Advance in research of microRNA in Caenorhabditis elegans.

abstract：:Reveromycin A (RM-A), a small natural product isolated from Streptomyces bacteria, is a potential osteoporosis therapeutic in that it specifically induces apoptosis in osteoclasts but not osteoblasts. The purpose of the study presented here was to further elucidate the intracellular mechanisms of RM-A death effects in...

journal_title：Journal of cellular biochemistry

authors： Mead B,Morgan H,Mann-Knowlton A,Tedeschi L,Sloan C,Lang S,Hines C,Gragg M,Stofer J,Riemann K,Derr T,Heller E,Collins D,Landis P,Linna N,Jones D

更新日期：2015-08-01 00:00:00

abstract：:Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unkn...

journal_title：Journal of cellular biochemistry

authors： Lim S,Jang HJ,Park EH,Kim JK,Kim JM,Kim EK,Yea K,Kim YH,Lee-Kwon W,Ryu SH,Suh PG

更新日期：2012-11-01 00:00:00

abstract：:Deregulation of microRNAs contributes to the abnormal cell growth which is frequently observed in cancer. In the current study, we detected the expression and regulatory relationship between miR-10a and Lysine-specific demethylase 4A (KDM4A) to reveal their function in prostate cancer (PCa) progression. We found that ...

journal_title：Journal of cellular biochemistry

authors： Mu H,Xiang L,Li S,Rao D,Wang S,Yu K

更新日期：2019-04-01 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) family function through Smad-dependent and Smad-independent pathways. The Smad-dependent pathway is stimulated through the phosphorylation of receptor-regulated Smad (R-Smad) and inhibited through the dephosphorylation of R-Smad or the gene induction of inhibitory Sm...

journal_title：Journal of cellular biochemistry

authors： Katakawa Y,Funaba M,Murakami M

更新日期：2016-08-01 00:00:00

abstract：:Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this study, we constructed HepG2 cell c...

journal_title：Journal of cellular biochemistry

authors： Shirako E,Hirayama N,Tsukada Y,Tanaka T,Kitamura N

更新日期：2008-05-01 00:00:00

abstract：:Solar ultraviolet light (sUV) has been shown to promote the development of skin disorders including inflammation, photoaging, and skin carcinogenesis. Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera, commonly referred to as the Osage orange. In this study, we observed that osajin inhi...

journal_title：Journal of cellular biochemistry

authors： Kim JE,Heo YS,Lee KW

更新日期：2017-11-01 00:00:00

abstract：:Regulation and function of PI 3K/Akt and mitogen-activated protein kinases (MAPKs) in doxorubicin-induced cell death were investigated in human lung adenocarcinoma cells. Doxorubicin induced dose-dependent apoptosis of human lung adenocarcinoma NCI-H522 cells. Prior to cell death, both Akt and the MAPK family members ...

journal_title：Journal of cellular biochemistry

authors： Zhao Y,You H,Yang Y,Wei L,Zhang X,Yao L,Fan D,Yu Q

更新日期：2004-02-15 00:00:00

abstract：:The microtubule binding protein, nucleolar spindle-associated protein 1 (NUSAP1), has a crucial function in mitosis and its expression is closely associated with carcinogenesis. Herein, we aimed to determine the function of NUSAP1 in the development of human esophageal squamous cell carcinoma (ESCC), and the associati...

journal_title：Journal of cellular biochemistry

authors： Guan C,Liu Z,Lu C,Xiao M,Shi H,Ni R,Bian Z

更新日期：2019-02-21 00:00:00

abstract：:The SON protein is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. Although several early studies implicated SON in DNA-binding, tumorigenesis and apoptosis, functional significance of this protein had not been recognized until recent studies discovered SON as a novel RNA...

journal_title：Journal of cellular biochemistry

authors： Hickey CJ,Kim JH,Ahn EY

更新日期：2014-02-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is an ATP-binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemotherapy. For stable reversal of BCRP-...

