Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma.

abstract：:Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

journal_title：Journal of cellular biochemistry

authors： Lee KM,Fung KP,Leung PC,Leung KS

更新日期：1996-03-15 00:00:00

abstract：:Electromagnetic field (EMF) exposures have been shown to induce heat shock proteins (HSPs), which help to maintain the conformation of cellular proteins during periods of stress. We have previously reported that short-term exposure of chick embryos to either 60 Hz (extremely low frequency: ELF), or radio-frequency (RF...

journal_title：Journal of cellular biochemistry

authors： Di Carlo A,White N,Guo F,Garrett P,Litovitz T

更新日期：2002-01-01 00:00:00

abstract：AIM:Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes-associated aortic endothelial dysfunction in a rat model of diabetes and its mec...

journal_title：Journal of cellular biochemistry

authors： Wang L,Li X,Zhang Y,Huang Y,Zhang Y,Ma Q

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Long noncoding RNA (lncRNA) is emerging as a vital regulator in various cancers. Recently, it was found that lncRNA colorectal neoplasia differentially expressed (CRNDE) plays an oncogenic role, promoting cell proliferation and migration in hepatocellular carcinoma (HCC). However, the underlying regulatory m...

journal_title：Journal of cellular biochemistry

authors： Tang D,Zhao L,Peng C,Ran K,Mu R,Ao Y

更新日期：2019-09-01 00:00:00

abstract：:We characterized a human cDNA clone encoding a 36-kDa carboxyl terminal LIM domain protein with a PDZ domain at the amino terminal. This full-length cDNA clone has a predicted open reading frame (ORF) of 329 amino-acid residues. The ORF of this cDNA encodes the human homolog of rat CLP36, and the putative protein is n...

journal_title：Journal of cellular biochemistry

authors： Kotaka M,Ngai SM,Garcia-Barcelo M,Tsui SK,Fung KP,Lee CY,Waye MM

更新日期：1999-02-01 00:00:00

abstract：:Lipopolysaccharide (LPS) released from gram-negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS-induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular...

journal_title：Journal of cellular biochemistry

authors： Tsai KD,Lee WX,Chen W,Chen BY,Chen KL,Hsiao TC,Wang SH,Lee YJ,Liang SY,Shieh JC,Lin TH

更新日期：2018-04-01 00:00:00

abstract：:The mitochondrial antioxidant enzyme Mn-Superoxide Dismutase (Sod2) is essential for mammalian survival. I82T mutation in human Sod2 has been linked to a wide variety of diseases, including Alzheimer's and Parkinson's diseases as well as some types of cancers. Yeast wild-type (WT) Sod2 and the mutant Sod2 I91T, which ...

journal_title：Journal of cellular biochemistry

authors： de Carvalho MD,De Mesquita JF,Eleutherio EC

更新日期：2017-05-01 00:00:00

abstract：:Vascular smooth-muscle cell (VSMC) proliferation plays a vital role in hypertension, atherosclerosis and restenosis. It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if emodin exerts similar anti-atherogenic effects in TNF-alpha...

journal_title：Journal of cellular biochemistry

authors： Heo SK,Yun HJ,Park WH,Park SD

更新日期：2008-09-01 00:00:00

abstract：:The major glycoproteins synthesized by human breast epithelial cells have been characterized [6,8]. The most consistently observed and prominent component in supernatants of organ cultures of breast surgical specimens and of MCF-7 cells was gp 68 which has been immunologically identified as alpha-1-antichymotrypsin (A...

journal_title：Journal of cellular biochemistry

authors： Gendler SJ,Tökés ZA

更新日期：1984-01-01 00:00:00

abstract：:One of the major problems in developmental biology concerns how differential gene activity is regionally controlled. One approach to this problem is the use of mesenchyme specification of epithelial-specific gene expression, such as, during tooth morphogenesis or lung morphogenesis. In the example of tooth morphogenes...

