Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro.

abstract：:Overweight and obesity are established factors underpin several metabolic impairments, including the cardiovascular. Although the diversity of factors involved in overweight/obesity-induced cardiovascular diseases, mitochondria has been highlighted due to its role in cardiac metabolism. As obesity can be originated in...

journal_title：Journal of cellular biochemistry

authors： de Moura Freitas C,Nascimento LCPD,Braz GRF,Andrade-Silva SC,Lima-Junior NC,de Araujo Silva T,Fernandes MP,Ferreira DJS,Lagranha CJ

更新日期：2018-10-28 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the development and progression of non-small cell lung cancer (NSCLC). Recently, several studies have shown that miR-99a is downregulated in various cancers, which can affect tumor initiation and maintenance. Herein, we found that miR-99a was downregulated in NSCLC tissues ...

journal_title：Journal of cellular biochemistry

authors： Yu SH,Zhang CL,Dong FS,Zhang YM

更新日期：2015-02-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a major process to regulate cell migration and invasion. Inhibition of epidermal growth factor receptor (EGFR)-mediated EMT by tyrosine kinase inhibitors (TKIs) is a strategy to prevent lung cancer invasion. However, drug resistance is emerged and accelerated invasion thro...

journal_title：Journal of cellular biochemistry

authors： Hsieh YS,Liao CH,Chen WS,Pai JT,Weng MS

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood. METHODS:The blood lnc...

journal_title：Journal of cellular biochemistry

authors： Sheng Y,Ma J,Zhao J,Qi S,Hu R,Yang Q

更新日期：2019-06-01 00:00:00

abstract：:The efficiency of in vitro mesenchymal stem cell (MSC) differentiation into the myocardial lineage is generally poor. In order to improve cardiac commitment, bone marrow GFP+MSCs obtained from transgenic rats were cultured with adult wild type rat cardiomyocytes for 5 days in the presence of difluoromethylornithine (D...

journal_title：Journal of cellular biochemistry

authors： Muscari C,Bonafé F,Carboni M,Govoni M,Stanic I,Gamberini C,Ricci F,Tazzari PL,Caldarera CM,Guarnieri C

更新日期：2008-03-01 00:00:00

abstract：:Large doses of bone morphogenetic protein 2 (BMP2) are used clinically to induce bone formation in challenging bone defects. However, complications after treatment include swelling, ectopic bone formation, and adjacent bone resorption. While BMP2 can be effective, it is important to characterize the mechanism of the d...

journal_title：Journal of cellular biochemistry

authors： Hyzy SL,Olivares-Navarrete R,Schwartz Z,Boyan BD

更新日期：2012-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. We analyzed 11 data sets from Gene Expression Omnibus Database and found that MMP7 and MMP15 were highly expressed in multiple carcinomas. GSE13204 showed that MMP7 and MM...

journal_title：Journal of cellular biochemistry

authors： Wu Y,Pan S,Leng J,Xie T,Jamal M,Yin Q,Li J,He C,Dong X,Shao L,Zhang Q

更新日期：2019-06-01 00:00:00

abstract：:Operons subject to catabolite repression (CR) in the gram-positive bacteria appear to be transcriptionally regulated by negative acting catabolite repressors. Cis elements within the promoter regions of a few CR operons have been identified as the target sequences for these repressors. It has also been proposed that s...

journal_title：Journal of cellular biochemistry

authors： Stewart GC

更新日期：1993-01-01 00:00:00

abstract：:Colorectal cancer (CRC) brings more than 600 000 deaths every year around the globe, making itself the third most frequently occurred carcinoma. The great progress human achieved in diagnosis and treatment of various cancers has failed to reverse this trend. Fortunately, growing evidence has implied the relationship b...

journal_title：Journal of cellular biochemistry

authors： Cui G,Zhao H,Li L

更新日期：2020-10-01 00:00:00

abstract：:Lysis of human culture-derived macrophages by extracellular ATP has recently been described, and treatment of macrophages with interferon-gamma rendered those cells significantly more sensitive to lysis. In addition, cell death occurred more rapidly in interferon (IFN)-treated cells than in untreated macrophages. In a...