journal_title：Journal of cellular biochemistry

authors： Lv H,He Z,Liu X,Yuan J,Yu Y,Chen Z

更新日期：2007-09-01 00:00:00

abstract：:In this study, we examined the effects of shark cartilage extract on the attachment and spreading properties and the focal adhesion structure of cultured bovine pulmonary artery endothelial cells. Treatment with cartilage extract resulted in cell detachment from the substratum. Immunofluorescence staining of those tre...

journal_title：Journal of cellular biochemistry

authors： Chen JS,Chang CM,Wu JC,Wang SM

更新日期：2000-06-06 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:Taxol, a microtubule stabilizing agent, has been extensively investigated for its antitumor activity. The cytotoxic effect of taxol is generally attributed to its antimicrotubule activity and is believed to be cell cycle dependent. Herein, we report that taxol induces hyperphosphorylation and reorganization of the vim...

journal_title：Journal of cellular biochemistry

authors： Chu JJ,Chen KD,Lin YL,Fei CY,Chiang AS,Chiang CD,Lai YK

更新日期：1998-03-15 00:00:00

abstract：:A series of rapidly dividing epithelial (RDE) cell lines have been isolated from primary cultures of rat ventral prostate (RVP) epithelial cells. Unlike androgen-dependent secretory epithelial cells, the RDE cells in culture do not express the androgen-dependent secretory proteins, nor do they express the androgen-rep...

journal_title：Journal of cellular biochemistry

authors： Montpetit ML,Tenniswood MP

更新日期：1989-03-01 00:00:00

abstract：:In a previous work, taking advantage of the gene-array screening technology, we analysed the effects of histone deacetylase (HDAC) inhibitor sodium butyrate (NaBt), on gene transcription in HT29 human adenocarcinoma cell line. In this study, we focused our attention on p55CDC/Cdc20 gene, whose expression was dramatica...

journal_title：Journal of cellular biochemistry

authors： Iacomino G,Medici MC,Napoli D,Russo GL

更新日期：2006-11-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two mi...

journal_title：Journal of cellular biochemistry

authors： Wu J,Chen Z,Zhang L,Cao J,Li X,Gong Z,Bo H,Zhang S,He D

更新日期：2020-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) stimulates the expression of a number of genes associated with entry of quiescent Balb/c-3T3 fibroblasts into the cell cycle. We determined that two of these genes, c-myc and c-fos, are induced equivalently in medium supplemented with platelet-poor plasma (PPP) and either PDGF-BB ...

journal_title：Journal of cellular biochemistry

authors： Coats SR,Olson JE,Pledger WJ

更新日期：1992-03-01 00:00:00

abstract：:Large doses of bone morphogenetic protein 2 (BMP2) are used clinically to induce bone formation in challenging bone defects. However, complications after treatment include swelling, ectopic bone formation, and adjacent bone resorption. While BMP2 can be effective, it is important to characterize the mechanism of the d...

journal_title：Journal of cellular biochemistry

authors： Hyzy SL,Olivares-Navarrete R,Schwartz Z,Boyan BD

更新日期：2012-10-01 00:00:00

abstract：:A23187 stimulates the metabolism of endogenous as well as exogenous arachidonic acid (AA) and eicosapentaenolc acid (EPA) to their corresponding leukotrienes in human neutrophils. In contrast, conflicting results have been obtained concerning the effect of FMLP on the metabolism of these fatty acids. In the present st...

journal_title：Journal of cellular biochemistry

authors： Mahadevappa VG,Powell WS

更新日期：1989-07-01 00:00:00

abstract：:Embryo development block seriously limits the success of in vitro embryo production and assisted reproductive technology. Although numerous researchers have explored this problem, it remains to be solved. In this study, we found that melatonin supplementation at 10-8 and 10-9 M in M16 significantly reduced two-cell bl...

