Stem cell-based cell therapy for neuroprotection in stroke: A review.


:Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells. Ischemic stroke remains a substantial problem for industrialized countries. Over the previous few decades our understanding about the pathophysiology of stroke has enhanced, nevertheless, more awareness is required to advance the field of stroke recovery. Existing therapies are incapable to adequately relief the disease outcome and are not appropriate to all patients. Meanwhile, the majority of patients continue to show neurological deficits even subsequent effective thrombolysis, recuperative therapies are immediately required that stimulate brain remodeling and repair once stroke damage has happened. Cell therapy is emergent as a hopeful new modality for increasing neurological recovery in ischemic stroke. Numerous types of stem cells from various sources have been identified and their possibility and efficiency for the treatment of stroke have been investigated. Stem cell therapy in patients with stroke using adult stem cells have been first practiced in clinical trials since 15 years ago. Even though stem cells have revealed a hopeful role in ischemic stroke in investigational studies besides early clinical pilot studies, cellular therapy in human is still at a primary stage. In this review, we summarize the types of stem cells, various delivery routes, and clinical application of stem cell-based therapy for stroke treatment.


J Cell Biochem


Rikhtegar R,Yousefi M,Dolati S,Kasmaei HD,Charsouei S,Nouri M,Shakouri SK




Has Abstract


2019-06-01 00:00:00












  • PAI-1 transcriptional regulation during the G0 --> G1 transition in human epidermal keratinocytes.

    abstract::Plasminogen activator inhibitor type-1 (PAI-1) is the major negative regulator of the plasmin-dependent pericellular proteolytic cascade. PAI-1 gene expression is normally growth state regulated but frequently elevated in chronic fibroproliferative and neoplastic diseases affecting both stromal restructuring and cellu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Qi L,Allen RR,Lu Q,Higgins CE,Garone R,Staiano-Coico L,Higgins PJ

    更新日期:2006-10-01 00:00:00

  • Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression.

    abstract::9-cis Retinoic acid (RA) induces gene expression in neuroblastoma cells more effectively and with different kinetics than other RA isomers, and could be acting in part through Retinoid X Receptors (RXRs). The aim of this study was to characterise the effects of an RXR agonist and RXR homodimer antagonist on the induct...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hewson QC,Lovat PE,Pearson AD,Redfern CP

    更新日期:2002-01-01 00:00:00

  • PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus.

    abstract::Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

    更新日期:2016-05-01 00:00:00

  • A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims.

    abstract::Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apop...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Panahi Y,Abdolghaffari AH,Sahebkar A

    更新日期:2018-01-01 00:00:00

  • The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells.

    abstract::A key step in human colon cancer development includes the hyperactivation of Wnt/beta-catenin signaling and the induction of beta-catenin-TCF target genes that participate in colon cancer progression. Recent studies identified members of the immunoglobulin-like cell adhesion molecules (IgCAM) of the L1CAM family (L1 a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Raveh S,Gavert N,Spiegel I,Ben-Ze'ev A

    更新日期:2009-09-01 00:00:00

  • Identification and characterization of a negative regulatory element within the epidermal growth factor receptor gene first intron in hormone-dependent breast cancer cells.

    abstract::The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associated with a more aggressive phenot...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wilson MA,Chrysogelos SA

    更新日期:2002-01-01 00:00:00

  • Embryonic stem cells and in vitro hematopoiesis.

    abstract::To study hematopoietic differentiation a variety of in vitro systems have been established using hematopoietic precursors derived from various explanted adult and fetal tissues. In this prospective we describe and discuss the potential of a novel system for studying the earliest stages of hematopoietic development. In...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Snodgrass HR,Schmitt RM,Bruyns E

    更新日期:1992-07-01 00:00:00

  • 3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells.

    abstract::Angiogenesis plays an important role in many pathological processes. Identification of novel anti-angiogenic agents will provide new insights into the mechanisms for angiogenesis as well as potential lead compounds for developing new drugs. In the present study, a series of resveratrol methylated derivatives have been...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang L,Jing H,Cui L,Li H,Zhou B,Zhou G,Dai F

    更新日期:2013-03-01 00:00:00

  • Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial.

    abstract::Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,随机对照试验


    authors: Gharipour M,Ouguerram K,Nazih EH,Salehi M,Behmanesh M,Roohafza H,Hosseini SM,Nezafati P,Dianatkhah M,Gharipour A,Haghjoo S,Sarrafzadegan N,Sadeghi M

    更新日期:2018-11-01 00:00:00

  • Cloning and characterization of human syndecan-3.

