Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury.

abstract：:The ATP-dependent transformation of crenated white human erythrocyte ghosts into smoothed disc and cup forms is inhibited by the soluble 40-45-kilodalton (kDa) cytoplasmic portion of the major transmembrane protein, band 3. The band 3 fragment was prepared by chymotryptic treatment of inverted vesicles stripped of per...

journal_title：Journal of cellular biochemistry

authors： Carter DP,Fairbanks G

更新日期：1984-01-01 00:00:00

abstract：:The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PT...

journal_title：Journal of cellular biochemistry

authors： Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen J

更新日期：2020-02-01 00:00:00

abstract：:Follicular thyroglobulin (TG) reflects the storage of both iodine and thyroid hormone. This is because it is a macromolecular precursor of thyroid hormone and organic iodinated compound in follicular lumen. Thus, it may have an important feedback role in thyroid function. In this study, monolayer cells were cultured a...

journal_title：Journal of cellular biochemistry

authors： Huang H,Shi Y,Lin L,Li L,Lin X,Li X,Xu D

更新日期：2011-03-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disabilities worldwide. MicroRNA-377 (miR-377) plays important roles in ischemic injury. The present study focused on the mechanisms of miR-377 in protecting ischemic brain injury in rats. Cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in rats. Primary ...

journal_title：Journal of cellular biochemistry

authors： Fan Y,Ding S,Sun Y,Zhao B,Pan Y,Wan J

更新日期：2018-01-01 00:00:00

abstract：:1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to vitamin D...

journal_title：Journal of cellular biochemistry

authors： Harant H,Spinner D,Reddy GS,Lindley IJ

更新日期：2000-04-01 00:00:00

abstract：:Carboxylic acids have various biological activities and play critical roles in cellular metabolic pathways such as the tricarboxylic acid (TCA) cycle. It has been shown that some carboxylic acids induce cell proliferation and production of cytokines or growth factors. However, there have been no reports on effects of ...

journal_title：Journal of cellular biochemistry

authors： Motoki T,Sugiura Y,Matsumoto Y,Tsuji T,Kubota S,Takigawa M,Gohda E

更新日期：2008-07-01 00:00:00

abstract：AIM:To detect the expression and identify the role of Ribosomal protein S15A (RPS15A) in human breast cancer (BC). METHODS:Immunohistochemistry (IHC) was carried out for detecting the levels of RPS15A protein. Quantitative PCR was used to evaluate the mRNA level of RPS15A in one normal breast and three BC cell lines. ...

journal_title：Journal of cellular biochemistry

authors： Kong L,Wei Q,Hu X,Chen L,Li J

更新日期：2020-01-01 00:00:00

abstract：:The retinoblastoma susceptibility gene product, p105Rb (RB), is generally believed to be an important regulator in the control of cell growth, differentiation, and apoptosis. Several cellular factors that form complexes with RB and exert their cellular regulatory functions have been identified, such as the newly ident...

journal_title：Journal of cellular biochemistry

authors： Cui Y,Mirkia K,Florence Fu YH,Zhu L,Yokoyama KK,Chiu R

更新日期：2002-01-01 00:00:00

abstract：:As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 in invasion of breast cancers is still unclear. Here we report that the expression of UCH-L1 is significantly higher in cancer cells with higher invasive abilit...

journal_title：Journal of cellular biochemistry

authors： Luo Y,He J,Yang C,Orange M,Ren X,Blair N,Tan T,Yang JM,Zhu H

更新日期：2018-01-01 00:00:00

abstract：:Glucocorticoids (GCs) modulate insulin-like growth factor action in cartilage through mechanisms that are complex and insufficiently defined, especially in the context of cranio-facial growth. Because the family of IGF-binding proteins (IGFBP-1 to -6) is important in the regulation of IGF availability and bioactivity,...

journal_title：Journal of cellular biochemistry

authors： Nadra R,Menuelle P,Chevallier S,Berdal A

更新日期：2003-04-01 00:00:00

abstract：:The objective of this study was to evaluate the genotoxic and mutagenic effects of the toxins present in Lachesis muta muta's venom on human peripheral blood leukocytes and the protective potential of ascorbic acid on DNA fragmentation. The venom of L. muta muta was incubated in different concentrations (1, 2.5, 5, 7....

