ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons.

Abstract:

:Evidence indicates that agonists of neuronal nicotinic receptors (nAChRs), including nicotine, can induce neuroprotective and anti-apoptotic effects in the CNS. To study these mechanisms, the present study focused on nicotine-mediated modulation of the extracellular regulated kinase 1 and 2 (ERK1/2) pathway in cultured spinal cord neurons. Exposure to nicotine (0.1-10 microM) for as short as 1 min markedly upregulated levels of phosphorylated ERK1/2 (pERK1/2) and increased total ERK1/2 activity. Inhibition studies with mecamylamine and alpha-bungarotoxin revealed that these effects were mediated by the alpha7 nicotinic receptor. In addition, pre-exposure to U0126, a specific inhibitor of the ERK1/2 signaling, prevented nicotine-mediated anti-apoptotic effects. To indicate if treatment with nicotine also can activate ERK1/2 in vivo, a moderate spinal cord injury (SCI) was induced in rats using a weight-drop device and nicotine was injected 2 h post-trauma. Consistent with in vitro data, nicotine increased levels of pERK1/2 in this animal model of spinal cord trauma. Results of the present study indicate that the ERK1/2 pathway is involved in anti-apoptotic effects of nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal cord trauma.

journal_name

J Cell Biochem

authors

Toborek M,Son KW,Pudelko A,King-Pospisil K,Wylegala E,Malecki A

doi

10.1002/jcb.21013

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

279-92

issue

2

eissn

0730-2312

issn

1097-4644

journal_volume

100

pub_type

杂志文章
  • Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments.

    abstract::Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24102

    authors: Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

    更新日期:2012-07-01 00:00:00

  • Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells.

    abstract::Phosphoinositide specific phospholipase C (PI-PLC) enzymes interfere with the metabolism of inositol phospholipids (PI), molecules involved in signal transduction, a complex process depending on various components. Many evidences support the hypothesis that, in the glia, isoforms of PI-PLC family display different exp...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22614

    authors: Lo Vasco VR,Fabrizi C,Panetta B,Fumagalli L,Cocco L

    更新日期:2010-07-01 00:00:00

  • Simultaneous contraction and buckling of stress fibers in individual cells.

    abstract::It has been proposed that buckling of actin stress fibers (SFs) may be associated with their disassembly. However, much of the detail remains unknown partly because the use of an elastic membrane sheet, conventionally necessary for inducing SF buckling with a mechanical compression to adherent cells, may limit high qu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.23410

    authors: Deguchi S,Matsui TS,Sato M

    更新日期:2012-03-01 00:00:00

  • Biochemical evidence on the potential role of methyl mercury in hepatic glucose metabolism through inflammatory signaling and free radical pathways.

    abstract::Methylmercury (MeHg) is an extremely important environmental toxicant posing serious health risks to human health and a big source of environmental pollutant. Numerous evidence available showing a link between nervous system toxicity and MeHg exposure. Other forms of mercury are reason of metabolic toxic effects and a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28899

    authors: Maqbool F,Bahadar H,Hassani S,Niaz K,Baeeri M,Rahimifard M,Ghasemi-Niri SF,Abdollahi M

    更新日期:2019-09-01 00:00:00

  • Oncogene expression in mammary epithelial cells.

    abstract::Mouse strains which develop tumors at a high incidence with characteristics very similar to human cancers have been derived over the last 8 years. The tumors are caused by defined genetic alterations in the mouse genome. Three areas of research have contributed to the derivation of these mouse strains: (1) Molecular a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240490205

    authors: Groner B

    更新日期:1992-06-01 00:00:00

  • Inhibition of extracellular ATP-mediated lysis of human macrophages by calmodulin antagonists.

    abstract::Lysis of human culture-derived macrophages by extracellular ATP has recently been described, and treatment of macrophages with interferon-gamma rendered those cells significantly more sensitive to lysis. In addition, cell death occurred more rapidly in interferon (IFN)-treated cells than in untreated macrophages. In a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240570311

    authors: Blanchard DK,Hoffman SL,Djeu JY

    更新日期:1995-03-01 00:00:00

  • Inhibitory effect of uremic solutions on protein-DNA-complex formation of the vitamin D receptor and other members of the nuclear receptor superfamily.

