Hydrogen sulfide protects against acetaminophen-induced acute liver injury by inhibiting apoptosis via the JNK/MAPK signaling pathway.

abstract：:A gene coding for the (pro)phospholipase A2 (PLA2) from bovine pancreas has been designed, synthesized, and expressed in Escherichia coli. The gene was designed with a variety of restriction sites that will facilitate future mutagenesis studies. Codons occurring frequently in prokaryotic systems were chosen whenever p...

journal_title：Journal of cellular biochemistry

authors： Noel JP,Tsai MD

更新日期：1989-07-01 00:00:00

abstract：:Epidemiological studies have shown that chronic exposure to arsenic can result in liver injury, peripheral neuropathy, arteriosclerosis, and an increased incidence of cancer of the lung, skin, bladder, and liver. The overexpression of inducible cyclooxygenase-2 (Cox-2) has been associated with vascular inflammation an...

journal_title：Journal of cellular biochemistry

authors： Tsai SH,Liang YC,Chen L,Ho FM,Hsieh MS,Lin JK

更新日期：2002-01-01 00:00:00

abstract：:In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling pathway leading to phosphorylation of the translational repressor, eIF-4E binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the primary mediator of these effects. The structure-activity relationships of a putative L-leucine r...

journal_title：Journal of cellular biochemistry

authors： Lynch CJ,Fox HL,Vary TC,Jefferson LS,Kimball SR

更新日期：2000-03-01 00:00:00

abstract：:Epidermal growth factor (EGF)-receptor is a 170 kDa transmembrane glycoprotein that contains a ligand-binding external domain, and a catalytically active cytoplasmic region. The expression of this receptor as well as a 100 kDa homolog that contains only the external domain is enhanced by the ligand EGF. EGF acts at tr...

journal_title：Journal of cellular biochemistry

authors： Das M,Kesavan P,Khire J

更新日期：1990-09-01 00:00:00

abstract：:Extracellular matrix (ECM) accumulation plays a key role in the progression of bladder outlet obstruction (BOO). Muscarinic receptors have been widely reported to serve as pivotal regulators in lung tissue remodeling. However, the influence of them on human bladder smooth muscle cells (HBSMCs) and the underlying molec...

journal_title：Journal of cellular biochemistry

authors： Chen S,Liao B,Jin X,Wei T,He Q,Lin Y,Ai J,Gong L,Li H,Wang K

更新日期：2020-11-01 00:00:00

abstract：:Cultured human melanoma cells were found to secrete TGF-beta mostly in latent biologically inactive form but in addition five of six melanoma cell lines studied produced in conditioned culture medium active TGF-beta in the range from 370 to 610 pg per 10(6) cells per 24 h. A distinct characteristic of these melanoma c...

journal_title：Journal of cellular biochemistry

authors： Bizik J,Felnerova D,Grofova M,Vaheri A

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore the mechanism of excessive apoptosis of nucleus pulposus cells induced by short hairpin RNA (shRNA) Piezo type mechanosensitive ion channel component 1 (Piezo1) under abnormal mechanical stretch stress. METHODS:In vitro mechanical stretch stress model of nucleus pulposus c...

journal_title：Journal of cellular biochemistry

authors： Yang Q,Zhou Y,Wang J,Fu W,Li X

更新日期：2019-03-01 00:00:00

abstract：:The signal transduction system that mediates bacterial chemotaxis allows cells to modulate their swimming behavior in response to fluctuations in chemical stimuli. Receptors at the cell surface receive information from the surroundings. Signals are then passed from the receptors to cytoplasmic chemotaxis components: C...

journal_title：Journal of cellular biochemistry

authors： Lukat GS,Stock JB

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world for early metastasis, extensive invasion, and poor prognosis with a 5-year survival rate less than 5%. However, the underlying mechanisms are poorly understood. Therefore, it is urgent to explore molecular markers for early diag...

journal_title：Journal of cellular biochemistry

authors： Yang Y,Wang Y,Liu S,Zhao X,Jia R,Xiao Y,Zhang M,Li X,Li J,Wang W

更新日期：2018-11-28 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：:Resident T lymphocytes have been found to exert helper and suppressor regulatory influences with regard to polyclonal activation of murine splenic B lymphocytes elicited by lipopolysaccharide. In the normal adult spleen, only T cell helper influences are exercised over polyclonal B cell activation. This activity is a ...