journal_title：Journal of cellular biochemistry

authors： Cardoso Trento MV,de Faria Eleutério MW,Silva Abreu T,Andrade Machado GH,Cesar PHS,Assaid Simão A,Marcussi S

更新日期：2019-03-01 00:00:00

abstract：:This study aimed to elucidate the precise mechanisms underlying the protective effects of phosphoseryl-tRNA kinase (PSTK) against cisplatin-induced podocyte injury. PSTK overexpression and knockdown vectors were generated and transfected into murine podocyte cells-5. PSTK levels were measured, and transcriptome sequen...

journal_title：Journal of cellular biochemistry

authors： Zheng D,Zhao Y,Liu L,Sun X,Xia Y,Sun L,Xie K

更新日期：2019-06-01 00:00:00

abstract：:The activity of S6 kinases (S6K) is highly induced in cancer cells highlighting an essential role in carcinogenesis. The S6K family has two members: S6K1 and S6K2 which bear common as well as distinct features. In an attempt to identify S6K2 unique sequence features compared to S6K1, we applied extensive bioinformatic...

journal_title：Journal of cellular biochemistry

authors： Ismail HM,Hurd PJ,Khalil MI,Kouzarides T,Bannister A,Gout I

更新日期：2014-06-01 00:00:00

abstract：:We have examined the concept of genomic instability in relation to the metastatic progression of low (F1) and high metastasis (BL6, ML8) clones of the B16 mouse melanoma, by using a mutation assay, and DNA strand break repair and repair fidelity assays. The frequency of induced ouabain resistant colonies between the v...

journal_title：Journal of cellular biochemistry

authors： Usmani BA,Lunec J,Sherbet GV

更新日期：1993-03-01 00:00:00

abstract：:Breast cancer is a highly aggressive disease contributing to high mortality rate among females across the globe owing to wide geographical variations, change in lifestyle along with rapid tumor growth, drug resistance, and high metastasis rate. To understand the molecular and genetic basis of breast cancer progression...

journal_title：Journal of cellular biochemistry

authors： Nazir SU,Kumar R,Dil-Afroze,Rasool I,Bondhopadhyay B,Singh A,Tripathi R,Singh N,Khan A,Tanwar P,Agrawal U,Mehrotra R,Hussain S

更新日期：2019-09-01 00:00:00

abstract：:The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the c...

journal_title：Journal of cellular biochemistry

authors： Fofie CK,Katekhaye S,Borse S,Sharma V,Nivsarkar M,Nguelefack-Mbuyo EP,Kamanyi A,Singh V,Nguelefack TB

更新日期：2019-02-14 00:00:00

abstract：:The present study was undertaken to investigate the regulation of P12(CDK2AP1) by miRNAs. A conserved target site for miR-21 within the CDK2AP1-3'-UTR at nt 349-370 was predicted by bioinformatics software and an inverse correlation of miR-21 and CDK2AP1 protein was observed. Highly specific amplification and quantifi...

journal_title：Journal of cellular biochemistry

authors： Zheng J,Xue H,Wang T,Jiang Y,Liu B,Li J,Liu Y,Wang W,Zhang B,Sun M

更新日期：2011-03-01 00:00:00

abstract：:Angiogenesis is the central pathological process in hepatocellular carcinoma (HCC), and its progression is affected by tumor cells and the microenvironment. Activated hepatic stellate cells (aHSCs) are the most significant stromal cells involved in HCC. This study was aimed to explore the effects and mechanisms of aHS...

journal_title：Journal of cellular biochemistry

authors： Lin N,Meng L,Lin J,Chen S,Zhang P,Chen Q,Lin Y

更新日期：2020-02-01 00:00:00

abstract：:Oral tumors are one of important tumors which could be associated with serious problems in infant and children. It has been showed that a variety of cellular and molecular pathways including genetics and epigenetics mechanisms (eg, chromosomal alterations, and microRNA) involved in pathogenesis events present in oral ...

journal_title：Journal of cellular biochemistry

authors： Khanmohammadi R,Mir F,Baniebrahimi G,Mirzaei H

更新日期：2018-03-01 00:00:00

abstract：:Berberine (BBR) is an isoquinoline alkaloid derived from various medicinal herbs. Previous studies have suggested that BBR exerts antimicrobial, antitumor, and antidiabetic effects and can be used to treat Helicobacter pylori-induced chronic gastritis. However, the exact mechanism by which BBR inhibits H. pylori infec...

