Abstract:
:The sex steroid hormones, androgens and estrogens, via their respective nuclear receptors, regulate bone mineral density in humans and mice. Very little is known about the direct targets of the androgen and estrogen receptors in bone cells. First, models of hormone and receptor deficiency in mouse and human bone are discussed. This review then focuses on the direct targets of the receptors in osteoblasts and osteoclasts. A direct target of a NR is defined here as a gene that is regulated by NR binding to the DNA (either through DNA binding or association with a DNA binding protein) at an enhancer or promoter of that gene. The experimental evidence that illustrates androgen and estrogen gene regulation in osteoblasts and osteoclasts will be summarized and compared with the phenotype of the hormones in vivo.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Krum SAdoi
10.1002/jcb.22970subject
Has Abstractpub_date
2011-02-01 00:00:00pages
401-8issue
2eissn
0730-2312issn
1097-4644journal_volume
112pub_type
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