Stathmin/Op18 depletion induces genomic instability and leads to premature senescence in human normal fibroblasts.

abstract：:From the mouse JB6 epidermal cell line C122 we have isolated a cDNA clone representing a 1.6-kilobase mRNA, called 2ar, that exhibits a biphasic induction in response to 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The first phase of induction in subconfluent cells is transient, peaking at 6 h after the addition of TP...

journal_title：Journal of cellular biochemistry

authors： Smith JH,Denhardt DT

更新日期：1987-05-01 00:00:00

abstract：:In order to assess, in a controlled in vitro model, the differentiation potential of adult bone marrow derived stem cells we have developed a coculture procedure using adult rat cardiomyocytes and mesenchymal stem cells (MSCs) from transgenic GFP positive rats. We investigated in the cocultured MSCs the time course of...

journal_title：Journal of cellular biochemistry

authors： Gallo MP,Ramella R,Alloatti G,Penna C,Pagliaro P,Marcantoni A,Bonafé F,Losano G,Levi R

更新日期：2007-01-01 00:00:00

abstract：:Because elevated ubiquitin ligase atrogin-1/MAFbx and MuRF1 mediate skeletal muscle wasting associated with various catabolic conditions, the signaling pathways involved in the upregulation of these genes under pathological conditions are considered therapeutic targets. AKT and NF-kappaB have been previously shown to ...

journal_title：Journal of cellular biochemistry

authors： Jin B,Li YP

更新日期：2007-03-01 00:00:00

abstract：:The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms' tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays....

journal_title：Journal of cellular biochemistry

authors： Xie W,Wei L,Guo J,Guo H,Song X,Sheng X

更新日期：2019-02-12 00:00:00

abstract：:Cancer is characterized by uncontrolled cell division resulting from multiple mutagenic events. Cancer chemoprevention strategies aim to inhibit or reverse these events using natural or synthetic pharmacologic agents. Ideally, this restores normal growth control mechanisms. Diverse classes of compounds have been ident...

journal_title：Journal of cellular biochemistry

authors： Freemantle SJ,Liu X,Feng Q,Galimberti F,Blumen S,Sekula D,Kitareewan S,Dragnev KH,Dmitrovsky E

更新日期：2007-11-01 00:00:00

abstract：:Insects possess an antimicrobial defense response that is similar to the mammalian innate immune response. The innate immune system is designed to recognize conserved components of microorganisms called pathogen-associated molecular patterns (PAMPs). How host receptors detect PAMPs and transmit the signals to mount th...

journal_title：Journal of cellular biochemistry

authors： Bettencourt R,Asha H,Dearolf C,Ip YT

更新日期：2004-07-01 00:00:00

abstract：:Due to the increasing incidence and mortality, the early diagnosis, specific targeted therapies, and prognosis for colorectal cancer (CRC) attract more and more attention. Wild-type p53-induced phosphatase 1 (Wip1) and karyopherin α2 (KPNA2) have been regarded as oncogenes in many cancers, including CRC. Wip1 dephosph...

journal_title：Journal of cellular biochemistry

authors： Wang P,Zhao Y,Liu K,Liu X,Liang J,Zhou H,Wang Z,Zhou Z,Xu N

更新日期：2019-09-01 00:00:00

abstract：:Osterix is a recently identified zinc-finger-containing transcription factor, which is required for skeletogenesis as no bone formation was observed in osterix-deficient mice. Osterix was first cloned as a gene whose expression was enhanced by BMP in C2C12 cells. As BMP induces ectopic bone formation in vivo via a pat...

journal_title：Journal of cellular biochemistry

authors： Yagi K,Tsuji K,Nifuji A,Shinomiya K,Nakashima K,DeCrombrugghe B,Noda M

更新日期：2003-04-15 00:00:00

abstract：:Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

journal_title：Journal of cellular biochemistry

authors： Fan CN,Ma L,Liu N

更新日期：2019-03-01 00:00:00

abstract：:Antibodies against pure discoidin I have been used as a tool to ascertain the role of this lectin in aggregation of Dictyostelium discoideum. Discoidin I is widely expressed over the cell surface of aggregation-competent AX-2 cells, as ascertained by indirect immunofluorescence with specific (antidiscoidin I) antibodi...