    abstract::Syndecans are cell-surface heparan sulfate proteoglycans, which perform a variety of functions in the cell. Most important, they are co-receptors for growth factors and mediate cell-cell and cell-matrix interactions. Four syndecans (syndecan 1-4) have been described in different species. The aim of this work was the c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Berndt C,Casaroli-Marano RP,Vilaró S,Reina M

    更新日期:2001-01-01 00:00:00

  • Adsorption of glycosaminoglycans to the cell surface is responsible for cellular donnan effects.

    abstract::In previous publications, we showed that extracellular glycosaminoglycans reduced the membrane potential, caused cell blebbing and swelling and decreased the intracellular pH independently of cell surface receptors. These phenomena were explained by Donnan effects. The effects were so large that they could not be attr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hagenfeld D,Kathagen N,Prehm P

    更新日期:2014-07-01 00:00:00

  • Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma.

    abstract:BACKGROUND:Cholangiocarcinoma (CC) is devastating neoplasm and very few specific biomarkers could be used in clinical diagnosis. A study was taken to find novel serum biomarkers for CC. METHODS:Surface enhanced laser desorption/ionization (SELDI) technology was used to analyze 427 serum samples including 56 CCs, 49 he...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Liu L,Wang J,Liu B,Dai S,Wang X,Chen J,Huang L,Xiao X,He D

    更新日期:2008-06-01 00:00:00

  • MicroRNA-182 promotes cell growth, invasion, and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas.

    abstract::As an important tumor suppressor, programmed cell death 4 (PDCD4) influences transcription and translation of multiple genes, and modulates different signal transduction pathways. However, the upstream regulation of this gene is largely unknown. In this study, we found that microRNA-182 (miRNA-182, miR-182) was upregu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang YQ,Guo RD,Guo RM,Sheng W,Yin LR

    更新日期:2013-07-01 00:00:00

  • Virtual screening of naphthoquinone analogs for potent inhibitors against the cancer-signaling PI3K/AKT/mTOR pathway.

    abstract::The PI3K/AKT/mTOR pathway is one of the most commonly disrupted signaling pathways that plays a role in the development and pathogenicity of multiple cancers. Therefore, the critical proteins of this pathway have been targeted for anticancer therapy. The scientific community has increasingly been realizing the anti-ca...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rehan M,Bajouh OS

    更新日期:2018-10-08 00:00:00

  • Linoleic acid induces an increased response to insulin in MDA-MB-231 breast cancer cells.

    abstract::Epidemiological studies and animal models suggest a link between high levels of dietary fat intake and an increased risk of developing breast cancer. Hyperinsulinemia is a feature of obesity, diabetes, and metabolic syndrome that is associated with an increased breast cancer risk. Insulin is a hormone involved in meta...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rodriguez-Monterrosas C,Diaz-Aragon R,Cortes-Reynosa P,Salazar EP

    更新日期:2018-07-01 00:00:00

  • Clinical aspects of circulating miRNA-335 in breast cancer patients: A prospective study.

    abstract:BACKGROUND:The impact of aberrant expression of miRNAs, small noncoding RNAs of 19 to 23 nucleotide, has been reported in different types of cancer, such as breast cancer. Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer. MATERIALS AND METHODS:miRNA-3...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Swellam M,Mahmoud MS,Hashim M,Hassan NM,Sobeih ME,Nageeb AM

    更新日期:2019-06-01 00:00:00

  • Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes.

    abstract::Osterix is a recently identified zinc-finger-containing transcription factor, which is required for skeletogenesis as no bone formation was observed in osterix-deficient mice. Osterix was first cloned as a gene whose expression was enhanced by BMP in C2C12 cells. As BMP induces ectopic bone formation in vivo via a pat...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yagi K,Tsuji K,Nifuji A,Shinomiya K,Nakashima K,DeCrombrugghe B,Noda M

    更新日期:2003-04-15 00:00:00

  • Stimulatory effect of regucalcin on mitochondrial ATP-dependent calcium uptake activity in rat kidney cortex.

    abstract::The effect of regucalcin, which is a regulatory protein of Ca(2+) signaling, on Ca(2+)-ATPase activity in isolated rat renal cortex mitochondria was investigated. The presence of regucalcin (50, 100, and 250 nM) in the enzyme reaction mixture led to a significant increase in Ca(2+)-ATPase activity. Regucalcin signific...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xue JH,Takahashi H,Yamaguchi M

    更新日期:2000-10-20 00:00:00

  • Calcium-dependent and calcium-independent adhesive mechanisms are present during initial binding events of neural retina cells.

    abstract::The hypothesis that intercellular adhesion can be subdivided into two separable phenomena, an initial recognition event and a subsequent stabilization, is supported by the use of a new cell binding assay that provides a quantitative measure of intercellular binding strengths. Radioactive single cells are brought into ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: McClay DR,Marchase RB

