Five genes as a novel signature for predicting the prognosis of patients with laryngeal cancer.

abstract：:Tissue factor, the cellular initiator of blood coagulation, has been implicated as a determinant of metastatic potential in human melanoma cells. Here, we report that differential expression of tissue factor in murine melanoma cell lines of known metastatic behavior is mediated by AP-1-dependent and 12S E1A oncoprotei...

journal_title：Journal of cellular biochemistry

authors： Voigtländer C,Rand A,Liu SL,Wilson TJ,Pittelkow MR,Getz MJ,Kelm RJ Jr

更新日期：2002-01-01 00:00:00

abstract：:The receptor for epidermal growth factor (EGF) is a glycosylated transmembrane phosphoprotein that exhibits EGF-stimulable protein tyrosine kinase activity. On EGF stimulation, the receptor undergoes a self-phosphorylation reaction at tyrosine residues located primarily in the extreme carboxyl-terminal region of the p...

journal_title：Journal of cellular biochemistry

authors： Bertics PJ,Weber W,Cochet C,Gill GN

更新日期：1985-01-01 00:00:00

abstract：:IQGAP1, is a recently discovered scaffold protein proposed to regulate membrane cytoskeleton events through protein-protein interactions with F-actin, E-cadherin, beta-catenin, and CLIP170. The binding of IQGAP1 to its partners is regulated by calcium/calmodulin (Ca(++)/CaM) and the small molecular weight guanine nucl...

journal_title：Journal of cellular biochemistry

authors： Nauert JB,Rigas JD,Lester LB

更新日期：2003-09-01 00:00:00

abstract：:The SON protein is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. Although several early studies implicated SON in DNA-binding, tumorigenesis and apoptosis, functional significance of this protein had not been recognized until recent studies discovered SON as a novel RNA...

journal_title：Journal of cellular biochemistry

authors： Hickey CJ,Kim JH,Ahn EY

更新日期：2014-02-01 00:00:00

abstract：:The BRCA1 tumor suppressor involved in breast and ovarian cancer is linked to several fundamental cell regulatory processes. Recently, it was reported that BRCA1 supports localization of XIST RNA to the inactive X chromosome (Xi) in women. The apparent cytological overlap between BRCA1 and XIST RNA across the Xi raise...

journal_title：Journal of cellular biochemistry

authors： Pageau GJ,Hall LL,Lawrence JB

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CC) is devastating neoplasm and very few specific biomarkers could be used in clinical diagnosis. A study was taken to find novel serum biomarkers for CC. METHODS:Surface enhanced laser desorption/ionization (SELDI) technology was used to analyze 427 serum samples including 56 CCs, 49 he...

journal_title：Journal of cellular biochemistry

authors： Liu L,Wang J,Liu B,Dai S,Wang X,Chen J,Huang L,Xiao X,He D

更新日期：2008-06-01 00:00:00

abstract：:Rhodopsin mutations cause autosomal dominant form of retinitis pigmentosa (RP). T17M rhodopsin predisposes cells to endoplasmic reticulum stress induced apoptosis. However, the pathogenic role of T17M rhodopsin in RP is not completely understood. Complement C3 has a protective role in RP pathogenesis. This study aimed...

journal_title：Journal of cellular biochemistry

authors： Xiong S,Yu Y,Zhou X,Xia X,Jiang H

更新日期：2017-12-01 00:00:00

abstract：:The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

journal_title：Journal of cellular biochemistry

authors： Ranga Rao S,Subbarayan R

更新日期：2019-03-01 00:00:00

abstract：:A chimeric long terminal repeat-thymidine kinase (LTR-tk) gene has been used to define the sequence requirements for glucocorticoid induction of gene expression. The original LTR-tk gene contains an entire mouse mammary tumor virus (MMTV) LTR preceding the tk gene. This gene can be expressed in a hormone-responsive fa...

journal_title：Journal of cellular biochemistry

authors： Groner B,Herrlich P,Kennedy N,Ponta H,Rahmsdorf U,Hynes NE

更新日期：1982-01-01 00:00:00

abstract：:Liver selected B16-LS9 melanoma cells show a dramatic overexpression of the proto-oncogene c-met, the cellular receptor for hepatocyte growth factor/scatter factor. As a consequence, c-met becomes constitutively active, and the cells become more responsive to hepatocyte growth factor stimulation. We have investigated ...

