Sea urchin zygote chromatin exhibit an unfolded nucleosomal array during the first S phase.

abstract：:To ascertain whether p53 deficiency in vivo leads to the deregulation of DNA methylation machinery prior to tumor development, we investigated the expression profile of DNA methyltransferases in the thymus and the liver of p53(+/+), p53(+/-), and p53(-/-) mice at 7 weeks of age before tumor development. The expression...

journal_title：Journal of cellular biochemistry

authors： Park IY,Sohn BH,Choo JH,Joe CO,Seong JK,Lee YI,Chung JH

更新日期：2005-02-15 00:00:00

abstract：:Cleft palate is one of the most common birth defects. Several environment factors are involved in the disorder, such as smoking, vitamin deficiency and teratogens. We investigated the teratogenic agent phenytoin and extract of the immunostimulant Echinacea purpurea in the etiology of cleft palate associated with the p...

journal_title：Journal of cellular biochemistry

authors： Hu X,Chen Z,Mao X,Tang S

更新日期：2011-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and angiopoietins regulate endothelial cell survival and migration and are essential for angiogenesis. Considerable progress has been made towards understanding hypoxia-mediated regulation of VEGF and its receptors. In contrast, little is known about the regulation of angiopoi...

journal_title：Journal of cellular biochemistry

authors： Christensen RA,Fujikawa K,Madore R,Oettgen P,Varticovski L

更新日期：2002-01-01 00:00:00

abstract：:Tributyltin oxide (TBTO) has been widely used as marine antifouling composition, preservative, biocide, and a stabilizer in plastic industry. Previous studies have indicated that TBTO can cause immunotoxicity as an environmental pollutant. However, little is known about its reproductive toxicity, especially on female ...

journal_title：Journal of cellular biochemistry

authors： Yang LL,Cui YX,Ma JY,Ge ZJ,Shen W,Yin S

更新日期：2019-01-01 00:00:00

abstract：:This study aimed to identify differential circular RNA (circRNA) in the plasma exosomes of patients with lung adenocarcinoma (LUAD) using high-throughput sequencing. First, exosomes were isolated using an exosome isolation kit and confirmed by Western blotting, transmission electron microscopy, and NanoSight Assay. Su...

journal_title：Journal of cellular biochemistry

authors： Chen F,Huang C,Wu Q,Jiang L,Chen S,Chen L

更新日期：2020-03-01 00:00:00

abstract：:AKT and its substrate BAD have been shown to promote prostate cancer cell survival. Agonists, such as carbachol, and hormones that increase intracellular calcium concentration can activate AKT leading to cancer cell survival. The LNCaP prostate cancer cells express the carbachol-sensitive M(3) -subtype of G protein-co...

journal_title：Journal of cellular biochemistry

authors： Schmitt JM,Smith S,Hart B,Fletcher L

更新日期：2012-05-01 00:00:00

abstract：:Stathmin/oncoprotein18 regulates microtubule dynamics and participates in mitotic entry and exit. We isolated stathmin as a physically interacting partner of KIFC1, a minus-end-directed kinesin functioning in bipolar spindle formation and maintenance. We found that stathmin depletion leads to multipolar spindle format...

journal_title：Journal of cellular biochemistry

authors： Shrestha D,Kim N,Song K

更新日期：2018-02-01 00:00:00

abstract：:Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short- and long-term repopulating stem cells when compared to more mature bone marrow...

journal_title：Journal of cellular biochemistry

authors： Krivtsov AV,Rozov FN,Zinovyeva MV,Hendrikx PJ,Jiang Y,Visser JW,Belyavsky AV

更新日期：2007-06-01 00:00:00

abstract：:Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanc...

journal_title：Journal of cellular biochemistry

authors： Johansson M,Tan T,de Visser KE,Coussens LM

更新日期：2007-07-01 00:00:00

abstract：:Gastric cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. Gastric infections, such as helicobacter pylori, can induce the occurrence of gastric cancers. However, the role of gastric infection in gastric cancer development is unclear. Programmed death-ligand 1 (PD-L1, B7-H1) is...

journal_title：Journal of cellular biochemistry

authors： Li H,Xia JQ,Zhu FS,Xi ZH,Pan CY,Gu LM,Tian YZ

更新日期：2018-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be a promising treatment for PDAC. The critical role of Wnt-signaling pathway in cancer pathogenesis has been widely recognized; cyclin-dependent kinase 14 (CDK14, PFTK1)-induced low-density lip...

