Inhibition of thyroid-restricted genes by follicular thyroglobulin involves iodinated degree.

abstract：:Betulinic acid (BA), a pentacyclic triterpene derived from the bark of the white birch tree, has been reported to have a variety of pharmacological effects, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and antiarthritis properties. However, the role of BA in rheumatoid arthritis (RA) remains ...

journal_title：Journal of cellular biochemistry

authors： Wang J,Zhao Q

更新日期：2018-10-26 00:00:00

abstract：:Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that ...

journal_title：Journal of cellular biochemistry

authors： Li Q,Tang H,Hu F,Qin C

更新日期：2019-03-01 00:00:00

abstract：:Limited information is available on the expression and role of matrix metalloproteinase (MMP)-12 in chondrocytes. We characterized the expression mechanism of MMP-12 and possible function in chondrocytes. Interleukin (IL)-1beta induced the expression and activation of MMP-12 in primary culture chondrocytes and cartila...

journal_title：Journal of cellular biochemistry

authors： Oh H,Yang S,Park M,Chun JS

更新日期：2008-12-15 00:00:00

abstract：:Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association wi...

journal_title：Journal of cellular biochemistry

authors： Isackson PJ,Dunbar JC,Bradshaw RA

更新日期：1987-01-01 00:00:00

abstract：:Osteoclasts are macrophage-derived polykaryons that degrade bone in an acidic extracellular space. This differentiation includes expression of proteinases and acid transport proteins, cell fusion, and bone attachment, but the sequence of events is unclear. We studied two proteins expressed at high levels only in the o...

journal_title：Journal of cellular biochemistry

authors： Blair HC,Sidonio RF,Friedberg RC,Khan NN,Dong SS

更新日期：2000-06-12 00:00:00

abstract：:Arsenic is a well-known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to examine the effect o...

journal_title：Journal of cellular biochemistry

authors： Habib GM

更新日期：2010-05-15 00:00:00

abstract：:Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas severa...

journal_title：Journal of cellular biochemistry

authors： Adamopoulos C,Gargalionis AN,Piperi C,Papavassiliou AG

更新日期：2017-02-01 00:00:00

abstract：:Anemia is associated with chemotherapy treatment in cancer patients. Erythropoietin (EPO) has been used to treat anemia of cancer patients, because it stimulates erythropoiesis. However, treatment of breast cancer patients with EPO has been associated with poor prognosis and decrease of survival. Epithelial to mesench...

journal_title：Journal of cellular biochemistry

authors： Ordoñez-Moreno A,Rodriguez-Monterrosas C,Cortes-Reynosa P,Perez-Carreon JI,Perez Salazar E

更新日期：2017-09-01 00:00:00

abstract：:We have compared the cytotoxic/cytostatic responses of the SKW6.4 lymphoblastoid B-cells to the alkylating agent chlorambucil, the purine analog fludarabine, the non-genotoxic activator of the p53 pathway, Nutlin-3, used alone or in association with the death-inducing ligand recombinant TRAIL. Exposure to chlorambucil...

journal_title：Journal of cellular biochemistry

authors： Barbarotto E,Corallini F,Rimondi E,Fadda R,Mischiati C,Grill V,Vaccarezza M,Celeghini C

更新日期：2008-05-15 00:00:00

abstract：:Formyl peptide receptors (FPRs) are a family of classical chemoattractant receptors. Although FPRs are mainly expressed in phagocytic innate immune cells including monocytes/macrophages and neutrophils, recent reports demonstrated that additional different cell types such as T-lymphocytes and several non-immune cells ...

journal_title：Journal of cellular biochemistry

authors： Lee HY,Lee M,Bae YS

更新日期：2017-06-01 00:00:00

abstract：:Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short- and long-term repopulating stem cells when compared to more mature bone marrow...

journal_title：Journal of cellular biochemistry

authors： Krivtsov AV,Rozov FN,Zinovyeva MV,Hendrikx PJ,Jiang Y,Visser JW,Belyavsky AV

