Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p.

abstract：:The bone marrow provides a protective environment for acute myeloid leukemia (AML) cells that often allows leukemic stem cells to survive standard chemotherapeutic regimens. Targeting these leukemic stem cells within the bone marrow is critical for preventing relapse. We recently demonstrated that SDF-1, a chemokine a...

journal_title：Journal of cellular biochemistry

authors： Kremer KN,Dudakovic A,McGee-Lawrence ME,Philips RL,Hess AD,Smith BD,van Wijnen AJ,Karp JE,Kaufmann SH,Westendorf JJ,Hedin KE

更新日期：2014-06-01 00:00:00

abstract：:The role of estrogen receptor alpha (ERα) in breast cancer has been studied extensively, and its protein expression is prognostic and a primary determinant of endocrine sensitivity. However, much less is known about the role of ERβ and its relevance remains unclear due to the publication of conflicting reports. Here, ...

journal_title：Journal of cellular biochemistry

authors： Wu X,Subramaniam M,Negron V,Cicek M,Reynolds C,Lingle WL,Goetz MP,Ingle JN,Spelsberg TC,Hawse JR

更新日期：2012-02-01 00:00:00

abstract：:The 4-quinolone antibiotics nalidixic acid and ciprofloxacin are potent inhibitors of the bacterial type II topoisomerase DNA gyrase. Treatment of mouse L1210 leukemia cells with these drugs resulted in a delayed inhibition of cell proliferation. Prior to inhibition of cell proliferation, there was a time-dependent de...

journal_title：Journal of cellular biochemistry

authors： Lawrence JW,Darkin-Rattray S,Xie F,Neims AH,Rowe TC

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore the mechanism of excessive apoptosis of nucleus pulposus cells induced by short hairpin RNA (shRNA) Piezo type mechanosensitive ion channel component 1 (Piezo1) under abnormal mechanical stretch stress. METHODS:In vitro mechanical stretch stress model of nucleus pulposus c...

journal_title：Journal of cellular biochemistry

authors： Yang Q,Zhou Y,Wang J,Fu W,Li X

更新日期：2019-03-01 00:00:00

abstract：:Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic modification in the development of this disease is now being recognized. The reversible and dynamic nature of epigenetic modifications provides a promising strategy in colorectal cancer chemoprevention and treatment. Luteolin (LUT),...

journal_title：Journal of cellular biochemistry

authors： Zuo Q,Wu R,Xiao X,Yang C,Yang Y,Wang C,Lin L,Kong AN

更新日期：2018-11-01 00:00:00

abstract：:Constitutive and benzo[a]pyrene (B[a]P) inducible expression of CYP1A1 and CYP1A2 in prostate cancer and normal prostate epithelial cells were examined by immunoblotting. Androgen independent prostate cancer cell lines DU145 and PC3 have constitutive expression of CYP1A and CYP1A1 and CYP1A2, respectively. Four microm...

journal_title：Journal of cellular biochemistry

authors： Sterling KM Jr,Cutroneo KR

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CC) is devastating neoplasm and very few specific biomarkers could be used in clinical diagnosis. A study was taken to find novel serum biomarkers for CC. METHODS:Surface enhanced laser desorption/ionization (SELDI) technology was used to analyze 427 serum samples including 56 CCs, 49 he...

journal_title：Journal of cellular biochemistry

authors： Liu L,Wang J,Liu B,Dai S,Wang X,Chen J,Huang L,Xiao X,He D

更新日期：2008-06-01 00:00:00

abstract：:We have investigated the actions of transforming growth factor (TGF) type alpha on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGF alpha results in elevated levels of EGF receptor mRNA. This increase in ...

journal_title：Journal of cellular biochemistry

authors： Fernandez-Pol JA,Klos DJ,Hamilton PD

更新日期：1989-11-01 00:00:00

abstract：:We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally observed for well-known marker of DNA lesions, 53BP1...

