Induction of hepatocyte-like cells from mouse embryonic stem cells by lentivirus-mediated constitutive expression of Foxa2/Hnf4a.

abstract：:Ataxia telangiectasia (AT) is a rare genetic disorder caused by mutations of ATM gene. ATM kinase is a "master controller" of DNA-damage response and signal transducer of external stimuli. The complex role of ATM may explain the pleiotropic phenotype characteristic of AT syndrome, only partially. In our hypothesis, th...

journal_title：Journal of cellular biochemistry

authors： Grattarola M,Borghi C,Emionite L,Lulli P,Chessa L,Vergani L

更新日期：2006-11-01 00:00:00

abstract：:The microenvironment of the cancer cell is pivotal to its phenotypic regulation. One of the central components of the microenvironment is temperature. An elevation in environmental temperature has been shown to increase the cancer cell's susceptibility to chemo- and radiation therapy. The goal of the studies described...

journal_title：Journal of cellular biochemistry

authors： Zeng Y,Kulkarni P,Inoue T,Getzenberg RH

更新日期：2009-05-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a unique population of multipotent cells that exhibit pluripotent properties to a certain extent and are significantly heterogeneous in terms of the cell population. We isolate a small cell subpopulation from bovine BMSCs, bovine small stem cells (bSSCs), and herein characterize t...

journal_title：Journal of cellular biochemistry

authors： Pan S,Chen YC,Zhao N,Feng X,Yang DD,Wang Y,Jin ZB

更新日期：2019-08-01 00:00:00

abstract：:We previously suggested that keratinocyte releasable factors might modulate the wound healing process by regulating the expression of key extracellular matrix components such as collagenase (matrix metalloproteinase-1) and type I collagen in fibroblasts. The first one, we called it keratinocyte-derived anti-fibrogenic...

journal_title：Journal of cellular biochemistry

authors： Chavez-Muñoz C,Hartwell R,Jalili RB,Jafarnejad SM,Lai A,Nabai L,Ghaffari A,Hojabrpour P,Kanaan N,Duronio V,Guns E,Cherkasov A,Ghahary A

更新日期：2012-08-01 00:00:00

abstract：:The mass and function of bones depend on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. An inhibitor of osteoclast differentiation and/or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid...

journal_title：Journal of cellular biochemistry

authors： Yonezawa T,Mase N,Sasaki H,Teruya T,Hasegawa S,Cha BY,Yagasaki K,Suenaga K,Nagai K,Woo JT

更新日期：2012-02-01 00:00:00

abstract：:The role of TatD DNases as DNA repair enzymes or cell death (apoptotic) nucleases is well established in prokaryotes as well as eukaryotes. The current study aims to characterize the TatD nuclease from Bacillus anthracis (Ba TatD) and to explore its key histidine catalytic residues. Ba TatD was found to be a metal-dep...

journal_title：Journal of cellular biochemistry

authors： Singh D,Rahi A,Kumari R,Gupta V,Gautam G,Aggarwal S,Rehan M,Bhatnagar R

更新日期：2019-02-05 00:00:00

abstract：:Arsenic is the first metal to be identified as a human carcinogen. Arsenite, one inorganic form of arsenic, has been found to induce sister chromatid exchange, chromosome aberrations, and gene amplification in a variety of in vitro systems. In this study of arsenite-induced genotoxicity represented a micronuclei produ...

journal_title：Journal of cellular biochemistry

authors： Liu YC,Huang H

更新日期：1997-03-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:Magnesium homeostasis in HL-60 promyelocytic leukemia cells was compared to that in neutrophyl-like HL-60 cells obtained by 1.3% DMSO treatment. Magnesium homeostasis was studied by the characterization of magnesium efflux, the identification of intracellular magnesium pools, and the regulation of intracellular ionize...

journal_title：Journal of cellular biochemistry

authors： Wolf FI,Covacci V,Bruzzese N,Di Francesco A,Sacchetti A,Corda D,Cittadini A

更新日期：1998-12-01 00:00:00

abstract：:Arsenic trioxide (ATO) is a first-line anti-cancer agent for acute promyelocytic leukemia, and induces apoptosis in other solid cancer cell lines including breast cancer cells. However, as with arsenites found in drinking water and used as raw materials for wood preservatives, insecticides, and herbicides, low doses o...