journal_title：Journal of cellular biochemistry

authors： Sun Y,Zhu Q,Yang W,Shan Y,Yu Z,Zhang Q,Wu H

更新日期：2019-03-01 00:00:00

abstract：:The initiation of DNA replication in T lymphocytes appears to be regulated by two distinct activities: one associated with proliferation which mediates initiation, and another associated with quiescence which blocks initiation. Activated lymphocytes and proliferating lymphoid cell lines produce an activity, termed ADR...

journal_title：Journal of cellular biochemistry

authors： Coffman FD,Fresa KL,Cohen S

更新日期：1991-01-01 00:00:00

abstract：:Transplantation of functional insulin-producing cells (IPCs) provides a novel mode for insulin replacement, but is often accompanied by many undesirable side effects. Our previous studies suggested that IPCs could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells. To obtain...

journal_title：Journal of cellular biochemistry

authors： Shi Q,Luo S,Jia H,Feng L,Lu X,Zhou L,Cai J

更新日期：2013-10-01 00:00:00

abstract：:The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Wang L,Cao L,Chen L,Liu Q

更新日期：2018-10-28 00:00:00

abstract：:Phosphoproteins produced by the incubation of crude extracts of Salmonella typhimurium and Escherichia coli with either [32P]phosphoenolpyruvate or [gamma 32P]ATP have been resolved and detected using sodium dodecyl sulphate polyacrylamide gel electrophoresis and autoradiography. Simple techniques were found such that...

journal_title：Journal of cellular biochemistry

authors： Waygood EB,Mattoo RL,Peri KG

更新日期：1984-01-01 00:00:00

abstract：:Vascularization is essential for bone development, fracture healing, and bone tissue engineering. We have previously described that coculture of primary human osteoblasts (hOBs) and human umbilical vein endothelial cells (HUVECs) improves differentiation of both cell types. Investigating the role of microRNAs (miRNAs)...

journal_title：Journal of cellular biochemistry

authors： Strassburg S,Nabar N,Lampert F,Goerke SM,Pfeifer D,Finkenzeller G,Stark GB,Simunovic F

更新日期：2017-07-01 00:00:00

abstract：:Inverted repeats occur nonrandomly in the DNA of most organisms. Stem-loops and cruciforms can form from inverted repeats. Such structures have been detected in pro- and eukaryotes. They may affect the supercoiling degree of the DNA, the positioning of nucleosomes, the formation of other secondary structures of DNA, o...

journal_title：Journal of cellular biochemistry

authors： Pearson CE,Zorbas H,Price GB,Zannis-Hadjopoulos M

更新日期：1996-10-01 00:00:00

abstract：:In vivo clearance studies have indicated that the clearance of proteinase complexes of the homologous serine proteinase inhibitors alpha 1-proteinase inhibitor and antithrombin III occurs via a specific and saturable pathway located on hepatocytes. In vitro hepatocyte-uptake studies with antithrombin III-proteinase co...

journal_title：Journal of cellular biochemistry

authors： Fuchs HE,Michalopoulos GK,Pizzo SV

更新日期：1984-01-01 00:00:00

abstract：:Baicalein, a flavonoid present in the root of Scutellaria baicalensis, is well known for its antibacterial, antiviral, anti-inflammatory, antithrombotic, and antioxidant effects. Here we show that baicalein also attenuates cardiac hypertrophy. Aortic banding (AB) was performed to induce cardiac hypertrophy secondary t...

journal_title：Journal of cellular biochemistry

authors： Zong J,Zhang DP,Zhou H,Bian ZY,Deng W,Dai J,Yuan Y,Gan HW,Guo HP,Tang QZ

更新日期：2013-05-01 00:00:00

abstract：:Avian progesterone receptor exists as two forms, A and B, with molecular weights of 79,000 and 110,000 daltons, respectively. The origin and significance of these two forms is an area of active investigation and debate. Monoclonal antibodies produced against these two forms were used to examine receptor stability in c...

journal_title：Journal of cellular biochemistry

authors： Sullivan WP,Smith DF,Beito TG,Krco CJ,Toft DO

更新日期：1988-02-01 00:00:00

abstract：:MUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT-PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse ...