journal_title：Journal of cellular biochemistry

authors： Elia G,Ren Y,Lorenzoni P,Zarnegar R,Burger MM,Rusciano D

更新日期：2001-01-01 00:00:00

abstract：:Dexmedetomidine, an agonist of alpha2-adrenergic receptors, is used for critically ill patients to induce and maintain sedation and analgesia. Brain ischemia/reperfusion (I/R) usually causes severe neuronal injuries to intensive care unit patients. This study was aimed to evaluate the effects of dexmedetomidine on I/R...

journal_title：Journal of cellular biochemistry

authors： Wu GJ,Chen JT,Tsai HC,Chen TL,Liu SH,Chen RM

更新日期：2017-09-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children and adolescents with high rate of incidence, high frequency of recurrence, and high degree of metastasis. This study aimed to investigate the effects of long noncoding RNA antisense ncRNA in the abundant in neuroepithelium area (ANA)/B-cell translocation...

journal_title：Journal of cellular biochemistry

authors： Zhao J,Zhang C,Gao Z,Wu H,Gu R,Jiang R

更新日期：2018-08-01 00:00:00

abstract：:Pristimerin is a natural product derived from the Celastraceae and Hippocrateaceae families that were used as folk medicines for anti inflammation in ancient times. Although it has been shown that pristimerin induces apoptosis in breast cancer cells, the involved mechanism of action is unknown. The purpose of the curr...

journal_title：Journal of cellular biochemistry

authors： Yang H,Landis-Piwowar KR,Lu D,Yuan P,Li L,Reddy GP,Yuan X,Dou QP

更新日期：2008-01-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), provide a new cell source for regenerative medicine, disease modeling, drug discovery, and preclinical toxicity screening. Understanding of the onset and the sequential process of hemat...

journal_title：Journal of cellular biochemistry

authors： Chen T,Wang F,Wu M,Wang ZZ

更新日期：2015-07-01 00:00:00

abstract：:Endothelins (ETs) are vasoconstrictive peptides produced mainly by endothelial cells. The ET receptors are expressed in many types of cells including osteoblast-like cells. The purpose of this study was to examine the effects of endothelin on the expression of osteoblastic phenotype-related genes. We found that endoth...

journal_title：Journal of cellular biochemistry

authors： Shioide M,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Promyelocytic leukemia nuclear bodies (PML-NBs) are multiprotein complexes that include PML protein and localize in nuclear foci. PML-NBs are implicated in multiple stress responses, including apoptosis, DNA repair, and p53-dependent growth inhibition. ALT-associated PML bodies (APBs) are specialized PML-NBs that incl...

journal_title：Journal of cellular biochemistry

authors： Shen H,Maki CG

更新日期：2010-12-01 00:00:00

abstract：:The inhibitor of growth (ING) family of proteins is an evolutionarily conserved family, with members present from yeast to humans. The mammalian ING proteins are candidate tumor suppressor proteins and accordingly can cooperate with p53 to arrest proliferation and induce apoptosis. ING proteins are also reported to fu...

journal_title：Journal of cellular biochemistry

authors： Shi X,Gozani O

更新日期：2005-12-15 00:00:00

abstract：:The role of circular RNAs (circRNAs) in regulating cartilage homeostasis in osteoarthritis (OA) has been reported. However, the regulatory mechanisms of circRNAs in OA synovium remains basically unidentified. The current study intended to divulge the expression profile of circRNAs in OA synovium and investigate the po...

journal_title：Journal of cellular biochemistry

authors： Xiang S,Li Z,Bian Y,Weng X

更新日期：2019-10-01 00:00:00

abstract：:Excitatory amino acids (EAAs) are found present in the nervous and reproductive systems of animals. Numerous studies have demonstrated a regulatory role for Glutamate (Glu), d-aspartate ( d-Asp) and N-methyl- d-aspartate (NMDA) in the control of spermatogenesis. EAAs are able to stimulate the Glutamate receptors, incl...

journal_title：Journal of cellular biochemistry

authors： Santillo A,Falvo S,Di Fiore MM,Di Giacomo Russo F,Chieffi P,Usiello A,Pinelli C,Baccari GC

更新日期：2019-02-14 00:00:00

abstract：:By Western blot and immunostaining we proved that polyvinylpyrrolidone (PVP)-wrapped fullerene molecules (PVP-fullerene) could combine the 8- and 53-kb proteins which localize in the membrane of human skin keratinocytes HaCaT. Only fullerene molecules are able to cross the lipid membrane and conjugate 53-kb proteins i...