    abstract::Chronic renal failure is often associated with a resistance to the biologically active form of vitamin D(3), the nuclear hormone 1alpha, 25-dihydroxyvitamin D(3) (VD). The actions of VD are mediated by the vitamin D receptor (VDR), a ligand-dependent transcription factor that binds as a dimeric complex with the retino...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19990901)74:3<386::aid-jcb

    authors: Toell A,Degenhardt S,Grabensee B,Carlberg C

    更新日期:1999-09-01 00:00:00

  • Evidence for inhibition of MyEF-2 binding to MBP promoter by MEF-1/Pur alpha.

    abstract::Myelin basic protein (MBP) is a major component of the myelin sheath whose production is developmentally controlled during myelinogenesis. Earlier studies have indicated that programmed expression of the MBP gene is regulated at the level of transcription. Evidently, the MB1 regulatory motif located between nucleotide...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19970915)66:4<524::aid-jcb

    authors: Muralidharan V,Tretiakova A,Steplewski A,Haas S,Amini S,Johnson E,Khalili K

    更新日期:1997-09-15 00:00:00

  • RECK-mediated inhibition of glioma migration and invasion.

    abstract::RECK is an anti-tumoral gene whose activity has been associated with its inhibitory effects regulating MMP-2, MMP-9, and MT1-MMP. RECK level decreases as gliobastoma progresses, varying from less invasive grade II gliomas to very invasive human glioblastoma multiforme (GBM). Since RECK expression and glioma invasivene...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22472

    authors: Silveira Corrêa TC,Massaro RR,Brohem CA,Taboga SR,Lamers ML,Santos MF,Maria-Engler SS

    更新日期:2010-05-01 00:00:00

  • Increased apoptosis of periprostatic adipose tissue in VDR null mice.

    abstract::The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that controls mineral ion homeostatis and has potential tumor-suppressive functions for various cancer types, specifically prostate cancer. A VDR ablated transgenic animal model (VDDRII, vitamin D-dependent ricke...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20172

    authors: Guzey M,Jukic D,Arlotti J,Acquafondata M,Dhir R,Getzenberg RH

    更新日期:2004-09-01 00:00:00

  • Oxidative damage in glutaric aciduria type I patients and the protective effects of l-carnitine treatment.

    abstract::The deficiency of the enzyme glutaryl-CoA dehydrogenase, known as glutaric acidemia type I (GA-I), leads to the accumulation of glutaric acid (GA) and glutarilcarnitine (C5DC) in the tissues and body fluids, unleashing important neurotoxic effects. l-carnitine (l-car) is recommended for the treatment of GA-I, aiming t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27332

    authors: Guerreiro G,Faverzani J,Jacques CED,Marchetti DP,Sitta A,de Moura Coelho D,Kayser A,Kok F,Athayde L,Manfredini V,Wajner M,Vargas CR

    更新日期:2018-12-01 00:00:00

  • lncRNA expression signatures in periodontitis revealed by microarray: the potential role of lncRNAs in periodontitis pathogenesis.

    abstract::Periodontitis, a common chronic inflammatory disease of the periodontium, is caused by dental plaque formation induced by microorganisms. Recent studies have demonstrated that lncRNAs play a critical role in the regulation of gene expression and in the pathogenesis of diseases. To demonstrate that periodontitis is ass...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25015

    authors: Zou Y,Li C,Shu F,Tian Z,Xu W,Xu H,Tian H,Shi R,Mao X

    更新日期:2015-04-01 00:00:00

  • A novel messenger RNA and long noncoding RNA signature associated with the progression of nonmuscle invasive bladder cancer.

    abstract:AIM:To explore the molecular mechanism of nonmuscle invasive bladder cancer (NMIBC), matched normal, and cancer tissues of 10 NMIBC were examined for RNA sequencing. METHODS:We profiled the messenger RNA (mRNA) and long noncoding RNA (lncRNA) expression of patients with NMIBC. Differentially expressed mRNAs and lncRNA...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28089

    authors: He YH,Deng YS,Peng PX,Wang N,Wang JF,Ding ZS,Chen X,Zhou XF

    更新日期:2018-11-13 00:00:00

  • Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.