journal_title：Journal of cellular biochemistry

authors： Cano A,Pestaña A

更新日期：1984-01-01 00:00:00

abstract：:Rhodopsin mutations cause autosomal dominant form of retinitis pigmentosa (RP). T17M rhodopsin predisposes cells to endoplasmic reticulum stress induced apoptosis. However, the pathogenic role of T17M rhodopsin in RP is not completely understood. Complement C3 has a protective role in RP pathogenesis. This study aimed...

journal_title：Journal of cellular biochemistry

authors： Xiong S,Yu Y,Zhou X,Xia X,Jiang H

更新日期：2017-12-01 00:00:00

abstract：:Primary cultures fill a unique niche among the repertoire of in vitro model systems available to investigate the biology of the normal and malignant human prostate. This review summarizes some of the properties of primary cultures, with special emphasis on two questions: are primary cultures from adenocarcinomas reall...

journal_title：Journal of cellular biochemistry

authors： Peehl DM

更新日期：2004-01-01 00:00:00

abstract：:The aim of this study was to determine: (1) whether the Short Chain Fatty Acids (SCFA) Acetate, Propionate, and Butyrate enhance the synthesis and secretion of intestinal apolipoprotein A-IV-containing lipoproteins and (2) if so, whether these particles are able to promote cholesterol efflux in vitro. For this purpose...

journal_title：Journal of cellular biochemistry

authors： Nazih H,Nazih-Sanderson F,Krempf M,Michel Huvelin J,Mercier S,Marie Bard J

更新日期：2001-08-01 00:00:00

abstract：:The promoter of the mouse thymidylate synthase (TS) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter also plays an essential role in the p...

journal_title：Journal of cellular biochemistry

authors： Kapadia F,Johnson LF

更新日期：2006-02-15 00:00:00

abstract：:Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have ...

journal_title：Journal of cellular biochemistry

authors： Sarvizadeh M,Ghasemi F,Tavakoli F,Sadat Khatami S,Razi E,Sharifi H,Biouki NM,Taghizadeh M

更新日期：2019-06-01 00:00:00

abstract：:Entry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell sign...

journal_title：Journal of cellular biochemistry

authors： Qureshi MZ,Attar R,Romero MA,Sabitaliyevich UY,Nurmurzayevich SB,Ozturk O,Wakim LH,Lin X,Ozbey U,Yelekenova AB,Farooqi AA

更新日期：2019-08-01 00:00:00

abstract：:Skin is a representative self-renewing tissue containing stem cells. Although many attempts have been made to define and isolate skin-derived stem cells, establishment of a simple and reliable isolation procedure remains a goal to be achieved. Here, we report the isolation of cells having stem cell properties from mou...

journal_title：Journal of cellular biochemistry

authors： Medina RJ,Kataoka K,Takaishi M,Miyazaki M,Huh NH

更新日期：2006-05-01 00:00:00

abstract：:Human eosinophil-derived neurotoxin (EDN, RNase2) and eosinophil cationic protein (ECP, RNase3) sequences possess as high as 92% identity in their promoter regions. The major difference within this region is a 34-nucleotide (34-nt) segment appeared only in the edn promoter. In addition, six discrete segments existed i...

journal_title：Journal of cellular biochemistry

authors： Wang HY,Ho PC,Lan CY,Chang MD

更新日期：2009-02-01 00:00:00

abstract：:Neutrophils are essential for host defense and their programmed cell death and removal are critical for the optimal expression as well as for efficient resolution of inflammation. Delayed neutrophil apoptosis or impaired clearance of apoptotic neutrophils by macrophages contributes to the progression of chronic inflam...

journal_title：Journal of cellular biochemistry

authors： Filep JG,El Kebir D

更新日期：2009-12-01 00:00:00

abstract：:Coriander (Coriandrum sativum L.) is such an herb from the Apiaceae family, used both for its medicinal and nutritional properties for many centuries. In this study, the effects of C. sativum extract on gene expression, viability, colony formation, migration, and invasion of PC-3 and LNCaP prostate cancer cell lines h...