journal_title：Journal of cellular biochemistry

authors： Liu Y,Hock JM,Sullivan C,Fang G,Cox AJ,Davis KT,Davis BH,Li X

更新日期：2010-12-15 00:00:00

abstract：:NS5ATP9, a gene up-regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions, such as starvation, and plays a crucial role in tu...

journal_title：Journal of cellular biochemistry

authors： Quan M,Liu S,Wang Q,Li G,Zhang Y,Feng S,Liang J,Cheng J

更新日期：2015-08-01 00:00:00

abstract：:Reveromycin A (RM-A), a small natural product isolated from Streptomyces bacteria, is a potential osteoporosis therapeutic in that it specifically induces apoptosis in osteoclasts but not osteoblasts. The purpose of the study presented here was to further elucidate the intracellular mechanisms of RM-A death effects in...

journal_title：Journal of cellular biochemistry

authors： Mead B,Morgan H,Mann-Knowlton A,Tedeschi L,Sloan C,Lang S,Hines C,Gragg M,Stofer J,Riemann K,Derr T,Heller E,Collins D,Landis P,Linna N,Jones D

更新日期：2015-08-01 00:00:00

abstract：:Osteosarcoma (OS) is a highly aggressive bone tumor with a poor prognosis. MicroRNAs are revealed to exerts essential roles in the carcinogenesis and tumor invasion of OS. But, the function of miR-1296-5p and its related mechanism in OS progression have not yet been studied. This study discovered the levels of miR-129...

journal_title：Journal of cellular biochemistry

authors： Wang L,Hu K,Chao Y,Wang X

更新日期：2020-02-01 00:00:00

abstract：:Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Sily...

journal_title：Journal of cellular biochemistry

authors： Prack Mc Cormick B,Langle Y,Belgorosky D,Vanzulli S,Balarino N,Sandes E,Eiján AM

更新日期：2018-07-01 00:00:00

abstract：:Escherichia coli is frequently exploited for genetic manipulations and heterologous gene expression studies. We have evaluated the metabolic profile of E. coli strain BL21 (DE3) RIL CodonPlus after genetic modifications and subjecting to the production of recombinant protein. Three genetically variable E. coli cell ty...

journal_title：Journal of cellular biochemistry

authors： Nadeem MS,Razeeth M,Choudhry HMZ,Anwar F,Zamzami MA,Murtaza BN,Al-Abbasi FAM,Khan MI,Shakoori AR

更新日期：2020-01-01 00:00:00

abstract：:Oxidative stress is an important underlying cause of many disease processes and may arise due to either increasing free radical generation or decreasing antioxidant defense systems. MicroRNAs (miRs) are 22-nucleotide non-coding RNAs that may regulate many intracellular processes; and, more recently, they have been imp...

journal_title：Journal of cellular biochemistry

authors： Yaribeygi H,Atkin SL,Sahebkar A

更新日期：2018-08-30 00:00:00

abstract：:LipN (Rv2970c) belongs to the Lip family of M. tuberculosis H37Rv and is homologous to the human Hormone Sensitive Lipase. The enzyme demonstrated preference for short carbon chain substrates with optimal activity at 45°C/pH 8.0 and stability between pH 6.0-9.0. The specific activity of the enzyme was 217 U/mg protein...

journal_title：Journal of cellular biochemistry

authors： Jadeja D,Dogra N,Arya S,Singh G,Singh G,Kaur J

更新日期：2016-02-01 00:00:00

abstract：:Human bone marrow stromal cells (hBMSC) are pluripotent cells that have the ability to differentiate into bone, cartilage, hematopoietic-supportive stroma, and adipocytes in a process modulated by dexamethasone (DEX). To characterize changes in hBMSC in response to DEX, we carried out differential display experiments ...

journal_title：Journal of cellular biochemistry

authors： Dieudonné SC,Kerr JM,Xu T,Sommer B,DeRubeis AR,Kuznetsov SA,Kim IS,Gehron Robey P,Young MF

更新日期：1999-12-01 00:00:00

abstract：:Melanoma is a disease which has been shown to be responsive to immune intervention. This has been suggested by reports of spontaneous responses of metastatic disease with strong immune infiltrates, and supported by recent data correlating clinical response after IFNalpha treatment with development of generalized autoi...