journal_title：Journal of cellular biochemistry

authors： Goodman MG,Weigle WO

更新日期：1982-01-01 00:00:00

abstract：:The oviduct is a dynamic organ which modulates gamete physiology. Two subpopulations of sperm have been described in the oviduct of sows, a majority with normal appearance in the deep furrows and a minority, centrally located, and showing damaged membranes. Sperm-oviduct interaction provides the formation of a sperm s...

journal_title：Journal of cellular biochemistry

authors： Teijeiro JM,Cabada MO,Marini PE

更新日期：2008-04-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitoge...

journal_title：Journal of cellular biochemistry

authors： Polte TR,Naftilan AJ,Hanks SK

更新日期：1994-05-01 00:00:00

abstract：:Several molecules extracted from natural products exhibit different biological activities, such as ion channel modulation, activation of signaling pathways, and anti-inflammatory or antitumor activity. In this study, we tested the antitumor ability of natural compounds extracted from the Raputia praetermissa plant. Am...

journal_title：Journal of cellular biochemistry

authors： Vital WD,Torquato HFV,Jesus LOP,Judice WAS,Silva MFDGFD,Rodrigues T,Justo GZ,Veiga TAM,Paredes-Gamero EJ

更新日期：2019-06-01 00:00:00

abstract：:Selected clones of Syrian hamster DDT1-MF2 cells are responsive to testosterone for growth. Heparin binding growth factor 1 (HBGF-1) or acidic fibroblast growth factor (aFGF) can replace testosterone (T) in the stimulation of growth in these cells. This phenomena is correlated with testosterone's ability to elevate aF...

journal_title：Journal of cellular biochemistry

authors： Hall JA,Harris MA,Intres R,Harris SE

更新日期：1993-01-01 00:00:00

abstract：:Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. Genital warts are also reported to be linked with HPV infection types 11 and 6. In turn, clinical characteristics and morphological features of warts may be useful in the prediction of prognos...

journal_title：Journal of cellular biochemistry

authors： Hasanzadeh M,Rejali M,Mehramiz M,Akbari M,Mousavi Seresht L,Yazdandoost Y,Farokhi S,Mahdian Z,Maleki F,Emamdadi-Aliabad Z,Jalilvand N,Khorrami S,Fadaei Z,Movahedi M,Hosseini Z,Razmi F,Takamoli T,Ferns GA,Avan A

更新日期：2019-08-01 00:00:00

abstract：:Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor cells in a dose- and time-dependent manner. ApoE inhibited both de novo DNA synthesis and proliferation as assessed by an increase in cell number. Maximal inhibiti...

journal_title：Journal of cellular biochemistry

authors： Vogel T,Guo NH,Guy R,Drezlich N,Krutzsch HC,Blake DA,Panet A,Roberts DD

更新日期：1994-03-01 00:00:00

abstract：:AIMP1 was first found as a factor associated with the aminoacyl-tRNA synthetase (ARS) complex. However, it is also secreted and acts on different target cells such as endothelial cells, macrophages, and fibroblasts as an extracellular regulator, respectively, of angiogenesis, inflammatory responses and dermal regenera...

journal_title：Journal of cellular biochemistry

authors： Jackson VC,Dewilde S,Albo AG,Lis K,Corpillo D,Canepa B

更新日期：2011-07-01 00:00:00

abstract：:Labeled oligonucleotide analogues for antisense imaging of messenger RNA (mRNA) have great potential for detection of endogenous gene expression in vivo. Successful antisense imaging may be useful for detecting cellular gene expression patterns and early molecular changes in disease. Conclusive demonstration of this t...

journal_title：Journal of cellular biochemistry

authors： Lewis MR,Jia F

更新日期：2003-10-15 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) appears to be a significant threat to public health worldwide. MicroRNAs have been identified as significant regulators for the development of NSCLC. Previous reports have suggested that hsa-mir-485-5p is dysregulated in various cancers. RXRα, as a kind of nuclear receptor, is an eff...

