journal_title：Journal of cellular biochemistry

authors： Huang G,Zheng Q,Sun J,Guo C,Yang J,Chen R,Xu Y,Wang G,Shen D,Pan Z,Jin J,Wang J

更新日期：2008-03-01 00:00:00

abstract：:The in vitro growth of primary erythroleukemia cells has been examined in the presence and absence of the hormone erythropoietin (EPO). Although these leukemic cells had previously been considered to be hormone-independent, addition of EPO was found to be essential for maximum growth in culture. Erythroid colonies tha...

journal_title：Journal of cellular biochemistry

authors： Hossain A,Kim JK,Hankins WD

更新日期：1986-01-01 00:00:00

abstract：:In 1981, Chugai Pharmaceutical succeeded in marketing alfacalcidol, a prodrug of calcitriol, as a therapeutic agent for renal osteodystrophy. In 1983, Chugai succeeded in extending the application of alfacalcidol to the treatment of osteoporosis as well. Clinicians in Japan have accepted alfacalcidol as a remedy for o...

journal_title：Journal of cellular biochemistry

authors： Nishii Y

更新日期：2003-02-01 00:00:00

abstract：:Numerous data indicate that hyperhomocysteinemia is a risk factor for cardio- and cerebrovascular diseases. At least in part, homocysteine (HCY) impairs cerebrovascular function because it generates large numbers of free radicals. Since melatonin is a well-known antioxidant, which reduces oxidative stress and decrease...

journal_title：Journal of cellular biochemistry

authors： Ortega-Gutiérrez S,Fuentes-Broto L,García JJ,López-Vicente M,Martínez-Ballarín E,Miana-Mena FJ,Millán-Plano S,Reiter RJ

更新日期：2007-10-15 00:00:00

abstract：:Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that help...

journal_title：Journal of cellular biochemistry

authors： Upadhyay S,Sharma N,Gupta KB,Dhiman M

更新日期：2018-07-01 00:00:00

abstract：:Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single agents, HDAC inhibitors may cause c...

journal_title：Journal of cellular biochemistry

authors： Marchion DC,Bicaku E,Daud AI,Richon V,Sullivan DM,Munster PN

更新日期：2004-05-15 00:00:00

abstract：:A23187 stimulates the metabolism of endogenous as well as exogenous arachidonic acid (AA) and eicosapentaenolc acid (EPA) to their corresponding leukotrienes in human neutrophils. In contrast, conflicting results have been obtained concerning the effect of FMLP on the metabolism of these fatty acids. In the present st...

journal_title：Journal of cellular biochemistry

authors： Mahadevappa VG,Powell WS

更新日期：1989-07-01 00:00:00

abstract：:The current study was designed to explore the therapeutic effect and mechanism of different extraction, which came from hypoglycemic granule on diabetes-induced liver injury. The ethanol fraction (HGEF) and aqueous fraction (HGAF) from hypoglycemic granule were prepared and administered p.o. to diabetic mice for 17 we...

journal_title：Journal of cellular biochemistry

authors： Yang X,Zhang P,Zhang F,Ke Z,Chen Q,Liu C

更新日期：2020-06-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is known to have a number of biological properties including promoting tumor progression of human carcinomas. Metastasis involves a number of events that are attributed to induction by paracrine factors such as HGF. Identification of natural inhibitors of these events would allow better ...

journal_title：Journal of cellular biochemistry

authors： Uchiyama A,Essner R,Doi F,Nguyen T,Ramming KP,Nakamura T,Morton DL,Hoon DS

更新日期：1996-09-15 00:00:00

abstract：:PKCalpha was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the gamma/gamma + beta globin expression...

journal_title：Journal of cellular biochemistry

authors： Di Baldassarre A,Di Rico M,Di Noia A,Bonfini T,Iacone A,Marchisio M,Miscia S,Alfani E,Migliaccio AR,Stamatoyannopoulos G,Migliaccio G

更新日期：2007-05-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and angiopoietins regulate endothelial cell survival and migration and are essential for angiogenesis. Considerable progress has been made towards understanding hypoxia-mediated regulation of VEGF and its receptors. In contrast, little is known about the regulation of angiopoi...

journal_title：Journal of cellular biochemistry

authors： Christensen RA,Fujikawa K,Madore R,Oettgen P,Varticovski L

更新日期：2002-01-01 00:00:00

abstract：:Extracts of thymic lymphoma that are obtained from AKR mice and are kept in the cold for at least several days can induce lipolytic activity in rat adipocyte suspensions. Freshly prepared extracts have low activity but contain a low molecular weight material of less than 10,000 daltons that aggregates on standing in t...

journal_title：Journal of cellular biochemistry

authors： Kitada S,Hays EF,Mead JF,Zabin I

更新日期：1982-01-01 00:00:00

abstract：:ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression o...

journal_title：Journal of cellular biochemistry

authors： Wang D,Wang H,Gao F,Wang K,Dong F

更新日期：2017-06-01 00:00:00

abstract：:This study investigated the influence of miR-150 expression on osteoblast matrix mineralization and its mechanisms. The mouse osteoblast cell line MC3T3-E1 was used as an in vitro model of bone formation. On the fifth day of mineralization, transfection experiments using agomiR-150, agomiR-NC, antagomiR-150 antagomiR-...

journal_title：Journal of cellular biochemistry

authors： Dong CL,Liu HZ,Zhang ZC,Zhao HL,Zhao H,Huang Y,Yao JH,Sun TS

更新日期：2015-12-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:Acid-electrolyzed functional water (FW) is obtained through the electrolysis of sodium chloride solution. Stimulation of the human fibroblastic cell line HeLa by FW led to the augmented secretion of basic fibroblast growth factor (bFGF). Immunoprecipitation followed by Western blot analysis revealed that both high and...

journal_title：Journal of cellular biochemistry

authors： Motozawa K,Motoyoshi M,Saiki A,Sasaki H,Shimizu N,Asano M

更新日期：2018-09-01 00:00:00

abstract：:IFI 16 is a member of the HIN-200 family of transcriptional regulators that suppress cell growth, modulate the cell cycle and have been linked to cellular differentiation. We hypothesized that the activity of IFI 16 depends on its level of expression and therefore studied the transcriptional activity of the IFI 16 pro...

journal_title：Journal of cellular biochemistry

authors： Clarke CJ,Apostolidis V,Hii LL,Gough DJ,Trapani JA,Johnstone RW

更新日期：2003-05-01 00:00:00

abstract：:We used non-insulin producing pancreatic carcinoma cell line, MIA PaCa-2 and have modulated its culture conditions by using 1% matrigel as extracellular matrix, N2, B27 growth supplements and serum free conditions. Expression of markers was analyzed using qRT-PCR, immunofluorescence and in vitro functional assay for i...

journal_title：Journal of cellular biochemistry

authors： Bose B,Shenoy P S

更新日期：2013-07-01 00:00:00

abstract：:Stimulation of gonadotropin-releasing hormone (GnRH) receptors with the GnRH analogue buserelin enhances expression of the zinc finger transcription factor Egr-1 in a pituitary gonadotroph cell line. The signaling cascade is blocked by overexpression of MAP kinase phosphatase-1 that dephosphorylates extracellular sign...

journal_title：Journal of cellular biochemistry

authors： Mayer SI,Willars GB,Nishida E,Thiel G

更新日期：2008-12-01 00:00:00

abstract：:Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

journal_title：Journal of cellular biochemistry

authors： Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

更新日期：1996-06-01 00:00:00