A carboxy terminal BMP/TGF-β binding site in secreted phosphoprotein 24 kD independently affects BMP-2 activity.

abstract：:Proper bone remodeling requires an active process of angiogenesis which in turn supplies the necessary growth factors and stem cells. This tissue cooperation suggests a cross-talk between osteoblasts and endothelial cells. This work aims to identify the role of paracrine communication through vascular endothelial grow...

journal_title：Journal of cellular biochemistry

authors： Grellier M,Ferreira-Tojais N,Bourget C,Bareille R,Guillemot F,Amédée J

更新日期：2009-02-15 00:00:00

abstract：:Adamts17 is a member of a family of secreted metalloproteinases. In this report, we show that knockdown of Adamts17 expression induces apoptosis and inhibits breast cancer cell growth. Adamts17 expression can rapidly be induced by estrogens. siRNA knockdown of Sp1 or Myc demonstrated that Sp1 is required to induce Ada...

journal_title：Journal of cellular biochemistry

authors： Jia Z,Gao S,M'Rabet N,De Geyter C,Zhang H

更新日期：2014-10-01 00:00:00

abstract：:Na+/D-glucose symport is a secondary active glucose transport mechanism expressed only in kidney proximal tubule and in small intestine. A monoclonal antibody that recognized the Na+/glucose symporter of pig renal brush border membranes also recognized a 75-kD protein in apical membranes isolated from highly different...

journal_title：Journal of cellular biochemistry

authors： Wu JS,Lever JE

更新日期：1989-05-01 00:00:00

abstract：:Inflammation, elicited in the skin following tissue damage or pathogen invasion, may become chronic with deleterious consequences. Tumor necrosis factor (TNF) is a key mediator of cutaneous inflammation and the keratinocyte an important protagonist of skin immunity. Calcitriol, the hormonally active vitamin D metaboli...

journal_title：Journal of cellular biochemistry

authors： Ziv E,Rotem C,Miodovnik M,Ravid A,Koren R

更新日期：2008-05-15 00:00:00

abstract：:Cancer stem cells (CSCs) are tumoral cells which have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of articles have been published abo...

journal_title：Journal of cellular biochemistry

authors： Graziano A,d'Aquino R,Tirino V,Desiderio V,Rossi A,Pirozzi G

更新日期：2008-02-01 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00

abstract：:The present study aimed to determine the roles of miRNA-543 in osteoporosis in rats induced by ovariectomy. The osteoporosis rat model was established by ovariectomy induction. MiRNA-543 expression in osteoblasts was measured by quantitative real-time polymerase chain reaction. The cell proliferation and apoptosis wer...

journal_title：Journal of cellular biochemistry

authors： Li X,Ning L,Zhao X,Wan S

更新日期：2018-12-02 00:00:00

abstract：:Heavy metals are toxic to living organisms. Some have no known beneficial biological function, while others have essential roles in physiological reactions. Mechanisms which deal with heavy metal stress must protect against the deleterious effects of heavy metals, yet avoid depleting the cell of a heavy metal which is...

journal_title：Journal of cellular biochemistry

authors： Brown NL,Camakaris J,Lee BT,Williams T,Morby AP,Parkhill J,Rouch DA

更新日期：1991-06-01 00:00:00

abstract：:We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...

journal_title：Journal of cellular biochemistry

authors： Hubberstey A,Yu G,Loewith R,Lakusta C,Young D

更新日期：1996-06-01 00:00:00

abstract：:The mitochondrial antioxidant enzyme Mn-Superoxide Dismutase (Sod2) is essential for mammalian survival. I82T mutation in human Sod2 has been linked to a wide variety of diseases, including Alzheimer's and Parkinson's diseases as well as some types of cancers. Yeast wild-type (WT) Sod2 and the mutant Sod2 I91T, which ...

journal_title：Journal of cellular biochemistry

authors： de Carvalho MD,De Mesquita JF,Eleutherio EC

更新日期：2017-05-01 00:00:00

abstract：:Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calcul...