journal_title：Journal of cellular biochemistry

authors： Xiao L,Aoshima H,Saitoh Y,Miwa N

更新日期：2010-11-01 00:00:00

abstract：:We used non-insulin producing pancreatic carcinoma cell line, MIA PaCa-2 and have modulated its culture conditions by using 1% matrigel as extracellular matrix, N2, B27 growth supplements and serum free conditions. Expression of markers was analyzed using qRT-PCR, immunofluorescence and in vitro functional assay for i...

journal_title：Journal of cellular biochemistry

authors： Bose B,Shenoy P S

更新日期：2013-07-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) can participate in the pathological process of multiple myeloma (MM) via regulation of specific gene expression and function. This research aimed to study the role of MALAT-1 and the underlying mechanism in MM. In this study, the expression of MALAT-1 and HMGB1 protein in the bone marrow...

journal_title：Journal of cellular biochemistry

authors： Gao D,Lv AE,Li HP,Han DH,Zhang YP

更新日期：2017-10-01 00:00:00

abstract：:The myelin basic protein (MBP)-phosphorylating enzymes present during maturation and early embryogenesis of the sea star (Pisaster ochraceus) were investigated. The major maturation-activated MBP kinase (p45 Mapk) was molecularly cloned based on tryptic sequence information obtained with the purified enzyme and shown ...

journal_title：Journal of cellular biochemistry

authors： Lefebvre DL,Charest DL,Yee A,Crawford BJ,Pelech SL

更新日期：1999-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) play an important role in regulating angiogenesis and immune balance. The abnormal MSCs in proliferation and function were reported at maternal fetal interface in patients with pre-eclampsia (PE). Long non-coding RNA MALAT1 was known to regulate the function of trophoblast cells. However,...

journal_title：Journal of cellular biochemistry

authors： Li X,Song Y,Liu F,Liu D,Miao H,Ren J,Xu J,Ding L,Hu Y,Wang Z,Hou Y,Zhao G

更新日期：2017-09-01 00:00:00

abstract：:The retinoblastoma is the most common intraocular malignant tumor in infants and children; it is one of the deadliest forms of cancer due to its limited sensitivity to chemotherapy and radiotherapy. In several cancers, chemoresistance is associated with autophagy induction. Non-coding RNAs, including long non-coding R...

journal_title：Journal of cellular biochemistry

authors： Huang J,Yang Y,Fang F,Liu K

更新日期：2018-05-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the molecular pat...

journal_title：Journal of cellular biochemistry

authors： Ogata Y,Niisato N,Furuyama S,Cheifetz S,Kim RH,Sugiya H,Sodek J

更新日期：1997-06-15 00:00:00

abstract：:Diabetic retinopathy (DR) is a leading cause of adult visual impairment and loss. This study aims to explore the effects of microRNA-9 (miR-9) on retinal neovascularization during DR by targeting the vascular endothelial growth factor A (VEGFA). DR rat models were successfully established. Retinal microvascular endoth...

journal_title：Journal of cellular biochemistry

authors： Liu WL

更新日期：2018-11-28 00:00:00

abstract：:The effects of a ligand regulated neu tyrosine kinase were examined in NIH 3T3 cells. A chimeric construct encoding the human EGF receptor extracellular domain fused to the tyrosine kinase domain of the rat neu cDNA was expressed under the transcriptional control of the Moloney murine leukemia virus LTR promoter. This...

journal_title：Journal of cellular biochemistry

authors： Lehväslaiho H,Sistonen L,diRenzo F,Partanen J,Comoglio P,Hölttä E,Alitalo K

更新日期：1990-03-01 00:00:00

abstract：:Thrombin increases the cytosolic Ca(2+) concentrations and induces NO production by activating proteinase-activated receptor 1 (PAR(1)) in vascular endothelial cells. The store-operated Ca(2+) influx is a major Ca(2+) influx pathway in non-excitable cells including endothelial cells and it has been reported to play a ...

journal_title：Journal of cellular biochemistry

authors： Hirano K,Hirano M,Hanada A

更新日期：2009-10-01 00:00:00

abstract：:Published data indicate that the protease-activated receptor (PAR) 2 is involved in the pathogenesis of some cardiovascular diseases; the underlying mechanism is to be further investigated. Ve-cadherin is a critical molecule in maintaining the endothelial barrier integrity. This study aims to investigate the role of P...

journal_title：Journal of cellular biochemistry

authors： Zhang R,Ge J

更新日期：2017-12-01 00:00:00