journal_title：Journal of cellular biochemistry

authors： Elmas L,Secme M,Mammadov R,Fahrioglu U,Dodurga Y

更新日期：2019-03-01 00:00:00

abstract：:Previously we have shown that transforming growth factor beta (TGF beta) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not known. IGFBP-6 b...

journal_title：Journal of cellular biochemistry

authors： Gabbitas B,Canalis E

更新日期：1997-07-01 00:00:00

abstract：:In this study, we purpose to investigate a novel five-gene signature for predicting the prognosis of patients with laryngeal cancer. The laryngeal cancer datasets were obtained from The Cancer Genome Atlas (TCGA). Both univariate and multivariate Cox regression analysis was applied to screening for prognostic differen...

journal_title：Journal of cellular biochemistry

authors： Zhang G,Fan E,Yue G,Zhong Q,Shuai Y,Wu M,Feng G,Chen Q,Gou X

更新日期：2019-10-31 00:00:00

abstract：:Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

journal_title：Journal of cellular biochemistry

authors： Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

更新日期：2018-04-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a serious complication of diabetes contributing to blindness in patients. Inhibiting retinal neovascularization is a potent strategy for diabetic retinopathy treatment. Reportedly, the stable expression of lin-28 homolog B (LIN28B), a member of the highly conserved RNA-binding protein LIN2...

journal_title：Journal of cellular biochemistry

authors： Fu X,Ou B

更新日期：2020-02-01 00:00:00

abstract：:Hyaluronan (HA) is a ubiquitous component of the extracellular matrix (ECM) and occurs transiently in both the cell nucleus and cytoplasm. It has been shown to promote cell motility, adhesion, and proliferation and thus it has an important role in such processes as morphogenesis, wound repair, inflammation, and metast...

journal_title：Journal of cellular biochemistry

authors： Entwistle J,Hall CL,Turley EA

更新日期：1996-06-15 00:00:00

abstract：:Endogenous peptides play crucial roles in various biological processes. Their effects on the pathogenesis of human infantile hemangioma remains poorly understood. In this study, we construct a comparative peptidomic profiling between human infantile hemangioma tissue and matched normal skin using liquid chromatography...

journal_title：Journal of cellular biochemistry

authors： Li Q,Li J,Chen L,Gao Y,Li J

更新日期：2018-06-01 00:00:00

abstract：:This study aims to explore how microRNA-133a (miR-133a) affects cell apoptosis and radio-sensitivity by targeting EGFR via regulating MEK/ERK pathway in esophageal cancer (EC). A total of 358 EC patients were selected and assigned into the resistant and sensitive groups. Human EC KYSE 150 cell line was assigned into t...

journal_title：Journal of cellular biochemistry

authors： Yang QS,Jiang LP,He CY,Tong YN,Liu YY

更新日期：2017-09-01 00:00:00

abstract：:The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration an...

journal_title：Journal of cellular biochemistry

authors： Li S,Huang NF,Hsu S

更新日期：2005-12-15 00:00:00

abstract：:Myelin basic protein (MBP) is a major component of the myelin sheath whose production is developmentally controlled during myelinogenesis. Earlier studies have indicated that programmed expression of the MBP gene is regulated at the level of transcription. Evidently, the MB1 regulatory motif located between nucleotide...

journal_title：Journal of cellular biochemistry

authors： Muralidharan V,Tretiakova A,Steplewski A,Haas S,Amini S,Johnson E,Khalili K

更新日期：1997-09-15 00:00:00

abstract：:As the aged population is soaring, prevalence of osteoporosis is increasing. However, the molecular basis underlying the regulation of bone mass is still incompletely understood. Sympathetic tone acts via beta2 adrenergic receptors in bone and regulates the mass of bone which is the target organ of parathyroid hormone...

journal_title：Journal of cellular biochemistry

authors： Moriya S,Hayata T,Notomi T,Aryal S,Nakamaoto T,Izu Y,Kawasaki M,Yamada T,Shirakawa J,Kaneko K,Ezura Y,Noda M

更新日期：2015-01-01 00:00:00