DNA repair and repair fidelity in metastatic variants of the B16 murine melanoma.

abstract：:Osteopontin is a multifunctional matricellular protein identified as one of the most upregulated genes in pulmonary fibrosis. Experimental animal models have identified early pro-fibrotic cytokines as essential to the pathogenesis of inflammation-induced pulmonary fibrosis. However, the principal sources of osteoponti...

journal_title：Journal of cellular biochemistry

authors： Serlin DM,Kuang PP,Subramanian M,O'Regan A,Li X,Berman JS,Goldstein RH

更新日期：2006-02-15 00:00:00

abstract：:The low density lipoprotein receptor related protein-1 (LRP-1) is a cargo transport receptor that undergoes constitutive endocytosis and recycling. Platelet-derived growth factor-BB (PDGF-BB) binds to LRP-1 and may bridge LRP-1 to PDGF receptors. Bridging of LRP-1 to other receptors by bifunctional ligands may represe...

journal_title：Journal of cellular biochemistry

authors： Wu L,Arandjelovic S,Gonias SL

更新日期：2004-12-15 00:00:00

abstract：:The tetrazolium salt 3(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) is reduced to formazan by the succinate dehydrogenase system of active mitochondria, and hence, specifically used to assay for the viable cells, such as measurement of cell proliferation, cytotoxicity, and cell number. However, in ...

journal_title：Journal of cellular biochemistry

authors： Chakrabarti R,Kundu S,Kumar S,Chakrabarti R

更新日期：2000-09-18 00:00:00

abstract：:Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metaboli...

journal_title：Journal of cellular biochemistry

authors： Kikani CK,Dong LQ,Liu F

更新日期：2005-12-15 00:00:00

abstract：:Intrauterine growth restriction leads to the development of adult onset obesity/metabolic syndrome, diabetes mellitus, cardiovascular disease, hypertension, stroke, dyslipidemia, and non-alcoholic fatty liver disease/steatohepatitis. Continued postnatal growth restriction has been shown to ameliorate many of these seq...

journal_title：Journal of cellular biochemistry

authors： Freije WA,Thamotharan S,Lee R,Shin BC,Devaskar SU

更新日期：2015-04-01 00:00:00

abstract：:The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment ...

journal_title：Journal of cellular biochemistry

authors： Beck GR Jr

更新日期：2003-10-01 00:00:00

abstract：:Lysozyme (LYZ) c-like proteins are primarily present in the testis and epididymis of male reproductive tissues. Here, we report a novel member of the c-type LYZ family, the seminal vesicle-secreted LYZ c-like protein (SVLLP). Three forms of SVLLP were purified from mouse seminal vesicle secretions and characterized as...

journal_title：Journal of cellular biochemistry

authors： Ou CM,Lee RK,Lin MH,Lu CH,Yang TH,Yeh LY,Tsai PJ,Li SH

更新日期：2021-01-19 00:00:00

abstract：:Loss of mechanical stress causes bone loss. However, the mechanisms underlying the unloading-induced bone loss are largely unknown. Here, we examined the effects of gold-thioglucose (GTG) treatment, which destroys ventromedial hypothalamus (VMH), on unloading-induced bone loss. Unloading reduced bone volume in control...

journal_title：Journal of cellular biochemistry

authors： Hino K,Nifuji A,Morinobu M,Tsuji K,Ezura Y,Nakashima K,Yamamoto H,Noda M

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:Curcuminoids are polyphenols with documented anti-inflammatory activity and has been shown to improve the symptoms of several inflammatory diseases. We aimed to evaluate the effectiveness of a nanoformulation of curcuminoids in the treatment of ulcerative colitis. METHODS:This randomized double-blinded cont...

journal_title：Journal of cellular biochemistry

authors： Masoodi M,Mahdiabadi MA,Mokhtare M,Agah S,Kashani AHF,Rezadoost AM,Sabzikarian M,Talebi A,Sahebkar A

更新日期：2018-11-01 00:00:00

abstract：:Previously we have shown that transforming growth factor beta (TGF beta) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not known. IGFBP-6 b...

journal_title：Journal of cellular biochemistry

authors： Gabbitas B,Canalis E

更新日期：1997-07-01 00:00:00

abstract：:Gastric cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. Gastric infections, such as helicobacter pylori, can induce the occurrence of gastric cancers. However, the role of gastric infection in gastric cancer development is unclear. Programmed death-ligand 1 (PD-L1, B7-H1) is...