journal_title：Journal of cellular biochemistry

authors： Slavkin HC,Snead ML,Zeichner-David M,Jaskoll TF,Smith BT

更新日期：1984-01-01 00:00:00

abstract：:Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

journal_title：Journal of cellular biochemistry

authors： Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

更新日期：1996-06-01 00:00:00

abstract：:Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related si...

journal_title：Journal of cellular biochemistry

authors： Stein GS,Stein JL,Lian JB,van Wijnen AJ,Montecino M

更新日期：1996-08-01 00:00:00

abstract：:The low density lipoprotein receptor related protein-1 (LRP-1) is a cargo transport receptor that undergoes constitutive endocytosis and recycling. Platelet-derived growth factor-BB (PDGF-BB) binds to LRP-1 and may bridge LRP-1 to PDGF receptors. Bridging of LRP-1 to other receptors by bifunctional ligands may represe...

journal_title：Journal of cellular biochemistry

authors： Wu L,Arandjelovic S,Gonias SL

更新日期：2004-12-15 00:00:00

abstract：:Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive aldehydes, foremost of which is 4-hydroxy-2-nonenal (4HNE). 4HNE forms co...

journal_title：Journal of cellular biochemistry

authors： Pan G,Deshpande M,Pang H,Stemmer PM,Carruthers NJ,Shearn CT,Backos DS,Palaniyandi SS

更新日期：2020-07-06 00:00:00

abstract：:The present study aimed to determine the roles of miRNA-543 in osteoporosis in rats induced by ovariectomy. The osteoporosis rat model was established by ovariectomy induction. MiRNA-543 expression in osteoblasts was measured by quantitative real-time polymerase chain reaction. The cell proliferation and apoptosis wer...

journal_title：Journal of cellular biochemistry

authors： Li X,Ning L,Zhao X,Wan S

更新日期：2018-12-02 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) was reported to be involved in adipogenesis. However, the regulating mechanism of STAT3 remains unclear. The present results showed that STAT3 was activated within 2-h adipogenic induction, in which the phosphorylated STAT3 translocated from cytoplasm to the n...

journal_title：Journal of cellular biochemistry

authors： Zhang K,Guo W,Yang Y,Wu J

更新日期：2011-02-01 00:00:00

abstract：:Vascular smooth muscle cells (SMCs), the major cellular constituent of an artery, synthesize the bulk of fibrillar collagens, including type V/XI, which regulates heterotypic collagen fibril assembly. Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide growth factor that has been implicated in impor...

journal_title：Journal of cellular biochemistry

authors： Kypreos KE,Sonenshein GE

更新日期：1998-02-01 00:00:00

abstract：:Evidence is presented for the first time that the cytochrome P450XVII-catalysed androgen formation from progesterone (P) in rat testicular microsomal membranes represents a metabolic sequence that exhibits the ability of intrinsic regulation of intermediate transfer and product formation efficiency. Exposure of this s...

journal_title：Journal of cellular biochemistry

authors： Kühn-Velten WN

更新日期：1990-06-01 00:00:00

abstract：:In a previous study, we have shown that the gene promoter of a protein termed KIAA0082 is regulated by interferon and that this protein interacts with the RNA polymerase II. It has been subsequently shown that KIAA0082 is the human cap-specific messenger RNA (mRNA) (nucleoside-2'-O-)-methyltransferase 1 (hMTr1), which...

journal_title：Journal of cellular biochemistry

authors： Simabuco FM,Pavan ICB,Pestana NF,Carvalho PC,Basei FL,Campos Granato D,Paes Leme AF,Zanchin NIT

更新日期：2019-04-01 00:00:00

abstract：:The nucleolus is a multifunctional nuclear compartment widely known to be involved in several cellular processes, including mRNA maturation and shuttling to cytoplasmic sites, control of the cell cycle, cell proliferation, and apoptosis; thus, it is logical that many viruses, including herpesvirus, target the nucleolu...

journal_title：Journal of cellular biochemistry

authors： Arcangeletti MC,Rodighiero I,Mirandola P,De Conto F,Covan S,Germini D,Razin S,Dettori G,Chezzi C

