Clinical aspects of circulating miRNA-335 in breast cancer patients: A prospective study.


BACKGROUND:The impact of aberrant expression of miRNAs, small noncoding RNAs of 19 to 23 nucleotide, has been reported in different types of cancer, such as breast cancer. Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer. MATERIALS AND METHODS:miRNA-335 expression was measured in primary breast cancer patients (n = 106), patients with benign breast lesion (n = 49) and healthy individuals as control (n = 40) using quantitative real-time polymerase chain reaction and its diagnostic efficacy, relation with clinicopathological factors, and disease-free survival (DFS) and overall survival (OS) were assessed. RESULTS:A significant decrease in miRNA-335 expression was reported in patients with breast cancer as compared to the other two investigated groups. The positivity rate for miRNA were related to adverse clinical features of primary breast cancer as high histological grading (X2  = 7.72, P = 0.016), presence of metastasis to lymph node (X2  = 21.8, P < 0.001), large tumor size (X2  = 6.41, P = 0.041), and hormonal status (P < 0.001). miRNA-335 mean rank level was significantly different among breast cancer subtypes and its level was inferior in triple negative breast cancer. Worse DFS (X2  = 7.76, P = 0.005) and OS (X2  = 9.3, P = 0.002) were reported with decreased miRNA-335 level. CONCLUSION:Assessment of circulating miRNA expression level is a promising minimal invasive marker for diagnosis and prediction of breast cancer prognosis with significant discrepancies among molecular breast cancer subtypes.


J Cell Biochem


Swellam M,Mahmoud MS,Hashim M,Hassan NM,Sobeih ME,Nageeb AM




Has Abstract


2019-06-01 00:00:00












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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Otth C,Torres M,Ramírez A,Fernandez JC,Castro M,Rauch MC,Brito M,Yañez AJ,Rodríguez-Gil JE,Slebe JC,Concha II

    更新日期:2007-01-01 00:00:00

  • Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.

    abstract::In our previous study, preliminary data indicates that Poria cocos polysaccharides (PCP) shows beneficial hepatoprotection against acetaminophen (APAP)-induced liver injury in mice. However, biological molecular mechanism warrants to be further discussed. In current study, a number of biochemical tests and immunoassay...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wu K,Guo C,Yang B,Wu X,Wang W

    更新日期:2019-05-01 00:00:00

  • Comprehensive analysis of novel three-long noncoding RNA signatures as a diagnostic and prognostic biomarkers of human triple-negative breast cancer.

    abstract::Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Fan CN,Ma L,Liu N

    更新日期:2019-03-01 00:00:00

  • Remodelling of the nuclear periphery during muscle cell differentiation in vitro.

    abstract::We have examined the composition and ultrastructure of the nuclear periphery during in vitro myogenesis of the rat myoblast cell line, L6E9. Immunofluorescence labelling and immunoblotting showed that lamins A/C and B were all present in undifferentiated cells, but that they increased significantly before extensive ce...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Chaly N,Munro SB,Swallow MA

    更新日期:1996-07-01 00:00:00

  • Celecoxib enhanced the sensitivity of cancer cells to anticancer drugs by inhibition of the expression of P-glycoprotein through a COX-2-independent manner.

    abstract::The P-glycoprotein (p170, P-gp) encoded by human MDR1 gene functions as a pump to extrude anticancer drugs from cancer cells. Over-expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression of cyclooxygenase-2 (COX-2) is posit...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xia W,Zhao T,Lv J,Xu S,Shi J,Wang S,Han X,Sun Y

    更新日期:2009-09-01 00:00:00

  • Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes.

    abstract::In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a putative L-leucine r...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lynch CJ,Fox HL,Vary TC,Jefferson LS,Kimball SR

    更新日期:2000-03-01 00:00:00

  • Signaling roles of diacylglycerol kinases.

    abstract::Diacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution. Their kinase activity is regulated by mechanisms that modify th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Topham MK

    更新日期:2006-02-15 00:00:00

  • Microrna-139-5p inhibits epithelial-mesenchymal transition and fibrosis in post-menopausal women with interstitial cystitis by targeting LPAR4 via the PI3K/Akt signaling pathway.

    abstract::The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jiang C,Tong Z,Fang WL,Fu QB,Gu YJ,Lv TT,Liu DM,Xue W,Lv JW

    更新日期:2018-08-01 00:00:00

  • Functional comparison of high and low molecular weight basic fibroblast growth factors.

    abstract::Acid-electrolyzed functional water (FW) is obtained through the electrolysis of sodium chloride solution. Stimulation of the human fibroblastic cell line HeLa by FW led to the augmented secretion of basic fibroblast growth factor (bFGF). Immunoprecipitation followed by Western blot analysis revealed that both high and...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Motozawa K,Motoyoshi M,Saiki A,Sasaki H,Shimizu N,Asano M

