miR-21 downregulates the tumor suppressor P12 CDK2AP1 and stimulates cell proliferation and invasion.

abstract：:Individual protein kinase C (PKC) isoforms fulfill distinct roles in the regulation of the commitment to differentiation, cell cycle arrest, and apoptosis in both monocytes and T-cells. The human monocyte like cell line U937 and T-cells were exposed to microgravity, during spaceflight and the translocation (a critical...

journal_title：Journal of cellular biochemistry

authors： Hatton JP,Gaubert F,Cazenave JP,Schmitt D

更新日期：2002-01-01 00:00:00

abstract：:Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial-mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in an inflammatory microenvironment. B...

journal_title：Journal of cellular biochemistry

authors： Ye K,Chen QW,Sun YF,Lin JA,Xu JH

更新日期：2018-02-01 00:00:00

abstract：:Evidence for multiprotein complexes playing a role in DNA replication has been growing over the years. We have previously reported on a replication-competent multiprotein form of DNA polymerase isolated from human (HeLa) cell extracts. The proteins that were found at that time to co-purify with the human cell multipro...

journal_title：Journal of cellular biochemistry

authors： Applegren N,Hickey RJ,Kleinschmidt AM,Zhou Q,Coll J,Wills P,Swaby R,Wei Y,Quan JY,Lee MY

更新日期：1995-09-01 00:00:00

abstract：:Bladder cancer is the most common malignancy with high recurrence. Currently, the long noncoding RNAs (lncRNAs) have been suggested to play vital roles in the pathogenesis of bladder cancer. The present study investigated the role of lncRNA MIR503 host gene (MIR503HG) in the pathogenesis of bladder cancer by using bot...

journal_title：Journal of cellular biochemistry

authors： Qiu F,Zhang MR,Zhou Z,Pu JX,Zhao XJ

更新日期：2019-06-01 00:00:00

abstract：:The cholesterol hydroxylase/lyase (CHL) system, consisting of cytochrome P450scc, adrenodoxin (Adx) and adrenodoxin reductase (AdR), initiates mammalian steroidogenesis, converting cholesterol to pregnenolone. The foot-and-mouth disease virus 2A-based method allows to express multiple proteins from a single transcript...

journal_title：Journal of cellular biochemistry

authors： Efimova VS,Isaeva LV,Labudina AA,Tashlitsky VN,Rubtsov MA,Novikova LA

更新日期：2019-03-01 00:00:00

abstract：:In our previous study, preliminary data indicates that Poria cocos polysaccharides (PCP) shows beneficial hepatoprotection against acetaminophen (APAP)-induced liver injury in mice. However, biological molecular mechanism warrants to be further discussed. In current study, a number of biochemical tests and immunoassay...

journal_title：Journal of cellular biochemistry

authors： Wu K,Guo C,Yang B,Wu X,Wang W

更新日期：2019-05-01 00:00:00

abstract：:Electrical activity in embryonic brain tissue has typically been studied using Micro Electrode Array (MEA) technology to make dozens of simultaneous recordings from dissociated neuronal cultures, brain stem cell progenitors, or brain slices from fetal rodents. Although these rodent neuronal primary culture electrical ...

journal_title：Journal of cellular biochemistry

authors： Napoli A,Obeid I

更新日期：2016-03-01 00:00:00

abstract：:Phospholipase D (PLD) and ADP-ribosylation factor 6 (ARF6) have been implicated in vesicular trafficking and rearrangement of the actin cytoskeleton. We have explored the co-localization of rat PLD1b and rat PLD2 with wild type and mutant forms of ARF6 in HeLa cells and studied their activation by ARF6 and the role of...

journal_title：Journal of cellular biochemistry

authors： Hiroyama M,Exton JH

更新日期：2005-05-01 00:00:00

abstract：:Metastatic cancer is a complex positive feedback loop system. Such as system has a tendency to acquire extreme robustness. Signaling pathways controlling that robustness can fail completely if an essential element from the signaling is removed. That element is a locus of fragility. Targeting that locus represents the ...

journal_title：Journal of cellular biochemistry

authors： Radisavljevic Z

更新日期：2008-08-15 00:00:00

abstract：:Hepatocytes can be generated from embryonic stem cells (ESCs) using inducers such as chemical compounds and cytokines, but issues related to low differentiation efficiencies remain to be resolved. Recent work has shown that overexpression of lineage-specific transcription factors can directly cause cells phenotypic ch...