更新日期：2011-01-01 00:00:00

abstract：:Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited. Human telomerase catalytic subunit (hTERT) gene transduction can prolong the life span of hMSCs and maintain their potential of osteogenic differ...

journal_title：Journal of cellular biochemistry

authors： Huang G,Zheng Q,Sun J,Guo C,Yang J,Chen R,Xu Y,Wang G,Shen D,Pan Z,Jin J,Wang J

更新日期：2008-03-01 00:00:00

abstract：:Fibrosis, the deadly pathological manifestation of an abnormal tissue remodeling in any organ due to excessive collagen deposition, is associated with a wide variety of organ failure-related human diseases. Chronic stress or repeated injury in a particular organ induces abnormal molecular signals that lead to super-ac...

journal_title：Journal of cellular biochemistry

authors： Ghosh AK

更新日期：2014-09-01 00:00:00

abstract：:Extracellular matrix accumulation and fibrosis are the features of diabetic nephropathy. PI3K (phosphatidylinositol 3-kinase)/Akt (protein kinase B) signal pathway and its inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome 10) are revealed to modulate renal fibrosis. However, the exact mechanism is s...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Zhao S,Liu S,Liu Q,Li F,Hao J

更新日期：2016-05-01 00:00:00

abstract：:We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

journal_title：Journal of cellular biochemistry

authors： Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

更新日期：2017-12-01 00:00:00

abstract：:Oxoglutarate receptor 1 (OXGR1), as one of the intermediates in G protein-coupled receptors (GPCRs), plays a crucial role in the citric acid cycle receptor of α-ketoglutarate and metabolism. GPCR can control the cell proliferation by regulating the downstream signaling of G protein signaling pathways. The PI3K/AKT pat...

journal_title：Journal of cellular biochemistry

authors： Wang Q,Zhang Q,Zhang Y,Zhao X

更新日期：2019-04-01 00:00:00

abstract：:Phosphoinositides (PIs) and proteins involved in the PI signaling pathway are distributed in the nucleus as well as at the plasma membrane and in the cytoplasm, although their nuclear localization mechanisms have not been clarified in detail. Generally, proteins that shuttle between the cytoplasm and nucleus contain n...

journal_title：Journal of cellular biochemistry

authors： Yagisawa H

更新日期：2006-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) were once viewed only as mediators of toxicity, but it is now recognized that they also contribute to redox signaling through oxidation of specific cysteine thiols on regulatory proteins. Cells in sparse cultures have increased ROS relative to confluent cultures, but it is not known wheth...

journal_title：Journal of cellular biochemistry

authors： Spielberger JC,Moody AD,Watson WH

更新日期：2008-08-01 00:00:00

abstract：:Dystrophin and utrophin are known to link the intracellular cytoskeleton to the extracellular matrix via a transmembraneous glycoprotein complex. Four short C-terminal isoforms (Dp71, Dp116, Dp140, and Dp260) are described for dystrophin and three for utrophin (Up71, Up113, and Up140). We describe here for the first t...

journal_title：Journal of cellular biochemistry

authors： Zuellig RA,Bornhauser BC,Knuesel I,Heller F,Fritschy JM,Schaub MC

更新日期：2000-04-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully ortho-substituted PCB, 2,2',6,6'-tetrachlorobiphenyl (2,2',6,6'-TeCB). ...

journal_title：Journal of cellular biochemistry

authors： Arcaro KF,Yi L,Seegal RF,Vakharia DD,Yang Y,Spink DC,Brosch K,Gierthy JF

更新日期：1999-01-01 00:00:00

abstract：:Rat CYP1A1 promoter-luciferase, transiently transfected wild-type and 4S PAH receptor (glycine N-methyl transferase, GNMT)-transformed Chinese hamster ovary (CHO) cells were exposed to benzo[a]pyrene and assayed for luciferase activity as an indicator of CYP1A1 promoter activity. CHO cells transformed with the rat 4S ...

journal_title：Journal of cellular biochemistry

authors： Sterling KM

更新日期：2011-08-01 00:00:00