journal_title：Journal of cellular biochemistry

authors： Rucci N,Migliaccio S,Zani BM,Taranta A,Teti A

更新日期：2002-01-01 00:00:00

abstract：:The present study aimed to investigate the long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) involved in the progression of gallbladder cancer and explore the potential physiopathologic mechanisms of gallbladder cancer in terms of competing endogenous RNAs (ceRNAs). The original lncRNA and mRNA expression profi...

journal_title：Journal of cellular biochemistry

authors： Kong L,Wu Q,Zhao L,Ye J,Li N,Yang H

更新日期：2019-12-01 00:00:00

abstract：:New perinatal care technologies have improved the survival rate of preterm neonates, but the prevalence of bronchopulmonary dysplasia (BPD), one of the most intractable problems in neonatal intensive care unit (NICU), remains unchanged. In present study, high-throughput sequencing (HTS) was performed to detect the exp...

journal_title：Journal of cellular biochemistry

authors： Wang J,Yin J,Wang X,Liu H,Hu Y,Yan X,Zhuang B,Yu Z,Han S

更新日期：2019-06-01 00:00:00

abstract：:Hamster embryo cells metabolize benzo(a)pyrene to derivatives that covalently modify the nuclear macromolecules including proteins. Not all proteins are modified to the same extent nor by the same metabolites. In particular, a protein of apparent molecular weight 32,000 is highly modified by derivatives of trans-9,10-...

journal_title：Journal of cellular biochemistry

authors： MacLeod MC,Mansfield BK,Selkirk JK

更新日期：1982-01-01 00:00:00

abstract：:The effect of regucalcin, which is a regulatory protein of Ca(2+) signaling, on Ca(2+)-ATPase activity in isolated rat renal cortex mitochondria was investigated. The presence of regucalcin (50, 100, and 250 nM) in the enzyme reaction mixture led to a significant increase in Ca(2+)-ATPase activity. Regucalcin signific...

journal_title：Journal of cellular biochemistry

authors： Xue JH,Takahashi H,Yamaguchi M

更新日期：2000-10-20 00:00:00

abstract：:Toxoplasma gondii an obligate intracellular parasite causes toxoplasmosis in homeothermic animals. Host invasion of this parasite is mediated by the formation of Moving Junction (MJ) complex which encompasses a network of microneme and Rhoptry Neck proteins (RONs) 2/4/5/8. Among these proteins, RON4 is the only cytoso...

journal_title：Journal of cellular biochemistry

authors： Vetrivel U,Nagarajan H,Thirumudi I

更新日期：2018-04-01 00:00:00

abstract：:Genome-wide screening of the yeast Saccharomyces cerevisiae knockout collection was used to characterize chemical-genetic interactions of cycloheximide (CHX). The results showed that while the act1Δ mutant was the only deletion mutant in the heterozygous essential gene deletion collection that showed hypersensitivity ...

journal_title：Journal of cellular biochemistry

authors： Darvishi E,Woldemichael GM

更新日期：2016-12-01 00:00:00

abstract：:Breast cancer cells preferentially metastasize to bone, leading to the formation of primarily osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of osteolytic bone metastases. An increase in the ratio of receptor activator of nuclear factor kappaB ligand (RANKL) to OPG increases os...

journal_title：Journal of cellular biochemistry

authors： Kapoor P,Suva LJ,Welch DR,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:Sonic hedgehog (Shh) is a key signal protein in early embryological patterning of limb bud development. Its analog, Indian hedgehog (Ihh), primarily expressed during early cartilage development in prehypertrophic chondrocytes, regulates proliferation and suppresses terminal differentiation of postnatal growth plate (G...

journal_title：Journal of cellular biochemistry

authors： Wu LN,Lu M,Genge BR,Guo GY,Nie D,Wuthier RE

更新日期：2002-01-01 00:00:00

abstract：:Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1). However, the underlying mechanisms involved in the effect of OA on HO-1 expression are unclear. In the current study, prima...