    更新日期:2018-09-01 00:00:00

  • Further characterization of the human cell multiprotein DNA replication complex.

    abstract::Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

    更新日期:1995-09-01 00:00:00

  • IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry.

    abstract::Insulin-like growth factor I (IGF-1) is a well-established mitogen to many different cell types and is implicated in progression of a number of human cancers, notably breast cancer. The prolyl isomerase Pin1 plays an important role in cell cycle regulation through its specific interaction with proteins that are phosph...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: You H,Zheng H,Murray SA,Yu Q,Uchida T,Fan D,Xiao ZX

    更新日期:2002-01-01 00:00:00

  • AUF1-like protein binds specifically to DAS cis-acting element that regulates mouse alpha-fetoprotein gene expression.

    abstract::Alpha-fetoprotein (AFP) is one of the major serum proteins in the early life of mammals. We have previously identified a novel cis-acting element designated as DAS at the 5'-flanking region of the AFP gene and demonstrated that the DAS sequence can be specifically recognized by nuclear protein DAP-II in AFP-producing ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jiao R,He QY,Chen H,Hua Z,Jiao Q,Chiu JF

    更新日期:2006-08-01 00:00:00

  • Loss of BMI-1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD-2/MyD88-mediated NF-κB signaling.

    abstract::Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ye K,Chen QW,Sun YF,Lin JA,Xu JH

    更新日期:2018-02-01 00:00:00

  • The detergent solubility properties of a malarial (Plasmodium knowlesi) variant antigen expressed on the surface of infected erythrocytes.

    abstract::Four detergents have been compared for identification of the Plasmodium knowlesi variant antigen on infected erythrocytes by immunoprecipitation analysis. Erythrocytes infected with late trophozoite and schizont forms of cloned asexual parasites were labeled by lactoperoxidase-catalyzed radioiodination and extracted e...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Howard RJ,Barnwell JW

    更新日期:1984-01-01 00:00:00

  • Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial.

    abstract::Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Gharipour M,Ouguerram K,Nazih EH,Salehi M,Behmanesh M,Roohafza H,Hosseini SM,Nezafati P,Dianatkhah M,Gharipour A,Haghjoo S,Sarrafzadegan N,Sadeghi M

    更新日期:2018-11-01 00:00:00

  • Oxidative stress-induced attenuation of thrombospondin-1 expression in primary rat astrocytes.

    abstract::Astrocytes, the major glial population in the central nervous system (CNS), can secrete thrombospondin (TSP)-1 that plays the role in synaptogenesis and axonal sprouting during CNS development and tissue repair. However, little is known about the regulation of TSP-1 expression in astrocytes under oxidative stress cond...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Chen JK,Zhan YJ,Yang CS,Tzeng SF

    更新日期:2011-01-01 00:00:00

  • Bevacizumab and ranibizumab on microvascular endothelial cells: A comparative study.

    abstract::Given its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate-limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two of these therapeutic agents already in clinical use. Bevacizumab was first used for c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Costa R,Carneiro A,Rocha A,Pirraco A,Falcão M,Vasques L,Soares R

    更新日期:2009-12-15 00:00:00

  • Characterization of tumors produced by signal peptide-basic fibroblast growth factor-transformed cells.

    abstract::Basic fibroblast growth factor (bFGF) is found in a variety of cells and tissues. We have previously shown that bFGF is a transforming growth factor, but only when fused to a signal peptide (sp-bFGF). Cells expressing the native bFGF are tumorigenic in nude mice only, where the tumors form at a low frequency and grow ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rogelj S,Weinberg RA,Fanning P,Klagsbrun M

    更新日期:1989-01-01 00:00:00

  • Comparative proteome analysis of 3T3-L1 adipocyte differentiation using iTRAQ-coupled 2D LC-MS/MS.

    abstract::Adipose tissue is critical in obesity and type II diabetes. Blocking of adipocyte differentiation is one of the anti-obesity strategies targeting on strong rise in fat storage and secretion of adipokine(s). However, the molecular basis of adipocyte differentiation and its regulation remains obscure. Therefore, we expo...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ye F,Zhang H,Yang YX,Hu HD,Sze SK,Meng W,Qian J,Ren H,Yang BL,Luo MY,Wu X,Zhu W,Cai WJ,Tong JB

    更新日期:2011-10-01 00:00:00

  • LncRNA CRNDE promotes the epithelial-mesenchymal transition of hepatocellular carcinoma cells via enhancing the Wnt/β-catenin signaling pathway.

    abstract::Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and functi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhu L,Yang N,Du G,Li C,Liu G,Liu S,Xu Y,Di Y,Pan W,Li X

    更新日期:2018-11-14 00:00:00

  • Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes.

