Abstract:
:The dysregulation of miR-125a-3p has been observed in multiple tumor types. Nevertheless, the function of miR-125a-3p in papillary thyroid carcinoma (PTC) is yet to be explored. Herein, we find that miR-125a-3p is markedly downregulated in PTC tissues, and its level is inversely related to the histological grade of PTC. Upregulation of miR-125a-3p suppresses the pulmonary metastatic ability as well as the tumor growth of PTC cell in vivo. Consistently, the colony formation ability and other metastasis-related traits of PTC cell are inhibited by miR-125a-3p transfection in vitro. In addition, we identify that matrix metalloprotease 11 (MMP11) is the direct target gene of miR-125a-3p, and that miR-125a-3p inhibits cell viability, migration, and invasiveness of PTC cell by reducing MMP11 expression in vitro. Together, these data testify that the miR-125a-3p/MMP11 axis plays vital roles in the growth and progression of human PTC cells.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Song M,Wang N,Li Z,Zhang Y,Zheng Y,Yi P,Chen Jdoi
10.1002/jcb.29333subject
Has Abstractpub_date
2020-02-01 00:00:00pages
984-995issue
2eissn
0730-2312issn
1097-4644journal_volume
121pub_type
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