journal_title：Journal of cellular biochemistry

authors： Feng J,Zhang P,Chen X,He G

更新日期：2011-06-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:The influence of concentration of simvastatin (SIM) on free radicals in A-2058 human melanoma malignum cells was studied. The proliferation assay for melanoma A-2058 cells with SIM in concentration range from 0.1 to 20 µM was performed. SIM in the concentrations of 0.1, 0.3, and 1 μM only slightly changed the growth o...

journal_title：Journal of cellular biochemistry

authors： Zdybel M,Chodurek E,Pilawa B

更新日期：2018-09-11 00:00:00

abstract：:There is increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in the tumorigenesis and development of colorectal cancer (CRC). Nevertheless, the clinical significances and functions of FENDRR in CRC remain unknown. In this study, we reveal that lncRNA FENDRR is downregulated in CRC and ...

journal_title：Journal of cellular biochemistry

authors： Yin SL,Xiao F,Liu YF,Chen H,Guo GC

更新日期：2019-11-13 00:00:00

abstract：:ABP50 is a polypeptide elongation factor 1 alpha from Dictyostelium that is associated with the actin cytoskeleton. Upon chemotactic stimulation, ABP50 undergoes a dramatic cytoplasmic redistribution into newly formed surface projections and in vitro binds to and bundles actin filaments. Many questions are raised by t...

journal_title：Journal of cellular biochemistry

authors： Edmonds BT

更新日期：1993-06-01 00:00:00

abstract：:The myelin basic protein (MBP)-phosphorylating enzymes present during maturation and early embryogenesis of the sea star (Pisaster ochraceus) were investigated. The major maturation-activated MBP kinase (p45 Mapk) was molecularly cloned based on tryptic sequence information obtained with the purified enzyme and shown ...

journal_title：Journal of cellular biochemistry

authors： Lefebvre DL,Charest DL,Yee A,Crawford BJ,Pelech SL

更新日期：1999-11-01 00:00:00

abstract：:The role of regucalcin, which is a regulatory protein in intracellular signaling pathway, in the regulation of glucose utilization and lipid production was investigated using the cloned rat hepatoma H4-II-E cells overexpressing regucalcin. The hepatoma cells (wild-type) and stable regucalcin/pCXN2-transfected cells (t...

journal_title：Journal of cellular biochemistry

authors： Nakashima C,Yamaguchi M

更新日期：2006-12-15 00:00:00

abstract：:Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apop...

journal_title：Journal of cellular biochemistry

authors： Panahi Y,Abdolghaffari AH,Sahebkar A

更新日期：2018-01-01 00:00:00

abstract：:The bone marrow stroma contains pre-adipocyte cells which are part of the hemopoietic microenvironment. Cloned stromal cell lines differ both in their ability to support myeloid and lymphoid development and in their ability to undergo adipocyte differentiation in vitro. These processes have been examined in the +/+2.4...

journal_title：Journal of cellular biochemistry

authors： Gimble JM,Youkhana K,Hua X,Bass H,Medina K,Sullivan M,Greenberger J,Wang CS

更新日期：1992-09-01 00:00:00

abstract：:During the life cycle of human papillomaviruses (HPVs), the L1 capsid proteins seem to enter the nucleus twice: once after the virions infect the cells, and later during the productive phase when they assemble the replicated HPV genomic DNA into infectious virions. We established for the high-risk HPV45 that when digi...

journal_title：Journal of cellular biochemistry

authors： Nelson LM,Rose RC,LeRoux L,Lane C,Bruya K,Moroianu J

更新日期：2000-08-02 00:00:00

abstract：:Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymorphism (SNP) in the...

journal_title：Journal of cellular biochemistry

authors： Benbow U,Tower GB,Wyatt CA,Buttice G,Brinckerhoff CE

更新日期：2002-01-01 00:00:00