journal_title：Journal of cellular biochemistry

authors： Chapela PJ,Broaddus RR,Hawkins SM,Lessey BA,Carson DD

更新日期：2015-11-01 00:00:00

abstract：:Rabbit lymphocytes exposed to hyposmotic media first swell and then recover their initial volume within 6 min. During volume recovery, free amino acids (FAA) decrease from 451.1 to 208 nmoles/mg protein. Taurine was the dominating FAA, accounting for 70% of the FAA pool. The time course of 3H-taurine release induced b...

journal_title：Journal of cellular biochemistry

authors： Jesuś García J,Sánchez Olea R,Pasantes-Morales H

更新日期：1991-02-01 00:00:00

abstract：:The purpose of this study was to investigate ultrasound-triggered effects of the glial cell line-derived neurotrophic factor (GDNF) + nuclear receptor-related factor 1 (Nurr1)-polyethylene glycol (PEG)ylated liposomes-coupled microbubbles (PLs-GDNF + Nurr1-MBs) on behavioral impairment and neuron loss in a rat model o...

journal_title：Journal of cellular biochemistry

authors： Yue P,Gao L,Wang X,Ding X,Teng J

更新日期：2018-06-01 00:00:00

abstract：:We have recently demonstrated that transforming growth factor (TGF)-beta 1 and TGF-beta 2 are potent inhibitors of the growth and differentiation of murine and human hematopoietic cells. The proliferation of primary unfractionated murine bone marrow by interleukin-3 (IL-3) and human bone marrow by IL-3 or granulocyte/...

journal_title：Journal of cellular biochemistry

authors： Keller JR,Sing GK,Ellingsworth LR,Ruscetti FW

更新日期：1989-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short noncoding ribonucleic acids known to affect gene expression at the translational level and there is mounting evidence that miRNAs play a role in the function of tumor-associated macrophages (TAMs). To aid the functional analyses of miRNAs in an in-vitro model of TAMs known as M2 macrophage...

journal_title：Journal of cellular biochemistry

authors： Ng YS,Roca H,Fuller D,Sud S,Pienta KJ

更新日期：2012-05-01 00:00:00

abstract：:Interleukin-1 beta-converting enzyme (ICE) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. ICE and homologous proteases also appear to mediate intracellular protein degradation during programmed cell death. Inhibit...

journal_title：Journal of cellular biochemistry

authors： Livingston DJ

更新日期：1997-01-01 00:00:00

abstract：:Proliferation of endothelial cells is regulated by angiogenic and antiangiogenic factors whose actions are mediated by complex interactions of multiple signaling pathways. Both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulate cell proliferation and activate the mitogen-acti...

journal_title：Journal of cellular biochemistry

authors： D'Angelo G,Lee H,Weiner RI

更新日期：1997-12-01 00:00:00

abstract：:Smoothened (SMO) is a significant signalling protein which functions as a key transducer for the hedgehog signalling pathway, an important signalling mechanism with key roles in development and oncogenesis. The correlation of expression dynamics of SMO with pancreatic and colorectal cancer genesis has been known but w...

journal_title：Journal of cellular biochemistry

authors： Niyaz M,Khan MS,Wani RA,Shah OJ,Besina S,Mudassar S

更新日期：2019-02-19 00:00:00

abstract：:Pancreatic adenocarcinomas induced in Syrian hamsters by treatment with N-nitrosobis(2-oxopropyl) amine express blood group A antigen, which is absent in normal pancreatic cells. On membrane glycoproteins purified from tumors, blood group A antigen has been found to be expressed on multiantennary Asn-linked complex gl...

journal_title：Journal of cellular biochemistry

authors： Hirota M,Mogaki M,Pour PM,Chaney WG

更新日期：1992-09-01 00:00:00

abstract：:Although several studies have shown that an induction of insulin-like growth factor (IGF) components occurs during hyperoxia-mediated lung injury, the role of these components in tissue repair is not well known. The present study aimed to elucidate the role of IGF system components in normal tissue remodeling. We used...

journal_title：Journal of cellular biochemistry

authors： Narasaraju TA,Chen H,Weng T,Bhaskaran M,Jin N,Chen J,Chen Z,Chinoy MR,Liu L

更新日期：2006-04-01 00:00:00