    abstract::Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26673

    authors: Yang JA,He JM,Lu JM,Jie LJ

    更新日期:2018-06-01 00:00:00

  • Sexual differences in 5'-deiodinase activity in the Harderian gland of Syrian hamsters and the effect of pinealectomy: regulation by androgens.

    abstract::Sexual differences on thyroxin 5'-deiodinase (5'-D) in the Harderian gland of Syrian hamsters were investigated. We compared the 24-h profile of 5'-D activity in male and female hamsters, observing a clear rhythm in males but not in females. Female values were always significantly higher than male ones. After pinealec...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4644(199609)62:3%3C397::AID-JCB

    authors: Rubio A,Menendez-Pelaez A,Buzzell GR,Vaughan MK,Vaughan GM,Reiter RJ

    更新日期:1996-09-01 00:00:00

  • 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside eliminates ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis involving in Bcl-2, Bax, caspase-3, and Akt activation.

    abstract:OBJECTIVE:This study was designed to explore the protective effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against ischemia/reperfusion (I/R) injury-induced cardiomyocytes apoptosis. METHODS:The H9c2 cell I/R injury model was induced by simultaneous shortage of nutrients and oxygen. TSG administration...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27949

    authors: Sun T,Liu H,Cheng Y,Yan L,Krittanawong C,Li S,Qian W,Su W,Chen X,Hou X,Zhang H

    更新日期:2019-03-19 00:00:00

  • Kips off to Myc: implications for TGF beta signaling.

    abstract::Loss of sensitivity to the negative growth regulator transforming growth factor beta (TGF beta) is a feature of many different tumor types and is likely involved in tumor progression. In some cases this loss of sensitivity to TGF beta has been shown to be manifest in the absence of membrane-associated TGF beta recepto...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Alexandrow MG,Moses HL

    更新日期:1997-09-15 00:00:00

  • Effects of S100A12 gene silencing on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats through the ERK signaling pathway.

    abstract::We explored the effect of S100A12 gene on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats by activating the extracellular signal-regulated kinase (ERK) signaling pathway. A total of 180 specific pathogen-free (SPF) rats were purchased to establish cecal ligation and puncture (CLP) model. Ra...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26568

    authors: Wen X,Han XR,Wang YJ,Fan SH,Zhang ZF,Wu DM,Lu J,Zheng YL

    更新日期:2018-05-01 00:00:00

  • Protected regions in the chicken alpha 2(1) procollagen promoter in differentiated tissues.

    abstract::The higher ordered structure of the chicken alpha 2(1) procollagen gene was analyzed in chromatin isolated from expressing (lung) and nonexpressing (reticulocyte and erythrocyte) tissues. Digestion of DNA with methylation sensitive restriction endonucleases revealed that this gene was methylated in all tissues examine...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240540204

    authors: Truter SL,Parker MI

    更新日期:1994-02-01 00:00:00

  • Fluid flow induces Rankl expression in primary murine calvarial osteoblasts.

    abstract::Mechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor kappa B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20864

    authors: Mehrotra M,Saegusa M,Wadhwa S,Voznesensky O,Peterson D,Pilbeam C

    更新日期:2006-08-01 00:00:00

  • Advance in research of microRNA in Caenorhabditis elegans.

    abstract::microRNA (miRNA) is a family of small, non-coding RNA first discovered as an important regulator of development in Caenorhabditis elegans (C. elegans). Numerous miRNAs have been found in C. elegans, and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.24448

    authors: Liu J,Yang B,Ai J

    更新日期:2013-05-01 00:00:00

  • Ebselen inhibits the activity of acetylcholinesterase globular isoform G4 in vitro and attenuates scopolamine-induced amnesia in mice.

    abstract::There is a well-known relationship between the cholinergic system and learning, memory, and other common cognitive processes. The process for researching and developing new drugs has lead researchers to repurpose older ones. This study investigated the effects of ebselen on the activity of acethylcholinesterase (AChE)...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26731

    authors: Martini F,Pesarico AP,Brüning CA,Zeni G,Nogueira CW

    更新日期:2018-07-01 00:00:00

  • Regulation of 25-hydroxyvitamin D3-24-hydroxylase mRNA by 1,25-dihydroxyvitamin D3 and parathyroid hormone.