journal_title：Journal of cellular biochemistry

authors： Blanchard DK,Hoffman SL,Djeu JY

更新日期：1995-03-01 00:00:00

abstract：:The transcription factors of the nuclear hormone receptor family regulate gene expression via a complex network of macromolecular interactions. The ligand dependent activity of the vitamin D receptor is of particular interest because it modulates gene expression by the heterodimeric interaction with retinoid X recepto...

journal_title：Journal of cellular biochemistry

authors： Berghöfer-Hochheimer Y,Zurek C,Langer G,Munder T

更新日期：1997-08-01 00:00:00

abstract：:Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship betw...

journal_title：Journal of cellular biochemistry

authors： He S,Choi YH,Choi JK,Yeo CY,Chun C,Lee KY

更新日期：2014-10-01 00:00:00

abstract：:Forkhead box class O6 (FOXO6) is an important member of FOXO family, which has been demonstrated to be implicated in tumor development. However, the role of FOXO6 in colorectal cancer (CRC) is still unclear. The study aimed to investigate the potential roles of FOXO6 in the development of CRC. Our results showed that ...

journal_title：Journal of cellular biochemistry

authors： Li Q,Tang H,Hu F,Qin C

更新日期：2019-03-01 00:00:00

abstract：:The G(0) growth arrest (quiescent) state is highly conserved in evolution to promote survival under adverse environmental conditions. To maintain viability, G(0) growth arrested cells limit gene expression to essential growth control and pro-survival genes. CCAAT enhancer binding protein delta (C/EBPdelta), a member o...

journal_title：Journal of cellular biochemistry

authors： Li B,Si J,DeWille JW

更新日期：2008-04-01 00:00:00

abstract：:Multidrug-resistance due to "β lactamases having the expanded spectrum" (ESBLs) in members of Enterobacteriaceae is a matter of continued clinical concern. CTX-M is among the most common ESBLs in Enterobacteriaceae family. In the present study, a nanoformulation of cefotaxime was prepared using gold nanoparticles to c...

journal_title：Journal of cellular biochemistry

authors： Shaikh S,Rizvi SMD,Shakil S,Hussain T,Alshammari TM,Ahmad W,Tabrez S,Al-Qahtani MH,Abuzenadah AM

更新日期：2017-09-01 00:00:00

abstract：:It has been reported that the antitumor drug doxorubicin (Dox) exerts its toxic effects via GATA-4 depletion and that over-expression of GATA-4 reverses Dox-induced toxicity and apoptosis; however, the precise mechanisms remain unclear. In this study, we observed, for the first time, that EGF protects cells against Do...

journal_title：Journal of cellular biochemistry

authors： Yao CX,Shi JC,Ma CX,Xiong CJ,Song YL,Zhang SF,Zhang SF,Zang MX,Xue LX

更新日期：2015-08-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitoge...

journal_title：Journal of cellular biochemistry

authors： Polte TR,Naftilan AJ,Hanks SK

更新日期：1994-05-01 00:00:00

abstract：:Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatmen...

journal_title：Journal of cellular biochemistry

authors： Zhu D,Wu L,Li CR,Wang XW,Ma YJ,Zhong ZY,Zhao HB,Cui J,Xun SF,Huang XL,Zhou Z,Wang SQ

更新日期：2009-09-01 00:00:00

abstract：:ATP-dependent protein kinase activities were detected in both membrane and cytoplasmic fractions from the oral pathogen Streptococcus mutans. Different polypeptides were phosphorylated by endogenous kinase(s) in the two fractions. In membranes, five phosphoproteins were detected with apparent masses of 82, 37, 22, 12,...

journal_title：Journal of cellular biochemistry

authors： Mimura CS,Poy F,Jacobson GR

更新日期：1987-03-01 00:00:00

abstract：:We have previously demonstrated that the ultraviolet (UV) light is effective against a variety of cancer cells in vivo as well as in vitro. In the present report, we imaged the DNA damage repair response of minimal cancer after UVC irradiation. DNA-damage repair response to UV irradiation was imaged on tumors growing ...

journal_title：Journal of cellular biochemistry

authors： Miwa S,Yano S,Hiroshima Y,Tome Y,Uehara F,Mii S,Efimova EV,Kimura H,Hayashi K,Tsuchiya H,Hoffman RM