journal_title：Journal of cellular biochemistry

authors： Li H,Xia JQ,Zhu FS,Xi ZH,Pan CY,Gu LM,Tian YZ

更新日期：2018-12-01 00:00:00

abstract：:APC and PTEN are tumor suppressor proteins that bind through their C-termini to the PDZ domain containing-hDlg scaffolding protein. We have found that co-expression of PTEN and hDlg enhanced the negative regulation of the PI3K/Akt pathway by PTEN, indicating the physiologic importance of these interactions. APC and PT...

journal_title：Journal of cellular biochemistry

authors： Sotelo NS,Valiente M,Gil A,Pulido R

更新日期：2012-08-01 00:00:00

abstract：:Arctigenin is a dibenzylbutyrolactone lignan isolated from Bardanae fructus, Arctium lappa L, Saussureamedusa, Torreya nucifera, and Ipomea cairica. It has been reported to exhibit anti-inflammatory activities, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB (NF-κB). But t...

journal_title：Journal of cellular biochemistry

authors： Yao X,Zhu F,Zhao Z,Liu C,Luo L,Yin Z

更新日期：2011-10-01 00:00:00

abstract：:The pathways of transduction of oxidative stress signals have been studied using the Jurkat T cell model. The oxidative stress was induced by exposure of the cells to 100 microM H(2)O(2). DNA damage was detected within 15 min after commencement of treatment. DNA damage repair occurred within about 1 h in cells exposed...

journal_title：Journal of cellular biochemistry

authors： Chiaramonte R,Bartolini E,Riso P,Calzavara E,Erba D,Testolin G,Comi P,Sherbet GV

更新日期：2001-01-01 00:00:00

abstract：:We have recently described the isolation and purification to homogeneity of a new sialoglycopeptide from bovine brain cell surfaces that reversibly inhibits protein synthesis and DNA synthesis of normal but not transformed cells. Active inhibitory preparations, however, were shown to contain a protease activity that w...

journal_title：Journal of cellular biochemistry

authors： Sharifi BG,Bascom CC,Fattaey H,Nash S,Johnson TC

更新日期：1986-01-01 00:00:00

abstract：:Platelet-derived growth factor-D (PDGF-D) can enhance invasion and metastasis in several human malignancies. Although several studies have been performed to investigate the association between clinicopathological characteristics and prognosis in epithelial ovarian cancer (EOC), the mediation effect of PDGF-D on above-...

journal_title：Journal of cellular biochemistry

authors： Yang C,Zhang M,Cai Y,Rong Z,Wang C,Xu Z,Xu H,Song W,Hou Y,Lou G

更新日期：2019-01-16 00:00:00

abstract：:Interleukin-1 beta-converting enzyme (ICE) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. ICE and homologous proteases also appear to mediate intracellular protein degradation during programmed cell death. Inhibit...

journal_title：Journal of cellular biochemistry

authors： Livingston DJ

更新日期：1997-01-01 00:00:00

abstract：:Pulmonary fibrosis is a lethal inflammatory disease. In this study, we aimed to explore the potential-related circular RNAs (circRNAs) and genes that are associated with pulmonary fibrosis. Pulmonary fibrosis rat models were constructed and the fibrosis deposition was detected using hematoxylin and eosin and Masson st...

journal_title：Journal of cellular biochemistry

authors： Yang L,Liu X,Zhang N,Chen L,Xu J,Tang W

更新日期：2019-02-14 00:00:00

abstract：:Previously we have reported the production of a monoclonal antibody (Mab 1.2) which recognizes a cytoplasmic protein, terminin, in three different molecular weights: 90 (Tp90), 60 (Tp60), and 30 kDa (Tp30) forms. Further characterization shows that Tp90 is found in young growing and nongrowing quiescent fibroblasts, w...

journal_title：Journal of cellular biochemistry

authors： Wang E,Liu D

更新日期：1996-01-01 00:00:00

abstract：:Primary cultures fill a unique niche among the repertoire of in vitro model systems available to investigate the biology of the normal and malignant human prostate. This review summarizes some of the properties of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas reall...