    abstract::The 25-hydroxyvitamin D(3)-24-hydroxylase mRNA is tightly and reciprocally regulated by 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) and parathyroid hormone (PTH). The upregulation of the 24-hydroxylase by 1,25(OH)(2)D(3) is well established and occurs at the transcriptional level through two vitamin D response elemen...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.10341

    authors: Zierold C,Mings JA,DeLuca HF

    更新日期:2003-02-01 00:00:00

  • Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest.

    abstract::Melphalan (MEL) is a chemotherapeutic agent used in breast cancer therapy; however, MEL's side effects limit its clinical applications. In the last 20 years, resveratrol (RSV), a polyphenol found in grape skins, has been proposed to reduce the risk of cancer development. The aim of this study was to investigate whethe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24134

    authors: Casanova F,Quarti J,da Costa DC,Ramos CA,da Silva JL,Fialho E

    更新日期:2012-08-01 00:00:00

  • Inhibition of metastatic potential by fucosidase: an NMR study identifies a cell surface metastasis marker.

    abstract::NMR spectroscopy is able to detect subtle changes to the surface chemistry of cells. We have previously shown that high-resolution 1H NMR methods can identify tumor cells with the capacity to metastasize, and we now report that the long T2 relaxation value (500-800 ms) observed in metastatic rat mammary adenocarcinoma...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240370106

    authors: Wright LC,May GL,Gregory P,Dyne M,Holmes KT,Williams PG,Mountford CE

    更新日期:1988-05-01 00:00:00

  • Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts.

    abstract::Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20473

    authors: Fang Y,Svoboda KK

    更新日期:2005-08-15 00:00:00

  • Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells.

    abstract::Occupational exposure to nickel has been epidemiologically linked to increased cancer risk in the respiratory tract. Nickel-induced cell transformation is associated with both genotoxic and epigenetic mechanisms that are poorly understood. Prolidase [E.C.3.4.13.9] is a cytosolic Mn(II)-activated metalloproteinase that...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20384

    authors: Miltyk W,Surazynski A,Kasprzak KS,Fivash MJ Jr,Buzard GS,Phang JM

    更新日期:2005-04-15 00:00:00

  • miR-150-504-519d inhibits the growth of human colorectal cancer cell line SW48 and downregulates c-FLIP receptor.

    abstract::microRNAs (miRNAs) are noncoding RNAs that regulates the expression of target messenger RNAs (mRNAs). c-FLIP is an inhibitor of cell apoptosis through inhibition of caspase 8. miR-150, miR-504, and miR-519d were related to cancer cell proliferation, invasion, and migration in colorectal cancer (CRC). However, the role...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28073

    authors: Rong G,Yang X,Wu H,Wu Y

    更新日期:2018-12-12 00:00:00

  • Repression of let-7b-5p prevents the development of multifidus muscle dysfunction by promoting vitamin D accumulation via upregulation of electron transfer flavoprotein alpha subunit in a rat model of multifidus muscle injury.

    abstract::Multifidus muscle dysfunction is associated with the multifidus muscle injury (MMI), which ultimately result in the low-back pain. Increasing evidence shows that microRNAs (miRs) may be involved in multifidus muscle dysfunction. In this study, we tested the hypothesis that downregulation of let-7b-5p may inhibit the m...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28020

    authors: Yu HM,Yao XD,Zhang RM,Zhuang HF,Wang PW,Li YZ

    更新日期:2018-11-01 00:00:00

  • Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644.

    abstract::The effect of regucalcin, a regulatory protein in intracellular signaling pathway, on cell death was investigated by using the cloned rat hepatoma H4-II-E cells overexpressing regucalcin. The hepatoma cells (wild-type) and stable regucalcin (RC)/pCXN2 transfectants were cultured for 72 h in medium containing 10% fetal...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20214

    authors: Izumi T,Yamaguchi M

    更新日期:2004-10-15 00:00:00