更新日期：2007-06-01 00:00:00

abstract：:The transcription factors of the nuclear hormone receptor family regulate gene expression via a complex network of macromolecular interactions. The ligand dependent activity of the vitamin D receptor is of particular interest because it modulates gene expression by the heterodimeric interaction with retinoid X recepto...

journal_title：Journal of cellular biochemistry

authors： Berghöfer-Hochheimer Y,Zurek C,Langer G,Munder T

更新日期：1997-08-01 00:00:00

abstract：:Several studies have shown the important actions of cytokine leptin that regulates food intake and energy expenditure. Additionally, the ability to modulate hematopoiesis has also been demonstrated. Previous reports have shown that some synthetic sequences of leptin molecules can activate leptin receptor. Herein, deca...

journal_title：Journal of cellular biochemistry

authors： Dias CC,Nogueira-Pedro A,Tokuyama PY,Martins MN,Segreto HR,Buri MV,Miranda A,Paredes-Gamero EJ

更新日期：2015-07-01 00:00:00

abstract：:We have cloned and sequenced a genomic DNA fragment of chicken containing a cluster of DNase I hypersensitive sites (DHS) located 11-15 kb upstream from the first gene of the alpha-globin gene domain and including a constitutive DHS flanked by two erythroid-specific ones. A 1.2-kb subfragment of the DNA fragment under...

journal_title：Journal of cellular biochemistry

authors： Razin SV,Shen K,Ioudinkova E,Scherrer K

更新日期：1999-07-01 00:00:00

abstract：:Given its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate-limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two of these therapeutic agents already in clinical use. Bevacizumab was first used for c...

journal_title：Journal of cellular biochemistry

authors： Costa R,Carneiro A,Rocha A,Pirraco A,Falcão M,Vasques L,Soares R

更新日期：2009-12-15 00:00:00

abstract：:The higher ordered structure of the chicken alpha 2(1) procollagen gene was analyzed in chromatin isolated from expressing (lung) and nonexpressing (reticulocyte and erythrocyte) tissues. Digestion of DNA with methylation sensitive restriction endonucleases revealed that this gene was methylated in all tissues examine...

journal_title：Journal of cellular biochemistry

authors： Truter SL,Parker MI

更新日期：1994-02-01 00:00:00

abstract：:Whitmania pigra is a unique, fluid-sucking ectoparasite and an anticoagulant medical leech. The codon usage bias (CUB) is the nonuniform usage of synonymous codons in which some codons are more preferred than others. Here, we performed a comprehensive analysis of CUB of genes in W. pigra, analyzing 140 780 transcripts...

journal_title：Journal of cellular biochemistry

authors： Khan MS,Guan DL,Ma LB,Xie JY,Xu SQ

更新日期：2019-06-01 00:00:00

abstract：:Emerging evidence indicates that activation of Wnt/β-catenin signaling at the cell surface results in inhibition of glycogen synthase kinase 3β (GSK3β), leading to activation of mTORC1 signaling in cancer cells. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-cat...

journal_title：Journal of cellular biochemistry

authors： Lu W,Li Y

更新日期：2014-10-01 00:00:00

abstract：:Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

journal_title：Journal of cellular biochemistry

authors： Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

更新日期：2012-07-01 00:00:00

abstract：:Autophosphorylation is an important mechanism by which protein kinases regulate their own biological activities. Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also features autophosphorylation activity. We provide evidence that Ser186 i...

journal_title：Journal of cellular biochemistry

authors： Hashimoto YK,Satoh T,Okamoto M,Takemori H

更新日期：2008-08-01 00:00:00

abstract：:Inhibition of metabolic features which distinguish cancer cells from their non-malignant counterparts is a promising approach to cancer treatment. Energy support for drug extrusion in multidrug resistance (MDR) is a potential target for metabolic inhibition. Two major sources of ATP-based metabolic energy are partial ...