journal_title：Journal of cellular biochemistry

authors： Vujanovic L,Butterfield LH

更新日期：2007-10-01 00:00:00

abstract：:Matrine, a natural product extracted from the root of Sophora flavescens Ait, was the main chemical ingredient of compounds of Kushen injection, which has been widely used for its remarkable anticancer effects for years. The underlying mechanisms for Matrine regulations of human breast cancer stem cells (BrCSCs) are b...

journal_title：Journal of cellular biochemistry

authors： Li X,Liang T,Chen SS,Wang M,Wang R,Li K,Wang JC,Xu CW,Du N,Qin S,Ren H

更新日期：2020-03-01 00:00:00

abstract：:This report demonstrates that the expression of melanoma growth stimulatory activity (MGSA) mRNA can be modulated in a positive fashion in the Hs294T human melanoma cell line by PDGF and MGSA. There is close correlation between MGSA expression and the pattern of cell growth in Hs294T cells. ...

journal_title：Journal of cellular biochemistry

authors： Bordoni R,Thomas G,Richmond A

更新日期：1989-04-01 00:00:00

abstract：:A non-toxic and efficient gene carrier is one requirement for clinical gene therapy. In this study, amphiphilic peptides composed of arginines and valines were synthesized and characterized as plasmid DNA (pDNA) carriers. The peptides have a cationic region containing 1-4 arginines and a hydrophobic region containing ...

journal_title：Journal of cellular biochemistry

authors： Ryu DW,Kim HA,Song H,Kim S,Lee M

更新日期：2011-05-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was ...

journal_title：Journal of cellular biochemistry

authors： Liu Z,Wang X,Yang G,Zhong C,Zhang R,Ye J,Zhong Y,Hu J,Ozal B,Zhao S

更新日期：2020-07-01 00:00:00

abstract：:Fibrosis, the deadly pathological manifestation of an abnormal tissue remodeling in any organ due to excessive collagen deposition, is associated with a wide variety of organ failure-related human diseases. Chronic stress or repeated injury in a particular organ induces abnormal molecular signals that lead to super-ac...

journal_title：Journal of cellular biochemistry

authors： Ghosh AK

更新日期：2014-09-01 00:00:00

abstract：:Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but its role in regulating liver regeneration is unknown. Here we investigated the effects of GSK-3beta inhibition on liver regeneration after partial hepatectomy in the rat. The potent and selective GSK-...

journal_title：Journal of cellular biochemistry

authors： Chen H,Yang S,Yang Z,Ma L,Jiang D,Mao J,Jiao B,Cai Z

更新日期：2007-12-01 00:00:00

abstract：:Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for anti inflammation in ancient times. Although it has been shown that pristimerin induces apoptosis in breast cancer cells, the involved mechanism of action is unknown. The purpose of the curr...

journal_title：Journal of cellular biochemistry

authors： Yang H,Landis-Piwowar KR,Lu D,Yuan P,Li L,Reddy GP,Yuan X,Dou QP

更新日期：2008-01-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：:This study aims to explore the effects of shRNA-mediated silencing on Pyruvate kinase type M2 (PKM2) gene during aerobic glycolysis in colorectal cancer (CRC) cells. CRC tissues and adjacent normal tissues were obtained from 136 patients diagnosed with qRT-PCR, Western blotting, and immunohistochemistry (IHC) were per...

journal_title：Journal of cellular biochemistry

authors： Yan XL,Zhang XB,Ao R,Guan L

更新日期：2017-12-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common cancers worldwide and has especially high morbidity and mortality in China. LEM domain containing 1 (LEMD1), an important cancer-testis antigen, has been reported to be overexpressed in various cancers and promotes the progression of cancers. However, the biological charac...

journal_title：Journal of cellular biochemistry

authors： Li Q,Ge Y,Chen X,Wang L,Xia Y,Xu Z,Li Z,Wang W,Yang L,Zhang D,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:p150(glued) is the largest subunit of dynactin protein complex, through which cargo vesicles link to the microtubule minus-end directed motor protein dynein. In addition, p150(glued) also locates in the mother centriole where it organizes the subdistal appendage. The components of appendage are dynamically regulated t...

journal_title：Journal of cellular biochemistry

authors： Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

更新日期：2015-09-01 00:00:00