journal_title：Journal of cellular biochemistry

authors： Jiang P,Xu C,Chen L,Chen A,Wu X,Zhou M,Haq IU,Mariyam Z,Feng Q

更新日期：2018-11-01 00:00:00

abstract：:Colorectal cancer remains a leading malignancy in humans. The importance of epigenetic modification in the development of this disease is now being recognized. The reversible and dynamic nature of epigenetic modifications provides a promising strategy in colorectal cancer chemoprevention and treatment. Luteolin (LUT),...

journal_title：Journal of cellular biochemistry

authors： Zuo Q,Wu R,Xiao X,Yang C,Yang Y,Wang C,Lin L,Kong AN

更新日期：2018-11-01 00:00:00

abstract：:Phospholipids, sphingolipids, and cholesterol are integral components of eukaryotic cell organelles, including the nucleus. Recent evidence shows characteristic features of nuclear lipid composition and signaling, which are distinct from that of the cytoplasm and plasma membrane. While the nuclear phosphoinositol lipi...

journal_title：Journal of cellular biochemistry

authors： Fu P,Ebenezer DL,Ha AW,Suryadevara V,Harijith A,Natarajan V

更新日期：2018-08-01 00:00:00

abstract：:Serous ovarian cancer (SOC) is the most common form of the histological subtype of epithelial ovarian cancer, with the worst clinical outcome. Despite improvements in surgery and chemotherapy, most patients with SOC experience recurrence within 12-18 months of first-line treatment. Current studies are unable to robust...

journal_title：Journal of cellular biochemistry

authors： Deng K,Zhang F,Song W,Zhao W,Rong Z,Cai Y,Xu H,Lu M,Wang W,Li A,Hou Y,Li Z,Li K

更新日期：2018-11-01 00:00:00

abstract：:Bladder cancer-associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small-cell lung cancer (SCLC) remained unknown. The aim of our...

journal_title：Journal of cellular biochemistry

authors： Chen W,Hang Y,Xu W,Wu J,Chen L,Chen J,Mao Y,Song J,Song J,Wang H

更新日期：2018-09-11 00:00:00

abstract：:Circular RNAs (circRNAs) are a newly validated type of noncoding RNAs recently found to be deregulated in several human cancers. More accurate and specific noninvasive biomarkers are strongly needed for better diagnosis and prognosis of hepatocellular carcinoma (HCC). We performed a bioinformatics analysis to retrieve...

journal_title：Journal of cellular biochemistry

authors： Matboli M,Shafei AE,Ali MA,Ashry AM,Kamal KM,Agag MA,Reda I,Tash EF,Ali M

更新日期：2018-11-13 00:00:00

abstract：:Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship betw...

journal_title：Journal of cellular biochemistry

authors： He S,Choi YH,Choi JK,Yeo CY,Chun C,Lee KY

更新日期：2014-10-01 00:00:00

abstract：:ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression o...

journal_title：Journal of cellular biochemistry

authors： Wang D,Wang H,Gao F,Wang K,Dong F

更新日期：2017-06-01 00:00:00

abstract：:The human myeloid nuclear differentiation antigen (MNDA) is expressed specifically in maturing cells of the myelomonocytic lineage and in monocytes and granulocytes. Epitope enhancement was used to confirm the strict lineage- and stage-specific expression of MNDA in bone marrow as well as in other paraffin-embedded fi...

journal_title：Journal of cellular biochemistry

authors： Kao WY,Briggs JA,Kinney MC,Jensen RA,Briggs RC

更新日期：1997-05-01 00:00:00

abstract：:Regulation of mesenchymal stem cell (MSC) lineage selection is important for the generation of bone mass. Inhibition of cyclooxygenase-2 (COX2) may increase adipogenesis at the cost of decreasing osteoprogenitor output. Here we investigated the role of COX2 and its products during MSC differentiation. Indomethacin sti...

journal_title：Journal of cellular biochemistry

authors： Styner M,Sen B,Xie Z,Case N,Rubin J

更新日期：2010-11-01 00:00:00

abstract：:Given its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate-limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two of these therapeutic agents already in clinical use. Bevacizumab was first used for c...

journal_title：Journal of cellular biochemistry

authors： Costa R,Carneiro A,Rocha A,Pirraco A,Falcão M,Vasques L,Soares R

更新日期：2009-12-15 00:00:00