journal_title：Journal of cellular biochemistry

authors： Koshkin V,Ailles LE,Liu G,Krylov SN

更新日期：2016-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is one of the malignant type of breast cancer. Previous study indicated that long noncoding RNA (lncRNA) ZEB1-AS1 was associated with the progression of several cancers. However, its underlying molecular mechanism in TNBC remains to be elucidated. In this study, ZEB1-AS1 expression...

journal_title：Journal of cellular biochemistry

authors： Luo N,Zhang K,Li X,Hu Y

更新日期：2020-10-01 00:00:00

abstract：:Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induct...

journal_title：Journal of cellular biochemistry

authors： Al-Rasheed NM,Al-Rasheed NM,Al-Rabeeah DA,Al-Barrak HS,Al-Salman SA,Ibrahim SA,Al-Hassab SA,Al-Amin MA,Hasan IH,Al-Ajmi HN,Al-Shammari TK

更新日期：2018-05-01 00:00:00

abstract：:9-cis Retinoic acid (RA) induces gene expression in neuroblastoma cells more effectively and with different kinetics than other RA isomers, and could be acting in part through Retinoid X Receptors (RXRs). The aim of this study was to characterise the effects of an RXR agonist and RXR homodimer antagonist on the induct...

journal_title：Journal of cellular biochemistry

authors： Hewson QC,Lovat PE,Pearson AD,Redfern CP

更新日期：2002-01-01 00:00:00

abstract：:Alkaline phosphatase (ALP) refers to a group of nonspecific phosphomonoesterases located primarily in cell plasma membrane. It has been described in different cell lines that ecto-ALP is directly or indirectly involved in the modulation of organic cation transport. We aimed to investigate, in Caco-2 cells, a putative ...

journal_title：Journal of cellular biochemistry

authors： Calhau C,Martel F,Hipólito-Reis C,Azevedo I

更新日期：2002-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the main subtype of renal cell carcinoma with varied prognosis. We aimed to identify and assess the possible prognostic long noncoding RNA (lncRNA) biomarkers. LncRNAs expression data and corresponding clinical information of 619 ccRCC patients were downloaded from The Cancer...

journal_title：Journal of cellular biochemistry

authors： Zhang C,Huang D,Liu A,Xu Y,Na R,Xu D

更新日期：2020-03-01 00:00:00

abstract：:Homocysteine-thiolactone (HcyT) is a toxic product whose synthesis is directly proportional to plasma homocysteine (Hcy) levels. Previous studies demonstrated that the interaction between HcyT and low density lipoproteins (LDL) induces the formation of homocystamide-LDL adducts (Hcy-LDL). Structural and functional alt...

journal_title：Journal of cellular biochemistry

authors： Ferretti G,Bacchetti T,Moroni C,Vignini A,Nanetti L,Curatola G

更新日期：2004-05-15 00:00:00

abstract：AIM:To detect the expression and identify the role of Ribosomal protein S15A (RPS15A) in human breast cancer (BC). METHODS:Immunohistochemistry (IHC) was carried out for detecting the levels of RPS15A protein. Quantitative PCR was used to evaluate the mRNA level of RPS15A in one normal breast and three BC cell lines. ...

journal_title：Journal of cellular biochemistry

authors： Kong L,Wei Q,Hu X,Chen L,Li J

更新日期：2020-01-01 00:00:00

abstract：:Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated...

journal_title：Journal of cellular biochemistry

authors： Yang F,Li T,Dong Z,Mi R

更新日期：2018-02-01 00:00:00

abstract：:We previously identified human CAP, a homolog of the yeast adenylyl cyclase-associated protein. Previous studies suggest that the N-terminal and C-terminal domains of CAP have distinct functions. We have explored the interactions of human CAP with various proteins. First, by performing yeast two-hybrid screens, we hav...

journal_title：Journal of cellular biochemistry

authors： Hubberstey A,Yu G,Loewith R,Lakusta C,Young D

更新日期：1996-06-01 00:00:00