    更新日期:1982-01-01 00:00:00

  • Molecular cloning of a tumor promoter-inducible mRNA found in JB6 mouse epidermal cells: induction is stable at high, but not at low, cell densities.

    abstract::From the mouse JB6 epidermal cell line C122 we have isolated a cDNA clone representing a 1.6-kilobase mRNA, called 2ar, that exhibits a biphasic induction in response to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The first phase of induction in subconfluent cells is transient, peaking at 6 h after the addition of TP...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Smith JH,Denhardt DT

    更新日期:1987-05-01 00:00:00

  • The Ultrastructural Signature of Human Embryonic Stem Cells.

    abstract::The epigenetics and molecular biology of human embryonic stem cells (hES cells) have received much more attention than their architecture. We present a more complete look at hES cells by electron microscopy, with a special emphasis on the architecture of the nucleus. We propose that there is an ultrastructural signatu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Underwood JM,Becker KA,Stein GS,Nickerson JA

    更新日期:2017-04-01 00:00:00

  • Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2 signaling.

    abstract::Baicalein, a flavonoid present in the root of Scutellaria baicalensis, is well known for its antibacterial, antiviral, anti-inflammatory, antithrombotic, and antioxidant effects. Here we show that baicalein also attenuates cardiac hypertrophy. Aortic banding (AB) was performed to induce cardiac hypertrophy secondary t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zong J,Zhang DP,Zhou H,Bian ZY,Deng W,Dai J,Yuan Y,Gan HW,Guo HP,Tang QZ

    更新日期:2013-05-01 00:00:00

  • Requirements for DNA transcription and replication at the beginning of mouse development.

    abstract::In mice, the first round of DNA replication occurs in fertilized eggs (1-cell embryos), while the onset of zygotic gene transcription begins approximately 20 hours after fertilization, a time that normally coincides with formation of a 2-cell embryo. One approach to investigating the mechanisms that control these deve...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Majumder S,DePamphilis ML

    更新日期:1994-05-01 00:00:00

  • Recycling and LFA-1-dependent trafficking of ICAM-1 to the immunological synapse.

    abstract::Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM-1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen-priming T-cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells,...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jo JH,Kwon MS,Choi HO,Oh HM,Kim HJ,Jun CD

    更新日期:2010-12-01 00:00:00

  • microRNA-193b protects against myocardial ischemia-reperfusion injury in mouse by targeting mastermind-like 1.

    abstract::The current study aimed to explore the functions and roles of microRNA-193b (miR-193b) in the myocardium with ischemia-reperfusion (I/R) injury and a potential therapeutic method for myocardial I/R injury. The mice were subjected to myocardial I/R with or without miR-193b pretreatment. The infarct size and myocardial ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang J,Niu J,Tian B,Zhao M

    更新日期:2019-08-01 00:00:00

  • Effect of 3,6-anhydro-l-galactose on α-melanocyte stimulating hormone-induced melanogenesis in human melanocytes and a skin-equivalent model.

    abstract::3,6-Anhydro-l-galactose (l-AHG) is a bioactive sugar that is a major component of agarose. Recently, l-AHG was reported to have anti-melanogenic potential in human epidermal melanocytes (HEMs) and B16F10 melanoma cells; however, its underlying molecular mechanisms remain unknown. At noncytotoxic concentrations, l-AHG ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kim JH,Kim DH,Cho KM,Kim KH,Kang NJ

    更新日期:2018-09-01 00:00:00

  • Kips off to Myc: implications for TGF beta signaling.

    abstract::Loss of sensitivity to the negative growth regulator transforming growth factor beta (TGF beta) is a feature of many different tumor types and is likely involved in tumor progression. In some cases this loss of sensitivity to TGF beta has been shown to be manifest in the absence of membrane-associated TGF beta recepto...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Alexandrow MG,Moses HL

    更新日期:1997-09-15 00:00:00

  • Gamma-secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF-κB signaling pathway induced by IL-1β and TNF-α in nucleus pulposus cells.

    abstract::In this experiment, the cross-talk betweenNotch and the NF-κB signaling pathway was examined to reveal the mechanism of slowing down the type II collagen (ColII) and aggrecan degeneration affected by inflammatory cytokines. The expression levels of ColII and aggrecan in the intervertebral disc were observed through im...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

    更新日期:2018-10-26 00:00:00

  • "New"-clear functions of PDK1: beyond a master kinase in the cytosol?

    abstract::Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metaboli...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Kikani CK,Dong LQ,Liu F

    更新日期:2005-12-15 00:00:00

  • Matrix influence on the tumor cell stimulation of fibroblast collagenase production.

    abstract::Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced b...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Biswas C

    更新日期:1985-01-01 00:00:00