更新日期：2013-11-01 00:00:00

abstract：:ABP50 is a polypeptide elongation factor 1 alpha from Dictyostelium that is associated with the actin cytoskeleton. Upon chemotactic stimulation, ABP50 undergoes a dramatic cytoplasmic redistribution into newly formed surface projections and in vitro binds to and bundles actin filaments. Many questions are raised by t...

journal_title：Journal of cellular biochemistry

authors： Edmonds BT

更新日期：1993-06-01 00:00:00

abstract：:We have purified and characterized a collagenase/gelatinase activity expressed during sea urchin embryonic development. The native molecular mass was determined to be 160 kDa, while gelatin substrate gel zymography revealed an active species of 41 kDa, suggesting that the native enzyme is a tetramer of active subunits...

journal_title：Journal of cellular biochemistry

authors： Mayne J,Robinson JJ

更新日期：1998-12-15 00:00:00

abstract：:Pyruvate kinase M2 (M2-PK) controls the rate-limiting step at the end of the glycolytic pathway in normal proliferating and tumor cells. Other functions of M2-PK in addition to its role in glycolysis are little understood. The aim of this study was to identify new cellular interaction partners of M2-PK in order to dis...

journal_title：Journal of cellular biochemistry

authors： Spoden GA,Morandell D,Ehehalt D,Fiedler M,Jansen-Dürr P,Hermann M,Zwerschke W

更新日期：2009-05-15 00:00:00

abstract：:Recent studies have shown that only breast cancer epithelial cells with intact p53 can induce metallothionein (MT) synthesis after exposure to metals. In this study, the potential role of p53 on regulation of MT was investigated. Results demonstrate that zinc and copper increased metal response elements (MREs) activit...

journal_title：Journal of cellular biochemistry

authors： Ostrakhovitch EA,Olsson PE,von Hofsten J,Cherian MG

更新日期：2007-12-15 00:00:00

abstract：:Exposure of cells to ionizing radiation (IR) determines cellular lesions, such as DNA and membrane damage, which involve a coordinate network of signal transduction pathways responsible for resistance to or delay of apoptosis, depending on cell type and administered dose. Since, after IR exposure, the apoptotic profil...

journal_title：Journal of cellular biochemistry

authors： Cataldi A,Rapino M,Centurione L,Sabatini N,Grifone G,Garaci F,Rana R

更新日期：2003-08-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy disease that causes maternal death and threatens the health of newborns. Accumulating evidence has revealed the essential roles of long noncoding RNAs (lncRNAs) in the progression of PE. The present investigation determined lncRNA ZEB2 antisense RNA 1 (ZEB2-AS1) expression in PE and l...

journal_title：Journal of cellular biochemistry

authors： Gao Y,Guo X,Li Y,Sha W,She R

更新日期：2019-10-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was ...

journal_title：Journal of cellular biochemistry

authors： Liu Z,Wang X,Yang G,Zhong C,Zhang R,Ye J,Zhong Y,Hu J,Ozal B,Zhao S

更新日期：2020-07-01 00:00:00

abstract：:In the present paper we aimed to characterize epigenetic aspects and analyze TP53 transcription in the 21 T series, composed of breast cell lines: non-cancerous H16N2; Atypical Ductal Hyperplasia 21PT; Ductal Carcinoma in situ 21NT and Invasive Metastatic Carcinoma 21MT1. We detected a global genomic hypomethylation i...

journal_title：Journal of cellular biochemistry

authors： Santos GC Jr,da Silva AP,Feldman L,Ventura GM,Vassetzky Y,de Moura Gallo CV

更新日期：2015-04-01 00:00:00

abstract：:Our laboratory pioneered patient-derived orthotopic xenograft (PDOX) mouse models using surgical orthotopic implantation (SOI). PDOX models are patient-like, in contrast to the ectopic subcutaneous-transplant cancer models. In the present study, we demonstrate that an undifferentiated pleomorphic soft-tissue sarcoma (...

journal_title：Journal of cellular biochemistry

authors： Kiyuna T,Murakami T,Tome Y,Igarashi K,Kawaguchi K,Russell T,Eckardt MA,Crompton J,Singh A,Bernthal N,Bukata S,Federman N,Kanaya F,Eilber FC,Hoffman RM

更新日期：2017-02-01 00:00:00

abstract：:Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

journal_title：Journal of cellular biochemistry

authors： Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

更新日期：2018-11-28 00:00:00