journal_title：Journal of cellular biochemistry

authors： Liu T,Zhang S,Xiang D,Wang Y

更新日期：2013-11-01 00:00:00

abstract：:Pyrimidine-specific ribonucleases are a superfamily of structurally related enzymes with distinct catalytic and biological properties. We used a combination of enzymatic and non-enzymatic assays to investigate the release of such enzymes by isolated cells in serum-free and serum-containing media. We found that human e...

journal_title：Journal of cellular biochemistry

authors： Landré JB,Hewett PW,Olivot JM,Friedl P,Ko Y,Sachinidis A,Moenner M

更新日期：2002-01-01 00:00:00

abstract：:Cigarette smoking has been suggested as a risk factor for several periodontal diseases. It has also been found that smokers respond less favorably than non-smokers to periodontal therapy. Previous work in our lab has shown that nicotine inhibits human gingival cell migration. Since myofibroblasts play an important rol...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Svoboda KK

更新日期：2005-08-15 00:00:00

abstract：:Oleanolic acid (OA), a widely used plant-derived triterpenoid, has been shown to possess potent antiatherosclerotic effects, which may be associated with the induction of heme oxygenase-1 (HO-1). However, the underlying mechanisms involved in the effect of OA on HO-1 expression are unclear. In the current study, prima...

journal_title：Journal of cellular biochemistry

authors： Feng J,Zhang P,Chen X,He G

更新日期：2011-06-01 00:00:00

abstract：:The non-receptor tyrosine kinase c-Src is activated in many human cancer types, and induces deregulation of cadherin-based cell-cell contacts and actin cytoskeleton. Because ezrin, a protein which cross-links the plasma membrane with the actin cytoskeleton, is often over-expressed in human cancers, and participates in...

journal_title：Journal of cellular biochemistry

authors： Elliott BE,Qiao H,Louvard D,Arpin M

更新日期：2004-05-01 00:00:00

abstract：:Pancreatic AR42J cells have the feature of pluripotency of the precursor cells of the gut endoderm. Betacellulin (BTC) and activin A (Act) convert them into insulin-secreting cells. Using mRNA differential display techniques, we have identified a novel mitochondrial transporter, which is highly expressed during the co...

journal_title：Journal of cellular biochemistry

authors： Yoshikumi Y,Mashima H,Ueda N,Ohno H,Suzuki J,Tanaka S,Hayashi M,Sekine N,Ohnishi H,Yasuda H,Iiri T,Omata M,Fujita T,Kojima I

更新日期：2005-08-15 00:00:00

abstract：:Every year about 500,000 people in the United States die as a result of cancer. Among them, 90% exhibit systemic disease with metastasis. Considering this high rate of incidence and mortality, it is critical to understand the mechanisms behind metastasis and identify new targets for therapy. In recent years, two broad...

journal_title：Journal of cellular biochemistry

authors： Tse JC,Kalluri R

更新日期：2007-07-01 00:00:00

abstract：:Cancer prevalence is critically increasing worldwide; accordingly, improved prediction and therapeutic tools are necessary. Interleukin (IL)-21 is a potent antitumor cytokine, and the relationship between its gene variations and cancer risk is well established. Nevertheless, so far no study has investigated its role i...

journal_title：Journal of cellular biochemistry

authors： Bakr NM,Awad A,Moustafa EA,El-Gebaly AM

更新日期：2019-10-01 00:00:00

abstract：:Pancreatic-cancer-patient tumor specimens were initially established subcutaneously in NOD/SCID mice immediately after surgery. The patient tumors were then harvested from NOD/SCID mice and passaged orthotopically in transgenic nude mice ubiquitously expressing red fluorescent protein (RFP). The primary patient tumors...

journal_title：Journal of cellular biochemistry

authors： Suetsugu A,Katz M,Fleming J,Truty M,Thomas R,Moriwaki H,Bouvet M,Saji S,Hoffman RM

更新日期：2012-07-01 00:00:00

abstract：:Selected clones of Syrian hamster DDT1-MF2 cells are responsive to testosterone for growth. Heparin binding growth factor 1 (HBGF-1) or acidic fibroblast growth factor (aFGF) can replace testosterone (T) in the stimulation of growth in these cells. This phenomena is correlated with testosterone's ability to elevate aF...

journal_title：Journal of cellular biochemistry

authors： Hall JA,Harris MA,Intres R,Harris SE

更新日期：1993-01-01 00:00:00

abstract：:Although numerous miRNAs are reported to contribute to the carcinogenesis of malignant tumor, the specific role of miR-424 in endometrial carcinoma is seldom reported. To explore the effect of miR-424 on epithelial-mesenchymal transition and its underlying mechanism, we detected miR-424 expression in endometrial carci...