journal_title：Journal of cellular biochemistry

authors： Peehl DM

更新日期：2004-01-01 00:00:00

abstract：:Hepatocytes can be generated from embryonic stem cells (ESCs) using inducers such as chemical compounds and cytokines, but issues related to low differentiation efficiencies remain to be resolved. Recent work has shown that overexpression of lineage-specific transcription factors can directly cause cells phenotypic ch...

journal_title：Journal of cellular biochemistry

authors： Liu T,Zhang S,Xiang D,Wang Y

更新日期：2013-11-01 00:00:00

abstract：:We have investigated the actions of transforming growth factor (TGF) type alpha on epidermal growth factor (EGF) receptor mRNA expression in MDA-468 human mammary carcinoma cells in serum-free media. We found that exposure of MDA-468 cells to TGF alpha results in elevated levels of EGF receptor mRNA. This increase in ...

journal_title：Journal of cellular biochemistry

authors： Fernandez-Pol JA,Klos DJ,Hamilton PD

更新日期：1989-11-01 00:00:00

abstract：:The role of beta-catenin in skeletal development and osteogenic cell differentiation is well established, but the molecular mechanisms attending these effects remain largely unknown. We conducted a structure/function analysis of beta-catenin to gain further insights on these mechanisms. Retroviral transduction of a fu...

journal_title：Journal of cellular biochemistry

authors： Salazar VS,Mbalaviele G,Civitelli R

更新日期：2008-06-01 00:00:00

abstract：:ZC3H12D belongs to a recently discovered family of proteins containing four members of which the most studied and best described is the RNase ZC3H12A (MCPIP1/Regnase-1). ZC3H12A is a crucial negative regulator of inflammation. It accelerates the turnover of transcripts of a spectrum of proinflammatory cytokines, as we...

journal_title：Journal of cellular biochemistry

authors： Wawro M,Kochan J,Krzanik S,Jura J,Kasza A

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as glyoxylate reductase 1 homolog, is a new nuclear protein recently implicated in tumor biology. However, the role of NPAC in HCC remains unclear...

journal_title：Journal of cellular biochemistry

authors： Zhang J,Sun N,Guo W,Wu X,Yang X,Jin H,Zhang Y,Wu X,Zhang F,Hu L,Hu H,Gao Y

更新日期：2018-11-26 00:00:00

abstract：:NMR spectroscopy is able to detect subtle changes to the surface chemistry of cells. We have previously shown that high-resolution 1H NMR methods can identify tumor cells with the capacity to metastasize, and we now report that the long T2 relaxation value (500-800 ms) observed in metastatic rat mammary adenocarcinoma...

journal_title：Journal of cellular biochemistry

authors： Wright LC,May GL,Gregory P,Dyne M,Holmes KT,Williams PG,Mountford CE

更新日期：1988-05-01 00:00:00

abstract：:The levels of organic pollutants, such as optical brightener (OB) compounds, in the global environment have been increasing in recent years. The toxicological effects and signal transduction systems associated with OB toxicity have not been thoroughly studied. The ubiquitin-proteasome system (UPS) plays a crucial role...

journal_title：Journal of cellular biochemistry

authors： Castro I,Ekinci E,Huang X,Cheaito HA,Ahn YH,Olivero-Verbel J,Dou QP

更新日期：2019-08-01 00:00:00

abstract：:Arsenic is the first metal to be identified as a human carcinogen. Arsenite, one inorganic form of arsenic, has been found to induce sister chromatid exchange, chromosome aberrations, and gene amplification in a variety of in vitro systems. In this study of arsenite-induced genotoxicity represented a micronuclei produ...

journal_title：Journal of cellular biochemistry

authors： Liu YC,Huang H

更新日期：1997-03-01 00:00:00

abstract：:Breast cancer frequently metastasizes to the bone, often leading to the formation of osteolytic lesions. This work compares the paracrine-induced osteoclastogenesis mediated by four human breast cancer cell lines, the estrogen-receptor positive T47D and MCF-7 and the estrogen-negative SK-BR-3 and Hs-578T cell lines. H...

journal_title：Journal of cellular biochemistry

authors： Costa-Rodrigues J,Moniz KA,Teixeira MR,Fernandes MH

更新日期：2012-03-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta1 and BMP-2 treatment of primar...

journal_title：Journal of cellular biochemistry

authors： Nesti LJ,Caterson EJ,Li WJ,Chang R,McCann TD,Hoek JB,Tuan RS

更新日期：2007-05-15 00:00:00