    abstract::Osterix is a recently identified zinc-finger-containing transcription factor, which is required for skeletogenesis as no bone formation was observed in osterix-deficient mice. Osterix was first cloned as a gene whose expression was enhanced by BMP in C2C12 cells. As BMP induces ectopic bone formation in vivo via a pat...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yagi K,Tsuji K,Nifuji A,Shinomiya K,Nakashima K,DeCrombrugghe B,Noda M

    更新日期:2003-04-15 00:00:00

  • A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing.

    abstract::A variant human H2B histone gene (GL105), previously shown to encode a 2300 nt replication independent mRNA, has been cloned. We demonstrate this gene expresses alternative mRNAs regulated differentially during the HeLa S3 cell cycle. The H2B-Gl105 gene encodes both a 500 nt cell cycle dependent mRNA and a 2300 nt con...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Collart D,Romain PL,Huebner K,Pockwinse S,Pilapil S,Cannizzaro LA,Lian JB,Croce CM,Stein JL,Stein GS

    更新日期:1992-12-01 00:00:00

  • Effects of c-Jun and a negative dominant mutation of c-Jun on differentiation and gene expression in lens epithelial cells.

    abstract::We have used a retroviral vector (RCAS) to overexpress wild-type chicken c-Jun or a deletion mutant of chicken c-Jun (Jun delta 7) lacking the DNA binding region to investigate the possible role of c-Jun in lens epithelial cell proliferation and differentiation. Both constructs were efficiently expressed in primary cu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rinaudo JA,Vacchiano E,Zelenka PS

    更新日期:1995-06-01 00:00:00

  • Control of expression and maturation of epidermal growth factor receptor.

    abstract::Epidermal growth factor (EGF)-receptor is a 170 kDa transmembrane glycoprotein that contains a ligand-binding external domain, and a catalytically active cytoplasmic region. The expression of this receptor as well as a 100 kDa homolog that contains only the external domain is enhanced by the ligand EGF. EGF acts at tr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Das M,Kesavan P,Khire J

    更新日期:1990-09-01 00:00:00

  • Differentiation in Acanthamoeba castellanii is induced by specific monoclonal antibodies.

    abstract::Monoclonal antibodies that bind a large molecular weight plasma membrane protein of Acanthamoeba castellanii cause the cells to differentiate. A different monoclonal antibody that binds specifically to the major plasma membrane protein has no effect upon cell division or differentiation. The induction of differentiati...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Villemez CL,Carlo PL,Russell MA

    更新日期:1985-01-01 00:00:00

  • Molecular profile of ultrastructure changes of the ligamentum flavum related to lumbar spinal canal stenosis.

    abstract::Lumbar spinal canal stenosis (LSCS) is a degenerative disease observed by hypertrophy of the ligamentum flavum (LF) that cause compression of the lumbar neural content. Diabetes mellitus (DM) is a risk factor for the disease and we have shown previously that DM increases the fibrosis and elastic fiber loss in patients...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sidon E,Shemesh SS,Mor-Yossef Moldovan L,Wiesenfeld Y,Ohana N,Benayahu D

    更新日期:2019-03-01 00:00:00

  • The haemochromatosis candidate gene HFE (HLA-H) of man and mouse is located in syntenic regions within the histone gene cluster.

    abstract::The HFE (HLA-H) gene is a strong candidate gene for hereditary haemochromatosis and was localized on the short arm of chromosome 6 to 6p21.3-p22. In addition, the sequence of the homologous mouse and rat cDNA and a partial sequence from the mouse gene have been reported recently. In this report, we describe the locati...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Albig W,Drabent B,Burmester N,Bode C,Doenecke D

    更新日期:1998-05-01 00:00:00

  • Identification of the chick neural retina cell surface N-acetylgalactosaminyltransferase using monoclonal antibodies.

    abstract::Intact embryonic chick neural retina cells have at their surface an N-acetylgalactosaminyltransferase which catalyzes the incorporation of N-acetylgalactosamine from UDP-N-acetylgalactosamine into endogenous macromolecular acceptors. The enzyme along with its endogenous acceptors can be isolated as a particulate compl...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Balsamo J,Pratt RS,Emmerling MR,Grunwald GB,Lilien J

    更新日期:1986-01-01 00:00:00

  • Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells.

    abstract::It has drawn a lot of attention to target signal transducer and activator of transcription 3 (STAT3) as a potential strategy for cancer therapeutics. Using several myelogenous cell lines, the effect of genipin (an active compound of Gardenia fruit) on the STAT3 pathway and apoptosis was investigated. Genipin suppresse...

    journal_title:Journal of cellular biochemistry

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    authors: Lee JC,Ahn KS,Jeong SJ,Jung JH,Kwon TR,Rhee YH,Kim SH,Kim SY,Yoon HJ,Zhu S,Chen CY,Kim SH

    更新日期:2011-06-01 00:00:00

  • Role of immune system in tumor progression and carcinogenesis.

    abstract::Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that help...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Upadhyay S,Sharma N,Gupta KB,Dhiman M

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