journal_title：Journal of cellular biochemistry

authors： Bártová E,Legartová S,Krejčí J,Řezníčková P,Kovaříková AS,Suchánková J,Fedr R,Smirnov E,Hornáček M,Raška I

更新日期：2018-11-01 00:00:00

abstract：:The specific lysis of bloodstream trypanosomes by serum from a nonpermissive mammalian host is the result of interaction between the serum trypanocidal factor (high-density lipoprotein) and the trypanosome surface. The studies described in this paper attempt to define further the mode of action of this cytotoxic lipop...

journal_title：Journal of cellular biochemistry

authors： Rifkin MR

更新日期：1983-01-01 00:00:00

abstract：:Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins. Its catalytic activity depends upon both its copper cofactor an...

journal_title：Journal of cellular biochemistry

authors： Kagan HM,Li W

更新日期：2003-03-01 00:00:00

abstract：:The transcription factors of the nuclear hormone receptor family regulate gene expression via a complex network of macromolecular interactions. The ligand dependent activity of the vitamin D receptor is of particular interest because it modulates gene expression by the heterodimeric interaction with retinoid X recepto...

journal_title：Journal of cellular biochemistry

authors： Berghöfer-Hochheimer Y,Zurek C,Langer G,Munder T

更新日期：1997-08-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases have been implicated as important mediators of the inflammatory response. Here we report that c-Jun NH(2)-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 MAP kinase activities are reprogrammed during the IL-6 induced macrophage-like differentiation of...

journal_title：Journal of cellular biochemistry

authors： Hall JP,Davis RJ

更新日期：2002-01-01 00:00:00

abstract：:Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines h...

journal_title：Journal of cellular biochemistry

authors： Elmas L,Secme M,Mammadov R,Fahrioglu U,Dodurga Y

更新日期：2019-03-01 00:00:00

abstract：:Based on a consideration of the probable structure of calmodulin and some natural peptides known to interact with it, two calmodulin-binding peptides were designed. These peptides bind to calmodulin in helical conformations and are capable of forming electrostatic and hydrophobic interactions with calmodulin. Their di...

journal_title：Journal of cellular biochemistry

authors： DeGrado WF,Prendergast FG,Wolfe HR Jr,Cox JA

更新日期：1985-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a unique population of multipotent cells that exhibit pluripotent properties to a certain extent and are significantly heterogeneous in terms of the cell population. We isolate a small cell subpopulation from bovine BMSCs, bovine small stem cells (bSSCs), and herein characterize t...

journal_title：Journal of cellular biochemistry

authors： Pan S,Chen YC,Zhao N,Feng X,Yang DD,Wang Y,Jin ZB

更新日期：2019-08-01 00:00:00

abstract：:Rhodopsin mutations cause autosomal dominant form of retinitis pigmentosa (RP). T17M rhodopsin predisposes cells to endoplasmic reticulum stress induced apoptosis. However, the pathogenic role of T17M rhodopsin in RP is not completely understood. Complement C3 has a protective role in RP pathogenesis. This study aimed...

journal_title：Journal of cellular biochemistry

authors： Xiong S,Yu Y,Zhou X,Xia X,Jiang H

更新日期：2017-12-01 00:00:00

abstract：:Metastatic variant cell lines of the murine RAW117 large cell lymphoma were used to study the cell surface components involved in syngeneic tumor cell/microvessel endothelial cell interactions. Poorly liver-metastatic parental RAW117-P cell line adhered to murine hepatic sinusoidal endothelial cell monolayers at signi...

journal_title：Journal of cellular biochemistry

authors： Tressler RJ,Nicolson GL

更新日期：1992-02-01 00:00:00

abstract：:Amplification of MYCN is one of the most important prognostic markers for neuroblastoma and is correlated with rapid tumor progression and poor prognosis. MYCN belongs to the Myc/Max/Mad/Mnt network of proteins that regulate proliferation, apoptosis, and differentiation. It is well established that MYCN is downregulat...