journal_title：Journal of cellular biochemistry

authors： Shi F,Li H,Wang E,Chen ZJ,Zhang C

更新日期：2018-11-01 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：:Among ciliates, Paramecium has become a privileged model for the study of "species problem" particularly in the case of the "Paramecium aurelia complex" that has been intensely investigated. Despite extensive studies, the taxonomy of Paramecium is still challenging. The major problem is an uneven sampling of Parameciu...

journal_title：Journal of cellular biochemistry

authors： Tasneem F,Shakoori FR,Ilyas M,Shahzad N,Potekhin A,Shakoori AR

更新日期：2019-11-06 00:00:00

abstract：:Arsenic is the first metal to be identified as a human carcinogen. Arsenite, one inorganic form of arsenic, has been found to induce sister chromatid exchange, chromosome aberrations, and gene amplification in a variety of in vitro systems. In this study of arsenite-induced genotoxicity represented a micronuclei produ...

journal_title：Journal of cellular biochemistry

authors： Liu YC,Huang H

更新日期：1997-03-01 00:00:00

abstract：:We performed a network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different antiplatelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios and 95% credible intervals. E...

journal_title：Journal of cellular biochemistry

authors： Wa D,Zhu P,Long Z

更新日期：2019-06-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a newly validated type of noncoding RNAs recently found to be deregulated in several human cancers. More accurate and specific noninvasive biomarkers are strongly needed for better diagnosis and prognosis of hepatocellular carcinoma (HCC). We performed a bioinformatics analysis to retrieve...

journal_title：Journal of cellular biochemistry

authors： Matboli M,Shafei AE,Ali MA,Ashry AM,Kamal KM,Agag MA,Reda I,Tash EF,Ali M

更新日期：2018-11-13 00:00:00

abstract：:Uroplakin II (UPII) gene expression is highly tissue and cell specific, with mRNA present in the suprabasal cell layers of the bladder and urethra. Previous reports described the mouse UPII (mUPII) promoter as primarily urothelium selective. However, ectopic expression of a transgene under the 3.6 kb mUPII promoter wa...

journal_title：Journal of cellular biochemistry

authors： Kwon DN,Choi YJ,Park JY,Cho SK,Kim MO,Lee HT,Kim JH

更新日期：2006-10-01 00:00:00

abstract：:Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel with decreased bone formation by osteoblasts. A widely accepted strategy for improving bone health is targeting osteoprogenitor cells in order to stimulate thei...

journal_title：Journal of cellular biochemistry

authors： Amantea CM,Kim WK,Meliton V,Tetradis S,Parhami F

更新日期：2008-10-01 00:00:00

abstract：:The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1,25(OH)(2)D(3) ind...

journal_title：Journal of cellular biochemistry

authors： Jurutka PW,Thompson PD,Whitfield GK,Eichhorst KR,Hall N,Dominguez CE,Hsieh JC,Haussler CA,Haussler MR

更新日期：2005-04-01 00:00:00

abstract：:Thymosin β-4 (Tβ4) is a ubiquitous protein, which has been suggested to regulate multiple cell signal pathways and a variety of cellular functions. However, the role Tβ4 plays in the cardiac microvascular endothelial cells (CMECs) under myocardial ischemia/reperfusion injury is currently unknown. Here we investigated ...

journal_title：Journal of cellular biochemistry

authors： Li Y,Zhu X,Liu X,Du A,Yu B

更新日期：2019-11-01 00:00:00

abstract：:Adamts17 is a member of a family of secreted metalloproteinases. In this report, we show that knockdown of Adamts17 expression induces apoptosis and inhibits breast cancer cell growth. Adamts17 expression can rapidly be induced by estrogens. siRNA knockdown of Sp1 or Myc demonstrated that Sp1 is required to induce Ada...

journal_title：Journal of cellular biochemistry

authors： Jia Z,Gao S,M'Rabet N,De Geyter C,Zhang H

更新日期：2014-10-01 00:00:00