journal_title：Journal of cellular biochemistry

authors： Wu X,Li X,Dang Z,Jia Y

更新日期：2018-07-01 00:00:00

abstract：:To investigate changes in chromatin organization associated with DNA replication during the first stages of development of the sea urchin Tetrapygus niger, we compared micrococcal nuclease (MNase) digestion patterns of chromatin from zygotes harvested during the first S phase and from unfertilized eggs. We observed th...

journal_title：Journal of cellular biochemistry

authors： Imschenetzky M,Puchi M,Gutierrez S,Montecino M

更新日期：1995-10-01 00:00:00

abstract：:Acetaminophen (APAP) is a widely used over-the-counter analgesic and antipyretic. It can cause hepatotoxicity. Recent studies demonstrated that hydrogen sulfide (H2 S) exhibits cell protection in several cell types. This study was designed to investigate whether H 2 S ameliorated APAP-induced acute liver injury and to...

journal_title：Journal of cellular biochemistry

authors： Li X,Lin J,Lin Y,Huang Z,Pan Y,Cui P,Yu C,Cai C,Xia J

更新日期：2019-03-01 00:00:00

abstract：:In order to better understand the mechanism by which changes in the fatty acid composition of cellular lipids occur in leukemia cell lines induced to differentiate, the activity of the first enzyme of fatty acid biosynthesis, acetyl-CoA carboxylase (EC 6.4.1.2) was measured in HL-60 promyelocytic leukemia cells before...

journal_title：Journal of cellular biochemistry

authors： Fischkoff SA,Papuchis GC,Nickols WA

更新日期：1984-01-01 00:00:00

abstract：:Strikingly increased expression of notch-1 has been demonstrated in several human malignancies and pre-neoplastic lesions. However, the functional consequences of notch-1 overexpression in transformed cells remain unclear. We investigated whether endogenously expressed notch-1 controls cell fate determination in mouse...

journal_title：Journal of cellular biochemistry

authors： Shelly LL,Fuchs C,Miele L

更新日期：1999-05-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) mediated attenuation of insulin signaling pathway is an important cause in several disorders like obesity, obesity linked diabetes mellitus. TNF-alpha actions vary depending upon concentration and time of exposure in various cells. In the present study, the effects of long-term ...

journal_title：Journal of cellular biochemistry

authors： Gupta D,Varma S,Khandelwal RL

更新日期：2007-02-15 00:00:00

abstract：:Evidence is reviewed which suggests a linkage may exist between certain forms of de novo or acquired drug resistance and metastasis. This includes the finding that expression of certain dominantly acting mutant oncogenes or tumor suppressor genes, i.e., genes which normally act to "drive" tumor progression and metasta...

journal_title：Journal of cellular biochemistry

authors： Kerbel RS,Kobayashi H,Graham CH

更新日期：1994-09-01 00:00:00

abstract：:Zbed3, a BED finger domain-containing protein was found to promote cancer proliferation by regulating β-catenin expression through interacting with Axin. But whether and how BED finger domain function in regulating cancer proliferation is unknown. We constructed five mutants of Zbed3, which lacks the Axin-Zbed3 bindin...

journal_title：Journal of cellular biochemistry

authors： Liu H,Shi X,Fan X,Zhang D,Jiang B,Zhao Y,Fan C

更新日期：2019-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and angiopoietins regulate endothelial cell survival and migration and are essential for angiogenesis. Considerable progress has been made towards understanding hypoxia-mediated regulation of VEGF and its receptors. In contrast, little is known about the regulation of angiopoi...

journal_title：Journal of cellular biochemistry

authors： Christensen RA,Fujikawa K,Madore R,Oettgen P,Varticovski L

更新日期：2002-01-01 00:00:00

abstract：:Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

journal_title：Journal of cellular biochemistry

authors： Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

更新日期：2018-11-28 00:00:00

abstract：:Rapid detection and classification of cancer cells with label-free and non-destructive methods are helpful for rapid screening of cancer patients in clinical settings. Here, surface-enhanced Raman scattering (SERS) was used for rapid, unlabeled, and non-destructive detection of seven different cell types, including hu...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Lin T,Zheng D,Zhu Y,Wang L,Fu Y,Wang H,Wu X,Zhang P

更新日期：2021-02-01 00:00:00