journal_title：Journal of cellular biochemistry

authors： Smith AG,Popov N,Imreh M,Axelson H,Henriksson M

更新日期：2004-08-15 00:00:00

abstract：:Stimulation of osteoblast survival signals may be an important mechanism of regulating bone anabolism. Protein kinase B (PKB/Akt), a serine-threonine protein kinase, is a critical regulator of normal cell growth, cell cycle progression, and cell survival. In this study we have investigated the signaling pathways activ...

journal_title：Journal of cellular biochemistry

authors： Chaudhary LR,Hruska KA

更新日期：2001-03-26 00:00:00

abstract：:Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

journal_title：Journal of cellular biochemistry

authors： Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (M...

journal_title：Journal of cellular biochemistry

authors： Xiang Z,Zhou Q,Hu M,Sanders YY

更新日期：2020-07-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is currently the third most common cause of end stage liver disease necessitating transplantation. The question remains how inflammation and NASH develop in the setting of nonalcoholic fatty liver disease (NAFLD) and steatosis. Understand the roles of toll-like receptor 4 (TLR4) and...

journal_title：Journal of cellular biochemistry

authors： Sutter AG,Palanisamy AP,Lench JH,Esckilsen S,Geng T,Lewin DN,Cowart LA,Chavin KD

更新日期：2016-07-01 00:00:00

abstract：:The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibro...

journal_title：Journal of cellular biochemistry

authors： Weich HA,Iberg N,Klagsbrun M,Folkman J

更新日期：1991-10-01 00:00:00

abstract：:Ovarian cancer (OC) is a lethal disease diagnosed at advanced stages due to the lack of specific biomarkers. Tyrosine receptor kinase B (TrkB), which has recently been found to be related to OC progression, represents a promising potential biomarker for OC diagnosis and prognosis. The discovery of circulating exosomes...

journal_title：Journal of cellular biochemistry

authors： Li W,Lu Y,Yu X,Yong M,Ma D,Gao Q

更新日期：2019-04-01 00:00:00

abstract：:Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

journal_title：Journal of cellular biochemistry

authors： Yang JA,He JM,Lu JM,Jie LJ

更新日期：2018-06-01 00:00:00

abstract：:Decreased translation initiation adversely impacts protein synthesis and contributes to the myocardial dysfunction produced by sepsis. Therefore, the purpose of the present study was to identify sepsis-induced changes in signal transduction pathways known to regulate translation initiation in cardiac muscle and to det...

journal_title：Journal of cellular biochemistry

authors： Lang CH,Pruznak AM,Frost RA

更新日期：2005-02-01 00:00:00

abstract：:We examined the action of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA-damage as evidenced by Comet measurements. Despite appearance of DNA lesions, p53 protein was not ...

journal_title：Journal of cellular biochemistry

authors： Wesierska-Gadek J,Gueorguieva M,Schloffer D,Uhl M,Wojciechowski J

更新日期：2003-08-15 00:00:00

abstract：:Colorectal cancer (CRC), regardless of standard procedures of treatment and screening, is still considered one of the deadliest cancers in the Western world, and in economically developed Asian countries, especially Iran. The current study was undertaken to investigate whether changes in the level of Cripto-1 (CR-1) e...

journal_title：Journal of cellular biochemistry

authors： Igder S,Mohammadiasl J,Azadpour S,Mansouri E,Ashktorab H,Mokarram P

更新日期：2020-04-01 00:00:00

abstract：:Vascularization is essential for bone development, fracture healing, and bone tissue engineering. We have previously described that coculture of primary human osteoblasts (hOBs) and human umbilical vein endothelial cells (HUVECs) improves differentiation of both cell types. Investigating the role of microRNAs (miRNAs)...

journal_title：Journal of cellular biochemistry

authors： Strassburg S,Nabar N,Lampert F,Goerke SM,Pfeifer D,Finkenzeller G,Stark GB,Simunovic F

更新日期：2017-07-01 00:00:00