journal_title：Journal of cellular biochemistry

authors： Shu S,Liu X,Xu M,Gao X,Fan J,Liu H,Li R

更新日期：2018-09-06 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of cell function and differentiation. We examined NR expression during osteogenic versus adipogenic differentiation of primary mouse calvarial osteoblasts (MOBs). MOBs were cultured for 21 days in osteogenic or adipogenic differentiation media. von Kossa and Oil Red O stainin...

journal_title：Journal of cellular biochemistry

authors： Pirih FQ,Abayahoudian R,Elashoff D,Parhami F,Nervina JM,Tetradis S

更新日期：2008-12-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) PTCSC3 (hereafter PTCSC3 is used to represent lncRNA PTCSC3) inhibits glioma and thyroid cancer, indicating its potential tumor suppression function in other types of cancers. We explored the potential involvement of PTCSC3 in triple-negative breast cancer (TNBC). In the current study, we f...

journal_title：Journal of cellular biochemistry

authors： Wang N,Hou M,Zhan Y,Sheng X

更新日期：2019-09-01 00:00:00

abstract：:The retinoblastoma susceptibility gene product, p105Rb (RB), is generally believed to be an important regulator in the control of cell growth, differentiation, and apoptosis. Several cellular factors that form complexes with RB and exert their cellular regulatory functions have been identified, such as the newly ident...

journal_title：Journal of cellular biochemistry

authors： Cui Y,Mirkia K,Florence Fu YH,Zhu L,Yokoyama KK,Chiu R

更新日期：2002-01-01 00:00:00

abstract：:Several independent assay procedures were used to estimate the activities of the enzyme constituents of the phosphoenolpyruvate-sugar phosphotransferase system (PTS) in osmotically shocked bacterial membrane vesicles. The soluble enzymes of the system were found to be in association with the membrane by several criter...

journal_title：Journal of cellular biochemistry

authors： Saier MH Jr,Cox DF,Feucht BU,Novotny MJ

更新日期：1982-01-01 00:00:00

abstract：:Because irradiation may cause osteoradionecrosis, antioxidant supplementation is often used to suppress irradiation-mediated injury. This study examined whether a synthetic phenethyl urea compound, (E)-1-(3,4-dihydroxyphenethyl)-3-(3,4-dihydroxystyryl)urea (DPDS-U), prevents irradiation-mediated cellular damage in MC3...

journal_title：Journal of cellular biochemistry

authors： Kim KA,Kook SH,Song JH,Lee JC

更新日期：2014-11-01 00:00:00

abstract：:Published data indicate that the protease-activated receptor (PAR) 2 is involved in the pathogenesis of some cardiovascular diseases; the underlying mechanism is to be further investigated. Ve-cadherin is a critical molecule in maintaining the endothelial barrier integrity. This study aims to investigate the role of P...

journal_title：Journal of cellular biochemistry

authors： Zhang R,Ge J

更新日期：2017-12-01 00:00:00

abstract：:The sex steroid hormones, androgens and estrogens, via their respective nuclear receptors, regulate bone mineral density in humans and mice. Very little is known about the direct targets of the androgen and estrogen receptors in bone cells. First, models of hormone and receptor deficiency in mouse and human bone are d...

journal_title：Journal of cellular biochemistry

authors： Krum SA

更新日期：2011-02-01 00:00:00

abstract：:Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kina...

journal_title：Journal of cellular biochemistry

authors： Romano FJ,Guadagno E,Solari D,Borrelli G,Pignatiello S,Cappabianca P,Del Basso De Caro M

更新日期：2018-06-01 00:00:00

abstract：:Growing evidence has shown that a large number of miRNAs are abnormally expressed in cervical cancer (CC) tissues and play irreplaceable roles in tumorigenesis, progression, and metastasis. This study aimed to identify new biomarkers and pivotal genes associated with CC prognosis through comprehensive bioinformatics a...

journal_title：Journal of cellular biochemistry

authors： Gao C,Zhou C,Zhuang J,Liu L,Liu C,Li H,Liu G,Wei J,Sun C

更新日期：2018-08-01 00:00:00

abstract：:We studied how deficiency in lamins A/C and lamina-associated polypeptide 2α (Lap2α) affects DNA repair after irradiation. A-type lamins and Lap2α were not recruited to local DNA lesions and did not accumulate to γ-irradiation-induced foci (IRIF), as it is generally observed for well-known marker of DNA lesions, 53BP1...

journal_title：Journal of cellular biochemistry

authors： Bártová E,Legartová S,Krejčí J,Řezníčková P,Kovaříková AS,Suchánková J,Fedr R,Smirnov E,Hornáček M,Raška I

更新日期：2018-11-01 00:00:00